{"id":"https://openalex.org/W3081663272","doi":"https://doi.org/10.3390/ph13090225","title":"Characterization of Resveratrol, Oxyresveratrol, Piceatannol and Roflumilast as Modulators of Phosphodiesterase Activity. Study of Yeast Lifespan","display_name":"Characterization of Resveratrol, Oxyresveratrol, Piceatannol and Roflumilast as Modulators of Phosphodiesterase Activity. Study of Yeast Lifespan","publication_year":2020,"publication_date":"2020-08-30","ids":{"openalex":"https://openalex.org/W3081663272","doi":"https://doi.org/10.3390/ph13090225","mag":"3081663272","pmid":"https://pubmed.ncbi.nlm.nih.gov/32872677","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7559934"},"language":"en","primary_location":{"id":"doi:10.3390/ph13090225","doi":"https://doi.org/10.3390/ph13090225","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph13090225","pdf_url":"https://www.mdpi.com/1424-8247/13/9/225/pdf?version=1598794274","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8247/13/9/225/pdf?version=1598794274","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080829885","display_name":"Adri\u00e1n Matencio","orcid":"https://orcid.org/0000-0001-8203-0673","observed_orcids":["https://orcid.org/0000-0001-8203-0673"]},"institutions":[{"id":"https://openalex.org/I80180929","display_name":"Universidad de Murcia","ror":"https://ror.org/03p3aeb86","country_code":"ES","type":"education","lineage":["https://openalex.org/I80180929"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Adri\u00e1n Matencio","raw_affiliation_strings":["Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular A, Unidad Docente de Biolog\u00eda, Facultad de Veterinaria, Regional Campus of International Excellence \u201cCampus Mare Nostrum\u201d, Universidad de Murcia, 30003 Murcia, Spain"],"raw_orcid":"https://orcid.org/0000-0001-8203-0673","affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular A, Unidad Docente de Biolog\u00eda, Facultad de Veterinaria, Regional Campus of International Excellence \u201cCampus Mare Nostrum\u201d, Universidad de Murcia, 30003 Murcia, Spain","institution_ids":["https://openalex.org/I80180929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019913842","display_name":"Francisco Garc\u00eda\u2010Carmona","orcid":"https://orcid.org/0000-0002-1318-7690","observed_orcids":["https://orcid.org/0000-0002-1318-7690"]},"institutions":[{"id":"https://openalex.org/I80180929","display_name":"Universidad de Murcia","ror":"https://ror.org/03p3aeb86","country_code":"ES","type":"education","lineage":["https://openalex.org/I80180929"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Garc\u00eda-Carmona","raw_affiliation_strings":["Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular A, Unidad Docente de Biolog\u00eda, Facultad de Veterinaria, Regional Campus of International Excellence \u201cCampus Mare Nostrum\u201d, Universidad de Murcia, 30003 Murcia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular A, Unidad Docente de Biolog\u00eda, Facultad de Veterinaria, Regional Campus of International Excellence \u201cCampus Mare Nostrum\u201d, Universidad de Murcia, 30003 Murcia, Spain","institution_ids":["https://openalex.org/I80180929"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045333721","display_name":"Manuel L\u00f3pez-Nicol\u00e1s","orcid":"https://orcid.org/0000-0003-0944-3994","observed_orcids":["https://orcid.org/0000-0003-0944-3994"]},"institutions":[{"id":"https://openalex.org/I80180929","display_name":"Universidad de Murcia","ror":"https://ror.org/03p3aeb86","country_code":"ES","type":"education","lineage":["https://openalex.org/I80180929"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jos\u00e9 Manuel L\u00f3pez-Nicol\u00e1s","raw_affiliation_strings":["Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular A, Unidad Docente de Biolog\u00eda, Facultad de Veterinaria, Regional Campus of International Excellence \u201cCampus Mare Nostrum\u201d, Universidad de Murcia, 30003 Murcia, Spain"],"raw_orcid":"https://orcid.org/0000-0003-0944-3994","affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular A, Unidad Docente de Biolog\u00eda, Facultad de Veterinaria, Regional Campus of International Excellence \u201cCampus Mare Nostrum\u201d, Universidad de Murcia, 30003 Murcia, Spain","institution_ids":["https://openalex.org/I80180929"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045333721"],"corresponding_institution_ids":["https://openalex.org/I80180929"],"apc_list":{"value":1400,"currency":"CHF","value_usd":1479},"apc_paid":{"value":1400,"currency":"CHF","value_usd":1479},"fwci":0.917,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.69441181,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":"9","first_page":"225","last_page":"225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.43849998712539673,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.43849998712539673,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.37720000743865967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.13349999487400055,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxyresveratrol","display_name":"oxyresveratrol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/piceatannol","display_name":"piceatannol","score":1.0},{"id":"https://openalex.org/keywords/roflumilast","display_name":"roflumilast","score":0.9850000143051147},{"id":"https://openalex.org/keywords/pde2","display_name":"PDE2","score":0.796999990940094},{"id":"https://openalex.org/keywords/stilbenes","display_name":"stilbenes","score":0.8220000267028809},{"id":"https://openalex.org/keywords/chronological-lifespan","display_name":"chronological lifespan","score":0.7490000128746033},{"id":"https://openalex.org/keywords/anti-aging","display_name":"anti-aging","score":0.5690000057220459},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8980000019073486},{"id":"https://openalex.org/keywords/phosphodiesterase-4-inhibitors","display_name":"phosphodiesterase-4 inhibitors","score":0.7200000286102295},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C2778926808","wikidata":"https://www.wikidata.org/wiki/Q693482","display_name":"Roflumilast","level":3,"score":0.9053749442100525},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.859252393245697},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.6943077445030212},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6043989062309265},{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.5682380199432373},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5076647996902466},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.47831252217292786},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47099369764328003},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4657725989818573},{"id":"https://openalex.org/C2779746291","wikidata":"https://www.wikidata.org/wiki/Q7190608","display_name":"Piceatannol","level":3,"score":0.45076972246170044},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.4472082555294037},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36969947814941406},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.36727583408355713},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.299618661403656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2424476444721222},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20568951964378357},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.14046481251716614},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.06907707452774048},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.053970545530319214},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/ph13090225","doi":"https://doi.org/10.3390/ph13090225","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph13090225","pdf_url":"https://www.mdpi.com/1424-8247/13/9/225/pdf?version=1598794274","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7559934","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7559934","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel)","raw_type":"Text"},{"id":"pmid:32872677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32872677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unito.it:2318/1869009","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2318/1869009","pdf_url":"https://iris.unito.it/bitstream/2318/1869009/1/pharmaceuticals-13-00225.pdf","source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:e10410458898468d9e983704f929572b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e10410458898468d9e983704f929572b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceuticals, Vol 13, Iss 9, p 225 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ph13090225","doi":"https://doi.org/10.3390/ph13090225","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph13090225","pdf_url":"https://www.mdpi.com/1424-8247/13/9/225/pdf?version=1598794274","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1231928259","display_name":null,"funder_award_id":"AGL 2017-86526-P","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G1563568275","display_name":null,"funder_award_id":"AGL2017","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G2344252141","display_name":null,"funder_award_id":"R-1042/2015","funder_id":"https://openalex.org/F4320322805","funder_display_name":"Universidad de Murcia"},{"id":"https://openalex.org/G3756377764","display_name":null,"funder_award_id":"AGL2017-86526","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G4510461357","display_name":null,"funder_award_id":"19893/GERM/15","funder_id":"https://openalex.org/F4320310087","funder_display_name":"Fundaci\u00f3n S\u00e9neca"}],"funders":[{"id":"https://openalex.org/F4320310087","display_name":"Fundaci\u00f3n S\u00e9neca","ror":"https://ror.org/03q68pf65"},{"id":"https://openalex.org/F4320321204","display_name":"Chungnam National University","ror":"https://ror.org/0227as991"},{"id":"https://openalex.org/F4320322805","display_name":"Universidad de Murcia","ror":"https://ror.org/03p3aeb86"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":"https://ror.org/003x0zc53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3081663272.pdf","grobid_xml":"https://content.openalex.org/works/W3081663272.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W187782327","https://openalex.org/W1605065814","https://openalex.org/W1954701421","https://openalex.org/W1973613293","https://openalex.org/W1974605099","https://openalex.org/W1981592350","https://openalex.org/W1981969227","https://openalex.org/W1987927672","https://openalex.org/W2004332892","https://openalex.org/W2020513326","https://openalex.org/W2034833162","https://openalex.org/W2068897578","https://openalex.org/W2074631079","https://openalex.org/W2079184489","https://openalex.org/W2088381487","https://openalex.org/W2094225592","https://openalex.org/W2101078720","https://openalex.org/W2108148925","https://openalex.org/W2112247858","https://openalex.org/W2138134399","https://openalex.org/W2159218555","https://openalex.org/W2167348821","https://openalex.org/W2168042606","https://openalex.org/W2172227666","https://openalex.org/W2330009142","https://openalex.org/W2564232696","https://openalex.org/W2581191710","https://openalex.org/W2604397363","https://openalex.org/W2604454272","https://openalex.org/W2743436456","https://openalex.org/W2750598473","https://openalex.org/W2804822363","https://openalex.org/W2806133832","https://openalex.org/W2890684893","https://openalex.org/W2921180751","https://openalex.org/W2974107582","https://openalex.org/W2981316385","https://openalex.org/W3033298088","https://openalex.org/W3041079708","https://openalex.org/W6640971516"],"related_works":["https://openalex.org/W2088381487","https://openalex.org/W2103405642","https://openalex.org/W4242335534","https://openalex.org/W2060814375","https://openalex.org/W2529628657","https://openalex.org/W1992657370","https://openalex.org/W185983343","https://openalex.org/W2102646072","https://openalex.org/W2553671280","https://openalex.org/W2026976390"],"abstract_inverted_index":{"Our":[0],"desire":[1],"to":[2,7,26],"live":[3],"longer":[4],"has":[5],"led":[6],"an":[8,115],"ever-increasing":[9],"number":[10],"of":[11,39,67,84,145,177],"novel":[12,183],"antiaging":[13],"products.":[14],"However,":[15],"few":[16],"molecules":[17],"have":[18],"any":[19],"real":[20],"effect":[21],"and":[22,52,76,80,89,96,125,181],"new":[23],"ones":[24],"need":[25],"be":[27,32],"studied":[28,46],"before":[29],"they":[30],"can":[31,138],"used":[33,108],"commercially.":[34],"In":[35,158],"this":[36],"contribution,":[37],"activation":[38],"the":[40,81,90,143,146,162,165,175],"caloric":[41],"restriction":[42],"(CR)":[43],"pathway":[44],"was":[45,70,87,130,134],"using":[47,121],"different":[48],"three":[49],"(resveratrol,":[50],"oxyresveratrol":[51],"piceatannol)\u2014a":[53],"family":[54],"with":[55,99,102,155],"demonstrated":[56,135],"bioactivity":[57],"on":[58],"phosphodiesterase":[59,63],"activity.":[60],"The":[61,78,168],"high-affinity":[62],"type":[64],"2":[65],"(PDE2)":[66],"Saccharomyces":[68],"cerevisiae":[69,124,128],"expressed":[71],"in":[72,94,97,109,116,164],"Escherichia":[73],"coli,":[74],"purified":[75],"characterized.":[77],"activity":[79,83],"inhibitory":[82],"each":[85],"stilbene":[86],"studied,":[88],"findings":[91,169],"were":[92],"compared":[93],"vitro":[95],"silico":[98],"those":[100],"obtained":[101],"roflumilast\u2014a":[103],"human":[104],"PDE4":[105],"inhibitor":[106],"widely":[107],"chronic":[110],"obstructive":[111],"pulmonary":[112],"diseases.":[113],"Finally,":[114],"vivo":[117],"chronological":[118],"lifespan":[119,144,163,178],"assay":[120],"WT":[122,166],"S.":[123,127],"\u0394PDE2":[126],"strains":[129],"carried":[131],"out.":[132],"It":[133],"that":[136],"stilbenes":[137],"modulate":[139],"yPDE2":[140],"activity,":[141],"increasing":[142],"yeast":[147],"by":[148],"18%":[149],"over":[150],"a":[151,171],"control":[152],"(in":[153],"combination":[154],"other":[156],"pathways).":[157],"addition,":[159],"roflumilast":[160],"increased":[161],"strain.":[167],"as":[170],"whole":[172],"would":[173],"increase":[174],"range":[176],"products":[179],"available":[180],"suggest":[182],"uses":[184],"for":[185],"approved":[186],"drugs.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-09-08T00:00:00"}