{"id":"https://openalex.org/W3080968229","doi":"https://doi.org/10.1016/j.copbio.2020.07.005","title":"Metabolic engineering strategies to overcome precursor limitations in isoprenoid biosynthesis","display_name":"Metabolic engineering strategies to overcome precursor limitations in isoprenoid biosynthesis","publication_year":2020,"publication_date":"2020-08-24","ids":{"openalex":"https://openalex.org/W3080968229","doi":"https://doi.org/10.1016/j.copbio.2020.07.005","mag":"3080968229","pmid":"https://pubmed.ncbi.nlm.nih.gov/32853882"},"language":"en","primary_location":{"id":"doi:10.1016/j.copbio.2020.07.005","doi":"https://doi.org/10.1016/j.copbio.2020.07.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.copbio.2020.07.005","pdf_url":null,"source":{"id":"https://openalex.org/S23939942","display_name":"Current Opinion in Biotechnology","issn_l":"0958-1669","issn":["0958-1669","1879-0429"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Current Opinion in Biotechnology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.copbio.2020.07.005","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001271104","display_name":"Yuexuan Zu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuexuan Zu","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005731990","display_name":"Kristala L. J. Prather","orcid":"https://orcid.org/0000-0003-0437-3157","observed_orcids":["https://orcid.org/0000-0003-0437-3157"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristala LJ Prather","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA"],"raw_orcid":"https://orcid.org/0000-0003-0437-3157","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009763658","display_name":"Gregory N Stephanopoulos","orcid":"https://orcid.org/0000-0001-6909-4568","observed_orcids":["https://orcid.org/0000-0001-6909-4568"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory Stephanopoulos","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA. Electronic address: gregstep@mit.edu","Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA. Electronic address: gregstep@mit.edu","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009763658"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":0.5026,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.45775663,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"66","issue":null,"first_page":"171","last_page":"178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.10270000249147415,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14150","display_name":"Biochemical and biochemical processes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isoprenoid-biosynthesis","display_name":"isoprenoid biosynthesis","score":0.996999979019165},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"metabolic engineering","score":0.8930000066757202},{"id":"https://openalex.org/keywords/substrate-depletion","display_name":"substrate depletion","score":0.6190000176429749},{"id":"https://openalex.org/keywords/metabolic-burden","display_name":"metabolic burden","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.8596231937408447},{"id":"https://openalex.org/C206103511","wikidata":"https://www.wikidata.org/wiki/Q426694","display_name":"Terpenoid","level":2,"score":0.6677663922309875},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.6537830233573914},{"id":"https://openalex.org/C2780513914","wikidata":"https://www.wikidata.org/wiki/Q18210350","display_name":"Bottleneck","level":2,"score":0.6343237161636353},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5169510245323181},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.49990129470825195},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.4992539882659912},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.4835891127586365},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.47206953167915344},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4400525689125061},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4073062539100647},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.355596125125885},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.30086514353752136},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2921975255012512},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.16759765148162842},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D010944","descriptor_name":"Plants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.copbio.2020.07.005","doi":"https://doi.org/10.1016/j.copbio.2020.07.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.copbio.2020.07.005","pdf_url":null,"source":{"id":"https://openalex.org/S23939942","display_name":"Current Opinion in Biotechnology","issn_l":"0958-1669","issn":["0958-1669","1879-0429"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Current Opinion in Biotechnology","raw_type":"journal-article"},{"id":"pmid:32853882","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32853882","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in biotechnology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.copbio.2020.07.005","doi":"https://doi.org/10.1016/j.copbio.2020.07.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.copbio.2020.07.005","pdf_url":null,"source":{"id":"https://openalex.org/S23939942","display_name":"Current Opinion in Biotechnology","issn_l":"0958-1669","issn":["0958-1669","1879-0429"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Current Opinion in Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320765","display_name":"Singapore-MIT Alliance for Research and Technology Centre","ror":"https://ror.org/05yb3w112"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1900473455","https://openalex.org/W1993596974","https://openalex.org/W2001362170","https://openalex.org/W2019892938","https://openalex.org/W2023893346","https://openalex.org/W2073604361","https://openalex.org/W2295491699","https://openalex.org/W2322671676","https://openalex.org/W2332641124","https://openalex.org/W2502769832","https://openalex.org/W2511831309","https://openalex.org/W2580848968","https://openalex.org/W2730800840","https://openalex.org/W2767217582","https://openalex.org/W2780448920","https://openalex.org/W2782809032","https://openalex.org/W2796704092","https://openalex.org/W2799414564","https://openalex.org/W2801219176","https://openalex.org/W2801280665","https://openalex.org/W2802871016","https://openalex.org/W2804315099","https://openalex.org/W2806157403","https://openalex.org/W2808315342","https://openalex.org/W2810587442","https://openalex.org/W2875755779","https://openalex.org/W2884672223","https://openalex.org/W2888074930","https://openalex.org/W2888277298","https://openalex.org/W2889216082","https://openalex.org/W2896514813","https://openalex.org/W2898924116","https://openalex.org/W2901121611","https://openalex.org/W2906085386","https://openalex.org/W2910553151","https://openalex.org/W2910613147","https://openalex.org/W2916929354","https://openalex.org/W2917348108","https://openalex.org/W2931049843","https://openalex.org/W2943640323","https://openalex.org/W2944768714","https://openalex.org/W2947406717","https://openalex.org/W2947430420","https://openalex.org/W2951170587","https://openalex.org/W2955115303","https://openalex.org/W2963229028","https://openalex.org/W2966043690","https://openalex.org/W2967284686","https://openalex.org/W2969469154","https://openalex.org/W2969682794","https://openalex.org/W2970949504","https://openalex.org/W2972767862","https://openalex.org/W2972961160","https://openalex.org/W2973533038","https://openalex.org/W2976981603","https://openalex.org/W2985716551","https://openalex.org/W2999261318","https://openalex.org/W3012569809","https://openalex.org/W4230893133"],"related_works":["https://openalex.org/W3023757646","https://openalex.org/W1983727564","https://openalex.org/W201883925","https://openalex.org/W1598282860","https://openalex.org/W2944543437","https://openalex.org/W79412729","https://openalex.org/W4411424035","https://openalex.org/W3025682174","https://openalex.org/W4361270540","https://openalex.org/W261643718"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-09-01T00:00:00"}