{"id":"https://openalex.org/W3081744633","doi":"https://doi.org/10.1016/j.bioorg.2020.104219","title":"New indole-7-aldehyde derivatives as melatonin analogues; synthesis and screening their antioxidant and anticancer potential","display_name":"New indole-7-aldehyde derivatives as melatonin analogues; synthesis and screening their antioxidant and anticancer potential","publication_year":2020,"publication_date":"2020-09-01","ids":{"openalex":"https://openalex.org/W3081744633","doi":"https://doi.org/10.1016/j.bioorg.2020.104219","mag":"3081744633","pmid":"https://pubmed.ncbi.nlm.nih.gov/32916391"},"language":"en","primary_location":{"id":"doi:10.1016/j.bioorg.2020.104219","doi":"https://doi.org/10.1016/j.bioorg.2020.104219","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bioorg.2020.104219","pdf_url":null,"source":{"id":"https://openalex.org/S165482960","display_name":"Bioorganic Chemistry","issn_l":"0045-2068","issn":["0045-2068","1090-2120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109259851","display_name":"Hanif Shirinzadeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176037994","display_name":"Erzincan Binali Y\u0131ld\u0131r\u0131m University","ror":"https://ror.org/02h1e8605","country_code":"TR","type":"education","lineage":["https://openalex.org/I176037994"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Hanif Shirinzadeh","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Erzincan Binali YildirimUniversity, Yanl\u0131zbag Yerleskesi, 24100 Erzincan, Turkey. Electronic address: hanif.shirinzade@gmail.com","Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Erzincan Binali YildirimUniversity, Yanl\u0131zbag Yerleskesi, 24100 Erzincan, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Erzincan Binali YildirimUniversity, Yanl\u0131zbag Yerleskesi, 24100 Erzincan, Turkey. Electronic address: hanif.shirinzade@gmail.com","institution_ids":["https://openalex.org/I176037994"]},{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Erzincan Binali YildirimUniversity, Yanl\u0131zbag Yerleskesi, 24100 Erzincan, Turkey","institution_ids":["https://openalex.org/I176037994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014138224","display_name":"Eddy Neuhaus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Eddy Neuhaus","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandogan-06100, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandogan-06100, Ankara, Turkey","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102723360","display_name":"Elif \u0130nce Erg\u00fc\u00e7","orcid":"https://orcid.org/0000-0003-0764-7694","observed_orcids":["https://orcid.org/0000-0003-0764-7694"]},"institutions":[{"id":"https://openalex.org/I250383648","display_name":"Izmir K\u00e2tip \u00c7elebi University","ror":"https://ror.org/024nx4843","country_code":"TR","type":"education","lineage":["https://openalex.org/I250383648"]},{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Elif Ince Erguc","raw_affiliation_strings":["Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ege University, 35040 Izmir, Turkey; Department of Pharmaceutical Toxicology, Faculty of Pharmacy, \u0130zmir Katip Celebi University, 35620 Izmir, Turkey","Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ege University, 35040 Izmir, Turkey","Department of Pharmaceutical Toxicology, Faculty of Pharmacy, \u0130zmir Katip Celebi University, 35620 Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ege University, 35040 Izmir, Turkey; Department of Pharmaceutical Toxicology, Faculty of Pharmacy, \u0130zmir Katip Celebi University, 35620 Izmir, Turkey","institution_ids":["https://openalex.org/I250383648","https://openalex.org/I41641357"]},{"raw_affiliation_string":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ege University, 35040 Izmir, Turkey","institution_ids":["https://openalex.org/I41641357"]},{"raw_affiliation_string":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy, \u0130zmir Katip Celebi University, 35620 Izmir, Turkey","institution_ids":["https://openalex.org/I250383648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070969630","display_name":"Alev Tascioglu Aliyev","orcid":"https://orcid.org/0000-0003-0185-9530","observed_orcids":["https://orcid.org/0000-0003-0185-9530"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Alev Tascioglu Aliyev","raw_affiliation_strings":["Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ege University, 35040 Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ege University, 35040 Izmir, Turkey","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046696950","display_name":"Hande G\u00fcrer-Orhan","orcid":"https://orcid.org/0000-0002-4890-299X","observed_orcids":["https://orcid.org/0000-0002-4890-299X"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hande Gurer-Orhan","raw_affiliation_strings":["Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ege University, 35040 Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ege University, 35040 Izmir, Turkey","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024910770","display_name":"S\u00edbel S\u00fczen","orcid":"https://orcid.org/0000-0003-3413-6152","observed_orcids":["https://orcid.org/0000-0003-3413-6152"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sibel Suzen","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandogan-06100, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandogan-06100, Ankara, Turkey","institution_ids":["https://openalex.org/I149218525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5109259851"],"corresponding_institution_ids":["https://openalex.org/I176037994"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":1.5209,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.77721751,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"104","issue":null,"first_page":"104219","last_page":"104219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.13539999723434448,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12973","display_name":"Synthesis of Indole Derivatives","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin-analogues","display_name":"melatonin analogues","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hydrazide-derivatives","display_name":"hydrazide derivatives","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hydrazones","display_name":"hydrazones","score":0.9909999966621399},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9480000138282776},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.746999979019165},{"id":"https://openalex.org/keywords/ros-scavenging","display_name":"reactive oxygen species scavenging","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.871999979019165},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8750797510147095},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.822583794593811},{"id":"https://openalex.org/C192527728","wikidata":"https://www.wikidata.org/wiki/Q1465700","display_name":"Indole test","level":2,"score":0.8216090798377991},{"id":"https://openalex.org/C2781401929","wikidata":"https://www.wikidata.org/wiki/Q5205953","display_name":"DPPH","level":3,"score":0.7543478012084961},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.57469642162323},{"id":"https://openalex.org/C2775998212","wikidata":"https://www.wikidata.org/wiki/Q419637","display_name":"Hydrazide","level":2,"score":0.5003845691680908},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.4861154556274414},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4798802435398102},{"id":"https://openalex.org/C2780349576","wikidata":"https://www.wikidata.org/wiki/Q416007","display_name":"Hydrazone","level":2,"score":0.42814886569976807},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.41565725207328796},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3902025818824768},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.382531076669693},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2846536636352539},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17606911063194275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.04439482092857361},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010851","descriptor_name":"Picrates","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bioorg.2020.104219","doi":"https://doi.org/10.1016/j.bioorg.2020.104219","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bioorg.2020.104219","pdf_url":null,"source":{"id":"https://openalex.org/S165482960","display_name":"Bioorganic Chemistry","issn_l":"0045-2068","issn":["0045-2068","1090-2120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic Chemistry","raw_type":"journal-article"},{"id":"pmid:32916391","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32916391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1150165331","display_name":null,"funder_award_id":"109S099","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"}],"funders":[{"id":"https://openalex.org/F4320309936","display_name":"Ankara Universitesi","ror":"https://ror.org/01wntqw50"},{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W21387480","https://openalex.org/W1544419680","https://openalex.org/W1550572740","https://openalex.org/W1553430971","https://openalex.org/W1680879198","https://openalex.org/W1818833679","https://openalex.org/W1852941485","https://openalex.org/W1968366699","https://openalex.org/W1969980829","https://openalex.org/W1972045169","https://openalex.org/W1974629173","https://openalex.org/W1988010651","https://openalex.org/W2007200071","https://openalex.org/W2010239903","https://openalex.org/W2021698295","https://openalex.org/W2024887238","https://openalex.org/W2026479674","https://openalex.org/W2028835139","https://openalex.org/W2028860096","https://openalex.org/W2031596649","https://openalex.org/W2032391094","https://openalex.org/W2043643079","https://openalex.org/W2047547987","https://openalex.org/W2048608017","https://openalex.org/W2062693583","https://openalex.org/W2077197304","https://openalex.org/W2079308945","https://openalex.org/W2088778229","https://openalex.org/W2098619885","https://openalex.org/W2105864875","https://openalex.org/W2109521648","https://openalex.org/W2114918609","https://openalex.org/W2117559646","https://openalex.org/W2131278010","https://openalex.org/W2132217313","https://openalex.org/W2158817614","https://openalex.org/W2165268116","https://openalex.org/W2166756219","https://openalex.org/W2233052904","https://openalex.org/W2235279702","https://openalex.org/W2274748607","https://openalex.org/W2608114135","https://openalex.org/W2733079821","https://openalex.org/W2752822150","https://openalex.org/W2770779648","https://openalex.org/W2771489286","https://openalex.org/W2888801897","https://openalex.org/W2911884991","https://openalex.org/W2913928534","https://openalex.org/W2949233074","https://openalex.org/W2987991219","https://openalex.org/W3015776699","https://openalex.org/W4230800510","https://openalex.org/W6638912505"],"related_works":["https://openalex.org/W2233052904","https://openalex.org/W2043643079","https://openalex.org/W2021698295","https://openalex.org/W3015776699","https://openalex.org/W2079308945","https://openalex.org/W1504449953","https://openalex.org/W2951259848","https://openalex.org/W2288340762","https://openalex.org/W2010239903","https://openalex.org/W4400033030"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-09-08T00:00:00"}
