{"id":"https://openalex.org/W3082231834","doi":null,"title":"Towards Safe Genome Editing and Rapid Disease Detection: Deep Bayesian Active Learning for Model-Driven CRISPR Guide Design","display_name":"Towards Safe Genome Editing and Rapid Disease Detection: Deep Bayesian Active Learning for Model-Driven CRISPR Guide Design","publication_year":2020,"publication_date":"2020-06-18","ids":{"openalex":"https://openalex.org/W3082231834","mag":"3082231834"},"language":"en","primary_location":{"id":"pmh:oai:dash.harvard.edu:1/37364719","doi":null,"is_oa":false,"landing_page_url":"https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37364719","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030721728","display_name":"Neil Band","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Neil Band","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5030721728"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bayesian-neural-networks","display_name":"Bayesian neural networks","score":0.8669999837875366},{"id":"https://openalex.org/keywords/crispr-cas-systems","display_name":"CRISPR-Cas","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cas13","display_name":"Cas13","score":0.9089999794960022},{"id":"https://openalex.org/keywords/sars-cov-2-detection","display_name":"COVID-19 detection","score":0.9959999918937683},{"id":"https://openalex.org/keywords/genome-editing-safety","display_name":"genome editing safety","score":0.5879999995231628},{"id":"https://openalex.org/keywords/data-scarcity","display_name":"data scarcity","score":0.6650000214576721},{"id":"https://openalex.org/keywords/disease-detection","display_name":"disease detection","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.8992327451705933},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.6659759283065796},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5244938731193542},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5186449885368347},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.45162007212638855},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3836058974266052},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.37981724739074707},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3751642107963562},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2685592770576477},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17755168676376343},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15208697319030762}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dash.harvard.edu:1/37364719","doi":null,"is_oa":false,"landing_page_url":"https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37364719","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},{"id":"mag:3082231834","doi":null,"is_oa":false,"landing_page_url":"https://dash.harvard.edu/handle/1/37364719","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1498373892","https://openalex.org/W1516111018","https://openalex.org/W1567512734","https://openalex.org/W1580375566","https://openalex.org/W1678356000","https://openalex.org/W1995875735","https://openalex.org/W2016381774","https://openalex.org/W2031594487","https://openalex.org/W2040665850","https://openalex.org/W2054931730","https://openalex.org/W2101234009","https://openalex.org/W2103143546","https://openalex.org/W2110399041","https://openalex.org/W2124715997","https://openalex.org/W2124741347","https://openalex.org/W2140658947","https://openalex.org/W2143726250","https://openalex.org/W2153350094","https://openalex.org/W2168909179","https://openalex.org/W2188338489","https://openalex.org/W2252568502","https://openalex.org/W2342249984","https://openalex.org/W2409671300","https://openalex.org/W2604763608","https://openalex.org/W2781417302","https://openalex.org/W2782551527","https://openalex.org/W2809368523","https://openalex.org/W2899807648","https://openalex.org/W2900803462","https://openalex.org/W2911964244","https://openalex.org/W2949071206","https://openalex.org/W2951061410","https://openalex.org/W2951595529","https://openalex.org/W2963341956","https://openalex.org/W2964573658","https://openalex.org/W2973312556"],"related_works":["https://openalex.org/W7203573789","https://openalex.org/W4415988392","https://openalex.org/W4297101338","https://openalex.org/W4406260259","https://openalex.org/W4412366549","https://openalex.org/W3084530934","https://openalex.org/W2782551527","https://openalex.org/W4224255906","https://openalex.org/W7165203802","https://openalex.org/W4414430442"],"abstract_inverted_index":{"Scientists":[0],"use":[1],"genome":[2,38,127],"editing":[3,39],"tools":[4],"\u2013":[5,14,117,125],"nucleases":[6],"which":[7,120,193],"cut":[8],"genetic":[9,32],"material":[10],"at":[11],"targeted":[12],"locations":[13],"to":[15,18,47,52,77,149,156],"associate":[16],"genes":[17],"diseases,":[19],"detect":[20],"viruses,":[21],"and":[22,62,101,154,177],"engineer":[23],"agriculture,":[24],"with":[25,147,161],"the":[26,53,60,109,135,141,184],"future":[27],"goal":[28],"of":[29,64,88,104,112,134,187],"correcting":[30],"human":[31,196],"disorders.":[33],"CRISPR-Cas":[34,65,89,138],"systems":[35],"enable":[36],"cheap":[37,176],"using":[40,73,96],"a":[41,49,74,82,99,118],"synthesized":[42],"ribonucleic":[43],"acid":[44],"(RNA)":[45],"guide":[46,92,169],"direct":[48],"Cas":[50],"nuclease":[51],"desired":[54],"cutsite.":[55],"\u201cGuide":[56],"design\u201d":[57],"procedures":[58],"improve":[59,167],"accuracy":[61,143,160],"safety":[63],"interventions":[66],"by":[67],"selecting":[68],"promising":[69],"candidate":[70],"RNA":[71],"guides":[72],"computational":[75],"model":[76],"predict":[78],"outcomes":[79],"based":[80],"on":[81,132],"training":[83,202],"dataset.":[84,203],"The":[85],"small":[86],"size":[87],"datasets":[90],"discourages":[91],"design":[93],"researchers":[94],"from":[95],"neural":[97,114],"networks,":[98],"powerful":[100],"data-hungry":[102],"class":[103],"models.":[105],"This":[106,181],"thesis":[107],"presents":[108],"first":[110,185],"application":[111],"Bayesian":[113],"networks":[115],"(BNNs)":[116],"variant":[119],"better":[121],"handles":[122],"data":[123,153],"scarcity":[124],"in":[126,172,192,198],"editing.":[128],"BNNs":[129,164,194],"are":[130],"applied":[131],"two":[133],"world\u2019s":[136],"largest":[137],"datasets,":[139],"achieving":[140],"same":[142],"as":[144],"state-of-the-art":[145],"approaches":[146],"up":[148,155],"141":[150],"times":[151],"less":[152],"37%":[157],"higher":[158],"relative":[159],"equal":[162],"data.":[163],"can":[165],"readily":[166],"CRISPR":[168,189],"design,":[170,191],"including":[171],"Cas13":[173],"protocols":[174],"for":[175],"rapid":[178],"SARS-CoV-2":[179],"detection.":[180],"work":[182],"demonstrates":[183],"instance":[186],"computer-driven":[188],"experiment":[190],"outperform":[195],"expertise":[197],"building":[199],"an":[200],"effective":[201]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2020-09-08T00:00:00"}