{"id":"https://openalex.org/W3080422972","doi":"https://doi.org/10.1016/j.jpeds.2020.08.051","title":"Up-Regulation of Nfat5 mRNA and Fzd4 mRNA as a Marker of Poor Outcome in Neonatal Hypoxic-Ischemic Encephalopathy","display_name":"Up-Regulation of Nfat5 mRNA and Fzd4 mRNA as a Marker of Poor Outcome in Neonatal Hypoxic-Ischemic Encephalopathy","publication_year":2020,"publication_date":"2020-08-20","ids":{"openalex":"https://openalex.org/W3080422972","doi":"https://doi.org/10.1016/j.jpeds.2020.08.051","mag":"3080422972","pmid":"https://pubmed.ncbi.nlm.nih.gov/32828883"},"language":"en","primary_location":{"id":"doi:10.1016/j.jpeds.2020.08.051","doi":"https://doi.org/10.1016/j.jpeds.2020.08.051","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jpeds.2020.08.051","pdf_url":null,"source":{"id":"https://openalex.org/S3774022","display_name":"The Journal of Pediatrics","issn_l":"0022-3476","issn":["0022-3476","1085-8695","1097-6833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025263935","display_name":"Marc Paul O\u2019Sullivan","orcid":"https://orcid.org/0000-0002-6184-3306","observed_orcids":["https://orcid.org/0000-0002-6184-3306"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4210101467","display_name":"Infant","ror":"https://ror.org/00men8398","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210101467"]},{"id":"https://openalex.org/I4210123869","display_name":"National Children\u2019s Research Centre","ror":"https://ror.org/02typaz40","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210123869"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Marc Paul O'Sullivan","raw_affiliation_strings":["INFANT Research Centre, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland; National Children's Research Centre, Crumlin, Dublin, Ireland. Electronic address: marc.osullivan@umail.ucc.ie","Department of Paediatrics and Child Health, University College Cork, Cork, Ireland","INFANT Research Centre, Ireland","National Children's Research Centre, Crumlin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INFANT Research Centre, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland; National Children's Research Centre, Crumlin, Dublin, Ireland. Electronic address: marc.osullivan@umail.ucc.ie","institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210101467","https://openalex.org/I4210123869"]},{"raw_affiliation_string":"Department of Paediatrics and Child Health, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]},{"raw_affiliation_string":"INFANT Research Centre, Ireland","institution_ids":["https://openalex.org/I4210101467"]},{"raw_affiliation_string":"National Children's Research Centre, Crumlin, Dublin, Ireland","institution_ids":["https://openalex.org/I4210123869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002852091","display_name":"Sophie Casey","orcid":"https://orcid.org/0000-0001-7704-3568","observed_orcids":["https://orcid.org/0000-0001-7704-3568"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4210101467","display_name":"Infant","ror":"https://ror.org/00men8398","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210101467"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Sophie Casey","raw_affiliation_strings":["INFANT Research Centre, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland","Department of Paediatrics and Child Health, University College Cork, Cork, Ireland","INFANT Research Centre, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INFANT Research Centre, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210101467"]},{"raw_affiliation_string":"Department of Paediatrics and Child Health, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]},{"raw_affiliation_string":"INFANT Research Centre, Ireland","institution_ids":["https://openalex.org/I4210101467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079129373","display_name":"Mikael Finder","orcid":"https://orcid.org/0000-0002-3788-5493","observed_orcids":["https://orcid.org/0000-0002-3788-5493"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mikael Finder","raw_affiliation_strings":["Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden; Neonatal Department, Karolinska University Hospital, Stockholm, Sweden","Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden","Neonatal Department, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden; Neonatal Department, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Neonatal Department, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007205193","display_name":"Caroline E. Ahearne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4210101467","display_name":"Infant","ror":"https://ror.org/00men8398","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210101467"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Caroline Ahearne","raw_affiliation_strings":["INFANT Research Centre, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland","Department of Paediatrics and Child Health, University College Cork, Cork, Ireland","INFANT Research Centre, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INFANT Research Centre, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210101467"]},{"raw_affiliation_string":"Department of Paediatrics and Child Health, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]},{"raw_affiliation_string":"INFANT Research Centre, Ireland","institution_ids":["https://openalex.org/I4210101467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003021083","display_name":"Gerard A. Clarke","orcid":"https://orcid.org/0000-0001-9771-3979","observed_orcids":["https://orcid.org/0000-0001-9771-3979"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4210101467","display_name":"Infant","ror":"https://ror.org/00men8398","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210101467"]},{"id":"https://openalex.org/I4210141138","display_name":"APC Microbiome Institute","ror":"https://ror.org/03f2ct267","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210141138"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Gerard Clarke","raw_affiliation_strings":["INFANT Research Centre, Ireland; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland; APC Microbiome, Ireland, University College Cork, Cork, Ireland","APC Microbiome, Ireland, University College Cork, Cork, Ireland","Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland","INFANT Research Centre, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INFANT Research Centre, Ireland; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland; APC Microbiome, Ireland, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210101467","https://openalex.org/I4210141138"]},{"raw_affiliation_string":"APC Microbiome, Ireland, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]},{"raw_affiliation_string":"Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]},{"raw_affiliation_string":"INFANT Research Centre, Ireland","institution_ids":["https://openalex.org/I4210101467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011863590","display_name":"Boubou Hallberg","orcid":"https://orcid.org/0000-0002-2928-3126","observed_orcids":["https://orcid.org/0000-0002-2928-3126"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Boubou Hallberg","raw_affiliation_strings":["Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden; Neonatal Department, Karolinska University Hospital, Stockholm, Sweden","Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden","Neonatal Department, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden; Neonatal Department, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Neonatal Department, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084014715","display_name":"Geraldine B. Boylan","orcid":"https://orcid.org/0000-0003-0920-5291","observed_orcids":["https://orcid.org/0000-0003-0920-5291"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4210101467","display_name":"Infant","ror":"https://ror.org/00men8398","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210101467"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Geraldine B. Boylan","raw_affiliation_strings":["INFANT Research Centre, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland","Department of Paediatrics and Child Health, University College Cork, Cork, Ireland","INFANT Research Centre, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INFANT Research Centre, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210101467"]},{"raw_affiliation_string":"Department of Paediatrics and Child Health, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]},{"raw_affiliation_string":"INFANT Research Centre, Ireland","institution_ids":["https://openalex.org/I4210101467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019262839","display_name":"Deirdre M. Murray","orcid":"https://orcid.org/0000-0002-2201-9912","observed_orcids":["https://orcid.org/0000-0002-2201-9912"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4210101467","display_name":"Infant","ror":"https://ror.org/00men8398","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210101467"]},{"id":"https://openalex.org/I4210123869","display_name":"National Children\u2019s Research Centre","ror":"https://ror.org/02typaz40","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210123869"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Deirdre M. Murray","raw_affiliation_strings":["INFANT Research Centre, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland; National Children's Research Centre, Crumlin, Dublin, Ireland","Department of Paediatrics and Child Health, University College Cork, Cork, Ireland","INFANT Research Centre, Ireland","National Children's Research Centre, Crumlin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INFANT Research Centre, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland; National Children's Research Centre, Crumlin, Dublin, Ireland","institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210101467","https://openalex.org/I4210123869"]},{"raw_affiliation_string":"Department of Paediatrics and Child Health, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]},{"raw_affiliation_string":"INFANT Research Centre, Ireland","institution_ids":["https://openalex.org/I4210101467"]},{"raw_affiliation_string":"National Children's Research Centre, Crumlin, Dublin, Ireland","institution_ids":["https://openalex.org/I4210123869"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5025263935"],"corresponding_institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210101467","https://openalex.org/I4210123869"],"apc_list":{"value":4570,"currency":"USD","value_usd":4570},"apc_paid":null,"fwci":1.4208,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.8255689,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"228","issue":null,"first_page":"74","last_page":"81.e2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11060","display_name":"Infant Development and Preterm Care","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neonatal-hypoxic-ischemic-encephalopathy","display_name":"neonatal hypoxic-ischemic encephalopathy","score":0.9789999723434448},{"id":"https://openalex.org/keywords/nfat5","display_name":"NFAT5","score":0.7039999961853027},{"id":"https://openalex.org/keywords/fzd4","display_name":"FZD4","score":0.9829999804496765},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8619999885559082},{"id":"https://openalex.org/keywords/perinatal-asphyxia","display_name":"perinatal asphyxia","score":0.9010000228881836},{"id":"https://openalex.org/keywords/neurodevelopmental-outcomes","display_name":"neurodevelopmental outcomes","score":0.9290000200271606},{"id":"https://openalex.org/keywords/long-term-outcome-prediction","display_name":"long-term outcome prediction","score":0.6000000238418579},{"id":"https://openalex.org/keywords/sarnat-score","display_name":"Sarnat score","score":0.6600000262260437},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C2909832856","wikidata":"https://www.wikidata.org/wiki/Q2249526","display_name":"Hypoxic Ischemic Encephalopathy","level":3,"score":0.7654608488082886},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7636435031890869},{"id":"https://openalex.org/C2780164069","wikidata":"https://www.wikidata.org/wiki/Q2694437","display_name":"Perinatal asphyxia","level":3,"score":0.6335559487342834},{"id":"https://openalex.org/C2777390192","wikidata":"https://www.wikidata.org/wiki/Q1036696","display_name":"Hypothermia","level":2,"score":0.6018236875534058},{"id":"https://openalex.org/C2779914510","wikidata":"https://www.wikidata.org/wiki/Q193840","display_name":"Asphyxia","level":2,"score":0.5891790986061096},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.5715853571891785},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4872566759586334},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42313000559806824},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3354509472846985}],"mesh":[{"descriptor_ui":"D001238","descriptor_name":"Asphyxia Neonatorum","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001238","descriptor_name":"Asphyxia Neonatorum","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001238","descriptor_name":"Asphyxia Neonatorum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051157","descriptor_name":"Frizzled Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051157","descriptor_name":"Frizzled Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jpeds.2020.08.051","doi":"https://doi.org/10.1016/j.jpeds.2020.08.051","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jpeds.2020.08.051","pdf_url":null,"source":{"id":"https://openalex.org/S3774022","display_name":"The Journal of Pediatrics","issn_l":"0022-3476","issn":["0022-3476","1085-8695","1097-6833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pediatrics","raw_type":"journal-article"},{"id":"pmid:32828883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32828883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pediatrics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1396147935","display_name":null,"funder_award_id":"CSA/2012/40","funder_id":"https://openalex.org/F4320312041","funder_display_name":"Health Research Board"},{"id":"https://openalex.org/G1749707191","display_name":null,"funder_award_id":"12/RC/2272","funder_id":"https://openalex.org/F4320312041","funder_display_name":"Health Research Board"},{"id":"https://openalex.org/G2342109668","display_name":null,"funder_award_id":"B/14/1","funder_id":"https://openalex.org/F4320315014","funder_display_name":"National Children's Research Centre"},{"id":"https://openalex.org/G3104299471","display_name":"Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine","funder_award_id":"12/RC/2273","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"}],"funders":[{"id":"https://openalex.org/F4320312041","display_name":"Health Research Board","ror":"https://ror.org/003hb2249"},{"id":"https://openalex.org/F4320315014","display_name":"National Children's Research Centre","ror":"https://ror.org/02typaz40"},{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1549826613","https://openalex.org/W1550814098","https://openalex.org/W1964232672","https://openalex.org/W1977789763","https://openalex.org/W1985230697","https://openalex.org/W1992659047","https://openalex.org/W1995665812","https://openalex.org/W1997309506","https://openalex.org/W2014086693","https://openalex.org/W2016497346","https://openalex.org/W2016619395","https://openalex.org/W2016962985","https://openalex.org/W2031522329","https://openalex.org/W2036178413","https://openalex.org/W2041935553","https://openalex.org/W2048203988","https://openalex.org/W2055313665","https://openalex.org/W2059767791","https://openalex.org/W2060985684","https://openalex.org/W2068074059","https://openalex.org/W2076852872","https://openalex.org/W2088727502","https://openalex.org/W2094358667","https://openalex.org/W2096981766","https://openalex.org/W2105788666","https://openalex.org/W2109476525","https://openalex.org/W2112187582","https://openalex.org/W2112251186","https://openalex.org/W2112963538","https://openalex.org/W2114570899","https://openalex.org/W2116178187","https://openalex.org/W2119043140","https://openalex.org/W2125411036","https://openalex.org/W2134118500","https://openalex.org/W2136875315","https://openalex.org/W2144987360","https://openalex.org/W2146619649","https://openalex.org/W2153032620","https://openalex.org/W2154266727","https://openalex.org/W2155688961","https://openalex.org/W2156246479","https://openalex.org/W2158021558","https://openalex.org/W2159473136","https://openalex.org/W2159668247","https://openalex.org/W2168630917","https://openalex.org/W2169597792","https://openalex.org/W2556227869","https://openalex.org/W2603009846","https://openalex.org/W2898668651","https://openalex.org/W2907935749"],"related_works":["https://openalex.org/W2358753984","https://openalex.org/W3133533695","https://openalex.org/W2907935749","https://openalex.org/W2026899473","https://openalex.org/W2327385479","https://openalex.org/W1550814098","https://openalex.org/W2891039026","https://openalex.org/W7204183597","https://openalex.org/W2531844691","https://openalex.org/W1976301180"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-09-01T00:00:00"}