{"id":"https://openalex.org/W30788142","doi":null,"title":"Analyzing laboratory marker changes in AIDS clinical trials.","display_name":"Analyzing laboratory marker changes in AIDS clinical trials.","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W30788142","mag":"30788142","pmid":"https://pubmed.ncbi.nlm.nih.gov/2051307"},"language":"en","primary_location":{"id":"pmid:2051307","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2051307","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of acquired immune deficiency syndromes","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076484817","display_name":"Jeffrey D. Dawson","orcid":"https://orcid.org/0000-0003-2709-0360","observed_orcids":["https://orcid.org/0000-0003-2709-0360"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J D Dawson","raw_affiliation_strings":["Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113529505","display_name":"Stephen W. Lagakos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S W Lagakos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.2852,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.94483787,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"4","issue":"7","first_page":"667","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.035100001841783524,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13500","display_name":"Probability and Statistical Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aids-clinical-trials","display_name":"AIDS clinical trials","score":0.8040000200271606},{"id":"https://openalex.org/keywords/laboratory-markers","display_name":"laboratory biomarkers","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.9169999957084656},{"id":"https://openalex.org/keywords/hiv-p24-antigen","display_name":"HIV p24 antigen","score":0.9919999837875366},{"id":"https://openalex.org/keywords/repeated-measures","display_name":"repeated measures","score":0.7979999780654907},{"id":"https://openalex.org/keywords/summary-statistics","display_name":"summary statistics","score":0.6669999957084656},{"id":"https://openalex.org/keywords/treatment-group-comparison","display_name":"treatment group comparison","score":0.5460000038146973},{"id":"https://openalex.org/keywords/statistical-power","display_name":"statistical power","score":0.9549999833106995},{"id":"https://openalex.org/keywords/distribution-free-methods","display_name":"distribution-free methods","score":0.6370000243186951},{"id":"https://openalex.org/keywords/missing-data","display_name":"missing data","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C89128539","wikidata":"https://www.wikidata.org/wiki/Q1949963","display_name":"Statistic","level":2,"score":0.6799968481063843},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.5790287256240845},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5657507181167603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4762030839920044},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.4453083276748657},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4186771810054779},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4000297784805298},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.312960684299469},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2944090962409973}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2051307","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2051307","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of acquired immune deficiency syndromes","raw_type":"Journal Article"},{"id":"mag:30788142","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2051307","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2265857565","display_name":"STATISTICAL AND DATA ANALYSIS CENTER","funder_award_id":"n01ai095030-033","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2320181930","https://openalex.org/W1998425450","https://openalex.org/W2088032465","https://openalex.org/W2054192965","https://openalex.org/W7011470203","https://openalex.org/W344091167","https://openalex.org/W2106144334","https://openalex.org/W4256453051","https://openalex.org/W2024410000","https://openalex.org/W2050314599"],"abstract_inverted_index":{"Repeated":[0],"measurements":[1],"of":[2,5,35,68,72,78,90,102,130,143],"laboratory":[3],"markers":[4],"immunologic":[6],"or":[7],"disease":[8],"status,":[9],"such":[10,41],"as":[11],"CD4":[12,144],"lymphocyte":[13],"counts":[14,145],"and":[15,83,94,138],"HIV":[16],"p24":[17],"antigen":[18],"levels,":[19],"can":[20],"be":[21],"important":[22],"end":[23],"points":[24],"in":[25,48,140],"comparative":[26],"clinical":[27,150],"trials.":[28],"In":[29],"this":[30],"report,":[31],"we":[32],"consider":[33],"comparison":[34],"treatment":[36],"groups":[37],"with":[38,110],"respect":[39],"to":[40,112],"markers,":[42],"focusing":[43],"on":[44],"a":[45,56,147],"distribution-free":[46],"approach":[47],"which":[49],"each":[50],"participant's":[51],"data":[52,135],"are":[53,64,108,136],"characterized":[54],"by":[55],"single":[57],"summary":[58,61],"statistic.":[59],"The":[60],"statistics":[62],"examined":[63],"(a)":[65],"the":[66,69,73,76,79,85,88,91,95,119,126],"slope":[67,120],"least-squares":[70],"regression":[71],"marker,":[74],"(b)":[75],"average":[77],"last":[80,92],"r":[81,93],"measurements,":[82],"(c)":[84],"difference":[86],"between":[87],"averages":[89],"first":[96],"s":[97],"measurements.":[98],"Under":[99],"various":[100],"models":[101],"marker":[103],"time":[104],"trends,":[105],"these":[106],"methods":[107],"compared":[109],"regard":[111],"statistical":[113],"power.":[114],"It":[115],"is":[116,121],"found":[117],"that":[118],"usually":[122],"more":[123],"efficient":[124],"than":[125],"other":[127],"two":[128],"types":[129],"summaries.":[131],"Adaptations":[132],"for":[133],"missing":[134],"discussed":[137],"illustrated":[139],"an":[141],"analysis":[142],"from":[146],"recent":[148],"AIDS":[149],"trial.":[151]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}