{"id":"https://openalex.org/W3082199857","doi":"https://doi.org/10.1038/s41598-020-71347-6","title":"Quantifying drug tissue biodistribution by integrating high content screening with deep-learning analysis","display_name":"Quantifying drug tissue biodistribution by integrating high content screening with deep-learning analysis","publication_year":2020,"publication_date":"2020-09-01","ids":{"openalex":"https://openalex.org/W3082199857","doi":"https://doi.org/10.1038/s41598-020-71347-6","mag":"3082199857","pmid":"https://pubmed.ncbi.nlm.nih.gov/32873881","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7463244"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-020-71347-6","doi":"https://doi.org/10.1038/s41598-020-71347-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-71347-6","pdf_url":"https://www.nature.com/articles/s41598-020-71347-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-020-71347-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065730749","display_name":"Zhuyin Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhuyin Li","raw_affiliation_strings":["Lead Discovery and Optimization, Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ, 08540, USA. Zhuyin.Li@bms.com","Lead Discovery and Optimization, Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ, 08540, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lead Discovery and Optimization, Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ, 08540, USA. Zhuyin.Li@bms.com","institution_ids":["https://openalex.org/I4210091812"]},{"raw_affiliation_string":"Lead Discovery and Optimization, Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ, 08540, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062270520","display_name":"Youping Xiao","orcid":"https://orcid.org/0000-0003-3954-3443","observed_orcids":["https://orcid.org/0000-0003-3954-3443"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youping Xiao","raw_affiliation_strings":["Information Technology for R&D, Bristol-Myers Squibb, Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Information Technology for R&D, Bristol-Myers Squibb, Princeton, NJ, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106184988","display_name":"Jia Peng","orcid":"https://orcid.org/0009-0008-6947-0373","observed_orcids":["https://orcid.org/0009-0008-6947-0373"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jia Peng","raw_affiliation_strings":["Lead Discovery and Optimization, Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ, 08540, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lead Discovery and Optimization, Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ, 08540, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111644750","display_name":"Darren Locke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darren Locke","raw_affiliation_strings":["Translational Medicine, Bristol-Myers Squibb, Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Medicine, Bristol-Myers Squibb, Princeton, NJ, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030069866","display_name":"Derek Holmes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek Holmes","raw_affiliation_strings":["Immunoscience Biology Discovery, Bristol-Myers Squibb, Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Biology Discovery, Bristol-Myers Squibb, Princeton, NJ, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100440421","display_name":"Lei Li","orcid":"https://orcid.org/0000-0003-4228-2096","observed_orcids":["https://orcid.org/0000-0003-4228-2096"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Li","raw_affiliation_strings":["Lead Discovery and Optimization, Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ, 08540, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lead Discovery and Optimization, Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ, 08540, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042424742","display_name":"Shannon M. Hamilton","orcid":"https://orcid.org/0000-0003-3324-854X","observed_orcids":["https://orcid.org/0000-0003-3324-854X"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon Hamilton","raw_affiliation_strings":["Lead Discovery and Optimization, Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ, 08540, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lead Discovery and Optimization, Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ, 08540, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112551119","display_name":"Erica M. Cook","orcid":"https://orcid.org/0009-0001-2315-1392","observed_orcids":["https://orcid.org/0009-0001-2315-1392"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erica Cook","raw_affiliation_strings":["Lead Discovery and Optimization, Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ, 08540, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lead Discovery and Optimization, Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ, 08540, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045578196","display_name":"Larnie Myer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larnie Myer","raw_affiliation_strings":["Lead Discovery and Optimization, Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ, 08540, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lead Discovery and Optimization, Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ, 08540, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032012119","display_name":"Dana E. Vanderwall","orcid":"https://orcid.org/0000-0003-1076-8788","observed_orcids":["https://orcid.org/0000-0003-1076-8788"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dana Vanderwall","raw_affiliation_strings":["Information Technology for R&D, Bristol-Myers Squibb, Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Information Technology for R&D, Bristol-Myers Squibb, Princeton, NJ, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021372154","display_name":"Normand J. Cloutier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Normand Cloutier","raw_affiliation_strings":["Information Technology for R&D, Bristol-Myers Squibb, Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Information Technology for R&D, Bristol-Myers Squibb, Princeton, NJ, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111433294","display_name":"Akbar M. Siddiqui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akbar M. Siddiqui","raw_affiliation_strings":["Information Technology for R&D, Bristol-Myers Squibb, Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Information Technology for R&D, Bristol-Myers Squibb, Princeton, NJ, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Paul Whitehead","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Whitehead","raw_affiliation_strings":["Information Technology for R&D, Bristol-Myers Squibb, Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Information Technology for R&D, Bristol-Myers Squibb, Princeton, NJ, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Richard Bishop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Bishop","raw_affiliation_strings":["Information Technology for R&D, Bristol-Myers Squibb, Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Information Technology for R&D, Bristol-Myers Squibb, Princeton, NJ, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344069","display_name":"Lei Zhao","orcid":"https://orcid.org/0000-0003-2524-7643","observed_orcids":["https://orcid.org/0000-0003-2524-7643"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Zhao","raw_affiliation_strings":["Cardiovascular Translational Research, Bristol-Myers Squibb, Hopewell, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Translational Research, Bristol-Myers Squibb, Hopewell, NJ, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073504315","display_name":"Mary Ellen Cvijic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Ellen Cvijic","raw_affiliation_strings":["Lead Discovery and Optimization, Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ, 08540, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lead Discovery and Optimization, Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ, 08540, USA","institution_ids":["https://openalex.org/I4210091812"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065730749"],"corresponding_institution_ids":["https://openalex.org/I4210091812"],"apc_list":{"value":1870,"currency":"USD","value_usd":1870},"apc_paid":{"value":1870,"currency":"USD","value_usd":1870},"fwci":0.1189,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.41200129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"10","issue":"1","first_page":"14408","last_page":"14408"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-content-screening","display_name":"high-content screening","score":0.8420000076293945},{"id":"https://openalex.org/keywords/deep-learning-image-analysis","display_name":"deep learning image analysis","score":0.890999972820282},{"id":"https://openalex.org/keywords/u-net","display_name":"U-Net","score":0.9819999933242798},{"id":"https://openalex.org/keywords/target-engagement","display_name":"target engagement","score":0.8180000185966492},{"id":"https://openalex.org/keywords/drug-binding-kinetics","display_name":"drug binding kinetics","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cellular-resolution-imaging","display_name":"cellular resolution imaging","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.7013368606567383},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6530858278274536},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6221513152122498},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5346665978431702},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5221355557441711},{"id":"https://openalex.org/C3019775314","wikidata":"https://www.wikidata.org/wiki/Q1781748","display_name":"Tissue distribution","level":2,"score":0.4802044630050659},{"id":"https://openalex.org/C157044486","wikidata":"https://www.wikidata.org/wiki/Q5754482","display_name":"High-content screening","level":3,"score":0.4190237820148468},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.39395594596862793},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.27989059686660767},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27969130873680115},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23910030722618103},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21886789798736572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1851661503314972},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.08757662773132324},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.07676753401756287},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06908208131790161},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002232","descriptor_name":"Carbocyanines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41598-020-71347-6","doi":"https://doi.org/10.1038/s41598-020-71347-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-71347-6","pdf_url":"https://www.nature.com/articles/s41598-020-71347-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7463244","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7463244","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:32873881","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32873881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41598-020-71347-6","doi":"https://doi.org/10.1038/s41598-020-71347-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-71347-6","pdf_url":"https://www.nature.com/articles/s41598-020-71347-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3082199857.pdf","grobid_xml":"https://content.openalex.org/works/W3082199857.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1964746150","https://openalex.org/W1993251792","https://openalex.org/W2029263147","https://openalex.org/W2042907121","https://openalex.org/W2067001382","https://openalex.org/W2087914076","https://openalex.org/W2122767035","https://openalex.org/W2141273399","https://openalex.org/W2191637929","https://openalex.org/W2415944105","https://openalex.org/W2460600979","https://openalex.org/W2559470805","https://openalex.org/W2592929672","https://openalex.org/W2606209624","https://openalex.org/W2606318636","https://openalex.org/W2783441257","https://openalex.org/W2787340517","https://openalex.org/W2899243736","https://openalex.org/W2900936384","https://openalex.org/W2905502540"],"related_works":["https://openalex.org/W4408665721","https://openalex.org/W6903597093","https://openalex.org/W2169493789","https://openalex.org/W4376109312","https://openalex.org/W4292442903","https://openalex.org/W2559470805","https://openalex.org/W2109126584","https://openalex.org/W2604816084","https://openalex.org/W7155186515","https://openalex.org/W2409411856"],"abstract_inverted_index":{"Quantitatively":[0],"determining":[1],"in":[2,7,52,81],"vivo":[3],"achievable":[4],"drug":[5,22,35,50,79,93],"concentrations":[6],"targeted":[8,82],"organs":[9],"of":[10,29,77],"animal":[11],"models":[12],"and":[13,24,45,75],"subsequent":[14],"target":[15],"engagement":[16],"confirmation":[17],"is":[18],"a":[19,43],"challenge":[20],"to":[21,27,48,90],"discovery":[23],"translation":[25],"due":[26],"lack":[28],"bioassay":[30],"technologies":[31],"that":[32],"can":[33],"discriminate":[34],"binding":[36,80,94],"with":[37,60,84],"different":[38],"mechanisms.":[39],"We":[40],"have":[41],"developed":[42],"multiplexed":[44],"high-throughput":[46],"method":[47],"quantify":[49],"distribution":[51],"tissues":[53,83],"by":[54],"integrating":[55],"high":[56],"content":[57],"screening":[58],"(HCS)":[59],"U-Net":[61],"based":[62],"deep":[63],"learning":[64],"(DL)":[65],"image":[66],"analysis":[67],"models.":[68],"This":[69],"technology":[70],"combination":[71],"allowed":[72],"direct":[73],"visualization":[74],"quantification":[76],"biologics":[78],"cellular":[85],"resolution,":[86],"thus":[87],"enabling":[88],"biologists":[89],"objectively":[91],"determine":[92],"kinetics.":[95]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-09-08T00:00:00"}