{"id":"https://openalex.org/W3082014282","doi":"https://doi.org/10.1186/s12936-020-03392-5","title":"Potential drug\u2013drug interactions associated with adverse clinical outcomes and abnormal laboratory findings in patients with malaria","display_name":"Potential drug\u2013drug interactions associated with adverse clinical outcomes and abnormal laboratory findings in patients with malaria","publication_year":2020,"publication_date":"2020-08-31","ids":{"openalex":"https://openalex.org/W3082014282","doi":"https://doi.org/10.1186/s12936-020-03392-5","mag":"3082014282","pmid":"https://pubmed.ncbi.nlm.nih.gov/32867788","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7461345"},"language":"en","primary_location":{"id":"doi:10.1186/s12936-020-03392-5","doi":"https://doi.org/10.1186/s12936-020-03392-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12936-020-03392-5","pdf_url":"https://malariajournal.biomedcentral.com/counter/pdf/10.1186/s12936-020-03392-5","source":{"id":"https://openalex.org/S93003929","display_name":"Malaria Journal","issn_l":"1475-2875","issn":["1475-2875"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malaria Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://malariajournal.biomedcentral.com/counter/pdf/10.1186/s12936-020-03392-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112521106","display_name":"Sidra Noor","orcid":"https://orcid.org/0000-0002-3453-3898","observed_orcids":["https://orcid.org/0000-0002-3453-3898"]},"institutions":[{"id":"https://openalex.org/I36001604","display_name":"University of Peshawar","ror":"https://ror.org/02t2qwf81","country_code":"PK","type":"education","lineage":["https://openalex.org/I36001604"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Sidra Noor","raw_affiliation_strings":["Department of Pharmacy, University of Peshawar, Khyber Pakhtunkhwa, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Peshawar, Khyber Pakhtunkhwa, Pakistan","institution_ids":["https://openalex.org/I36001604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100644881","display_name":"Mohammad Ismail","orcid":"https://orcid.org/0000-0001-7227-3399","observed_orcids":["https://orcid.org/0000-0001-7227-3399"]},"institutions":[{"id":"https://openalex.org/I36001604","display_name":"University of Peshawar","ror":"https://ror.org/02t2qwf81","country_code":"PK","type":"education","lineage":["https://openalex.org/I36001604"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Mohammad Ismail","raw_affiliation_strings":["Department of Pharmacy, University of Peshawar, Khyber Pakhtunkhwa, Pakistan. ismailrph@uop.edu.pk","Department of Pharmacy, University of Peshawar, Khyber Pakhtunkhwa, Pakistan"],"raw_orcid":"https://orcid.org/0000-0001-7227-3399","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Peshawar, Khyber Pakhtunkhwa, Pakistan. ismailrph@uop.edu.pk","institution_ids":["https://openalex.org/I36001604"]},{"raw_affiliation_string":"Department of Pharmacy, University of Peshawar, Khyber Pakhtunkhwa, Pakistan","institution_ids":["https://openalex.org/I36001604"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070306339","display_name":"Faiza Khadim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36001604","display_name":"University of Peshawar","ror":"https://ror.org/02t2qwf81","country_code":"PK","type":"education","lineage":["https://openalex.org/I36001604"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Faiza Khadim","raw_affiliation_strings":["Department of Pharmacy, University of Peshawar, Khyber Pakhtunkhwa, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Peshawar, Khyber Pakhtunkhwa, Pakistan","institution_ids":["https://openalex.org/I36001604"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100644881"],"corresponding_institution_ids":["https://openalex.org/I36001604"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":1.1225,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.75899012,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"19","issue":"1","first_page":"316","last_page":"316"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.06369999796152115,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.038600001484155655,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.9919999837875366},{"id":"https://openalex.org/keywords/malaria","display_name":"malaria","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hospitalized-patients","display_name":"hospitalized patients","score":0.8050000071525574},{"id":"https://openalex.org/keywords/polypharmacy","display_name":"polypharmacy","score":0.8880000114440918},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7730000019073486},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":1.0},{"id":"https://openalex.org/keywords/qt-interval-prolongation","display_name":"QT prolongation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ceftriaxone","display_name":"ceftriaxone","score":0.7990000247955322},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9570000171661377},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.75},{"id":"https://openalex.org/keywords/laboratory-abnormalities","display_name":"laboratory abnormalities","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9517132043838501},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6985096335411072},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6192559003829956},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5715506076812744},{"id":"https://openalex.org/C36434225","wikidata":"https://www.wikidata.org/wiki/Q1895998","display_name":"Polypharmacy","level":2,"score":0.542914628982544},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4847547709941864},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.43928971886634827},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2709164619445801}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010154","descriptor_name":"Pakistan","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12936-020-03392-5","doi":"https://doi.org/10.1186/s12936-020-03392-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12936-020-03392-5","pdf_url":"https://malariajournal.biomedcentral.com/counter/pdf/10.1186/s12936-020-03392-5","source":{"id":"https://openalex.org/S93003929","display_name":"Malaria Journal","issn_l":"1475-2875","issn":["1475-2875"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malaria Journal","raw_type":"journal-article"},{"id":"pmid:32867788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32867788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malaria journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7461345","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7461345/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malar J","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2bc7ef255ecb49549894118f4f695b1c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2bc7ef255ecb49549894118f4f695b1c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Malaria Journal, Vol 19, Iss 1, Pp 1-13 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12936-020-03392-5","doi":"https://doi.org/10.1186/s12936-020-03392-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12936-020-03392-5","pdf_url":"https://malariajournal.biomedcentral.com/counter/pdf/10.1186/s12936-020-03392-5","source":{"id":"https://openalex.org/S93003929","display_name":"Malaria Journal","issn_l":"1475-2875","issn":["1475-2875"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malaria Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3082014282.pdf","grobid_xml":"https://content.openalex.org/works/W3082014282.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W19324233","https://openalex.org/W177597118","https://openalex.org/W1964288753","https://openalex.org/W1967706050","https://openalex.org/W1971873386","https://openalex.org/W1981023949","https://openalex.org/W1982541999","https://openalex.org/W1998055925","https://openalex.org/W2002889253","https://openalex.org/W2014039301","https://openalex.org/W2047454670","https://openalex.org/W2052252723","https://openalex.org/W2061075125","https://openalex.org/W2066626023","https://openalex.org/W2068230945","https://openalex.org/W2068352763","https://openalex.org/W2072036446","https://openalex.org/W2075038555","https://openalex.org/W2085393530","https://openalex.org/W2089218471","https://openalex.org/W2091761591","https://openalex.org/W2092224812","https://openalex.org/W2097945185","https://openalex.org/W2132253722","https://openalex.org/W2144788030","https://openalex.org/W2146770978","https://openalex.org/W2152558468","https://openalex.org/W2162251320","https://openalex.org/W2168350311","https://openalex.org/W2515694866","https://openalex.org/W2592128079","https://openalex.org/W2592428844","https://openalex.org/W2599055373","https://openalex.org/W2605049517","https://openalex.org/W2605958969","https://openalex.org/W2616625093","https://openalex.org/W2743084849","https://openalex.org/W2791433809","https://openalex.org/W2795740701","https://openalex.org/W2921484131","https://openalex.org/W2965975984","https://openalex.org/W2966894054","https://openalex.org/W4229804223","https://openalex.org/W4289253303","https://openalex.org/W4304182209"],"related_works":["https://openalex.org/W4242299407","https://openalex.org/W4254934715","https://openalex.org/W6958320046","https://openalex.org/W6920853414","https://openalex.org/W6976944761","https://openalex.org/W4220850340","https://openalex.org/W2898161295","https://openalex.org/W2965975984","https://openalex.org/W2746196217","https://openalex.org/W2068230945"],"abstract_inverted_index":{"BACKGROUND:":[0],"Hospitalized":[1],"patients":[2,172,225,261],"with":[3,7,51,118,125,154,174,190,226,262],"malaria":[4],"often":[5,23],"present":[6],"comorbidities":[8],"or":[9],"associated":[10,153,243],"complications":[11],"for":[12],"which":[13,109],"a":[14],"variety":[15],"of":[16,45,63,67,81,103,108,112,150,178,188,207],"drugs":[17],"are":[18,221],"prescribed.":[19],"Multiple":[20],"drug":[21,144],"therapy":[22],"leads":[24],"to":[25,59,256],"drug-drug":[26],"interactions":[27,105],"(DDIs).":[28],"Therefore,":[29],"the":[30,34,61,78,119,147,155,175,232],"current":[31],"study":[32],"investigated":[33],"prevalence,":[35],"levels,":[36],"risk":[37,71],"factors,":[38],"clinical":[39,79,247],"relevance,":[40],"and":[41,69,114,127,138,163,213,241,253,267],"monitoring":[42],"parameters/management":[43],"guidelines":[44],"potential":[46,70],"DDIs":[47,68],"(pDDIs)":[48],"among":[49],"inpatients":[50],"malaria.":[52,227],"METHODS:":[53],".":[54],"Odds":[55],"ratios":[56],"were":[57,91,106,111,123,168],"calculated":[58],"identify":[60],"strength":[62],"association":[64,187],"between":[65],"presence":[66],"factors":[72],"via":[73],"logistic":[74],"regression":[75,182],"analysis.":[76],"Further,":[77],"relevance":[80],"frequent":[82],"pDDIs":[83,90,122,189,235,240],"was":[84],"investigated.":[85],"RESULTS:":[86],"Of":[87],"398":[88],"patients,":[89,95],"observed":[92,223],"in":[93,98,129,171,224,238,260],"37.2%":[94],"while":[96],"major-pDDIs":[97],"19.3%":[99],"patients.":[100],"A":[101],"total":[102],"325":[104],"found,":[107],"45.5%":[110],"major-":[113],"34.5%":[115],"moderate-severity.":[116],"Patients":[117],"most":[120,233],"common":[121,170,234],"found":[124],"signs/symptoms":[126,254],"abnormalities":[128],"laboratory":[130,251],"findings":[131,252],"representing":[132],"nephrotoxicity,":[133],"hepatotoxicity,":[134],"QT":[135],"interval":[136],"prolongation,":[137],"reduced":[139],"therapeutic":[140],"efficacy.":[141],"The":[142,165],"following":[143],"pairs":[145],"reported":[146],"highest":[148],"frequency":[149],"adverse":[151,166],"events":[152,167],"interactions;":[156],"calcium":[157],"containing":[158],"products-ceftriaxone,":[159],"isoniazid-rifampin,":[160],"pyrazinamide-rifampin,":[161],"isoniazid-acetaminophen,":[162],"ciprofloxacin-metronidazole.":[164],"more":[169],"prescribed":[173,192,199],"higher":[176],"doses":[177],"interacting":[179],"drugs.":[180],"Multivariate":[181],"analysis":[183],"showed":[184],"statistically":[185],"significant":[186],"5-6":[191],"medicines":[193,200],"(p":[194,201,210,216],"=":[195,211,217],"0.01),":[196],">":[197,204],"6":[198],"<":[202],"0.001),":[203],"5":[205],"days":[206],"hospital":[208,265],"stay":[209],"0.03),":[212],"diabetes":[214,268],"mellitus":[215],"0.04).":[218],"CONCLUSIONS:":[219],"PDDIs":[220],"commonly":[222],"Healthcare":[228],"professional's":[229],"knowledge":[230],"about":[231],"could":[236],"help":[237],"preventing":[239],"their":[242],"negative":[244],"effects.":[245],"Pertinent":[246],"parameters,":[248],"such":[249],"as":[250],"need":[255],"be":[257],"checked,":[258],"particularly":[259],"polypharmacy,":[263],"longer":[264],"stay,":[266],"mellitus.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2020-09-08T00:00:00"}
