{"id":"https://openalex.org/W3080618403","doi":"https://doi.org/10.1128/aac.01124-20","title":"In Vitro Activity of Manogepix against Multidrug-Resistant and Panresistant Candida auris from the New York Outbreak","display_name":"In Vitro Activity of Manogepix against Multidrug-Resistant and Panresistant Candida auris from the New York Outbreak","publication_year":2020,"publication_date":"2020-08-24","ids":{"openalex":"https://openalex.org/W3080618403","doi":"https://doi.org/10.1128/aac.01124-20","mag":"3080618403","pmid":"https://pubmed.ncbi.nlm.nih.gov/32839219","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7577132"},"language":"en","primary_location":{"id":"doi:10.1128/aac.01124-20","doi":"https://doi.org/10.1128/aac.01124-20","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.01124-20","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2020/06/03/2020.06.02.129916.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113208300","display_name":"YanChun Zhu","orcid":"https://orcid.org/0009-0004-7975-9964","observed_orcids":["https://orcid.org/0009-0004-7975-9964"]},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]},{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"YanChun Zhu","raw_affiliation_strings":["Mycology Laboratory, University at Albany School of Public Health, Albany, New York, USA","Mycology Laboratory, Wadsworth Center, New York State Department of Health, Albany, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mycology Laboratory, University at Albany School of Public Health, Albany, New York, USA","institution_ids":["https://openalex.org/I392282"]},{"raw_affiliation_string":"Mycology Laboratory, Wadsworth Center, New York State Department of Health, Albany, New York, USA","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026796598","display_name":"Shannon Kilburn","orcid":"https://orcid.org/0009-0001-9332-9440","observed_orcids":["https://orcid.org/0009-0001-9332-9440"]},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]},{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon Kilburn","raw_affiliation_strings":["Mycology Laboratory, University at Albany School of Public Health, Albany, New York, USA","Mycology Laboratory, Wadsworth Center, New York State Department of Health, Albany, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mycology Laboratory, University at Albany School of Public Health, Albany, New York, USA","institution_ids":["https://openalex.org/I392282"]},{"raw_affiliation_string":"Mycology Laboratory, Wadsworth Center, New York State Department of Health, Albany, New York, USA","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068879729","display_name":"Mili Kapoor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108517","display_name":"Amplyx Pharmaceuticals (United States)","ror":"https://ror.org/02jfsdq79","country_code":"US","type":"company","lineage":["https://openalex.org/I4210108517"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mili Kapoor","raw_affiliation_strings":["Amplyx Pharmaceuticals, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amplyx Pharmaceuticals, San Diego, California, USA","institution_ids":["https://openalex.org/I4210108517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047331908","display_name":"Sudha Chaturvedi","orcid":"https://orcid.org/0000-0003-0906-8426","observed_orcids":["https://orcid.org/0000-0003-0906-8426"]},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]},{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudha Chaturvedi","raw_affiliation_strings":["Mycology Laboratory, University at Albany School of Public Health, Albany, New York, USA","Wadsworth Center, New York State Department of Health, and Department of Biomedical Sciences, University at Albany School of Public Health, Albany, New York, USA","Department of Biomedical Sciences, University at Albany School of Public Health, Albany, New York, USA","Mycology Laboratory, Wadsworth Center, New York State Department of Health, Albany, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mycology Laboratory, University at Albany School of Public Health, Albany, New York, USA","institution_ids":["https://openalex.org/I392282"]},{"raw_affiliation_string":"Wadsworth Center, New York State Department of Health, and Department of Biomedical Sciences, University at Albany School of Public Health, Albany, New York, USA","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872","https://openalex.org/I392282"]},{"raw_affiliation_string":"Department of Biomedical Sciences, University at Albany School of Public Health, Albany, New York, USA","institution_ids":["https://openalex.org/I392282"]},{"raw_affiliation_string":"Mycology Laboratory, Wadsworth Center, New York State Department of Health, Albany, New York, USA","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086601088","display_name":"Karen Joy Shaw","orcid":"https://orcid.org/0000-0003-3060-1328","observed_orcids":["https://orcid.org/0000-0003-3060-1328"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Karen Joy Shaw","raw_affiliation_strings":["Hearts Consulting Group, San Diego, California, USA","Hearts Consulting Group, Poway, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hearts Consulting Group, San Diego, California, USA","institution_ids":[]},{"raw_affiliation_string":"Hearts Consulting Group, Poway, California, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066654372","display_name":"Vishnu P. Chaturvedi","orcid":"https://orcid.org/0000-0002-3922-9676","observed_orcids":["https://orcid.org/0000-0002-3922-9676"]},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]},{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vishnu Chaturvedi","raw_affiliation_strings":["Mycology Laboratory, University at Albany School of Public Health, Albany, New York, USA","Wadsworth Center, New York State Department of Health, and Department of Biomedical Sciences, University at Albany School of Public Health, Albany, New York, USA","Department of Biomedical Sciences, University at Albany School of Public Health, Albany, New York, USA","Mycology Laboratory, Wadsworth Center, New York State Department of Health, Albany, New York, USA"],"raw_orcid":"https://orcid.org/0000-0002-3922-9676","affiliations":[{"raw_affiliation_string":"Mycology Laboratory, University at Albany School of Public Health, Albany, New York, USA","institution_ids":["https://openalex.org/I392282"]},{"raw_affiliation_string":"Wadsworth Center, New York State Department of Health, and Department of Biomedical Sciences, University at Albany School of Public Health, Albany, New York, USA","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872","https://openalex.org/I392282"]},{"raw_affiliation_string":"Department of Biomedical Sciences, University at Albany School of Public Health, Albany, New York, USA","institution_ids":["https://openalex.org/I392282"]},{"raw_affiliation_string":"Mycology Laboratory, Wadsworth Center, New York State Department of Health, Albany, New York, USA","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5066654372","https://openalex.org/A5086601088"],"corresponding_institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872","https://openalex.org/I392282"],"apc_list":null,"apc_paid":null,"fwci":0.8256,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.86017045,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"64","issue":"11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11900","display_name":"Fungal Plant Pathogen Control","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/manogepix","display_name":"manogepix","score":0.9860000014305115},{"id":"https://openalex.org/keywords/candida-auris","display_name":"Candida auris","score":0.9580000042915344},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.871999979019165},{"id":"https://openalex.org/keywords/panresistance","display_name":"panresistance","score":0.984000027179718},{"id":"https://openalex.org/keywords/fluconazole-resistance","display_name":"fluconazole resistance","score":0.9470000267028809},{"id":"https://openalex.org/keywords/antifungal-resistance","display_name":"antifungal resistance","score":0.5580000281333923},{"id":"https://openalex.org/keywords/in-vitro-antifungal-activity","display_name":"in vitro antifungal activity","score":0.8510000109672546}],"concepts":[{"id":"https://openalex.org/C2909786013","wikidata":"https://www.wikidata.org/wiki/Q26816853","display_name":"Candida auris","level":3,"score":0.9703179001808167},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.8703538775444031},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.6884350776672363},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6116352677345276},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.5961998701095581},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5021142959594727},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.41292011737823486},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.40892916917800903},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.3564293682575226}],"mesh":[{"descriptor_ui":"D000631","descriptor_name":"Aminopyridines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002175","descriptor_name":"Candida","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004196","descriptor_name":"Disease Outbreaks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009518","descriptor_name":"New York","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009656","descriptor_name":"North America","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.01124-20","doi":"https://doi.org/10.1128/aac.01124-20","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.01124-20","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"doi:10.1101/2020.06.02.129916","doi":"https://doi.org/10.1101/2020.06.02.129916","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.06.02.129916","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/06/03/2020.06.02.129916.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:7577132","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7577132","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:32839219","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32839219","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/2020.06.02.129916","doi":"https://doi.org/10.1101/2020.06.02.129916","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.06.02.129916","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/06/03/2020.06.02.129916.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317395","display_name":"Amplyx","ror":"https://ror.org/02jfsdq79"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3080618403.pdf","grobid_xml":"https://content.openalex.org/works/W3080618403.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1559027872","https://openalex.org/W1900369848","https://openalex.org/W1902677919","https://openalex.org/W1916126117","https://openalex.org/W1987354838","https://openalex.org/W2020769754","https://openalex.org/W2065326954","https://openalex.org/W2067727396","https://openalex.org/W2114599108","https://openalex.org/W2184546388","https://openalex.org/W2428312993","https://openalex.org/W2536287248","https://openalex.org/W2547589532","https://openalex.org/W2563887580","https://openalex.org/W2606900189","https://openalex.org/W2746687770","https://openalex.org/W2754274550","https://openalex.org/W2783397783","https://openalex.org/W2792314560","https://openalex.org/W2795884050","https://openalex.org/W2805470919","https://openalex.org/W2885297341","https://openalex.org/W2887248591","https://openalex.org/W2890220120","https://openalex.org/W2900712152","https://openalex.org/W2901487294","https://openalex.org/W2903296371","https://openalex.org/W2923176952","https://openalex.org/W2956528092","https://openalex.org/W2963241446","https://openalex.org/W2969037002","https://openalex.org/W2977893734","https://openalex.org/W2979735618","https://openalex.org/W2996168925","https://openalex.org/W2999574124","https://openalex.org/W2999582351","https://openalex.org/W3000282644","https://openalex.org/W3000334428","https://openalex.org/W3011746056","https://openalex.org/W3020256411","https://openalex.org/W3021542388"],"related_works":["https://openalex.org/W3118881330","https://openalex.org/W4389029073","https://openalex.org/W3040732415","https://openalex.org/W7162533270","https://openalex.org/W7204957797","https://openalex.org/W2981471821","https://openalex.org/W3118716959","https://openalex.org/W3164751861","https://openalex.org/W2969037002","https://openalex.org/W4405511743"],"abstract_inverted_index":{"ABSTRACT":[0],"An":[1],"ongoing":[2],"Candida":[3],"auris":[4,26,105,144,207,244],"outbreak":[5],"in":[6,18,85,174],"the":[7,13,65,76,91,98,141,155,161,175,214,240],"New":[8,102],"York":[9,103],"metropolitan":[10],"area":[11],"is":[12,50,70,83],"largest":[14],"recorded":[15],"to":[16,30,35,63,107],"date":[17],"North":[19],"America.":[20],"Laboratory":[21],"surveillance":[22],"revealed":[23],"NY":[24],"C.":[25,104,143,206,243],"isolates":[27,45,106,145,195,209],"are":[28,46],"resistant":[29,248],"fluconazole,":[31],"with":[32,57],"variable":[33],"resistance":[34,66],"other":[36],"currently":[37,84],"used":[38],"broad-spectrum":[39],"antifungal":[40],"drugs,":[41],"and":[42,109,124,163,193,213,216],"that":[43,74,224],"several":[44],"pan-resistant.":[47],"Thus,":[48],"there":[49],"an":[51],"urgent":[52],"need":[53],"for":[54,90,140,204,239],"new":[55],"drugs":[56,112],"a":[58,71],"novel":[59],"mechanism":[60],"of":[61,93,100,190,200,237,242],"action":[62],"combat":[64],"challenge.":[67],"Manogepix":[68],"(MGX)":[69],"first-in-class":[72],"agent":[73],"targets":[75],"fungal":[77,94],"Gwt1":[78],"enzyme.":[79],"The":[80,132,198],"prodrug,":[81],"fosmanogepix,":[82],"Phase":[86],"2":[87],"clinical":[88,235],"development":[89],"treatment":[92,241],"infections.":[95],"We":[96],"evaluated":[97],"susceptibility":[99],"200":[101],"MGX":[108,116,133,149,176,201,225],"10":[110],"comparator":[111],"using":[113],"CLSI":[114],"methodology.":[115],"demonstrated":[117],"lower":[118],"MICs":[119],"than":[120,154,160,167],"comparators":[121],"(MIC":[122],"50":[123,180],"MIC":[125,179,182,202,218],"90":[126,183],"0.03":[127],"mg/L;":[128],"range":[129,199],"0.004-0.06":[130],"mg/L).":[131],"epidemiological":[134],"cutoff":[135],"value":[136],"(ECV,":[137],"99%":[138],"cutoff)":[139],"tested":[142],"was":[146,150,210],"0.06":[147],"mg/L.":[148],"8-32-fold":[151],"more":[152,158,165],"active":[153,159,166],"echinocandins,":[156],"16-64-fold":[157],"azoles,":[162],"64-fold":[164],"amphotericin":[168],"B.":[169],"No":[170],"differences":[171],"were":[172,196,220],"found":[173],"or":[177,185],"comparators\u2019":[178],",":[181,184],"GEOMEAN":[186],"values":[187,203,219],"when":[188],"subsets":[189],"clinical,":[191],"surveillance,":[192],"environmental":[194],"evaluated.":[197],"six":[205],"pan-resistant":[208],"0.008-0.015":[211],"mg/L,":[212,222],"median":[215],"mode":[217],"0.015":[221],"demonstrating":[223],"retains":[226],"activity":[227],"against":[228],"these":[229],"isolates.":[230,249],"These":[231],"data":[232],"support":[233],"further":[234],"evaluation":[236],"fosmanogepix":[238],"infections,":[245],"including":[246],"highly":[247]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-09-01T00:00:00"}