{"id":"https://openalex.org/W3082060955","doi":null,"title":"Memory-Related Electrophysiological Alterations in Rodent Models of Aging and Parkinson's Disease","display_name":"Memory-Related Electrophysiological Alterations in Rodent Models of Aging and Parkinson's Disease","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3082060955","mag":"3082060955"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/641728","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10150/641728","pdf_url":"https://repository.arizona.edu/bitstream/10150/641728/1/azu_etd_17952_sip1_m.pdf","source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repository.arizona.edu/bitstream/10150/641728/1/azu_etd_17952_sip1_m.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034494156","display_name":"Lindsey M. Crown","orcid":"https://orcid.org/0000-0003-3166-8065","observed_orcids":["https://orcid.org/0000-0003-3166-8065"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lindsey Crown","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3166-8065","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5034494156"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.5659000277519226,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.5659000277519226,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.36649999022483826,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.859000027179718},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.843999981880188},{"id":"https://openalex.org/keywords/memory","display_name":"memory","score":0.8610000014305115},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7360000014305115},{"id":"https://openalex.org/keywords/high-gamma-oscillations","display_name":"high-gamma oscillations","score":0.7900000214576721},{"id":"https://openalex.org/keywords/theta-oscillations","display_name":"theta oscillations","score":0.8180000185966492},{"id":"https://openalex.org/keywords/theta-gamma-coupling","display_name":"theta-gamma coupling","score":0.984000027179718},{"id":"https://openalex.org/keywords/single-unit-activity","display_name":"single-unit activity","score":0.7860000133514404},{"id":"https://openalex.org/keywords/eyeblink-conditioning","display_name":"eyeblink conditioning","score":0.871999979019165},{"id":"https://openalex.org/keywords/sleep-spindles","display_name":"sleep spindles","score":0.8949999809265137},{"id":"https://openalex.org/keywords/sleep-fragmentation","display_name":"sleep fragmentation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/prodromal-parkinson-s-disease","display_name":"prodromal Parkinson's disease","score":0.9729999899864197},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7670000195503235},{"id":"https://openalex.org/keywords/rodent-models","display_name":"rodent models","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5850726366043091},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5670539140701294},{"id":"https://openalex.org/C2992558993","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Rodent model","level":2,"score":0.552241861820221},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5479320883750916},{"id":"https://openalex.org/C2778914748","wikidata":"https://www.wikidata.org/wiki/Q10850","display_name":"Rodent","level":2,"score":0.5114368200302124},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.46655791997909546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.402274489402771},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3704889416694641},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2873331308364868},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.140935480594635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09867662191390991},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/641728","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10150/641728","pdf_url":"https://repository.arizona.edu/bitstream/10150/641728/1/azu_etd_17952_sip1_m.pdf","source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},{"id":"mag:3082060955","doi":null,"is_oa":false,"landing_page_url":"https://repository.arizona.edu/handle/10150/641728","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repository.arizona.edu:10150/641728","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10150/641728","pdf_url":"https://repository.arizona.edu/bitstream/10150/641728/1/azu_etd_17952_sip1_m.pdf","source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3082060955.pdf","grobid_xml":"https://content.openalex.org/works/W3082060955.grobid-xml"},"referenced_works_count":197,"referenced_works":["https://openalex.org/W1033515320","https://openalex.org/W1449283962","https://openalex.org/W1527671059","https://openalex.org/W1541267199","https://openalex.org/W1572294349","https://openalex.org/W1585564530","https://openalex.org/W1586971759","https://openalex.org/W1592793902","https://openalex.org/W1606916117","https://openalex.org/W1630370318","https://openalex.org/W1653233231","https://openalex.org/W1770958704","https://openalex.org/W1803658430","https://openalex.org/W1851069093","https://openalex.org/W1956450144","https://openalex.org/W1964063865","https://openalex.org/W1967659552","https://openalex.org/W1969608755","https://openalex.org/W1969769253","https://openalex.org/W1970476580","https://openalex.org/W1970792572","https://openalex.org/W1971603645","https://openalex.org/W1973275441","https://openalex.org/W1975221291","https://openalex.org/W1976211348","https://openalex.org/W1977261578","https://openalex.org/W1978178248","https://openalex.org/W1978250666","https://openalex.org/W1980751276","https://openalex.org/W1983540839","https://openalex.org/W1984532469","https://openalex.org/W1985858442","https://openalex.org/W1986409253","https://openalex.org/W1987095365","https://openalex.org/W1987662024","https://openalex.org/W1988404208","https://openalex.org/W1988407393","https://openalex.org/W1992104307","https://openalex.org/W1992365739","https://openalex.org/W1992510645","https://openalex.org/W1992715287","https://openalex.org/W1994218329","https://openalex.org/W1994583626","https://openalex.org/W1995540943","https://openalex.org/W1996552582","https://openalex.org/W1996867714","https://openalex.org/W1997144195","https://openalex.org/W1997673335","https://openalex.org/W1998581719","https://openalex.org/W1999027550","https://openalex.org/W2003326720","https://openalex.org/W2004725045","https://openalex.org/W2007037349","https://openalex.org/W2008887903","https://openalex.org/W2009114889","https://openalex.org/W2011678579","https://openalex.org/W2011894996","https://openalex.org/W2011974449","https://openalex.org/W2012087458","https://openalex.org/W2013651116","https://openalex.org/W2015822488","https://openalex.org/W2018144108","https://openalex.org/W2018739299","https://openalex.org/W2019006980","https://openalex.org/W2019970707","https://openalex.org/W2021417436","https://openalex.org/W2026884117","https://openalex.org/W2028054593","https://openalex.org/W2031740174","https://openalex.org/W2032223790","https://openalex.org/W2033134445","https://openalex.org/W2033485203","https://openalex.org/W2034110754","https://openalex.org/W2034208007","https://openalex.org/W2036987600","https://openalex.org/W2037628926","https://openalex.org/W2037897058","https://openalex.org/W2040810583","https://openalex.org/W2042911407","https://openalex.org/W2043476900","https://openalex.org/W2044908785","https://openalex.org/W2047701363","https://openalex.org/W2048734012","https://openalex.org/W2052151896","https://openalex.org/W2054347272","https://openalex.org/W2055632128","https://openalex.org/W2056061278","https://openalex.org/W2057470835","https://openalex.org/W2059110708","https://openalex.org/W2060841481","https://openalex.org/W2060961647","https://openalex.org/W2062205907","https://openalex.org/W2062678263","https://openalex.org/W2063103417","https://openalex.org/W2067065650","https://openalex.org/W2067765425","https://openalex.org/W2067944500","https://openalex.org/W2071290167","https://openalex.org/W2073461351","https://openalex.org/W2073630554","https://openalex.org/W2076327464","https://openalex.org/W2077614198","https://openalex.org/W2079363143","https://openalex.org/W2084588382","https://openalex.org/W2086162146","https://openalex.org/W2089530363","https://openalex.org/W2090315560","https://openalex.org/W2090348107","https://openalex.org/W2095492977","https://openalex.org/W2096347054","https://openalex.org/W2103032521","https://openalex.org/W2106935171","https://openalex.org/W2108531483","https://openalex.org/W2109955875","https://openalex.org/W2112575160","https://openalex.org/W2117503265","https://openalex.org/W2118168358","https://openalex.org/W2118587435","https://openalex.org/W2119051448","https://openalex.org/W2120127728","https://openalex.org/W2120852168","https://openalex.org/W2123714584","https://openalex.org/W2125737923","https://openalex.org/W2127274478","https://openalex.org/W2127389037","https://openalex.org/W2129356785","https://openalex.org/W2133488570","https://openalex.org/W2138223008","https://openalex.org/W2140826149","https://openalex.org/W2142864695","https://openalex.org/W2143662434","https://openalex.org/W2147496694","https://openalex.org/W2148201341","https://openalex.org/W2149615516","https://openalex.org/W2150857753","https://openalex.org/W2151528679","https://openalex.org/W2152372327","https://openalex.org/W2154262526","https://openalex.org/W2156959507","https://openalex.org/W2162013747","https://openalex.org/W2163770201","https://openalex.org/W2165031188","https://openalex.org/W2165130941","https://openalex.org/W2165730296","https://openalex.org/W2168487749","https://openalex.org/W2169473035","https://openalex.org/W2170430044","https://openalex.org/W2170656454","https://openalex.org/W2170972933","https://openalex.org/W2171668474","https://openalex.org/W2171776652","https://openalex.org/W2171826208","https://openalex.org/W2272666074","https://openalex.org/W2278064701","https://openalex.org/W2278616881","https://openalex.org/W2331977546","https://openalex.org/W2338210172","https://openalex.org/W2341812673","https://openalex.org/W2408417715","https://openalex.org/W2465591226","https://openalex.org/W2471911977","https://openalex.org/W2502954110","https://openalex.org/W2506612060","https://openalex.org/W2565156473","https://openalex.org/W2579604288","https://openalex.org/W2588958279","https://openalex.org/W2593308454","https://openalex.org/W2596654147","https://openalex.org/W2598477514","https://openalex.org/W2600811334","https://openalex.org/W2604294741","https://openalex.org/W2729250854","https://openalex.org/W2742044901","https://openalex.org/W2755670910","https://openalex.org/W2759570583","https://openalex.org/W2764433274","https://openalex.org/W2771688344","https://openalex.org/W2782386430","https://openalex.org/W2782430004","https://openalex.org/W2783710930","https://openalex.org/W2790646998","https://openalex.org/W2794377268","https://openalex.org/W2811255424","https://openalex.org/W2881486088","https://openalex.org/W2883053634","https://openalex.org/W2893109289","https://openalex.org/W2898268489","https://openalex.org/W2901519529","https://openalex.org/W2910527970","https://openalex.org/W2921561422","https://openalex.org/W2922209022","https://openalex.org/W2943260565","https://openalex.org/W2963486632","https://openalex.org/W2980920153","https://openalex.org/W4211123396","https://openalex.org/W4246364355","https://openalex.org/W7099038674"],"related_works":["https://openalex.org/W3081811149","https://openalex.org/W2324500457","https://openalex.org/W2197100519","https://openalex.org/W2519756114","https://openalex.org/W2338286399","https://openalex.org/W4225101457","https://openalex.org/W4399756373","https://openalex.org/W2767126573","https://openalex.org/W2789388911","https://openalex.org/W2939902608"],"abstract_inverted_index":{"As":[0],"the":[1,7,12,23,163,169,310,328],"population":[2],"grows":[3],"and":[4,62,88,99,103,110,118,145,191,241,281,288,337],"lifespan":[5],"increases,":[6],"need":[8],"to":[9,47,55,80,106,137,183,194,212,278],"better":[10,56,76],"understand":[11,57],"normative":[13],"aging":[14,33,61,87],"process":[15],"also":[16,40],"increases.":[17],"Furthermore,":[18],"with":[19,162,335],"these":[20,270],"global":[21],"changes,":[22],"number":[24],"of":[25,31,65,86,155,165,175,207,252,260,266,306,320],"people":[26],"who":[27],"suffer":[28],"from":[29],"diseases":[30],"pathological":[32,338],"such":[34],"as":[35,122,302],"Parkinson\u2019s":[36],"disease":[37],"(PD)":[38],"will":[39],"grow.":[41],"In-vivo":[42],"electrophysiology":[43],"provides":[44],"a":[45,125,172,195,204,222,247,263],"way":[46],"look":[48],"at":[49,75],"real-time":[50],"brain":[51],"dynamics":[52],"in":[53,60,70,83,178,188,227,246,283,293,313],"order":[54],"network":[58,119,228,321],"alterations":[59,322],"discover":[63],"biomarkers":[64,305],"disease.":[66],"The":[67,90,234],"studies":[68],"described":[69],"this":[71,314],"thesis":[72,315],"are":[73,114,244],"aimed":[74],"understanding":[77],"electrophysiological":[78,318],"changes":[79],"memory":[81],"systems":[82],"rodent":[84],"models":[85],"PD.":[89,255,268,308],"first":[91],"study":[92,236],"examines":[93,237],"how":[94,238],"hippocampal":[95],"low":[96],"gamma":[97,101,143,185,214,226],"(30-55Hz)":[98],"high":[100,184,213,225],"(65-90Hz),":[102],"their":[104],"relationship":[105],"single":[107],"unit":[108],"activity":[109,186,276],"theta":[111,134,141],"(6-9Hz)":[112],"oscillations,":[113],"modulated":[115],"by":[116],"age":[117],"instability":[120],"(remapping)":[121],"rats":[123,202],"perform":[124],"spatial":[126],"eye-blink":[127,166],"conditioning":[128],"task.":[129],"Aged":[130],"animals":[131,180],"showed":[132,258,272],"decreased":[133],"frequency":[135],"compared":[136,277],"young":[138,189],"animals,":[139,190],"but":[140],"power,":[142,144],"theta-gamma":[146],"coupling":[147,159],"did":[148],"not":[149],"differ":[150],"between":[151],"groups.":[152],"Overall":[153],"measures":[154],"session":[156],"theta-phase":[157],"gamma-amplitude":[158],"were":[160,181,192,210,286],"correlated":[161],"strength":[164],"conditioning.":[167],"At":[168],"single-unit":[170],"level,":[171],"higher":[173],"proportion":[174,206],"principal":[176,208],"cells":[177,209],"aged":[179],"phase-locked":[182,193],"than":[187,215,291],"greater":[196],"extent.":[197],"Finally,":[198],"on":[199,216],"days":[200],"when":[201],"remapped,":[203],"lower":[205],"locked":[211],"stable":[217],"days.":[218],"These":[219,295],"results":[220],"suggest":[221],"role":[223],"for":[224],"stability":[229],"or":[230],"age-related":[231],"compensatory":[232],"mechanisms.":[233],"second":[235],"sleep":[239,242,274,300],"behavior":[240],"spindles":[243,282,301],"altered":[245,273],"LRRK2-G2019S":[248],"knock-in":[249],"mouse":[250],"model":[251],"prodromal":[253,267,304],"genetic":[254],"G2019S":[256,284],"mice":[257,271,285],"patterns":[259],"fragmented":[261],"sleep,":[262],"common":[264],"feature":[265],"Additionally,":[269],"spindle":[275],"wild-type":[279],"controls,":[280],"longer":[287],"more":[289],"frequent":[290],"those":[292],"controls.":[294],"differences":[296],"may":[297,324],"point":[298],"towards":[299],"potential":[303,317],"LRRK2":[307],"Together":[309],"data":[311],"presented":[312],"reveal":[316],"signatures":[319],"that":[323],"provide":[325],"insights":[326],"into":[327],"neurobiological":[329],"mechanisms":[330],"underlying":[331],"cognitive":[332],"deficits":[333],"associated":[334],"normal":[336],"aging.":[339]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-09-08T00:00:00"}