{"id":"https://openalex.org/W3081035299","doi":"https://doi.org/10.1093/noajnl/vdaa107","title":"Multireceptor targeting of glioblastoma","display_name":"Multireceptor targeting of glioblastoma","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3081035299","doi":"https://doi.org/10.1093/noajnl/vdaa107","mag":"3081035299","pmid":"https://pubmed.ncbi.nlm.nih.gov/33150335","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7596893"},"language":"en","primary_location":{"id":"doi:10.1093/noajnl/vdaa107","doi":"https://doi.org/10.1093/noajnl/vdaa107","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdaa107","pdf_url":"https://academic.oup.com/noa/article-pdf/2/1/vdaa107/34058881/vdaa107.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/noa/article-pdf/2/1/vdaa107/34058881/vdaa107.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101145840","display_name":"Puja Sharma","orcid":"https://orcid.org/0009-0003-8171-7133","observed_orcids":["https://orcid.org/0009-0003-8171-7133"]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Puja Sharma","raw_affiliation_strings":["Brain Tumor Center of Excellence, Wake Forest Baptist Medical Center Comprehensive Cancer Center, Winston-Salem, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Tumor Center of Excellence, Wake Forest Baptist Medical Center Comprehensive Cancer Center, Winston-Salem, North Carolina, USA","institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I4387930303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069385878","display_name":"Poonam Sonawane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Poonam Sonawane","raw_affiliation_strings":["Brain Tumor Center of Excellence, Wake Forest Baptist Medical Center Comprehensive Cancer Center, Winston-Salem, North Carolina, USA","Children\u2019s Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Tumor Center of Excellence, Wake Forest Baptist Medical Center Comprehensive Cancer Center, Winston-Salem, North Carolina, USA","institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I4387930303"]},{"raw_affiliation_string":"Children\u2019s Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103921790","display_name":"Denise Herpai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise Herpai","raw_affiliation_strings":["Brain Tumor Center of Excellence, Wake Forest Baptist Medical Center Comprehensive Cancer Center, Winston-Salem, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Tumor Center of Excellence, Wake Forest Baptist Medical Center Comprehensive Cancer Center, Winston-Salem, North Carolina, USA","institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I4387930303"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ralph D\u2019Agostino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph D\u2019Agostino","raw_affiliation_strings":["Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029454626","display_name":"John Henry Rossmeisl","orcid":"https://orcid.org/0000-0003-1655-7076","observed_orcids":["https://orcid.org/0000-0003-1655-7076"]},"institutions":[{"id":"https://openalex.org/I39822340","display_name":"Virginia\u2013Maryland College of Veterinary Medicine","ror":"https://ror.org/010prmy50","country_code":"US","type":"education","lineage":["https://openalex.org/I39822340","https://openalex.org/I66946132","https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Rossmeisl","raw_affiliation_strings":["Neurology and Neurosurgery, Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology and Neurosurgery, Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia, USA","institution_ids":["https://openalex.org/I39822340"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059467122","display_name":"Stephen B. Tatter","orcid":"https://orcid.org/0000-0002-1063-0431","observed_orcids":["https://orcid.org/0000-0002-1063-0431"]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Tatter","raw_affiliation_strings":["Brain Tumor Center of Excellence, Wake Forest Baptist Medical Center Comprehensive Cancer Center, Winston-Salem, North Carolina, USA","Department of Neurosurgery, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Tumor Center of Excellence, Wake Forest Baptist Medical Center Comprehensive Cancer Center, Winston-Salem, North Carolina, USA","institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I4387930303"]},{"raw_affiliation_string":"Department of Neurosurgery, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA","institution_ids":["https://openalex.org/I1282516798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058075606","display_name":"Waldemar Debinski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Waldemar Debinski","raw_affiliation_strings":["Brain Tumor Center of Excellence, Wake Forest Baptist Medical Center Comprehensive Cancer Center, Winston-Salem, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Tumor Center of Excellence, Wake Forest Baptist Medical Center Comprehensive Cancer Center, Winston-Salem, North Carolina, USA","institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I4387930303"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5058075606"],"corresponding_institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I4387930303"],"apc_list":{"value":2615,"currency":"USD","value_usd":2615},"apc_paid":{"value":2615,"currency":"USD","value_usd":2615},"fwci":1.2931,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.79114613,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"2","issue":"1","first_page":"vdaa107","last_page":"vdaa107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.5073000192642212,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.5073000192642212,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.48170000314712524,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":1.0},{"id":"https://openalex.org/keywords/epha2","display_name":"EphA2","score":0.8849999904632568},{"id":"https://openalex.org/keywords/epha3","display_name":"EphA3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ephb2","display_name":"EphB2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8399999737739563},{"id":"https://openalex.org/keywords/neovasculature","display_name":"neovasculature","score":0.6790000200271606},{"id":"https://openalex.org/keywords/tumor-infiltrating-cells","display_name":"tumor-infiltrating cells","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6671961545944214},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6183022260665894},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.615610659122467},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6080254912376404},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.573962926864624},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5288382768630981},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.46486884355545044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38533514738082886},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3710482716560364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1689203977584839},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06367963552474976},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/noajnl/vdaa107","doi":"https://doi.org/10.1093/noajnl/vdaa107","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdaa107","pdf_url":"https://academic.oup.com/noa/article-pdf/2/1/vdaa107/34058881/vdaa107.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7596893","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7596893","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurooncol Adv","raw_type":"Text"},{"id":"pmid:33150335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33150335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-oncology advances","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/noajnl/vdaa107","doi":"https://doi.org/10.1093/noajnl/vdaa107","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdaa107","pdf_url":"https://academic.oup.com/noa/article-pdf/2/1/vdaa107/34058881/vdaa107.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2577419345","display_name":null,"funder_award_id":"P30CA012197","funder_id":"https://openalex.org/F4320313862","funder_display_name":"Comprehensive Cancer Center at Wake Forest Baptist Medical Center"},{"id":"https://openalex.org/G3999795818","display_name":"Maximizing Local Access to Therapeutic Deliveries in Glioblastoma","funder_award_id":"P01CA207206","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4053221465","display_name":null,"funder_award_id":"CA74145","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6841736574","display_name":null,"funder_award_id":"CA207206","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6922674174","display_name":null,"funder_award_id":"P01 NCI CA207206","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7048056497","display_name":"High-Grade Astrocytoma-Specific Molecular Targeting","funder_award_id":"R01CA074145","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000328302","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA012197","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320313862","display_name":"Comprehensive Cancer Center at Wake Forest Baptist Medical Center","ror":"https://ror.org/0512csj88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3081035299.pdf","grobid_xml":"https://content.openalex.org/works/W3081035299.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W138433727","https://openalex.org/W1792532087","https://openalex.org/W1980958559","https://openalex.org/W1983766005","https://openalex.org/W1987408132","https://openalex.org/W1997882452","https://openalex.org/W2005371778","https://openalex.org/W2007781192","https://openalex.org/W2009063639","https://openalex.org/W2012915029","https://openalex.org/W2030718440","https://openalex.org/W2036406012","https://openalex.org/W2040108818","https://openalex.org/W2040574920","https://openalex.org/W2042258261","https://openalex.org/W2045468193","https://openalex.org/W2071881888","https://openalex.org/W2083227014","https://openalex.org/W2094735628","https://openalex.org/W2098395274","https://openalex.org/W2111369212","https://openalex.org/W2118444588","https://openalex.org/W2131884474","https://openalex.org/W2135404870","https://openalex.org/W2137405984","https://openalex.org/W2148977460","https://openalex.org/W2165917993","https://openalex.org/W2168369189","https://openalex.org/W2170210185","https://openalex.org/W2187121413","https://openalex.org/W2370823328","https://openalex.org/W2432909692","https://openalex.org/W2480222331","https://openalex.org/W2481298264","https://openalex.org/W2567424265","https://openalex.org/W2622835960","https://openalex.org/W2752631734","https://openalex.org/W2756893676","https://openalex.org/W2759196897","https://openalex.org/W2764176750","https://openalex.org/W2778283729","https://openalex.org/W2783621854","https://openalex.org/W2797840027","https://openalex.org/W2810882198","https://openalex.org/W2898229107","https://openalex.org/W2901550816","https://openalex.org/W2904210127","https://openalex.org/W2911871569","https://openalex.org/W2990368704","https://openalex.org/W3020099303","https://openalex.org/W3070665510","https://openalex.org/W4211132876","https://openalex.org/W6684386963"],"related_works":["https://openalex.org/W2984386863","https://openalex.org/W3111814765","https://openalex.org/W2608189456","https://openalex.org/W2899731065","https://openalex.org/W4388590559","https://openalex.org/W3018329065","https://openalex.org/W2756893676","https://openalex.org/W2898229107","https://openalex.org/W2324853534","https://openalex.org/W2340304866"],"abstract_inverted_index":{"BACKGROUND:":[0],"Treatment":[1],"for":[2,115,185],"glioblastoma":[3],"(GBM)":[4],"remains":[5],"an":[6,71],"unmet":[7],"need":[8],"in":[9,19,99,102,134,143,176,182],"medicine.":[10],"Novel":[11],"therapies":[12],"that":[13,34],"address":[14],"GBM":[15,40,128,177],"complexity":[16],"and":[17,50,85,96,101,136,161,197],"heterogeneity":[18,163],"particular":[20],"are":[21],"warranted.":[22],"To":[23],"this":[24],"end,":[25],"we":[26,187],"target":[27],"4":[28,76,117],"tumor-associated":[29],"receptors":[30,180],"at":[31,165],"a":[32,58,91,144,154],"time":[33],"span":[35],"virtually":[36],"all":[37],"of":[38,77,111,159],"the":[39,78,112,116,137,157,166],"microenvironment":[41],"including":[42],"bulk":[43],"tumor":[44,47,174],"cells,":[45,48,129],"infiltrating":[46],"neovasculature,":[49],"tumor-infiltrating":[51],"cells":[52],"with":[53,70,90,146],"one":[54],"pharmaceutical":[55],"agent":[56],"delivering":[57],"cytotoxic":[59,126],"load.":[60],"METHODS:":[61],"We":[62,87],"engineered":[63],"multivalent":[64],"ligand-based":[65],"vector":[66],"proteins":[67],"termed":[68],"QUAD":[69,89,106,120,151],"ability":[72],"to":[73,75,127,153],"bind":[74],"following":[79],"GBM-associated":[80],"receptors:":[81],"IL-13RA2,":[82],"EphA2,":[83],"EphA3,":[84],"EphB2.":[86],"conjugated":[88],"modified":[92],"bacterial":[93],"toxin":[94],"PE38QQR":[95],"tested":[97],"it":[98,131,169],"vitro":[100],"vivo.":[103],"RESULTS:":[104],"The":[105,119,150],"variants":[107],"preserved":[108],"functional":[109],"characteristics":[110],"respective":[113],"ligands":[114],"receptors.":[118],"3.0":[121],"variant":[122],"conjugate":[123,138],"was":[124,132],"highly":[125],"but":[130],"nontoxic":[133],"mice,":[135],"exhibited":[139],"strong":[140],"antitumor":[141],"effect":[142],"dog":[145],"spontaneous":[147],"GBM.":[148],"CONCLUSION:":[149],"addresses,":[152],"large":[155],"extent,":[156],"issues":[158],"intra-":[160],"intertumoral":[162],"and,":[164],"same":[167],"time,":[168],"targets":[170],"several":[171],"pathophysiologically":[172],"important":[173],"compartments":[175],"through":[178],"multiple":[179],"overexpressed":[181],"tumors":[183],"allowing":[184],"what":[186],"call":[188],"\"molecular":[189],"resection.\"":[190],"QUAD-based":[191],"targeted":[192],"agents":[193],"warrant":[194],"further":[195],"pre-":[196],"clinical":[198],"development.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2020-09-01T00:00:00"}