{"id":"https://openalex.org/W30811722","doi":null,"title":"[Free radicals and brain damage in newborns with hypoxic-ischemic lesion].","display_name":"[Free radicals and brain damage in newborns with hypoxic-ischemic lesion].","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W30811722","mag":"30811722","pmid":"https://pubmed.ncbi.nlm.nih.gov/12046222"},"language":"it","primary_location":{"id":"pmid:12046222","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12046222","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annali dell'Istituto superiore di sanita","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080263193","display_name":"Giuseppe Buonocore","orcid":"https://orcid.org/0000-0002-7921-7485","observed_orcids":["https://orcid.org/0000-0002-7921-7485"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Buonocore","raw_affiliation_strings":["Dipartimento di Pediatria, Ostetricia e Medicina della Riproduzione, Universit\u00e0 degli Studi, Siena"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Pediatria, Ostetricia e Medicina della Riproduzione, Universit\u00e0 degli Studi, Siena","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082965767","display_name":"Serafina Perrone","orcid":"https://orcid.org/0000-0001-5478-5657","observed_orcids":["https://orcid.org/0000-0001-5478-5657"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Perrone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5014247948","display_name":"Maria Carmela Muraca","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M C Muraca","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.0045991,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"37","issue":"4","first_page":"527","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.9950000047683716},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9890000224113464},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9200000166893005},{"id":"https://openalex.org/keywords/hypoxic-ischemic-brain-injury","display_name":"hypoxic-ischemic brain injury","score":0.8539999723434448},{"id":"https://openalex.org/keywords/newborns","display_name":"neonates","score":0.8640000224113464},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.625},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8640000224113464},{"id":"https://openalex.org/keywords/oxidative-cell-injury","display_name":"oxidative cell injury","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.8882567882537842},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7698502540588379},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7342579960823059},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7013537883758545},{"id":"https://openalex.org/C60642223","wikidata":"https://www.wikidata.org/wiki/Q1129576","display_name":"Free-radical theory of aging","level":3,"score":0.6596653461456299},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6121892333030701},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5830468535423279},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.5267478823661804},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49145472049713135},{"id":"https://openalex.org/C186927785","wikidata":"https://www.wikidata.org/wiki/Q374793","display_name":"Unpaired electron","level":3,"score":0.47866925597190857},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.475147008895874},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.46823590993881226},{"id":"https://openalex.org/C2780369685","wikidata":"https://www.wikidata.org/wiki/Q5058184","display_name":"Cell damage","level":2,"score":0.4611722528934479},{"id":"https://openalex.org/C3020296196","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative damage","level":3,"score":0.41521257162094116},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3535236716270447},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3295663893222809},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25249361991882324},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19606956839561462},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17126426100730896},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10210222005844116},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001925","descriptor_name":"Brain Damage, Chronic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:12046222","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12046222","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annali dell'Istituto superiore di sanita","raw_type":"English Abstract"},{"id":"pmh:oai:usiena-air.unisi.it:11365/6370","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11365/6370","pdf_url":null,"source":{"id":"https://openalex.org/S4377196319","display_name":"Use Siena air (University of Siena)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102064193","host_organization_name":"University of Siena","host_organization_lineage":["https://openalex.org/I102064193"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:30811722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12046222","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":134,"referenced_works":["https://openalex.org/W10177979","https://openalex.org/W138097905","https://openalex.org/W153121858","https://openalex.org/W163749933","https://openalex.org/W1485368148","https://openalex.org/W1494531967","https://openalex.org/W1496473441","https://openalex.org/W1497735335","https://openalex.org/W1557712018","https://openalex.org/W1574108106","https://openalex.org/W1821918060","https://openalex.org/W1845459216","https://openalex.org/W1852779649","https://openalex.org/W1863797586","https://openalex.org/W1887857517","https://openalex.org/W1898554454","https://openalex.org/W1907068960","https://openalex.org/W1911339081","https://openalex.org/W1918311561","https://openalex.org/W1942214720","https://openalex.org/W1967597647","https://openalex.org/W1968581316","https://openalex.org/W1969761531","https://openalex.org/W1969789360","https://openalex.org/W1971344376","https://openalex.org/W1971495826","https://openalex.org/W1972877268","https://openalex.org/W1980046786","https://openalex.org/W1980090876","https://openalex.org/W1983634744","https://openalex.org/W1986728683","https://openalex.org/W1987429216","https://openalex.org/W1992282049","https://openalex.org/W1995782272","https://openalex.org/W2001110380","https://openalex.org/W2002046932","https://openalex.org/W2002698668","https://openalex.org/W2003471941","https://openalex.org/W2005031071","https://openalex.org/W2006759718","https://openalex.org/W2007322682","https://openalex.org/W2008602421","https://openalex.org/W2008895830","https://openalex.org/W2009055867","https://openalex.org/W2010107397","https://openalex.org/W2010298858","https://openalex.org/W2010394776","https://openalex.org/W2013255532","https://openalex.org/W2014746504","https://openalex.org/W2014945678","https://openalex.org/W2015197751","https://openalex.org/W2016982834","https://openalex.org/W2017946331","https://openalex.org/W2019035911","https://openalex.org/W2019588162","https://openalex.org/W2020126595","https://openalex.org/W2020247930","https://openalex.org/W2023743679","https://openalex.org/W2026312693","https://openalex.org/W2028534955","https://openalex.org/W2030953880","https://openalex.org/W2031675072","https://openalex.org/W2032255664","https://openalex.org/W2032756932","https://openalex.org/W2035754770","https://openalex.org/W2035888225","https://openalex.org/W2037485480","https://openalex.org/W2039674246","https://openalex.org/W2042741874","https://openalex.org/W2045079045","https://openalex.org/W2047643460","https://openalex.org/W2047936141","https://openalex.org/W2050900769","https://openalex.org/W2051083217","https://openalex.org/W2053124932","https://openalex.org/W2054192281","https://openalex.org/W2056813366","https://openalex.org/W2058925497","https://openalex.org/W2059640915","https://openalex.org/W2060363769","https://openalex.org/W2064939797","https://openalex.org/W2069994257","https://openalex.org/W2070585824","https://openalex.org/W2072579321","https://openalex.org/W2073345848","https://openalex.org/W2075068003","https://openalex.org/W2078171117","https://openalex.org/W2080611403","https://openalex.org/W2082259697","https://openalex.org/W2082566604","https://openalex.org/W2082914617","https://openalex.org/W2083223456","https://openalex.org/W2086476775","https://openalex.org/W2089758607","https://openalex.org/W2090734822","https://openalex.org/W2093942585","https://openalex.org/W2096111103","https://openalex.org/W2112257614","https://openalex.org/W2112587190","https://openalex.org/W2113430372","https://openalex.org/W2120332829","https://openalex.org/W2121142820","https://openalex.org/W2126495520","https://openalex.org/W2126681103","https://openalex.org/W2127072188","https://openalex.org/W2133901548","https://openalex.org/W2144648227","https://openalex.org/W2146508536","https://openalex.org/W2147049445","https://openalex.org/W2147357406","https://openalex.org/W2149276894","https://openalex.org/W2151175198","https://openalex.org/W2151210608","https://openalex.org/W2152166807","https://openalex.org/W2152374117","https://openalex.org/W2158347535","https://openalex.org/W2160099189","https://openalex.org/W2162716309","https://openalex.org/W2164074003","https://openalex.org/W2164162150","https://openalex.org/W2168290350","https://openalex.org/W2229288825","https://openalex.org/W2289974726","https://openalex.org/W2321941603","https://openalex.org/W2338229728","https://openalex.org/W2404104269","https://openalex.org/W2404258924","https://openalex.org/W2413638599","https://openalex.org/W2421961453","https://openalex.org/W2474259138","https://openalex.org/W2500241102","https://openalex.org/W2612733848","https://openalex.org/W2754370524","https://openalex.org/W2996868574"],"related_works":["https://openalex.org/W7033451236","https://openalex.org/W1606264717","https://openalex.org/W2537259800","https://openalex.org/W128506444","https://openalex.org/W2034340140","https://openalex.org/W305690480","https://openalex.org/W2556670871","https://openalex.org/W2002586582","https://openalex.org/W2884310275","https://openalex.org/W3045537608"],"abstract_inverted_index":{"Free":[0],"radicals":[1],"(FR)":[2],"are":[3,23,33,89],"highly":[4],"reactive":[5,19],"chemical":[6],"molecules":[7],"containing":[8],"one":[9],"or":[10],"more":[11],"unpaired":[12],"electrons.":[13],"Oxygen-derived":[14],"free":[15,47],"radicals,":[16],"collectively":[17],"termed":[18],"oxygen":[20],"species":[21],"(ROS),":[22],"normally":[24],"produced":[25],"in":[26,55],"living":[27],"organisms.":[28],"When":[29],"over":[30,64],"produced,":[31],"they":[32],"major":[34],"mediators":[35],"of":[36,68,76,102],"cell":[37],"and":[38,50,66,80,85,107],"tissue":[39],"injury.":[40,112],"There":[41],"is":[42,57,100],"a":[43,58],"critical":[44],"balance":[45],"between":[46,105],"radical":[48],"generation":[49],"antioxidant":[51,106],"defenses.":[52],"Oxidative":[53],"stress":[54],"vivo":[56],"degenerative":[59],"process":[60],"due":[61],"to":[62,74,81,92],"the":[63],"production":[65],"propagation":[67],"FR":[69,71,93],"reactions.":[70],"reactions":[72],"lead":[73],"oxidation":[75],"lipids,":[77],"proteins,":[78],"polysaccharides":[79],"DNA":[82],"damage.":[83,95],"Newborns":[84],"particularly":[86],"preterm":[87],"infants":[88],"very":[90],"susceptible":[91],"oxidative":[94],"In":[96],"these":[97],"subjects,":[98],"there":[99],"evidence":[101],"an":[103],"imbalance":[104],"oxidant-generating":[108],"systems":[109],"enhancing":[110],"oxidant":[111]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
