{"id":"https://openalex.org/W3081536093","doi":"https://doi.org/10.1158/1557-3265.ovca19-b56","title":"Abstract B56: Tissue transglutaminase/Frizzled receptor clusters regulate WNT transcriptional activity in ovarian cancer stem cells","display_name":"Abstract B56: Tissue transglutaminase/Frizzled receptor clusters regulate WNT transcriptional activity in ovarian cancer stem cells","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3081536093","doi":"https://doi.org/10.1158/1557-3265.ovca19-b56","mag":"3081536093"},"language":"en","primary_location":{"id":"doi:10.1158/1557-3265.ovca19-b56","doi":"https://doi.org/10.1158/1557-3265.ovca19-b56","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3265.ovca19-b56","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076427573","display_name":"Salvatore Condello","orcid":"https://orcid.org/0000-0003-4979-3681","observed_orcids":["https://orcid.org/0000-0003-4979-3681"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salvatore Condello","raw_affiliation_strings":["1Indiana University School of Medicine, Indianapolis, IN,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Indiana University School of Medicine, Indianapolis, IN,","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082803202","display_name":"Livia Elena Sima","orcid":"https://orcid.org/0000-0002-3404-4162","observed_orcids":["https://orcid.org/0000-0002-3404-4162"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Livia Sima","raw_affiliation_strings":["2Northwestern University, Chicago, IL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Northwestern University, Chicago, IL,","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082498438","display_name":"Cristina Ivan","orcid":"https://orcid.org/0000-0002-4848-0168","observed_orcids":["https://orcid.org/0000-0002-4848-0168"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina Ivan","raw_affiliation_strings":["3The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074942227","display_name":"Horacio C\u00e1rdenas","orcid":"https://orcid.org/0000-0002-2129-6766","observed_orcids":["https://orcid.org/0000-0002-2129-6766"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Horacio Cardenas","raw_affiliation_strings":["2Northwestern University, Chicago, IL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Northwestern University, Chicago, IL,","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079762031","display_name":"Gary E. Schiltz","orcid":"https://orcid.org/0000-0003-4180-5051","observed_orcids":["https://orcid.org/0000-0003-4180-5051"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Schiltz","raw_affiliation_strings":["2Northwestern University, Chicago, IL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Northwestern University, Chicago, IL,","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059724338","display_name":"Rama K. Mishra","orcid":"https://orcid.org/0000-0003-3608-2602","observed_orcids":["https://orcid.org/0000-0003-3608-2602"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rama Mishra","raw_affiliation_strings":["2Northwestern University, Chicago, IL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Northwestern University, Chicago, IL,","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067743297","display_name":"Daniela Elena Matei","orcid":"https://orcid.org/0000-0003-2169-5035","observed_orcids":["https://orcid.org/0000-0003-2169-5035"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniela Matei","raw_affiliation_strings":["2Northwestern University, Chicago, IL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Northwestern University, Chicago, IL,","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"13_Supplement","first_page":"B56","last_page":"B56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.06949999928474426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9079999923706055},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tissue-transglutaminase","display_name":"tissue transglutaminase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/frizzled-receptors","display_name":"Frizzled receptors","score":0.8859999775886536},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9580000042915344},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.8700000047683716},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8510000109672546},{"id":"https://openalex.org/keywords/spheroid-formation","display_name":"spheroid formation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7020000219345093},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.5479999780654907},{"id":"https://openalex.org/keywords/fzd8","display_name":"FZD8","score":0.3240000009536743}],"concepts":[{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.6513271331787109},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5984249114990234},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5770778656005859},{"id":"https://openalex.org/C10116572","wikidata":"https://www.wikidata.org/wiki/Q18033097","display_name":"LGR5","level":4,"score":0.513631284236908},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.5052421689033508},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.4938521981239319},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4674089252948761},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.45251229405403137},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.4447932243347168},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.42399129271507263},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3699110448360443},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3112418055534363},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2685246467590332},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.20526009798049927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12860265374183655},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1029958426952362},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1557-3265.ovca19-b56","doi":"https://doi.org/10.1158/1557-3265.ovca19-b56","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3265.ovca19-b56","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2887780345","https://openalex.org/W2792582780","https://openalex.org/W2237675218","https://openalex.org/W7148995434","https://openalex.org/W2009213090","https://openalex.org/W4284976869","https://openalex.org/W4282924160","https://openalex.org/W2048349559","https://openalex.org/W2885858372","https://openalex.org/W2063247389"],"abstract_inverted_index":{"Abstract":[0],"Ovarian":[1,454],"cancer":[2,35,228,276,440],"(OC)":[3],"is":[4,28,75,104,155],"the":[5,45,81,111,119,122,127,141,198,225,235,268,289,327,335,403,447],"most":[6],"lethal":[7],"gynecologic":[8],"cancer,":[9],"characterized":[10],"by":[11,88,139,206,357],"chemoresistance":[12],"and":[13,23,59,72,99,109,134,150,165,189,197,219,248,264,286,302,307,314,322,331,345,352,387,394],"fatal":[14],"tumor":[15,46,249],"recurrence":[16,25],"after":[17],"primary":[18],"treatment.":[19],"The":[20,64,279],"metastatic":[21],"progression":[22,108],"post-chemotherapy":[24],"of":[26,34,121,132,184,231,238,256,338,342,368,385,446],"OC":[27,107,136,169,192],"linked":[29],"to":[30,274,317,399],"a":[31,50,252,296,365,382,388],"small":[32],"population":[33],"stem":[36,441],"cells":[37,170,193,442],"(CSCs)":[38],"detectable":[39],"as":[40,96,172,195,408],"ALDH+/CD133+":[41],"phenotype.":[42,114],"In":[43],"OC,":[44],"microenvironment":[47],"(TME)":[48],"provides":[49,361],"favorable":[51],"milieu":[52],"that":[53,118,147,311,326,375],"protects":[54],"quiescent":[55],"CSCs":[56,133],"during":[57],"chemotherapy":[58],"supports":[60,135],"their":[61],"tumorigenic":[62,112],"functions.":[63],"multifunctional":[65],"protein":[66,320],"tissue":[67],"transglutaminase":[68],"(TG2),":[69],"with":[70,90,106,110,162,175,186,215,220,334],"enzymatic":[71],"scaffold":[73],"functions,":[74],"an":[76],"important":[77],"molecule":[78],"secreted":[79],"in":[80,158,168,191,203,224,251,265,292,371,438,453],"TME":[82],"where":[83],"it":[84],"modulates":[85],"oncogenic":[86,261],"signaling":[87,262,271],"interacting":[89],"extracellular":[91],"matrix":[92],"(ECM)":[93],"components,":[94],"such":[95],"fibronectin":[97],"(FN)":[98],"integrins.":[100],"Its":[101],"aberrant":[102],"expression":[103,154,211,355],"correlated":[105,214],"OCSC":[113],"Here,":[115],"we":[116,380],"hypothesized":[117],"formation":[120,138],"TG2/FN/integrins":[123],"ternary":[124],"complex":[125,246,258,301,344,407],"at":[126],"cell":[128,277],"membrane":[129],"promotes":[130],"survival":[131],"spheroid":[137,243],"regulating":[140],"Wnt/beta-catenin":[142],"pathway.":[143],"Our":[144],"data":[145],"demonstrate":[146],"TG2,":[148],"FN,":[149],"integrin":[151,187],"\u03b21":[152,188],"mRNA":[153],"markedly":[156],"increased":[157],"OCSCs":[159],"(ALDH+/CD133+)":[160],"compared":[161,174],"non-CSC":[163],"(ALDH-/CD133-)":[164],"highly":[166],"enriched":[167],"grown":[171,194],"spheroids":[173,350],"monolayers":[176],"(p<0.01).":[177],"Immunofluorescence":[178],"(IF)":[179],"staining":[180,309],"showed":[181,288],"abundant":[182],"complexes":[183,370],"TG2":[185,210,239,312,330,376,386],"FN":[190],"spheroids,":[196],"protein-protein":[199],"interactions":[200],"were":[201],"detected":[202],"human":[204],"tumors":[205],"proximity":[207],"ligation":[208],"assay.":[209],"was":[212],"strongly":[213],"ITGB1":[216],"(R=0.23,":[217],"P<0.0001)":[218,223],"FN1":[221],"(R=0.39,":[222],"TCGA":[226],"ovarian":[227,439],"database.":[229],"Use":[230],"function-inhibiting":[232],"antibody":[233],"against":[234],"FN-binding":[236,336],"domain":[237,337],"(4G3)":[240],"dramatically":[241],"suppressed":[242],"proliferation,":[244],"TG2/FN/integrin":[245],"formation,":[247],"growth":[250],"xenograft":[253],"model.":[254],"Disruption":[255],"TG2/FN":[257,300,343,369,400],"altered":[259],"key":[260,366],"pathways,":[263],"particular":[266],"blocked":[267],"canonical":[269],"Wnt/\u03b2-catenin":[270],"pathway":[272,304],"essential":[273],"sustaining":[275],"stemness.":[278],"Wnt":[280,303],"receptor":[281,432],"Frizzled":[282],"genes":[283],"(Fzd1,":[284],"Fzd7":[285,332,347],"Fzd8)":[287],"greatest":[290],"difference":[291],"gene":[293,354],"expression,":[294],"indicating":[295],"direct":[297],"correlation":[298],"between":[299,329],"activation.":[305],"Co-immunoprecipitation":[306],"IF":[308],"demonstrated":[310,325],"co-localizes":[313],"directly":[315,377],"binds":[316,378],"Fzd7.":[318],"Furthermore,":[319],"docking":[321],"peptide":[323],"inhibition":[324],"interaction":[328],"overlapped":[333],"TG2.":[339],"Finally,":[340],"blockade":[341],"shRNA-mediated":[346],"knockdown":[348],"attenuated":[349],"proliferation":[351,393],"targeted":[353],"induced":[356],"Wnt3a/7a.":[358],"This":[359],"study":[360],"strong":[362],"evidence":[363],"supporting":[364],"function":[367,384],"OCSCs.":[372],"By":[373],"demonstrating":[374],"Fzd7,":[379],"identified":[381],"novel":[383],"new":[389,410],"mechanism":[390],"promoting":[391],"CSCs\u2019":[392],"tumorigenicity.":[395],"These":[396],"results":[397],"point":[398],"clusters":[401,433],"or":[402],"newly":[404],"discovered":[405],"TG2/Fzd7":[406],"potential":[409],"therapeutic":[411],"CSC":[412],"targets.":[413],"Citation":[414],"Format:":[415],"Salvatore":[416],"Condello,":[417],"Livia":[418],"Sima,":[419],"Cristina":[420],"Ivan,":[421],"Horacio":[422],"Cardenas,":[423],"Gary":[424],"Schiltz,":[425],"Rama":[426],"Mishra,":[427],"Daniela":[428],"Matei.":[429],"Tissue":[430],"transglutaminase/Frizzled":[431],"regulate":[434],"WNT":[435],"transcriptional":[436],"activity":[437],"[abstract].":[443],"In:":[444],"Proceedings":[445],"AACR":[448],"Special":[449],"Conference":[450],"on":[451],"Advances":[452],"Cancer":[455,467],"Research;":[456],"2019":[457],"Sep":[458],"13-16,":[459],"2019;":[460],"Atlanta,":[461],"GA.":[462],"Philadelphia":[463],"(PA):":[464],"AACR;":[465],"Clin":[466],"Res":[468],"2020;26(13_Suppl):Abstract":[469],"nr":[470],"B56.":[471]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-09-08T00:00:00"}
