{"id":"https://openalex.org/W3080249907","doi":"https://doi.org/10.1016/j.phymed.2020.153312","title":"Curcumin inhibits proteasome activity in triple-negative breast cancer cells through regulating p300/miR-142\u20133p/PSMB5 axis","display_name":"Curcumin inhibits proteasome activity in triple-negative breast cancer cells through regulating p300/miR-142\u20133p/PSMB5 axis","publication_year":2020,"publication_date":"2020-08-25","ids":{"openalex":"https://openalex.org/W3080249907","doi":"https://doi.org/10.1016/j.phymed.2020.153312","mag":"3080249907","pmid":"https://pubmed.ncbi.nlm.nih.gov/32866906"},"language":"en","primary_location":{"id":"doi:10.1016/j.phymed.2020.153312","doi":"https://doi.org/10.1016/j.phymed.2020.153312","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phymed.2020.153312","pdf_url":null,"source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Le Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le Liu","raw_affiliation_strings":["Department of Pathology & Pathophysiology, Wuhan University School of Basic Medical Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology & Pathophysiology, Wuhan University School of Basic Medical Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059788283","display_name":"Yalin Fu","orcid":"https://orcid.org/0000-0002-9243-8637","observed_orcids":["https://orcid.org/0000-0002-9243-8637"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yalin Fu","raw_affiliation_strings":["Department of Pathology & Pathophysiology, Wuhan University School of Basic Medical Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology & Pathophysiology, Wuhan University School of Basic Medical Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112638177","display_name":"Yuyang Zheng","orcid":"https://orcid.org/0009-0004-4594-7115","observed_orcids":["https://orcid.org/0009-0004-4594-7115"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuyang Zheng","raw_affiliation_strings":["Department of Pathology & Pathophysiology, Wuhan University School of Basic Medical Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology & Pathophysiology, Wuhan University School of Basic Medical Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041072835","display_name":"Mingke Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingke Ma","raw_affiliation_strings":["Department of Pathology & Pathophysiology, Wuhan University School of Basic Medical Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology & Pathophysiology, Wuhan University School of Basic Medical Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101415306","display_name":"Changhua Wang","orcid":"https://orcid.org/0000-0003-2817-2552","observed_orcids":["https://orcid.org/0000-0003-2817-2552"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changhua Wang","raw_affiliation_strings":["Department of Pathology & Pathophysiology, Wuhan University School of Basic Medical Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China. Electronic address: chwang0525@whu.edu.cn","Department of Pathology & Pathophysiology, Wuhan University School of Basic Medical Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China"],"raw_orcid":"https://orcid.org/0000-0003-2817-2552","affiliations":[{"raw_affiliation_string":"Department of Pathology & Pathophysiology, Wuhan University School of Basic Medical Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China. Electronic address: chwang0525@whu.edu.cn","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"Department of Pathology & Pathophysiology, Wuhan University School of Basic Medical Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China","institution_ids":["https://openalex.org/I37461747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101415306"],"corresponding_institution_ids":["https://openalex.org/I37461747"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":null,"fwci":2.4515,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.88218924,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"78","issue":null,"first_page":"153312","last_page":"153312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.07289999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.02019999921321869,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9070000052452087},{"id":"https://openalex.org/keywords/20s-proteasome","display_name":"20S proteasome","score":0.8799999952316284},{"id":"https://openalex.org/keywords/proteasome-inhibition","display_name":"proteasome inhibition","score":0.8700000047683716},{"id":"https://openalex.org/keywords/psmb5","display_name":"PSMB5","score":0.9259999990463257},{"id":"https://openalex.org/keywords/mir-142-3p","display_name":"miR-142-3p","score":0.9419999718666077},{"id":"https://openalex.org/keywords/p300","display_name":"P300","score":0.9829999804496765},{"id":"https://openalex.org/keywords/histone-acetyltransferase","display_name":"histone acetyltransferase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/chymotrypsin-like-activity","display_name":"chymotrypsin-like activity","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.6890000104904175},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.8116379976272583},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.7769914865493774},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.6504349708557129},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4711301028728485},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4680022597312927},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4660813510417938},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.42948126792907715},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4293978214263916},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4025331735610962},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39580586552619934},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3873429000377655},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35001078248023987},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2762414813041687},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26560544967651367},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2277701199054718},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.20152318477630615},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050881","descriptor_name":"E1A-Associated p300 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050881","descriptor_name":"E1A-Associated p300 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061988","descriptor_name":"Proteasome Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.phymed.2020.153312","doi":"https://doi.org/10.1016/j.phymed.2020.153312","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phymed.2020.153312","pdf_url":null,"source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},{"id":"pmid:32866906","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32866906","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine : international journal of phytotherapy and phytopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3241471529","display_name":"APPL1\u5728\u8102\u8054\u7d20\u6291\u5236\u809d\u7ec6\u80de\u8461\u8404\u7cd6\u5f02\u751f\u4e2d\u7684\u4f5c\u7528\u4e0e\u673a\u5236","funder_award_id":"81170790","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3427458924","display_name":null,"funder_award_id":"TFJC2018001","funder_id":"https://openalex.org/F4320324116","funder_display_name":"Wuhan University"},{"id":"https://openalex.org/G4075122852","display_name":null,"funder_award_id":"81870550","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324116","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1844216079","https://openalex.org/W1988492454","https://openalex.org/W1989703280","https://openalex.org/W2024097609","https://openalex.org/W2038248439","https://openalex.org/W2043943641","https://openalex.org/W2052296178","https://openalex.org/W2068380884","https://openalex.org/W2069470172","https://openalex.org/W2106359723","https://openalex.org/W2123752216","https://openalex.org/W2132329932","https://openalex.org/W2132967023","https://openalex.org/W2138077682","https://openalex.org/W2144808673","https://openalex.org/W2148947476","https://openalex.org/W2161701924","https://openalex.org/W2335231316","https://openalex.org/W2553564883","https://openalex.org/W2593698871","https://openalex.org/W2625495108","https://openalex.org/W2732040307","https://openalex.org/W2798011605","https://openalex.org/W2811476529","https://openalex.org/W2861982167","https://openalex.org/W2885938058","https://openalex.org/W2887453177","https://openalex.org/W2892868770","https://openalex.org/W2901917768","https://openalex.org/W2902116368","https://openalex.org/W2903708756","https://openalex.org/W2914775587","https://openalex.org/W2978605903","https://openalex.org/W2997513201","https://openalex.org/W3012866857","https://openalex.org/W6757015488"],"related_works":["https://openalex.org/W4393223633","https://openalex.org/W2145887093","https://openalex.org/W2617444563","https://openalex.org/W3196556062","https://openalex.org/W3129774315","https://openalex.org/W2052327609","https://openalex.org/W4392093637","https://openalex.org/W4200084067","https://openalex.org/W2081372423","https://openalex.org/W2861982167"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-09-01T00:00:00"}