{"id":"https://openalex.org/W3081529752","doi":"https://doi.org/10.2174/1386207323666200901095003","title":"G-Lymphatic, Vascular and Immune Pathways for A\u03b2 Clearance Cascade and Therapeutic Targets For Alzheimer\u2019s Disease","display_name":"G-Lymphatic, Vascular and Immune Pathways for A\u03b2 Clearance Cascade and Therapeutic Targets For Alzheimer\u2019s Disease","publication_year":2020,"publication_date":"2020-09-02","ids":{"openalex":"https://openalex.org/W3081529752","doi":"https://doi.org/10.2174/1386207323666200901095003","mag":"3081529752","pmid":"https://pubmed.ncbi.nlm.nih.gov/32875981"},"language":"en","primary_location":{"id":"doi:10.2174/1386207323666200901095003","doi":"https://doi.org/10.2174/1386207323666200901095003","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1386207323666200901095003","pdf_url":null,"source":{"id":"https://openalex.org/S50933791","display_name":"Combinatorial Chemistry & High Throughput Screening","issn_l":"1386-2073","issn":["1386-2073","1875-5402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Combinatorial Chemistry & High Throughput Screening","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019219727","display_name":"Saurav Chakraborty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126824641","display_name":"JSS Academy of Higher Education and Research","ror":"https://ror.org/013x70191","country_code":"IN","type":"education","lineage":["https://openalex.org/I126824641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saurav Chakraborty","raw_affiliation_strings":["Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Tamilnadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Tamilnadu, India","institution_ids":["https://openalex.org/I126824641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041964502","display_name":"Jyothsna ThimmaReddygari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126824641","display_name":"JSS Academy of Higher Education and Research","ror":"https://ror.org/013x70191","country_code":"IN","type":"education","lineage":["https://openalex.org/I126824641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jyothsna ThimmaReddygari","raw_affiliation_strings":["Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Tamilnadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Tamilnadu, India","institution_ids":["https://openalex.org/I126824641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036761722","display_name":"Divakar Selvaraj","orcid":"https://orcid.org/0000-0002-6434-6583","observed_orcids":["https://orcid.org/0000-0002-6434-6583"]},"institutions":[{"id":"https://openalex.org/I126824641","display_name":"JSS Academy of Higher Education and Research","ror":"https://ror.org/013x70191","country_code":"IN","type":"education","lineage":["https://openalex.org/I126824641"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Divakar Selvaraj","raw_affiliation_strings":["Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Tamilnadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Tamilnadu, India","institution_ids":["https://openalex.org/I126824641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036761722"],"corresponding_institution_ids":["https://openalex.org/I126824641"],"apc_list":null,"apc_paid":null,"fwci":0.567,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.54000258,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"24","issue":"7","first_page":"1083","last_page":"1092"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/amyloid-beta-clearance","display_name":"amyloid-beta clearance","score":0.9819999933242798},{"id":"https://openalex.org/keywords/glymphatic-system","display_name":"glymphatic system","score":0.9769999980926514},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8040000200271606},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.7860000133514404},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.7950000166893005},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.8600000143051147},{"id":"https://openalex.org/keywords/lrp1","display_name":"LRP1","score":0.6200000047683716},{"id":"https://openalex.org/keywords/rage","display_name":"RAGE","score":0.7820000052452087},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9890000224113464},{"id":"https://openalex.org/keywords/clusterin","display_name":"clusterin","score":0.9350000023841858},{"id":"https://openalex.org/keywords/aquaporin-4","display_name":"aquaporin-4","score":0.9909999966621399},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.9150000214576721},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.871999979019165},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.7440000176429749},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6679999828338623},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.6626636385917664},{"id":"https://openalex.org/C2779476363","wikidata":"https://www.wikidata.org/wiki/Q14864935","display_name":"Clusterin","level":3,"score":0.6257186532020569},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.5619614720344543},{"id":"https://openalex.org/C180081513","wikidata":"https://www.wikidata.org/wiki/Q4914721","display_name":"Biochemistry of Alzheimer's disease","level":5,"score":0.5598769187927246},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.5369714498519897},{"id":"https://openalex.org/C177907266","wikidata":"https://www.wikidata.org/wiki/Q17155455","display_name":"P3 peptide","level":5,"score":0.5213571786880493},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5010538101196289},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.49260765314102173},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4921643137931824},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.4378218650817871},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.42801976203918457},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3556402623653412},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33641940355300903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33266493678092957},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.31034159660339355},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.2542772889137268},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.18254217505455017},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17423802614212036},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15045496821403503},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.127867192029953},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.09118786454200745}],"mesh":[{"descriptor_ui":"D000077502","descriptor_name":"Glymphatic System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000077502","descriptor_name":"Glymphatic System","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/1386207323666200901095003","doi":"https://doi.org/10.2174/1386207323666200901095003","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1386207323666200901095003","pdf_url":null,"source":{"id":"https://openalex.org/S50933791","display_name":"Combinatorial Chemistry & High Throughput Screening","issn_l":"1386-2073","issn":["1386-2073","1875-5402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Combinatorial Chemistry & High Throughput Screening","raw_type":"journal-article"},{"id":"pmid:32875981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32875981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Combinatorial chemistry & high throughput screening","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2795597697","https://openalex.org/W2931736102","https://openalex.org/W4403744196","https://openalex.org/W3004631942","https://openalex.org/W7160503570","https://openalex.org/W6979862691","https://openalex.org/W2766080780","https://openalex.org/W2008487250","https://openalex.org/W1588345803","https://openalex.org/W1767010801"],"abstract_inverted_index":{"Alzheimer's":[0,10,26,88],"disease":[1,11,27],"is":[2],"an":[3],"age-related":[4],"neurodegenerative":[5,169],"disease.":[6,89],"The":[7,90,141],"factors":[8,23],"causing":[9],"are":[12,98,130,207],"numerous.":[13],"Research":[14],"on":[15,202],"humans":[16],"and":[17,34,65,78,101,128,154,171,189],"rodent":[18],"models":[19],"predicted":[20],"various":[21],"causative":[22],"involved":[24,94,131],"in":[25,62,87,95,132,144,160],"progression.":[28],"Among":[29],"them,":[30],"neuroinflammation,":[31],"oxidative":[32],"stress,":[33],"apoptosis":[35],"play":[36],"a":[37,55,84,168,184],"major":[38,56,85],"role":[39,57,86],"because":[40,58],"of":[41,44,51,59,67,150,156],"the":[42,49,60,63,68,79,114,138,145,195],"accumulation":[43],"extracellular":[45],"amyloid-beta":[46,161,165,205],"peptides.":[47],"Here,":[48],"clearance":[50,66,92,135,206],"amyloid":[52,69,96,133,151],"beta-peptide":[53,97,134],"plays":[54],"imbalance":[61],"production":[64,155],"beta-peptide.":[70],"Additionally,":[71],"neuroinflammation":[72],"by":[73,147],"microglia,":[74],"astrocytes,":[75],"cytokines,":[76,127],"chemokines,":[77],"complement":[80,125],"system":[81],"also":[82],"has":[83],"physiological":[91],"pathways":[93,136,203],"glymphatic,":[99],"vascular,":[100],"immune":[102],"pathways.":[103],"Amyloid":[104],"precursor":[105,152],"protein,":[106],"low-density":[107],"lipoprotein":[108],"receptor-related":[109],"protein":[110,153,158],"1,":[111],"receptor":[112],"for":[113,187,198,204],"advanced":[115],"glycation":[116],"end":[117],"product,":[118],"apolipoprotein":[119],"E,":[120],"clusterin,":[121],"aquaporin":[122],"4,":[123],"auto-antibodies,":[124],"system,":[126],"microglia":[129],"across":[137],"blood-brain":[139],"barrier.":[140],"plaque":[142],"formation":[143],"brain":[146],"alternative":[148],"splicing":[149],"misfolded":[157],"results":[159],"agglomeration.":[162],"This":[163],"insoluble":[164],"leads":[166],"to":[167],"cascade":[170],"neuronal":[172],"cell":[173],"death":[174],"occurs.":[175],"Studies":[176],"had":[177],"shown":[178],"that":[179],"disturbed":[180],"sleep":[181],"may":[182],"be":[183],"risk":[185],"factor":[186],"dementia":[188],"cognitive":[190],"decline.":[191],"In":[192],"this":[193],"review,":[194],"therapeutic":[196],"targets":[197],"Alzheimer'sdisease":[199],"via":[200],"focusing":[201],"discussed.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-09-08T00:00:00"}