{"id":"https://openalex.org/W3080124705","doi":"https://doi.org/10.1038/s41598-020-71167-8","title":"Atrogin1-induced loss of aquaporin 4 in myocytes leads to skeletal muscle atrophy","display_name":"Atrogin1-induced loss of aquaporin 4 in myocytes leads to skeletal muscle atrophy","publication_year":2020,"publication_date":"2020-08-25","ids":{"openalex":"https://openalex.org/W3080124705","doi":"https://doi.org/10.1038/s41598-020-71167-8","mag":"3080124705","pmid":"https://pubmed.ncbi.nlm.nih.gov/32843684","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7447774"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-020-71167-8","doi":"https://doi.org/10.1038/s41598-020-71167-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-71167-8","pdf_url":"https://www.nature.com/articles/s41598-020-71167-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-020-71167-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031695731","display_name":"Seok Won Chung","orcid":"https://orcid.org/0000-0002-8221-9289","observed_orcids":["https://orcid.org/0000-0002-8221-9289"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]},{"id":"https://openalex.org/I4210091929","display_name":"Konkuk University Medical Center","ror":"https://ror.org/00jcx1769","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I24062138","https://openalex.org/I4210091929"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seok Won Chung","raw_affiliation_strings":["Department of Orthopedic Surgery, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I24062138","https://openalex.org/I4210091929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035832257","display_name":"Ja-Yeon Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]},{"id":"https://openalex.org/I4210091929","display_name":"Konkuk University Medical Center","ror":"https://ror.org/00jcx1769","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I24062138","https://openalex.org/I4210091929"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ja-Yeon Kim","raw_affiliation_strings":["Department of Orthopedic Surgery, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I24062138","https://openalex.org/I4210091929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002351215","display_name":"Jong Pil Yoon","orcid":"https://orcid.org/0000-0001-6446-6254","observed_orcids":["https://orcid.org/0000-0001-6446-6254"]},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong Pil Yoon","raw_affiliation_strings":["Department of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113903246","display_name":"Dong Won Suh","orcid":"https://orcid.org/0000-0003-0321-1551","observed_orcids":["https://orcid.org/0000-0003-0321-1551"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dong Won Suh","raw_affiliation_strings":["Joint Center, Barunsesang Hospital, #75-5, Yatap-ro, Seongnam-si, Gyeonggi-do, 13497, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Center, Barunsesang Hospital, #75-5, Yatap-ro, Seongnam-si, Gyeonggi-do, 13497, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081330705","display_name":"Woo Jin Yeo","orcid":"https://orcid.org/0009-0007-4518-4260","observed_orcids":["https://orcid.org/0009-0007-4518-4260"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Woo Jin Yeo","raw_affiliation_strings":["Joint Center, Barunsesang Hospital, #75-5, Yatap-ro, Seongnam-si, Gyeonggi-do, 13497, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Center, Barunsesang Hospital, #75-5, Yatap-ro, Seongnam-si, Gyeonggi-do, 13497, Republic of Korea","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063702772","display_name":"Yong\u2010Soo Lee","orcid":"https://orcid.org/0000-0003-1203-9327","observed_orcids":["https://orcid.org/0000-0003-1203-9327"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]},{"id":"https://openalex.org/I4210091929","display_name":"Konkuk University Medical Center","ror":"https://ror.org/00jcx1769","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I24062138","https://openalex.org/I4210091929"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yong-Soo Lee","raw_affiliation_strings":["Department of Orthopedic Surgery, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Republic of Korea. hrcyslee@yahoo.co.kr","Joint Center, Barunsesang Hospital, #75-5, Yatap-ro, Seongnam-si, Gyeonggi-do, 13497, Republic of Korea. hrcyslee@yahoo.co.kr","Joint Center, Barunsesang Hospital, #75-5, Yatap-ro, Seongnam-si, Gyeonggi-do, 13497, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Republic of Korea. hrcyslee@yahoo.co.kr","institution_ids":["https://openalex.org/I24062138","https://openalex.org/I4210091929"]},{"raw_affiliation_string":"Joint Center, Barunsesang Hospital, #75-5, Yatap-ro, Seongnam-si, Gyeonggi-do, 13497, Republic of Korea. hrcyslee@yahoo.co.kr","institution_ids":[]},{"raw_affiliation_string":"Joint Center, Barunsesang Hospital, #75-5, Yatap-ro, Seongnam-si, Gyeonggi-do, 13497, Republic of Korea","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063702772"],"corresponding_institution_ids":["https://openalex.org/I24062138","https://openalex.org/I4210091929"],"apc_list":{"value":1870,"currency":"USD","value_usd":1870},"apc_paid":{"value":1870,"currency":"USD","value_usd":1870},"fwci":0.7861,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.66087981,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"14189","last_page":"14189"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10333","display_name":"Meat and Animal Product Quality","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aquaporin-4","display_name":"aquaporin-4","score":0.996999979019165},{"id":"https://openalex.org/keywords/atrogin-1","display_name":"atrogin-1","score":0.9629999995231628},{"id":"https://openalex.org/keywords/skeletal-muscle-atrophy","display_name":"skeletal muscle atrophy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/rotator-cuff-tear","display_name":"rotator cuff tear","score":0.9520000219345093},{"id":"https://openalex.org/keywords/high-mobility-group-box-1","display_name":"high mobility group box 1","score":0.8669999837875366},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9580000042915344},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.9660000205039978},{"id":"https://openalex.org/keywords/aquaporins","display_name":"aquaporins","score":0.42800000309944153},{"id":"https://openalex.org/keywords/ubiquitin-ligase","display_name":"ubiquitin ligase","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.8073786497116089},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6533536911010742},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.6531372666358948},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.6477335691452026},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6370396018028259},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.5608641505241394},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5491436123847961},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5459720492362976},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5355090498924255},{"id":"https://openalex.org/C199096232","wikidata":"https://www.wikidata.org/wiki/Q1545001","display_name":"Sarcolemma","level":3,"score":0.4988243579864502},{"id":"https://openalex.org/C15755913","wikidata":"https://www.wikidata.org/wiki/Q14902502","display_name":"Aquaporin 4","level":2,"score":0.48343953490257263},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.46651068329811096},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4346258044242859},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41410428285598755},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.41098207235336304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39677828550338745},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3840222656726837},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17648732662200928},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14321789145469666},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.119444340467453},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.06322205066680908},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000070584","descriptor_name":"Tripartite Motif Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024243","descriptor_name":"HMGB1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044843","descriptor_name":"SKP Cullin F-Box Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051401","descriptor_name":"Aquaporin 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051401","descriptor_name":"Aquaporin 4","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41598-020-71167-8","doi":"https://doi.org/10.1038/s41598-020-71167-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-71167-8","pdf_url":"https://www.nature.com/articles/s41598-020-71167-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7447774","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7447774","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:32843684","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32843684","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41598-020-71167-8","doi":"https://doi.org/10.1038/s41598-020-71167-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-71167-8","pdf_url":"https://www.nature.com/articles/s41598-020-71167-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2610266275","display_name":null,"funder_award_id":"NRF-2020R1A2B5B01001936","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G6326792607","display_name":null,"funder_award_id":"2020R1A2B5B01001936","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G7853865091","display_name":null,"funder_award_id":"NRF-2017R1D1A1B03033758","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3080124705.pdf","grobid_xml":"https://content.openalex.org/works/W3080124705.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W161059828","https://openalex.org/W1607563537","https://openalex.org/W1767790527","https://openalex.org/W1871667039","https://openalex.org/W1967001670","https://openalex.org/W1967544564","https://openalex.org/W2004266769","https://openalex.org/W2035346913","https://openalex.org/W2037370931","https://openalex.org/W2039293070","https://openalex.org/W2048315186","https://openalex.org/W2051624153","https://openalex.org/W2052922251","https://openalex.org/W2054684834","https://openalex.org/W2061929833","https://openalex.org/W2065056367","https://openalex.org/W2073093324","https://openalex.org/W2075014636","https://openalex.org/W2075187617","https://openalex.org/W2078192607","https://openalex.org/W2087172707","https://openalex.org/W2094252860","https://openalex.org/W2100688137","https://openalex.org/W2122992751","https://openalex.org/W2124360225","https://openalex.org/W2139789661","https://openalex.org/W2144720369","https://openalex.org/W2153978690","https://openalex.org/W2167033587","https://openalex.org/W2167512318","https://openalex.org/W2414773926","https://openalex.org/W2428991781","https://openalex.org/W2481352856","https://openalex.org/W2522178152","https://openalex.org/W2590929482","https://openalex.org/W2605182222","https://openalex.org/W2612091477","https://openalex.org/W2624853265","https://openalex.org/W2765408009","https://openalex.org/W4320300814"],"related_works":["https://openalex.org/W2612091477","https://openalex.org/W2003023218","https://openalex.org/W3011234515","https://openalex.org/W3162678369","https://openalex.org/W2039293070","https://openalex.org/W7097934423","https://openalex.org/W2806263601","https://openalex.org/W4315781695","https://openalex.org/W4382010745","https://openalex.org/W2048315186"],"abstract_inverted_index":{"The":[0,77],"water":[1,10],"channel":[2],"aquaporin":[3],"4":[4],"(AQP4)":[5],"regulates":[6],"the":[7,12,23,57,80,139,184],"flux":[8],"of":[9,25,82,92,102,124,154,183,196],"across":[11],"cell":[13],"membrane,":[14],"maintaining":[15],"cellular":[16],"homeostasis.":[17],"Since":[18],"AQP4":[19,32,49,66,87,93,103,155],"is":[20,168],"enriched":[21],"in":[22,31,54,71,160,175],"sarcolemma":[24],"skeletal":[26,35,44],"muscle,":[27],"a":[28,40,120,179,193],"functional":[29],"defect":[30],"may":[33],"cause":[34],"muscle":[36,45,55,73,197],"dysfunction.":[37],"To":[38],"investigate":[39],"novel":[41,194],"mechanism":[42],"underlying":[43],"atrophy,":[46],"we":[47,111],"examined":[48],"expression":[50,67,130,143],"and":[51,64,79,138,165],"its":[52,166,176],"regulation":[53],"using":[56],"rotator":[58],"cuff":[59],"tear":[60],"(RCT)":[61],"model.":[62],"Human":[63],"mouse":[65,135],"was":[68,94,131,144,189],"significantly":[69],"decreased":[70],"atrophied":[72],"resulting":[74],"from":[75],"RCT.":[76],"size":[78],"number":[81],"myotubes":[83],"were":[84],"reduced":[85],"following":[86],"knockdown.":[88],"Atrogin":[89,128],"1-mediated":[90],"ubiquitination":[91,98],"verified":[95],"with":[96,104],"an":[97,105],"assay":[99],"after":[100,163],"immunoprecipitation":[101],"anti-AQP4":[106],"antibody.":[107],"In":[108],"this":[109],"study,":[110],"identified":[112],"high":[113],"mobility":[114],"group":[115],"box":[116],"1":[117,126,129,142],"(HMGB1)":[118],"as":[119,178],"potent":[121],"upstream":[122,182],"regulator":[123,195],"atrogin":[125,141,171,187],"expression.":[127],"increased":[132],"by":[133,170],"recombinant":[134],"HMGB1":[136],"protein,":[137],"HMGB1-induced":[140],"mediated":[145,169],"via":[146],"NF-\u03baB":[147],"signaling.":[148],"Our":[149],"study":[150],"suggests":[151],"that":[152],"loss":[153],"appears":[156],"to":[157,191],"be":[158,192],"involved":[159],"myocyte":[161],"shrinkage":[162],"RCT,":[164],"degradation":[167],"1-dependent":[172],"ubiquitination.":[173],"HMGB1,":[174],"function":[177],"signaling":[180],"molecule":[181],"ubiquitin":[185],"ligase":[186],"1,":[188],"found":[190],"atrophy.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-09-01T00:00:00"}
