{"id":"https://openalex.org/W3082060010","doi":"https://doi.org/10.1126/scitranslmed.abb3774","title":"C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy","display_name":"C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy","publication_year":2020,"publication_date":"2020-09-02","ids":{"openalex":"https://openalex.org/W3082060010","doi":"https://doi.org/10.1126/scitranslmed.abb3774","mag":"3082060010","pmid":"https://pubmed.ncbi.nlm.nih.gov/32878979","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7989020"},"language":"en","primary_location":{"id":"doi:10.1126/scitranslmed.abb3774","doi":"https://doi.org/10.1126/scitranslmed.abb3774","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.abb3774","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7989020","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032571276","display_name":"Casey N. Cook","orcid":"https://orcid.org/0000-0002-5963-8442","observed_orcids":["https://orcid.org/0000-0002-5963-8442"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Casey N. Cook","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN 55902, USA"],"raw_orcid":"https://orcid.org/0000-0002-5963-8442","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN 55902, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063285419","display_name":"Yanwei Wu","orcid":"https://orcid.org/0000-0001-7474-3470","observed_orcids":["https://orcid.org/0000-0001-7474-3470"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yanwei Wu","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA"],"raw_orcid":"https://orcid.org/0000-0001-7474-3470","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042257929","display_name":"Hana M. Odeh","orcid":"https://orcid.org/0000-0002-2164-7925","observed_orcids":["https://orcid.org/0000-0002-2164-7925"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hana M. Odeh","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"],"raw_orcid":"https://orcid.org/0000-0002-2164-7925","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086394733","display_name":"Tania F. Gendron","orcid":"https://orcid.org/0000-0002-7335-2627","observed_orcids":["https://orcid.org/0000-0002-7335-2627"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tania F. Gendron","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN 55902, USA"],"raw_orcid":"https://orcid.org/0000-0002-7335-2627","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN 55902, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023325412","display_name":"Karen R. Jansen\u2010West","orcid":"https://orcid.org/0000-0002-1234-7103","observed_orcids":["https://orcid.org/0000-0002-1234-7103"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Jansen-West","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA"],"raw_orcid":"https://orcid.org/0000-0002-1234-7103","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045415124","display_name":"Giulia del Rosso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giulia del Rosso","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113551046","display_name":"Mei Yue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mei Yue","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076140355","display_name":"Peizhou Jiang","orcid":"https://orcid.org/0000-0002-3761-3068","observed_orcids":["https://orcid.org/0000-0002-3761-3068"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peizhou Jiang","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055551417","display_name":"Edward Gomes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Gomes","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065828565","display_name":"Jimei Tong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jimei Tong","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030913073","display_name":"Lillian M. Daughrity","orcid":"https://orcid.org/0000-0003-4644-7265","observed_orcids":["https://orcid.org/0000-0003-4644-7265"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lillian M. Daughrity","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA"],"raw_orcid":"https://orcid.org/0000-0003-4644-7265","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045558718","display_name":"Nicole M. Avendano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole M. Avendano","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001754706","display_name":"Monica Castanedes\u2010Casey","orcid":"https://orcid.org/0000-0002-8441-7801","observed_orcids":["https://orcid.org/0000-0002-8441-7801"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Castanedes-Casey","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA"],"raw_orcid":"https://orcid.org/0000-0002-8441-7801","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020988407","display_name":"Wei Shao","orcid":"https://orcid.org/0000-0002-8782-4904","observed_orcids":["https://orcid.org/0000-0002-8782-4904"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Shao","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052581382","display_name":"Bj\u00f6rn Oskarsson","orcid":"https://orcid.org/0000-0002-1725-9866","observed_orcids":["https://orcid.org/0000-0002-1725-9866"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bj\u00f6rn Oskarsson","raw_affiliation_strings":["Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA"],"raw_orcid":"https://orcid.org/0000-0002-1725-9866","affiliations":[{"raw_affiliation_string":"Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031167838","display_name":"Giulio Srubek Tomassy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1297540436","display_name":"Biogen (United States)","ror":"https://ror.org/02jqkb192","country_code":"US","type":"company","lineage":["https://openalex.org/I1297540436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giulio S. Tomassy","raw_affiliation_strings":["Neurology Research, Biogen Idec, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Research, Biogen Idec, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I1297540436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065479049","display_name":"Alexander McCampbell","orcid":"https://orcid.org/0000-0002-1984-6052","observed_orcids":["https://orcid.org/0000-0002-1984-6052"]},"institutions":[{"id":"https://openalex.org/I1297540436","display_name":"Biogen (United States)","ror":"https://ror.org/02jqkb192","country_code":"US","type":"company","lineage":["https://openalex.org/I1297540436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander McCampbell","raw_affiliation_strings":["Neurology Research, Biogen Idec, Cambridge, MA 02142, USA"],"raw_orcid":"https://orcid.org/0000-0002-1984-6052","affiliations":[{"raw_affiliation_string":"Neurology Research, Biogen Idec, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I1297540436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041605141","display_name":"Frank Rigo","orcid":"https://orcid.org/0000-0001-6467-3309","observed_orcids":["https://orcid.org/0000-0001-6467-3309"]},"institutions":[{"id":"https://openalex.org/I2800035258","display_name":"Ionis Pharmaceuticals (United States)","ror":"https://ror.org/00t8bew53","country_code":"US","type":"company","lineage":["https://openalex.org/I2800035258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank Rigo","raw_affiliation_strings":["Ionis Pharmaceuticals, Carlsbad, CA 92010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ionis Pharmaceuticals, Carlsbad, CA 92010, USA","institution_ids":["https://openalex.org/I2800035258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009533777","display_name":"Dennis W. Dickson","orcid":"https://orcid.org/0000-0001-7189-7917","observed_orcids":["https://orcid.org/0000-0001-7189-7917"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis W. Dickson","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN 55902, USA"],"raw_orcid":"https://orcid.org/0000-0001-7189-7917","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN 55902, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084836766","display_name":"James Shorter","orcid":"https://orcid.org/0000-0001-5269-8533","observed_orcids":["https://orcid.org/0000-0001-5269-8533"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James Shorter","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"],"raw_orcid":"https://orcid.org/0000-0001-5269-8533","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100402819","display_name":"Yong\u2010Jie Zhang","orcid":"https://orcid.org/0000-0002-9900-4313","observed_orcids":["https://orcid.org/0000-0002-9900-4313"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yong-Jie Zhang","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN 55902, USA"],"raw_orcid":"https://orcid.org/0000-0002-9900-4313","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN 55902, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058278504","display_name":"Leonard Petrucelli","orcid":"https://orcid.org/0000-0003-2959-129X","observed_orcids":["https://orcid.org/0000-0003-2959-129X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leonard Petrucelli","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN 55902, USA"],"raw_orcid":"https://orcid.org/0000-0003-2959-129X","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN 55902, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5032571276","https://openalex.org/A5042257929","https://openalex.org/A5058278504","https://openalex.org/A5063285419","https://openalex.org/A5084836766","https://openalex.org/A5100402819"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":13.0724,"has_fulltext":false,"cited_by_count":188,"citation_normalized_percentile":{"value":0.99265525,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"12","issue":"559","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c9orf72","display_name":"C9orf72","score":0.9929999709129333},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tdp-43","display_name":"TDP-43","score":0.9020000100135803},{"id":"https://openalex.org/keywords/tdp-43-proteinopathy","display_name":"TDP-43 proteinopathy","score":0.9760000109672546},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.7720000147819519},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.6399999856948853},{"id":"https://openalex.org/keywords/neurofilament-light-chain","display_name":"neurofilament light chain","score":0.8679999709129333},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.6679999828338623},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.7174715995788574},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6024355292320251},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4968622028827667},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.4870884418487549},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.464335560798645},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34342366456985474},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30670425295829773},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14146950840950012},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10833093523979187},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.05617740750312805}],"mesh":[{"descriptor_ui":"D000073885","descriptor_name":"C9orf72 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000073885","descriptor_name":"C9orf72 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042622","descriptor_name":"DNA Repeat Expansion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057177","descriptor_name":"TDP-43 Proteinopathies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057177","descriptor_name":"TDP-43 Proteinopathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066263","descriptor_name":"Protein Aggregation, Pathological","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066263","descriptor_name":"Protein Aggregation, Pathological","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1126/scitranslmed.abb3774","doi":"https://doi.org/10.1126/scitranslmed.abb3774","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.abb3774","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},{"id":"pmid:32878979","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32878979","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7989020","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7989020","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Sci Transl Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7989020","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7989020","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Sci Transl Med","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3541714522","display_name":"Programming human protein disaggregases against FTD","funder_award_id":"R21AG065854","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4268738032","display_name":"Pathophysiology of genetically defined dementia and neurodegeneration: Defining therapeutic targets and pathways","funder_award_id":"P01NS099114","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5062540160","display_name":"Pathobiology of Neurodegeneration in C9ORF72 repeat expansion","funder_award_id":"P01NS084974","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6101020414","display_name":"Defining mechanisms of AAA+ disaggregases","funder_award_id":"R01GM099836","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6391731062","display_name":"Silencing C9or72 with rAAV Mediated RNAi","funder_award_id":"R01NS088689","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8338390464","display_name":"Expanding insights into FTD disease mechanisms","funder_award_id":"R35NS097273","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306232","display_name":"ALS Association","ror":"https://ror.org/00mwp5989"},{"id":"https://openalex.org/F4320308992","display_name":"Biogen Idec","ror":"https://ror.org/02jqkb192"},{"id":"https://openalex.org/F4320313994","display_name":"Target ALS","ror":"https://ror.org/03fsqvg68"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1137678651","https://openalex.org/W1533438796","https://openalex.org/W1610732998","https://openalex.org/W1673222863","https://openalex.org/W1796096082","https://openalex.org/W1797572428","https://openalex.org/W1980894900","https://openalex.org/W1984145170","https://openalex.org/W1984538960","https://openalex.org/W1998149691","https://openalex.org/W2003618511","https://openalex.org/W2013488820","https://openalex.org/W2016332933","https://openalex.org/W2020159880","https://openalex.org/W2031964319","https://openalex.org/W2054068057","https://openalex.org/W2054542675","https://openalex.org/W2069171272","https://openalex.org/W2092145129","https://openalex.org/W2110308292","https://openalex.org/W2116040140","https://openalex.org/W2128739333","https://openalex.org/W2131725903","https://openalex.org/W2150523249","https://openalex.org/W2154945114","https://openalex.org/W2160311330","https://openalex.org/W2165254352","https://openalex.org/W2308742329","https://openalex.org/W2338545563","https://openalex.org/W2340195634","https://openalex.org/W2533664860","https://openalex.org/W2595869676","https://openalex.org/W2599471352","https://openalex.org/W2606398663","https://openalex.org/W2773167564","https://openalex.org/W2775468657","https://openalex.org/W2777012891","https://openalex.org/W2786688711","https://openalex.org/W2796205057","https://openalex.org/W2797874870","https://openalex.org/W2802842075","https://openalex.org/W2809559846","https://openalex.org/W2884405068","https://openalex.org/W2914644978","https://openalex.org/W2917988060","https://openalex.org/W2921912860","https://openalex.org/W2927454832","https://openalex.org/W2939789416","https://openalex.org/W3009495554"],"related_works":["https://openalex.org/W2538604958","https://openalex.org/W2801185677","https://openalex.org/W7214991623","https://openalex.org/W3123468317","https://openalex.org/W4396849273","https://openalex.org/W3209375550","https://openalex.org/W4281727616","https://openalex.org/W3011809163","https://openalex.org/W4380877375","https://openalex.org/W2006096915"],"abstract_inverted_index":{"-targeted":[0],"therapeutics":[1],"reduce":[2],"TDP-43":[3],"pathology":[4],"in":[5,11],"vivo,":[6],"and":[7],"demonstrate":[8],"that":[9],"alterations":[10],"plasma":[12],"NFL":[13],"provide":[14],"insight":[15],"into":[16],"the":[17],"therapeutic":[18],"efficacy":[19],"of":[20],"disease-modifying":[21],"treatments.":[22]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":39},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":26},{"year":2022,"cited_by_count":37},{"year":2021,"cited_by_count":33},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-09-08T00:00:00"}
