{"id":"https://openalex.org/W3081337239","doi":"https://doi.org/10.1371/journal.pbio.3000757","title":"Metabolic excretion associated with nutrient\u2013growth dysregulation promotes the rapid evolution of an overt metabolic defect","display_name":"Metabolic excretion associated with nutrient\u2013growth dysregulation promotes the rapid evolution of an overt metabolic defect","publication_year":2020,"publication_date":"2020-08-24","ids":{"openalex":"https://openalex.org/W3081337239","doi":"https://doi.org/10.1371/journal.pbio.3000757","mag":"3081337239","pmid":"https://pubmed.ncbi.nlm.nih.gov/32833957","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7470746"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pbio.3000757","doi":"https://doi.org/10.1371/journal.pbio.3000757","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.3000757","pdf_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3000757&type=printable","source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3000757&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101974173","display_name":"Robin Green","orcid":"https://orcid.org/0000-0001-7411-0593","observed_orcids":["https://orcid.org/0000-0001-7411-0593"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robin Green","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103242875","display_name":"Sonal","orcid":"https://orcid.org/0000-0002-2361-4131","observed_orcids":["https://orcid.org/0000-0002-2361-4131"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonal","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100403208","display_name":"Lin Wang","orcid":"https://orcid.org/0000-0002-9370-6891","observed_orcids":["https://orcid.org/0000-0002-9370-6891"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Wang","raw_affiliation_strings":["Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA","Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071275598","display_name":"Samuel F. M. Hart","orcid":"https://orcid.org/0000-0002-5068-2199","observed_orcids":["https://orcid.org/0000-0002-5068-2199"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel F.M. Hart","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-5068-2199","affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003316821","display_name":"Wenyun Lu","orcid":"https://orcid.org/0000-0003-1787-2617","observed_orcids":["https://orcid.org/0000-0003-1787-2617"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenyun Lu","raw_affiliation_strings":["Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA","Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083110402","display_name":"David Skelding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Skelding","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Justin C. Burton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin C. Burton","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073596615","display_name":"Hanbing Mi","orcid":"https://orcid.org/0000-0002-6078-6274","observed_orcids":["https://orcid.org/0000-0002-6078-6274"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanbing Mi","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001393755","display_name":"Aric Capel","orcid":"https://orcid.org/0000-0002-2748-379X","observed_orcids":["https://orcid.org/0000-0002-2748-379X"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aric Capel","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075542698","display_name":"Hung Alex Chen","orcid":"https://orcid.org/0000-0001-5119-6208","observed_orcids":["https://orcid.org/0000-0001-5119-6208"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hung Alex Chen","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102916415","display_name":"Aaron Lin","orcid":"https://orcid.org/0000-0002-6006-0908","observed_orcids":["https://orcid.org/0000-0002-6006-0908"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Lin","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058650629","display_name":"Arvind Rasi Subramaniam","orcid":"https://orcid.org/0000-0001-6145-4303","observed_orcids":["https://orcid.org/0000-0001-6145-4303"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arvind R. Subramaniam","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053467552","display_name":"Joshua D. Rabinowitz","orcid":"https://orcid.org/0000-0002-1247-4727","observed_orcids":["https://orcid.org/0000-0002-1247-4727"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua D. Rabinowitz","raw_affiliation_strings":["Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA","Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033692642","display_name":"Wenying Shou","orcid":"https://orcid.org/0000-0001-5693-381X","observed_orcids":["https://orcid.org/0000-0001-5693-381X"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wenying Shou","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033692642","https://openalex.org/A5101974173"],"corresponding_institution_ids":["https://openalex.org/I4210089486"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":1.3781,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.80206863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"18","issue":"8","first_page":"e3000757","last_page":"e3000757"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.25369998812675476,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.02710000053048134,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reduced-glutathione","display_name":"reduced glutathione","score":0.7990000247955322},{"id":"https://openalex.org/keywords/lysine-auxotrophy","display_name":"lysine auxotrophy","score":0.7379999756813049},{"id":"https://openalex.org/keywords/yeast-evolution","display_name":"yeast evolution","score":0.44999998807907104},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.7450000047683716},{"id":"https://openalex.org/keywords/frequency-dependent-selection","display_name":"frequency-dependent selection","score":0.5920000076293945},{"id":"https://openalex.org/keywords/glucose-limitation","display_name":"glucose limitation","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7925105094909668},{"id":"https://openalex.org/C2776030549","wikidata":"https://www.wikidata.org/wiki/Q7829395","display_name":"Nutrient sensing","level":3,"score":0.5755907893180847},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5668443441390991},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.5641948580741882},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5321955680847168},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.5190794467926025},{"id":"https://openalex.org/C142796444","wikidata":"https://www.wikidata.org/wiki/Q181394","display_name":"Nutrient","level":2,"score":0.4830949306488037},{"id":"https://openalex.org/C20950039","wikidata":"https://www.wikidata.org/wiki/Q578111","display_name":"Auxotrophy","level":4,"score":0.47904765605926514},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3656088411808014},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.3408697247505188},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.22866222262382507},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22075167298316956},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.16387426853179932},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.1481458842754364},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.13920140266418457}],"mesh":[{"descriptor_ui":"D000078622","descriptor_name":"Nutrients","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000078622","descriptor_name":"Nutrients","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pbio.3000757","doi":"https://doi.org/10.1371/journal.pbio.3000757","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.3000757","pdf_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3000757&type=printable","source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Biology","raw_type":"journal-article"},{"id":"doi:10.1101/498543","doi":"https://doi.org/10.1101/498543","is_oa":true,"landing_page_url":"https://doi.org/10.1101/498543","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/04/26/498543.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:7470746","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7470746","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Biol","raw_type":"Text"},{"id":"pmid:32833957","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32833957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5f469e7fa11f4c4f9731f061a6e4123e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5f469e7fa11f4c4f9731f061a6e4123e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Biology, Vol 18, Iss 8, p e3000757 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pbio.3000757","doi":"https://doi.org/10.1371/journal.pbio.3000757","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.3000757","pdf_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3000757&type=printable","source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.40450000762939453,"id":"https://metadata.un.org/sdg/2"}],"sustainable_development_goals_aurora":[{"display_name":"Life on land","score":0.44999998807907104,"id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1473276417","display_name":null,"funder_award_id":"1917258","funder_id":"https://openalex.org/F4320332167","funder_display_name":"Directorate for Biological Sciences"},{"id":"https://openalex.org/G2308089594","display_name":null,"funder_award_id":"R35GM119835","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G394945183","display_name":null,"funder_award_id":"R50CA211437","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G5633565596","display_name":null,"funder_award_id":"DP2 OD006498-01","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G8046246768","display_name":"Understanding Robustness of a Cooperative Microbial Community during Evolution","funder_award_id":"R01GM124128","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8456975111","display_name":"Cellular Cooperation and Cheating: an Experimental and Mathematical Analysis","funder_award_id":"1dp2od006498-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8539455605","display_name":null,"funder_award_id":"GM119835","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8943706559","display_name":"BBSRC-NSF/BIO:  Understanding the origin and evolution of metabolic interactions using synthetic microbial communities","funder_award_id":"1917258","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8961918948","display_name":null,"funder_award_id":"1917258","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G9000860189","display_name":"Regulation of Protein Synthesis by Synonymous Codon Usage","funder_award_id":"R35GM119835","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000887998","display_name":"Revealing cancer metabolism via mass spectrometry and isotope tracers","funder_award_id":"R50CA211437","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320306159","display_name":"W. M. Keck Foundation","ror":"https://ror.org/000dswa46"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3081337239.pdf","grobid_xml":"https://content.openalex.org/works/W3081337239.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W1579467601","https://openalex.org/W1902685772","https://openalex.org/W1921951426","https://openalex.org/W1965766554","https://openalex.org/W1966822128","https://openalex.org/W1980444360","https://openalex.org/W1989864831","https://openalex.org/W1991864822","https://openalex.org/W1992681494","https://openalex.org/W1999514736","https://openalex.org/W2003609221","https://openalex.org/W2005025492","https://openalex.org/W2009744584","https://openalex.org/W2018511096","https://openalex.org/W2018666541","https://openalex.org/W2022913932","https://openalex.org/W2024335755","https://openalex.org/W2029945156","https://openalex.org/W2030114688","https://openalex.org/W2030154932","https://openalex.org/W2030763326","https://openalex.org/W2033172386","https://openalex.org/W2038926948","https://openalex.org/W2043451976","https://openalex.org/W2051648135","https://openalex.org/W2058333934","https://openalex.org/W2063623818","https://openalex.org/W2078198885","https://openalex.org/W2085568550","https://openalex.org/W2086655099","https://openalex.org/W2089938084","https://openalex.org/W2098066769","https://openalex.org/W2100057937","https://openalex.org/W2100485294","https://openalex.org/W2100605768","https://openalex.org/W2101807260","https://openalex.org/W2107465057","https://openalex.org/W2111813659","https://openalex.org/W2112263185","https://openalex.org/W2114684949","https://openalex.org/W2115588205","https://openalex.org/W2115955060","https://openalex.org/W2116524545","https://openalex.org/W2118529378","https://openalex.org/W2126801593","https://openalex.org/W2130337886","https://openalex.org/W2131223372","https://openalex.org/W2136947295","https://openalex.org/W2137372494","https://openalex.org/W2137564704","https://openalex.org/W2137683543","https://openalex.org/W2143753421","https://openalex.org/W2149457744","https://openalex.org/W2152855010","https://openalex.org/W2155277241","https://openalex.org/W2159007909","https://openalex.org/W2164683004","https://openalex.org/W2165934569","https://openalex.org/W2166068892","https://openalex.org/W2169010693","https://openalex.org/W2171968158","https://openalex.org/W2192486813","https://openalex.org/W2249224437","https://openalex.org/W2318425021","https://openalex.org/W2322000107","https://openalex.org/W2338811717","https://openalex.org/W2416065856","https://openalex.org/W2420040372","https://openalex.org/W2469570449","https://openalex.org/W2474520925","https://openalex.org/W2548176480","https://openalex.org/W2572193764","https://openalex.org/W2576890255","https://openalex.org/W2588053842","https://openalex.org/W2735465598","https://openalex.org/W2737557435","https://openalex.org/W2751830806","https://openalex.org/W2758942678","https://openalex.org/W2760023427","https://openalex.org/W2775053713","https://openalex.org/W2785703025","https://openalex.org/W2794647037","https://openalex.org/W2897355487","https://openalex.org/W2908663076","https://openalex.org/W2915795786","https://openalex.org/W2950607861","https://openalex.org/W2952138780","https://openalex.org/W2981055129","https://openalex.org/W2984555737","https://openalex.org/W3016589427","https://openalex.org/W4211186089","https://openalex.org/W4237666549","https://openalex.org/W4242025860"],"related_works":["https://openalex.org/W4409344585","https://openalex.org/W2964927477","https://openalex.org/W2098428745","https://openalex.org/W7095857112","https://openalex.org/W2085568550","https://openalex.org/W2130337886","https://openalex.org/W2042660565","https://openalex.org/W2895925087","https://openalex.org/W4389429443","https://openalex.org/W6906832562"],"abstract_inverted_index":{"In":[0],"eukaryotes,":[1],"conserved":[2],"mechanisms":[3],"ensure":[4],"that":[5,29,144],"cell":[6,24,136],"growth":[7,14,87,96,113,137],"is":[8,120],"coordinated":[9],"with":[10,122],"nutrient":[11,16],"availability.":[12],"Overactive":[13],"during":[15,83,92],"limitation":[17,85,94],"(\"nutrient-growth":[18],"dysregulation\")":[19],"can":[20,31,148],"lead":[21],"to":[22,33,62,66,106,133,138],"rapid":[23,123],"death.":[25],"Here,":[26],"we":[27],"demonstrate":[28],"cells":[30,54,82],"adapt":[32],"nutrient-growth":[34,56,118],"dysregulation":[35,119],"by":[36,80,108],"evolving":[37],"major":[38],"metabolic":[39,140],"defects.":[40],"Specifically,":[41],"when":[42,86,95],"yeast":[43],"lysine-auxotrophic":[44],"mutant":[45],"lys-":[46,81],"encountered":[47],"lysine":[48,84],"limitation,":[49],"an":[50],"evolutionarily":[51,145],"novel":[52,146],"stress,":[53],"suffered":[55],"dysregulation.":[57],"A":[58],"subpopulation":[59],"repeatedly":[60],"evolved":[61],"lose":[63],"the":[64,128,139,156,159],"ability":[65],"synthesize":[67],"organosulfurs":[68,100],"(lys-orgS-).":[69],"Organosulfurs,":[70],"mainly":[71],"reduced":[72],"glutathione":[73],"(GSH)":[74],"and":[75],"GSH":[76],"conjugates,":[77],"were":[78],"released":[79],"was":[88,97],"dysregulated,":[89],"but":[90],"not":[91],"glucose":[93],"regulated.":[98],"Limiting":[99],"conferred":[101],"a":[102,110],"frequency-dependent":[103],"fitness":[104],"advantage":[105],"lys-orgS-":[107],"eliciting":[109],"proper":[111],"slow":[112],"program,":[114],"including":[115],"autophagy.":[116],"Thus,":[117],"associated":[121],"organosulfur":[124,131],"release,":[125],"which":[126],"enables":[127],"selection":[129],"of":[130,152,161],"auxotrophy":[132],"better":[134],"tune":[135],"environment.":[141],"We":[142],"speculate":[143],"stresses":[147],"trigger":[149],"atypical":[150],"release":[151],"certain":[153],"metabolites,":[154],"setting":[155],"stage":[157],"for":[158],"evolution":[160],"new":[162],"ecological":[163],"interactions.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-09-01T00:00:00"}
