{"id":"https://openalex.org/W3082010726","doi":"https://doi.org/10.1097/01.tp.0000698604.45102.90","title":"TREG USE THE PD-1-PD-L1 AXIS FOR LYMPHATIC TRANSENDOTHELIAL MIGRATION","display_name":"TREG USE THE PD-1-PD-L1 AXIS FOR LYMPHATIC TRANSENDOTHELIAL MIGRATION","publication_year":2020,"publication_date":"2020-08-28","ids":{"openalex":"https://openalex.org/W3082010726","doi":"https://doi.org/10.1097/01.tp.0000698604.45102.90","mag":"3082010726"},"language":"en","primary_location":{"id":"doi:10.1097/01.tp.0000698604.45102.90","doi":"https://doi.org/10.1097/01.tp.0000698604.45102.90","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000698604.45102.90","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076702626","display_name":"Wenji Piao","orcid":"https://orcid.org/0000-0003-0005-3930","observed_orcids":["https://orcid.org/0000-0003-0005-3930"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenji Piao","raw_affiliation_strings":["Surgery, University of Maryland School of Medicine, Baltimore, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, University of Maryland School of Medicine, Baltimore, MD, United States","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046631941","display_name":"Lushen Li","orcid":"https://orcid.org/0000-0002-6701-7937","observed_orcids":["https://orcid.org/0000-0002-6701-7937"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lushen Li","raw_affiliation_strings":["Surgery, University of Maryland School of Medicine, Baltimore, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, University of Maryland School of Medicine, Baltimore, MD, United States","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045106225","display_name":"Christina Paluskievicz","orcid":"https://orcid.org/0009-0009-5020-0119","observed_orcids":["https://orcid.org/0009-0009-5020-0119"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Paluskievicz","raw_affiliation_strings":["Surgery, University of Maryland School of Medicine, Baltimore, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, University of Maryland School of Medicine, Baltimore, MD, United States","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072729295","display_name":"Keli Lee Hippen","orcid":"https://orcid.org/0000-0002-8050-270X","observed_orcids":["https://orcid.org/0000-0002-8050-270X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keli Hippen","raw_affiliation_strings":["Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yigang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yigang Zhang","raw_affiliation_strings":["Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019993665","display_name":"Vikas Saxena","orcid":"https://orcid.org/0000-0003-4816-4875","observed_orcids":["https://orcid.org/0000-0003-4816-4875"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikas Saxena","raw_affiliation_strings":["Surgery, University of Maryland School of Medicine, Baltimore, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, University of Maryland School of Medicine, Baltimore, MD, United States","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060082840","display_name":"Marina Willson Shirkey","orcid":"https://orcid.org/0009-0005-7902-9045","observed_orcids":["https://orcid.org/0009-0005-7902-9045"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Willson Shirkey","raw_affiliation_strings":["Surgery, University of Maryland School of Medicine, Baltimore, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, University of Maryland School of Medicine, Baltimore, MD, United States","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058268746","display_name":"Bruce R. Blazar","orcid":"https://orcid.org/0000-0002-9608-9841","observed_orcids":["https://orcid.org/0000-0002-9608-9841"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce Blazar","raw_affiliation_strings":["Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083826351","display_name":"Leonardo V. Riella","orcid":"https://orcid.org/0000-0002-7636-3196","observed_orcids":["https://orcid.org/0000-0002-7636-3196"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonardo Riella","raw_affiliation_strings":["Schuster Family Transplantation Research Center, Harvard Medical School, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schuster Family Transplantation Research Center, Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061721392","display_name":"Jonathan S. Bromberg","orcid":"https://orcid.org/0000-0002-1407-8795","observed_orcids":["https://orcid.org/0000-0002-1407-8795"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Bromberg","raw_affiliation_strings":["Surgery, University of Maryland School of Medicine, Baltimore, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, University of Maryland School of Medicine, Baltimore, MD, United States","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":"S3","first_page":"S70","last_page":"S70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6240000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6240000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.18359999358654022,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.15839999914169312,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":1.0},{"id":"https://openalex.org/keywords/lymphatic-endothelial-cells","display_name":"lymphatic endothelial cells","score":0.9549999833106995},{"id":"https://openalex.org/keywords/t-cell-migration","display_name":"T cell migration","score":0.7049999833106995},{"id":"https://openalex.org/keywords/immune-checkpoint-signaling","display_name":"immune checkpoint signaling","score":0.5690000057220459},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.5740000009536743},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.9480000138282776},{"id":"https://openalex.org/keywords/pi3k-akt","display_name":"PI3K/Akt","score":0.7080000042915344},{"id":"https://openalex.org/keywords/lymph-node-homing","display_name":"lymph node homing","score":0.5},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.7699999809265137},{"id":"https://openalex.org/keywords/pd-l1-blockade","display_name":"PD-L1 blockade","score":0.8679999709129333},{"id":"https://openalex.org/keywords/treg-homeostasis","display_name":"Treg homeostasis","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.5697869658470154},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5373873114585876},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5048189759254456},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.4872831106185913},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.48374056816101074},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4755494296550751},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.44060957431793213},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43149858713150024},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4222675561904907},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4213820695877075},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.4115898013114929},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3482595384120941},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32479462027549744},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3131292462348938},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07494193315505981}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.tp.0000698604.45102.90","doi":"https://doi.org/10.1097/01.tp.0000698604.45102.90","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000698604.45102.90","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4313405720","https://openalex.org/W4224248739","https://openalex.org/W2771561568","https://openalex.org/W4385688136","https://openalex.org/W4224253574","https://openalex.org/W3003387389","https://openalex.org/W4406947462","https://openalex.org/W3162359253","https://openalex.org/W2461482933","https://openalex.org/W7214613825"],"abstract_inverted_index":{"Background:":[0],"Programmed":[1],"death-1":[2],"(PD-1)":[3],"attenuates":[4],"immune":[5],"responses.":[6],"Ligand-engagement":[7],"of":[8,59,105,186,193,206,220,265,271,322,444],"PD-1":[9,23,34,61,78,139,158,169,211,254,276,284,313,327,375,391,404,438],"regulates":[10],"T":[11,28,42,113,127],"cell":[12,29],"development,":[13],"proliferation,":[14],"cytokine":[15],"production,":[16],"and":[17,47,93,102,111,115,124,135,149,157,248,255,259,273,296,318,338,366,396,414,420,433,439,447],"apoptosis.":[18],"Little":[19],"is":[20,35,49],"known":[21],"about":[22],"signaling":[24],"or":[25,120,140,162,170,191,209,233,401],"functions":[26],"in":[27,99,133,136,180,442],"migration.":[30],"We":[31,70,174],"observed":[32],"that":[33,74,176],"expressed":[36,51,252],"at":[37,369],"higher":[38],"levels":[39],"on":[40,82,217,285,309,324,406],"regulatory":[41],"cells":[43,55,114,128],"(Tregs)":[44],"than":[45],"non-Tregs,":[46,202],"PD-L1":[48,64,81,106,141,150,156,163,171,279,308,323,341,361,378,409,441],"highly":[50,251],"by":[52,277,326,334,349,363],"lymphatic":[53,87,381,388,445],"endothelial":[54,382],"(LECs).":[56],"The":[57],"interplay":[58],"Treg":[60,75,86,181,207,240,275,374,387,390,437,449],"with":[62,145,188,195,212,230,236,312],"LECs":[63,83,96,132,261,311,325],"has":[65],"not":[66,201,268,354],"been":[67],"previously":[68],"explored.":[69],"investigated":[71],"the":[72],"hypothesis":[73],"use":[76],"surface":[77,263,403],"to":[79,84,154,167,225,360,379,399,417,424],"engage":[80],"regulate":[85,425],"transendothelial":[88],"migration":[89,241,446],"(TEM).":[90],"Methods:":[91],"Human":[92,108,247],"murine":[94,116],"dermal":[95],"were":[97,129,152,165],"used":[98,153,166],"biochemical,":[100],"phenotypic,":[101],"functional":[103],"analyses":[104],"signaling.":[107,172,306],"na\u00efve":[109],"Tregs":[110,187,229,250,286,352],"effector":[112],"wild":[117],"type":[118],"(WT)":[119],"PD-1-/-":[121],"Tregs,":[122,199],"na\u00efve,":[123],"activated":[125],"CD4":[126],"migrated":[130],"across":[131],"vitro":[134],"vivo.":[137],"Recombinant":[138],"extracellular":[142,288],"domains":[143],"fused":[144],"IgG1":[146],"(PD-1":[147],"Ig":[148,280,314,328,362],"Ig)":[151],"induce":[155],"signaling,":[159],"respectively.":[160],"Anti-PD-1":[161],"mAbs":[164],"block":[168],"Results:":[173],"demonstrated":[175],"PD-1-PD-L1":[177],"was":[178,222,332,347],"involved":[179],"TEM":[182,219],"into":[183,242],"lymphatics.":[184],"Blockade":[185],"anti-PD-1":[189,231],"mAb,":[190],"blockade":[192,205],"LEC":[194,210,340,370,377,408,440],"anti-PD-L1":[196,237],"mAb":[197,213,232,238],"inhibited":[198,239,304,348],"but":[200,267,303,353],"TEM.":[203,218,282,389],"However,":[204],"PD-L1,":[208,256,266],"had":[214,262],"no":[215],"effect":[216],"PD-1-/-Tregs":[221],"decreased":[223,329],"compared":[224],"WT":[226],"Tregs.":[227,407],"Pretreating":[228],"pretreating":[234],"mice":[235],"local":[243],"draining":[244],"lymph":[245],"nodes.":[246],"mouse":[249,260,274,310],"both":[253],"while":[257],"human":[258,272],"expression":[264,405],"PD-1.":[269],"Ligation":[270,321],"immobilized":[278],"enhanced":[281,343],"Crosslinking":[283,307],"triggered":[287],"signal-regulated":[289],"kinase":[290,294,300],"(ERK),":[291],"c-Jun":[292],"NH2-terminal":[293],"(JNK),":[295],"PI3K":[297],"serine/threonine":[298],"protein":[299],"Akt":[301,319],"activation,":[302],"NF\u03baB-p65":[305,423],"induced":[315],"NF\u03baB-p65,":[316],"ERK,":[317,337,394],"activation.":[320],"VE-cadherin,":[330,419],"which":[331,346,384],"recovered":[333],"blocking":[335,350],"NF\u03baB-NIK,":[336,412],"PI3K.":[339],"ligation":[342],"VCAM-1":[344,368,426],"expression,":[345],"NF\u03baB-p65.":[351],"non-Tregs":[355],"also":[356],"caused":[357],"changes":[358],"similar":[359],"decreasing":[364],"VE-cadherin":[365],"increasing":[367],"cell-cell":[371],"junctions.":[372],"Conclusions:":[373],"engages":[376],"modulate":[380,418],"structure,":[383],"then":[385],"promotes":[386],"signals":[392,410],"through":[393,411,421],"JNK,":[395],"PI3K/Akt":[397,415],"pathways":[398],"maintain":[400],"increase":[402],"ERKs,":[413],"(Thr308)":[416],"classical":[422],"expression.":[427],"These":[428],"data":[429],"demonstrate":[430],"an":[431],"important":[432],"novel":[434],"role":[435],"for":[436],"regulation":[443],"hence":[448],"suppressive":[450],"function.":[451],"NIH":[452],"1RO1":[453],"AI062765":[454],"(JSB).":[455]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2020-09-08T00:00:00"}