{"id":"https://openalex.org/W3080211426","doi":"https://doi.org/10.1634/theoncologist.2020-0818","title":"Cladribine with Granulocyte Colony-Stimulating Factor, Cytarabine, and Aclarubicin Regimen in Refractory/Relapsed Acute Myeloid Leukemia: A Phase II Multicenter Study","display_name":"Cladribine with Granulocyte Colony-Stimulating Factor, Cytarabine, and Aclarubicin Regimen in Refractory/Relapsed Acute Myeloid Leukemia: A Phase II Multicenter Study","publication_year":2020,"publication_date":"2020-09-21","ids":{"openalex":"https://openalex.org/W3080211426","doi":"https://doi.org/10.1634/theoncologist.2020-0818","mag":"3080211426","pmid":"https://pubmed.ncbi.nlm.nih.gov/32845551","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7648354"},"language":"en","primary_location":{"id":"doi:10.1634/theoncologist.2020-0818","doi":"https://doi.org/10.1634/theoncologist.2020-0818","is_oa":true,"landing_page_url":"https://doi.org/10.1634/theoncologist.2020-0818","pdf_url":"https://academic.oup.com/oncolo/article-pdf/25/11/e1663/41920562/oncolo_25_11_e1663.pdf","source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/oncolo/article-pdf/25/11/e1663/41920562/oncolo_25_11_e1663.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021068259","display_name":"Hua Wang","orcid":"https://orcid.org/0000-0001-7311-4576","observed_orcids":["https://orcid.org/0000-0001-7311-4576"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Wang","raw_affiliation_strings":["Department of Hematological Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematological Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100456475","display_name":"Liang Wang","orcid":"https://orcid.org/0000-0001-6140-914X","observed_orcids":["https://orcid.org/0000-0001-6140-914X"]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Wang","raw_affiliation_strings":["Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chun Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun Li","raw_affiliation_strings":["Department of Hematological Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematological Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021353404","display_name":"Zhijun Wuxiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158567","display_name":"Hainan Medical College Hospital","ror":"https://ror.org/04jg69j33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158567"]},{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhijun Wuxiao","raw_affiliation_strings":["Department of Hematology, Lymphoma and Myeloma Center, HMC Cancer Institute, The First Affiliated Hospital of Hainan Medical College, Haikou, Hainan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Lymphoma and Myeloma Center, HMC Cancer Institute, The First Affiliated Hospital of Hainan Medical College, Haikou, Hainan, People's Republic of China","institution_ids":["https://openalex.org/I4210158567","https://openalex.org/I79731167"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021850139","display_name":"Ruonan Shao","orcid":"https://orcid.org/0000-0002-5566-1848","observed_orcids":["https://orcid.org/0000-0002-5566-1848"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruonan Shao","raw_affiliation_strings":["Department of Hematological Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematological Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073513161","display_name":"Huizhong Wang","orcid":"https://orcid.org/0000-0002-1469-714X","observed_orcids":["https://orcid.org/0000-0002-1469-714X"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huizhong Wang","raw_affiliation_strings":["Department of Hematological Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematological Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100677069","display_name":"Yue Lu","orcid":"https://orcid.org/0000-0003-0466-9257","observed_orcids":["https://orcid.org/0000-0003-0466-9257"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yue Lu","raw_affiliation_strings":["Department of Hematological Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematological Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100677069"],"corresponding_institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":{"value":1500,"currency":"USD","value_usd":1500},"fwci":0.4999,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.64927363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"25","issue":"11","first_page":"e1663","last_page":"e1670"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cladribine","display_name":"cladribine","score":0.9789999723434448},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.953000009059906},{"id":"https://openalex.org/keywords/low-dose-cytarabine","display_name":"low-dose cytarabine","score":0.9729999899864197},{"id":"https://openalex.org/keywords/aclarubicin","display_name":"aclarubicin","score":1.0},{"id":"https://openalex.org/keywords/salvage-chemotherapy","display_name":"salvage chemotherapy","score":0.7910000085830688},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.9359999895095825},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9100000262260437},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.9890000224113464},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.9610000252723694},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/purine-analogs","display_name":"purine analogues","score":0.7760000228881836},{"id":"https://openalex.org/keywords/hematopoietic-growth-factors","display_name":"hematopoietic growth factors","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C2780847677","wikidata":"https://www.wikidata.org/wiki/Q4674302","display_name":"Aclarubicin","level":4,"score":0.8998508453369141},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.8605676889419556},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7724689841270447},{"id":"https://openalex.org/C2779200787","wikidata":"https://www.wikidata.org/wiki/Q414030","display_name":"Cladribine","level":2,"score":0.724516749382019},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6593014597892761},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6359531283378601},{"id":"https://openalex.org/C2777767877","wikidata":"https://www.wikidata.org/wiki/Q419327","display_name":"Granulocyte colony-stimulating factor","level":3,"score":0.6072751879692078},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5434773564338684},{"id":"https://openalex.org/C2776730729","wikidata":"https://www.wikidata.org/wiki/Q1392130","display_name":"Flag (linear algebra)","level":3,"score":0.47180667519569397},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.46962714195251465},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.46244674921035767},{"id":"https://openalex.org/C2780775027","wikidata":"https://www.wikidata.org/wiki/Q17141389","display_name":"Salvage therapy","level":3,"score":0.4551635980606079},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.43288570642471313},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.41761264204978943},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3788921535015106},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09227725863456726},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C136119220","wikidata":"https://www.wikidata.org/wiki/Q1000660","display_name":"Algebra over a field","level":2,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003561","descriptor_name":"Cytarabine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015250","descriptor_name":"Aclarubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017338","descriptor_name":"Cladribine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1634/theoncologist.2020-0818","doi":"https://doi.org/10.1634/theoncologist.2020-0818","is_oa":true,"landing_page_url":"https://doi.org/10.1634/theoncologist.2020-0818","pdf_url":"https://academic.oup.com/oncolo/article-pdf/25/11/e1663/41920562/oncolo_25_11_e1663.pdf","source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7648354","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7648354","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncologist","raw_type":"Text"},{"id":"pmid:32845551","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32845551","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The oncologist","raw_type":"Clinical Trial, Phase II"}],"best_oa_location":{"id":"doi:10.1634/theoncologist.2020-0818","doi":"https://doi.org/10.1634/theoncologist.2020-0818","is_oa":true,"landing_page_url":"https://doi.org/10.1634/theoncologist.2020-0818","pdf_url":"https://academic.oup.com/oncolo/article-pdf/25/11/e1663/41920562/oncolo_25_11_e1663.pdf","source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3080211426.pdf","grobid_xml":"https://content.openalex.org/works/W3080211426.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W55108809","https://openalex.org/W180389927","https://openalex.org/W1569756545","https://openalex.org/W1992852707","https://openalex.org/W2029502691","https://openalex.org/W2044088883","https://openalex.org/W2045525494","https://openalex.org/W2141129374","https://openalex.org/W2338401802","https://openalex.org/W2408813205","https://openalex.org/W2462077090","https://openalex.org/W2593230508","https://openalex.org/W6718569814"],"related_works":["https://openalex.org/W2922272916","https://openalex.org/W4388466895","https://openalex.org/W2585672744","https://openalex.org/W2992822996","https://openalex.org/W1984480838","https://openalex.org/W2952351483","https://openalex.org/W2443331045","https://openalex.org/W2029502691","https://openalex.org/W2894893948","https://openalex.org/W2127281738"],"abstract_inverted_index":{"LESSONS":[0],"LEARNED:":[1],"Studies":[2],"targeting":[3],"cladribine":[4,114],"in":[5,17,115],"combination":[6,116],"with":[7,62,117,130,298],"granulocyte":[8,118],"colony-stimulating":[9,119],"factor,":[10],"low-dose":[11,122],"cytarabine,":[12,123],"and":[13,19,40,44,50,67,85,108,124,227,249,261,278,303],"aclarubicin":[14,125],"(C-CAG)":[15,126],"regimen":[16,37,55,82,127,215,290],"relapsed":[18,84],"refractory":[20,86],"acute":[21,87],"myeloid":[22,88],"leukemia":[23,89],"(R/R":[24,90],"AML)":[25,91],"are":[26],"limited.":[27],"The":[28,53,78,267],"complete":[29,153],"remission":[30,154,232,301],"rate":[31,302],"after":[32,159],"two":[33,160,211,218],"cycles":[34,190,212,219],"of":[35,105,110,162,188,213,220,238],"C-CAG":[36,54,214,289],"was":[38,99,156,272],"67.6%,":[39],"1-year":[41,245],"overall":[42,246],"survival":[43,46,247,251],"disease-free":[45,250],"rates":[47,253],"were":[48,145,166,172,183,198,254,276],"59.7%":[49,255],"72.9%,":[51],"respectively.":[52,266],"is":[56,292],"significantly":[57,293],"effective":[58,294],"against":[59,295],"R/R":[60,75,131,296,317],"AML":[61,297],"a":[63,95,186,235,299,304],"low":[64,305],"hematological":[65,306],"toxicity":[66],"thus":[68],"serves":[69],"as":[70,312],"an":[71,313],"alternative":[72,314],"treatment":[73,315],"for":[74,83,101,128,185,316],"AML.":[76,132,318],"BACKGROUND:":[77],"optimal":[79],"salvage":[80],"chemotherapy":[81,291],"remains":[92],"uncertain.":[93],"Therefore,":[94],"phase":[96],"II":[97],"study":[98,151],"conducted":[100],"the":[102,106,111,150,168,244,288],"prospective":[103],"evaluation":[104],"efficacy":[107],"safety":[109],"purine":[112],"analog":[113],"factor":[120],"(G-CSF),":[121],"patients":[129,169,207,223,229],"METHODS:":[133],"every":[134],"12":[135],"hours,":[136],"subcutaneously,":[137],"days":[138],"3-9;":[139],"4":[140],"weeks":[141],"per":[142],"cycle.":[143],"Patients":[144],"allowed":[146],"to":[147,174],"withdraw":[148],"from":[149],"if":[152],"(CR)":[155],"not":[157],"achieved":[158,225],"courses":[161],"chemotherapy.":[163,216],"If":[164],"conditions":[165],"right,":[167],"achieving":[170],"CR":[171],"recommended":[173],"receive":[175],"allogeneic":[176],"hematopoietic":[177],"stem":[178],"cell":[179],"transplantation.":[180],"Otherwise,":[181],"they":[182,201],"treated":[184],"total":[187],"six":[189],"unless":[191],"disease":[192],"progression":[193],"or":[194,200],"unacceptable":[195],"side":[196],"effects":[197],"observed":[199],"withdrew":[202],"their":[203],"consent.":[204],"RESULTS:":[205],"All":[206],"received":[208],"at":[209],"least":[210],"After":[217],"C-CAG,":[221],"23":[222],"(67.6%)":[224],"CR,":[226],"5":[228],"had":[230],"partial":[231],"(14.7%).":[233],"At":[234],"median":[236],"follow-up":[237],"15":[239],"months":[240],"(range,":[241],"3-38":[242],"months),":[243],"(OS)":[248],"(DFS)":[252],"(95%":[256,263],"confidence":[257],"interval":[258],"[CI],":[259],"42.6%-76.8%)":[260],"72.9%":[262],"CI,":[264],"54.3%-91.5%),":[265],"most":[268],"common":[269],"adverse":[270],"effect":[271],"myelosuppression.":[273],"Nonhematological":[274],"toxicities":[275],"mild,":[277],"no":[279],"treatment-related":[280],"deaths":[281],"occurred.":[282],"CONCLUSION:":[283],"Preliminary":[284],"data":[285],"indicate":[286],"that":[287],"high":[300],"toxicity.":[307],"Thus,":[308],"it":[309],"may":[310],"serve":[311]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-09-01T00:00:00"}