{"id":"https://openalex.org/W3081563294","doi":"https://doi.org/10.1186/s12977-020-00537-x","title":"Influence of the amino-terminal sequence on the structure and function of HIV integrase","display_name":"Influence of the amino-terminal sequence on the structure and function of HIV integrase","publication_year":2020,"publication_date":"2020-08-31","ids":{"openalex":"https://openalex.org/W3081563294","doi":"https://doi.org/10.1186/s12977-020-00537-x","mag":"3081563294","pmid":"https://pubmed.ncbi.nlm.nih.gov/32867805","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7457537"},"language":"en","primary_location":{"id":"doi:10.1186/s12977-020-00537-x","doi":"https://doi.org/10.1186/s12977-020-00537-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12977-020-00537-x","pdf_url":"https://retrovirology.biomedcentral.com/track/pdf/10.1186/s12977-020-00537-x","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://retrovirology.biomedcentral.com/track/pdf/10.1186/s12977-020-00537-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084829609","display_name":"Grant Eilers","orcid":"https://orcid.org/0000-0001-9191-5932","observed_orcids":["https://orcid.org/0000-0001-9191-5932"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grant Eilers","raw_affiliation_strings":["Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0001-9191-5932","affiliations":[{"raw_affiliation_string":"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050299360","display_name":"Kushol Gupta","orcid":"https://orcid.org/0000-0002-7006-2667","observed_orcids":["https://orcid.org/0000-0002-7006-2667"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kushol Gupta","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055526042","display_name":"Audrey Allen","orcid":"https://orcid.org/0000-0001-6580-7284","observed_orcids":["https://orcid.org/0000-0001-6580-7284"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Audrey Allen","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086832923","display_name":"Jeffrey O. Zhou","orcid":"https://orcid.org/0000-0001-9362-1882","observed_orcids":["https://orcid.org/0000-0001-9362-1882"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Zhou","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Young Hwang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Young Hwang","raw_affiliation_strings":["Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013325706","display_name":"Michael Cory","orcid":"https://orcid.org/0000-0002-2509-2939","observed_orcids":["https://orcid.org/0000-0002-2509-2939"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael B. Cory","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016535188","display_name":"Frederic D. Bushman","orcid":"https://orcid.org/0000-0003-4740-4056","observed_orcids":["https://orcid.org/0000-0003-4740-4056"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Frederic D. Bushman","raw_affiliation_strings":["Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. bushman@pennmedicine.upenn.edu","Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. bushman@pennmedicine.upenn.edu","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018267030","display_name":"Gregory D. Van Duyne","orcid":"https://orcid.org/0000-0003-0247-1626","observed_orcids":["https://orcid.org/0000-0003-0247-1626"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory Van Duyne","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. vanduyne@pennmedicine.upenn.edu","Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. vanduyne@pennmedicine.upenn.edu","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016535188","https://openalex.org/A5018267030"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.2557,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.69219799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"17","issue":"1","first_page":"28","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.10100000351667404,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-integrase","display_name":"HIV integrase","score":0.9449999928474426},{"id":"https://openalex.org/keywords/n-terminal-sequence","display_name":"N-terminal sequence","score":0.7680000066757202},{"id":"https://openalex.org/keywords/hiv-1-integrase","display_name":"HIV-1 integrase","score":0.6420000195503235},{"id":"https://openalex.org/keywords/raltegravir","display_name":"raltegravir","score":0.7979999780654907},{"id":"https://openalex.org/keywords/integrase-inhibitors","display_name":"integrase inhibitors","score":0.7039999961853027},{"id":"https://openalex.org/keywords/protein-oligomerization","display_name":"protein oligomerization","score":0.8109999895095825},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.593999981880188},{"id":"https://openalex.org/keywords/antiretroviral-drug-targets","display_name":"antiretroviral drug targets","score":0.7639999985694885},{"id":"https://openalex.org/keywords/viral-dna-integration","display_name":"viral DNA integration","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C14430832","wikidata":"https://www.wikidata.org/wiki/Q412550","display_name":"Integrase","level":3,"score":0.9229832887649536},{"id":"https://openalex.org/C2780404665","wikidata":"https://www.wikidata.org/wiki/Q421552","display_name":"Raltegravir","level":5,"score":0.6924368739128113},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.5205938816070557},{"id":"https://openalex.org/C57711820","wikidata":"https://www.wikidata.org/wiki/Q310425","display_name":"C-terminus","level":3,"score":0.5014908313751221},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4836777150630951},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4830477833747864},{"id":"https://openalex.org/C14053116","wikidata":"https://www.wikidata.org/wiki/Q284398","display_name":"N-terminus","level":4,"score":0.46955445408821106},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44852063059806824},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.44088461995124817},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4309002459049225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33704861998558044},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.32805901765823364},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3156284689903259},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2820497751235962},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2713510990142822},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.2516423463821411},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.24334749579429626},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068898","descriptor_name":"Raltegravir Potassium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019427","descriptor_name":"HIV Integrase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019427","descriptor_name":"HIV Integrase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019427","descriptor_name":"HIV Integrase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019428","descriptor_name":"HIV Integrase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12977-020-00537-x","doi":"https://doi.org/10.1186/s12977-020-00537-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12977-020-00537-x","pdf_url":"https://retrovirology.biomedcentral.com/track/pdf/10.1186/s12977-020-00537-x","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},{"id":"pmid:32867805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32867805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7457537","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7457537/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2db324d9f5ec4e568a8b4d7446e9db4e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2db324d9f5ec4e568a8b4d7446e9db4e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Retrovirology, Vol 17, Iss 1, Pp 1-16 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12977-020-00537-x","doi":"https://doi.org/10.1186/s12977-020-00537-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12977-020-00537-x","pdf_url":"https://retrovirology.biomedcentral.com/track/pdf/10.1186/s12977-020-00537-x","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2705185627","display_name":"BEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination Immunotherapy","funder_award_id":"UM1AI126620","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4355905063","display_name":"A New View of PAH Allostery - Correlation with Disease-Associated Alleles","funder_award_id":"R01NS100081","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4834511143","display_name":"The Lung DNA Virome in Health and Disease","funder_award_id":"R61HL137063","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4939131516","display_name":"HIV Pathogenesis, Vaccination and Cure","funder_award_id":"T32AI007632","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5259589433","display_name":"Optimization HIV Inhibition by Allosteric Integrase Inhibitors","funder_award_id":"R01AI129661","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6565101551","display_name":"Engineering T cells to Provide Durable Control of HIV-1 Replication","funder_award_id":"U19AI117950","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8173708265","display_name":"Lung Transplant Microbiome and Chronic Allograft Dysfunction","funder_award_id":"R01HL113252","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000887542","display_name":"Penn Center for AIDS Research","funder_award_id":"P30AI045008","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320332582","display_name":"Center for AIDS Research, University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320338289","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3081563294.pdf","grobid_xml":"https://content.openalex.org/works/W3081563294.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W255996521","https://openalex.org/W1488279264","https://openalex.org/W1501338560","https://openalex.org/W1527366061","https://openalex.org/W1534684640","https://openalex.org/W1546094383","https://openalex.org/W1547738547","https://openalex.org/W1551896540","https://openalex.org/W1572231208","https://openalex.org/W1601304840","https://openalex.org/W1601338457","https://openalex.org/W1601518034","https://openalex.org/W1685289055","https://openalex.org/W1738249403","https://openalex.org/W1770932653","https://openalex.org/W1804821915","https://openalex.org/W1806325608","https://openalex.org/W1966405882","https://openalex.org/W1966815449","https://openalex.org/W1975317507","https://openalex.org/W1975535299","https://openalex.org/W1980761527","https://openalex.org/W1983544779","https://openalex.org/W1985459186","https://openalex.org/W1985711767","https://openalex.org/W1994881558","https://openalex.org/W1997754834","https://openalex.org/W1999443522","https://openalex.org/W2000074281","https://openalex.org/W2000546717","https://openalex.org/W2001789973","https://openalex.org/W2006572311","https://openalex.org/W2008708467","https://openalex.org/W2015180601","https://openalex.org/W2017178787","https://openalex.org/W2017997170","https://openalex.org/W2020555083","https://openalex.org/W2025213793","https://openalex.org/W2025344323","https://openalex.org/W2026268551","https://openalex.org/W2030774002","https://openalex.org/W2032297596","https://openalex.org/W2032891258","https://openalex.org/W2038028931","https://openalex.org/W2038070445","https://openalex.org/W2044660041","https://openalex.org/W2050569727","https://openalex.org/W2056630573","https://openalex.org/W2057479340","https://openalex.org/W2063495925","https://openalex.org/W2071348779","https://openalex.org/W2075336365","https://openalex.org/W2075688918","https://openalex.org/W2077095206","https://openalex.org/W2077728594","https://openalex.org/W2077916498","https://openalex.org/W2082523699","https://openalex.org/W2085992210","https://openalex.org/W2090699693","https://openalex.org/W2109296787","https://openalex.org/W2110488501","https://openalex.org/W2123221690","https://openalex.org/W2124171592","https://openalex.org/W2126018286","https://openalex.org/W2126103104","https://openalex.org/W2127697961","https://openalex.org/W2132100443","https://openalex.org/W2133997592","https://openalex.org/W2139647182","https://openalex.org/W2140346705","https://openalex.org/W2140854337","https://openalex.org/W2143520648","https://openalex.org/W2144026217","https://openalex.org/W2158808161","https://openalex.org/W2166420278","https://openalex.org/W2169196764","https://openalex.org/W2171711893","https://openalex.org/W2275651183","https://openalex.org/W2282549557","https://openalex.org/W2483470278","https://openalex.org/W2516939124","https://openalex.org/W2536656830","https://openalex.org/W2559832357","https://openalex.org/W2567957174","https://openalex.org/W2568171404","https://openalex.org/W2608493085","https://openalex.org/W2793311671","https://openalex.org/W2912595221","https://openalex.org/W2916691697","https://openalex.org/W2917542248","https://openalex.org/W2946003116","https://openalex.org/W2973457155","https://openalex.org/W3004171189","https://openalex.org/W3004184083","https://openalex.org/W3149957759","https://openalex.org/W4255594044"],"related_works":["https://openalex.org/W2527278243","https://openalex.org/W2060125612","https://openalex.org/W2416687869","https://openalex.org/W2117358305","https://openalex.org/W218277912","https://openalex.org/W1521570954","https://openalex.org/W1827743573","https://openalex.org/W7005859656","https://openalex.org/W2077916498","https://openalex.org/W2146058166"],"abstract_inverted_index":{"BACKGROUND:":[0],"Antiretroviral":[1],"therapy":[2],"(ART)":[3],"can":[4,21],"mitigate":[5],"the":[6,12,68,83,91,104,133,161,203,206,233],"morbidity":[7],"and":[8,27,32,111,165,179,196,211,215,232],"mortality":[9],"caused":[10],"by":[11,24,79],"human":[13],"immunodeficiency":[14],"virus":[15],"(HIV).":[16],"Successful":[17],"development":[18,234],"of":[19,82,96,113,129,132,199,205,235],"ART":[20,39],"be":[22],"accelerated":[23],"accurate":[25],"structural":[26],"biochemical":[28,214],"data":[29],"on":[30,103],"targets":[31],"their":[33],"responses":[34],"to":[35,55,139,155,160,168,183],"inhibitors.":[36,171],"One":[37],"important":[38],"target,":[40],"HIV":[41],"integrase":[42,170],"(IN),":[43],"has":[44],"historically":[45],"been":[46],"studied":[47],"in":[48,50,74,123,127,152,181,227,230],"vitro":[49,124,231],"a":[51,59,62,88],"modified":[52],"form":[53],"adapted":[54],"bacterial":[56],"overexpression,":[57],"with":[58],"methionine":[60],"or":[61],"longer":[63],"fusion":[64],"protein":[65,109],"sequence":[66],"at":[67,90],"N-terminus.":[69],"In":[70,172],"contrast,":[71],"IN":[72,119,141,147,174,185,200,209,218],"present":[73],"viral":[75,135],"particles":[76],"is":[77],"produced":[78],"proteolytic":[80],"cleavage":[81],"Pol":[84],"polyprotein,":[85],"which":[86,187],"leaves":[87],"phenylalanine":[89],"N-terminus":[92,105,210],"(IN":[93],"1F).":[94],"Inspection":[95],"available":[97],"structures":[98],"suggested":[99],"that":[100],"added":[101],"residues":[102],"might":[106],"disrupt":[107],"proper":[108],"folding":[110],"formation":[112],"multimeric":[114],"complexes.":[115],"RESULTS:":[116],".":[117],"Full-length":[118],"1F":[120,148,175,201,219],"showed":[121],"increased":[122,166],"catalytic":[125],"activity":[126],"assays":[128],"coupled":[130],"joining":[131],"two":[134,140],"DNA":[136],"ends":[137],"compared":[138],"variants":[142],"containing":[143],"additional":[144],"N-terminal":[145],"residues.":[146],"was":[149],"also":[150],"altered":[151],"its":[153],"sensitivity":[154,159,167],"inhibitors,":[156],"showing":[157],"decreased":[158],"strand-transfer":[162],"inhibitor":[163],"raltegravir":[164],"allosteric":[169],"solution,":[173],"exists":[176],"as":[177,189],"monomers":[178],"dimers,":[180],"contrast":[182],"other":[184],"preparations":[186],"exist":[188],"higher-order":[190],"oligomers.":[191],"CONCLUSIONS:":[192],"The":[193],"structural,":[194],"biochemical,":[195],"biophysical":[197,216],"characterization":[198],"reveals":[202],"conformation":[204],"native":[207],"HIV-1":[208],"accompanying":[212],"unique":[213],"properties.":[217],"thus":[220],"represents":[221],"an":[222],"improved":[223],"reagent":[224],"for":[225],"use":[226],"integration":[228],"reactions":[229],"antiretroviral":[236],"agents.":[237]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-09-08T00:00:00"}