{"id":"https://openalex.org/W3081069367","doi":"https://doi.org/10.3892/ol.2020.12017","title":"Therapeutic effect of metformin in the treatment of endometrial cancer (Review)","display_name":"Therapeutic effect of metformin in the treatment of endometrial cancer (Review)","publication_year":2020,"publication_date":"2020-08-24","ids":{"openalex":"https://openalex.org/W3081069367","doi":"https://doi.org/10.3892/ol.2020.12017","mag":"3081069367","pmid":"https://pubmed.ncbi.nlm.nih.gov/32934724","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7471738"},"language":"en","primary_location":{"id":"doi:10.3892/ol.2020.12017","doi":"https://doi.org/10.3892/ol.2020.12017","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2020.12017","pdf_url":"https://www.spandidos-publications.com/10.3892/ol.2020.12017/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3081069367"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.spandidos-publications.com/10.3892/ol.2020.12017/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Nan Mu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I3018397418","display_name":"Yuhuangding Hospital","ror":"https://ror.org/05vawe413","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3018397418"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Mu","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I3018397418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069125232","display_name":"Tingting Xu","orcid":"https://orcid.org/0000-0002-5701-9859","observed_orcids":["https://orcid.org/0000-0002-5701-9859"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I3018397418","display_name":"Yuhuangding Hospital","ror":"https://ror.org/05vawe413","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3018397418"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Xu","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I3018397418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036400747","display_name":"Mingxiao Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I3018397418","display_name":"Yuhuangding Hospital","ror":"https://ror.org/05vawe413","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3018397418"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingxiao Gao","raw_affiliation_strings":["Department of Cardiology, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I3018397418"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mei Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I3018397418","display_name":"Yuhuangding Hospital","ror":"https://ror.org/05vawe413","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3018397418"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mei Dong","raw_affiliation_strings":["Department of Cardiology, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I3018397418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048419560","display_name":"Qing Tang","orcid":"https://orcid.org/0000-0002-2128-4810","observed_orcids":["https://orcid.org/0000-0002-2128-4810"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I3018397418","display_name":"Yuhuangding Hospital","ror":"https://ror.org/05vawe413","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3018397418"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Tang","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I3018397418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100348687","display_name":"Hao Li","orcid":"https://orcid.org/0000-0003-2832-4851","observed_orcids":["https://orcid.org/0000-0003-2832-4851","https://orcid.org/0009-0000-1988-2339","https://orcid.org/0009-0003-1496-6957"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I3018397418","display_name":"Yuhuangding Hospital","ror":"https://ror.org/05vawe413","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3018397418"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Hao","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I3018397418"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Guiqing Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I3018397418","display_name":"Yuhuangding Hospital","ror":"https://ror.org/05vawe413","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3018397418"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guiqing Wang","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I3018397418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101423755","display_name":"Zenghui Li","orcid":"https://orcid.org/0000-0003-3746-7088","observed_orcids":["https://orcid.org/0000-0003-3746-7088"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I3018397418","display_name":"Yuhuangding Hospital","ror":"https://ror.org/05vawe413","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3018397418"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zenghui Li","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I3018397418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057743504","display_name":"Wenshuang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I3018397418","display_name":"Yuhuangding Hospital","ror":"https://ror.org/05vawe413","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3018397418"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenshuang Wang","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I3018397418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101475007","display_name":"Ying Yang","orcid":"https://orcid.org/0009-0007-7833-8836","observed_orcids":["https://orcid.org/0009-0007-7833-8836"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I3018397418","display_name":"Yuhuangding Hospital","ror":"https://ror.org/05vawe413","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3018397418"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Yang","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I3018397418"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100725523","display_name":"Jianqing Hou","orcid":"https://orcid.org/0000-0001-7848-3856","observed_orcids":["https://orcid.org/0000-0001-7848-3856"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I3018397418","display_name":"Yuhuangding Hospital","ror":"https://ror.org/05vawe413","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3018397418"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianqing Hou","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R.\u00a0China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I3018397418"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4649,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.41796,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"20","issue":"5","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":1.0},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":1.0},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9779999852180481},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.6830000281333923},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.984000027179718},{"id":"https://openalex.org/keywords/sex-hormone-binding-globulin","display_name":"sex hormone-binding globulin","score":0.859000027179718},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.722000002861023},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6019999980926514},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.6600000262260437},{"id":"https://openalex.org/keywords/insulin-sensitizers","display_name":"insulin sensitizers","score":0.5860000252723694},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.9261547923088074},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6344462037086487},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6259214282035828},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6015375256538391},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.57551109790802},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5295206904411316},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5273773670196533},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5246682167053223},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4851883053779602},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.46391525864601135},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4557305574417114},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4490917921066284},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4097440540790558},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3570379912853241},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29245102405548096},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3892/ol.2020.12017","doi":"https://doi.org/10.3892/ol.2020.12017","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2020.12017","pdf_url":"https://www.spandidos-publications.com/10.3892/ol.2020.12017/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},{"id":"pmid:32934724","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32934724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology letters","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7471738","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7471738/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncol Lett","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3892/ol.2020.12017","doi":"https://doi.org/10.3892/ol.2020.12017","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2020.12017","pdf_url":"https://www.spandidos-publications.com/10.3892/ol.2020.12017/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3081069367.pdf","grobid_xml":"https://content.openalex.org/works/W3081069367.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W1487922930","https://openalex.org/W1535004310","https://openalex.org/W1758134847","https://openalex.org/W1829055256","https://openalex.org/W1892432125","https://openalex.org/W1964912188","https://openalex.org/W1969303884","https://openalex.org/W1969542174","https://openalex.org/W1977660708","https://openalex.org/W1987334928","https://openalex.org/W1988355907","https://openalex.org/W2006345894","https://openalex.org/W2009190388","https://openalex.org/W2048052296","https://openalex.org/W2054318449","https://openalex.org/W2065417819","https://openalex.org/W2092844822","https://openalex.org/W2093294518","https://openalex.org/W2102192525","https://openalex.org/W2109600717","https://openalex.org/W2111170135","https://openalex.org/W2116053582","https://openalex.org/W2117524198","https://openalex.org/W2117739987","https://openalex.org/W2118950260","https://openalex.org/W2119435263","https://openalex.org/W2124764963","https://openalex.org/W2126924946","https://openalex.org/W2131180390","https://openalex.org/W2138226825","https://openalex.org/W2139909998","https://openalex.org/W2151555736","https://openalex.org/W2173133541","https://openalex.org/W2265720901","https://openalex.org/W2393553112","https://openalex.org/W2399736083","https://openalex.org/W2416778927","https://openalex.org/W2427507452","https://openalex.org/W2517957586","https://openalex.org/W2518664213","https://openalex.org/W2520317305","https://openalex.org/W2521606331","https://openalex.org/W2531168605","https://openalex.org/W2560235505","https://openalex.org/W2588723373","https://openalex.org/W2606515107","https://openalex.org/W2624512627","https://openalex.org/W2664250820","https://openalex.org/W2763168003","https://openalex.org/W2772682581","https://openalex.org/W2775067476","https://openalex.org/W2781525129","https://openalex.org/W2785923234","https://openalex.org/W2786698551","https://openalex.org/W2789786349","https://openalex.org/W2791974325","https://openalex.org/W2800948411","https://openalex.org/W2802221824","https://openalex.org/W2804416221","https://openalex.org/W2806339653","https://openalex.org/W2831115559","https://openalex.org/W2883715442","https://openalex.org/W2886330190","https://openalex.org/W2894777162","https://openalex.org/W2896563494","https://openalex.org/W2916299755","https://openalex.org/W2916381136","https://openalex.org/W2923740184","https://openalex.org/W2927674720","https://openalex.org/W2935953043","https://openalex.org/W2937270878","https://openalex.org/W2937953640","https://openalex.org/W2939056166","https://openalex.org/W2944706951","https://openalex.org/W2947843095","https://openalex.org/W2955527965","https://openalex.org/W2963222754","https://openalex.org/W2963592446","https://openalex.org/W2964569023","https://openalex.org/W2975099017","https://openalex.org/W2978140932","https://openalex.org/W2978393342","https://openalex.org/W2981330428","https://openalex.org/W2981989842","https://openalex.org/W2984093425","https://openalex.org/W2985421076","https://openalex.org/W2995789987","https://openalex.org/W2997303760","https://openalex.org/W3000342649","https://openalex.org/W3004753443","https://openalex.org/W3005851693","https://openalex.org/W3007180795","https://openalex.org/W3015388014","https://openalex.org/W3024806418","https://openalex.org/W4211047904","https://openalex.org/W4247851346","https://openalex.org/W4253388123","https://openalex.org/W4293857365"],"related_works":["https://openalex.org/W2268569556","https://openalex.org/W3032717072","https://openalex.org/W7166858189","https://openalex.org/W2574451437","https://openalex.org/W2043847646","https://openalex.org/W4412507808","https://openalex.org/W2531168605","https://openalex.org/W2521606331","https://openalex.org/W3213245088","https://openalex.org/W2786698551"],"abstract_inverted_index":{"The":[0,52,122],"present":[1],"review":[2],"aims":[3],"at":[4],"reviewing":[5],"the":[6,11,19,48,60,74,78,84,89,105,133,140,151],"role":[7,131],"of":[8,13,31,50,55,59,80,92,102,108,135,139,142,153],"metformin":[9,43,56,87,127,143],"in":[10,117,132,144],"treatment":[12,134,152],"endometrial":[14],"cancer":[15],"(EC).":[16],"According":[17],"to":[18,115],"literature,":[20],"excessive":[21],"estrogen":[22,119],"levels":[23,101,107],"and":[24,38,45,65,76,95,120],"insulin":[25,36,90,98,103],"resistance":[26],"are":[27],"established":[28],"risk":[29],"factors":[30],"EC.":[32,51,136],"As":[33],"a":[34],"traditional":[35],"sensitizer":[37],"newly":[39],"discovered":[40],"anticancer":[41],"agent,":[42],"directly":[44],"indirectly":[46],"inhibits":[47],"development":[49],"direct":[53],"mechanisms":[54],"include":[57],"inhibition":[58],"LKB1-AMP-activated":[61],"protein":[62],"kinase-mTOR,":[63],"PI3K-Akt":[64],"insulin-like":[66],"growth":[67],"factor":[68],"1-related":[69],"signaling":[70],"pathways,":[71],"which":[72,113],"reduces":[73],"proliferation":[75],"promotes":[77],"apoptosis":[79],"EC":[81,145],"cells.":[82],"In":[83],"indirect":[85],"mechanism,":[86],"increases":[88],"sensitivity":[91],"body":[93],"tissues":[94],"decreases":[96],"circulating":[97,118],"levels.":[99],"Decreased":[100],"increase":[104],"blood":[106],"sex":[109],"hormone":[110],"binding":[111],"globulin,":[112],"leads":[114],"reductions":[116],"androgens.":[121],"aforementioned":[123],"findings":[124],"suggest":[125],"that":[126],"serves":[128],"an":[129],"important":[130],"Increased":[137],"understanding":[138],"mechanism":[141],"may":[146],"provide":[147],"novel":[148],"insights":[149],"into":[150],"this":[154],"malignancy.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-09-01T00:00:00"}