{"id":"https://openalex.org/W30787534","doi":null,"title":"5' upstream sequence and genomic structure of the human primary response gene, EGR-1/TIS8.","display_name":"5' upstream sequence and genomic structure of the human primary response gene, EGR-1/TIS8.","publication_year":1991,"publication_date":"1991-05-01","ids":{"openalex":"https://openalex.org/W30787534","mag":"30787534","pmid":"https://pubmed.ncbi.nlm.nih.gov/2052361"},"language":"en","primary_location":{"id":"pmid:2052361","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2052361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055213943","display_name":"Kathleen M. Sakamoto","orcid":"https://orcid.org/0000-0003-0494-8838","observed_orcids":["https://orcid.org/0000-0003-0494-8838"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K M Sakamoto","raw_affiliation_strings":["Children's Hospital of Los Angeles, Department of Hematology/Oncology, California 90054-0700"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Los Angeles, Department of Hematology/Oncology, California 90054-0700","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018647380","display_name":"Carolyne Bardeleben","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Bardeleben","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003857860","display_name":"Karen E. Yates","orcid":"https://orcid.org/0000-0002-1844-8431","observed_orcids":["https://orcid.org/0000-0002-1844-8431"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K E Yates","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109848339","display_name":"Maribeth A. Raines","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Raines","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110109686","display_name":"David W. Golde","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D W Golde","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110876233","display_name":"JC Gasson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J C Gasson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0571,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.74333346,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"6","issue":"5","first_page":"867","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egr1","display_name":"EGR1","score":0.9079999923706055},{"id":"https://openalex.org/keywords/primary-response-genes","display_name":"primary response genes","score":0.8029999732971191},{"id":"https://openalex.org/keywords/gene-structure","display_name":"gene structure","score":0.6570000052452087},{"id":"https://openalex.org/keywords/zinc-finger-proteins","display_name":"zinc finger proteins","score":0.859000027179718},{"id":"https://openalex.org/keywords/transcriptional-regulatory-elements","display_name":"transcriptional regulatory elements","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tata-box","display_name":"TATA box","score":0.9179999828338623},{"id":"https://openalex.org/keywords/sp1-binding-site","display_name":"Sp1 binding site","score":0.765999972820282},{"id":"https://openalex.org/keywords/serum-response-element","display_name":"serum response element","score":0.9089999794960022},{"id":"https://openalex.org/keywords/camp-response-element","display_name":"cAMP response element","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tpa-responsive-element","display_name":"TPA-responsive element","score":0.9649999737739563},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.746999979019165},{"id":"https://openalex.org/keywords/transient-transfection","display_name":"transient transfection","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8793842792510986},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.683391809463501},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.5727593898773193},{"id":"https://openalex.org/C65888428","wikidata":"https://www.wikidata.org/wiki/Q1413955","display_name":"TATA box","level":5,"score":0.5047546625137329},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4953261911869049},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4950231909751892},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4643770754337311},{"id":"https://openalex.org/C2910670019","wikidata":"https://www.wikidata.org/wiki/Q907394","display_name":"Serum Response Element","level":5,"score":0.4614139795303345},{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.45990440249443054},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4565214514732361},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44288215041160583},{"id":"https://openalex.org/C132376346","wikidata":"https://www.wikidata.org/wiki/Q7315962","display_name":"Response element","level":5,"score":0.4427207410335541},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.4372524917125702},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.35866013169288635},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3200055956840515},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.21430626511573792},{"id":"https://openalex.org/C69053785","wikidata":"https://www.wikidata.org/wiki/Q907394","display_name":"Serum response factor","level":4,"score":0.07220298051834106}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002895","descriptor_name":"Chromosomes, Human, Pair 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015183","descriptor_name":"Restriction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016335","descriptor_name":"Zinc Fingers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016385","descriptor_name":"TATA Box","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051766","descriptor_name":"Early Growth Response Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2052361","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2052361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Comparative Study"},{"id":"mag:30787534","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2052361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.46000000834465027}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5331502463","display_name":"Signal Transduction in Oncogenesis","funder_award_id":"P01CA032737","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8930945653","display_name":"MECHANISM OF ACTION OF A HUMAN GRANULOPOIETIN--GM-CSF","funder_award_id":"5r01ca040163-13","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2067409703","https://openalex.org/W1987110949","https://openalex.org/W3135372211","https://openalex.org/W2048456023","https://openalex.org/W2052224971","https://openalex.org/W1839759909","https://openalex.org/W1971203960","https://openalex.org/W1518221901","https://openalex.org/W1964304127","https://openalex.org/W7106221948"],"abstract_inverted_index":{"EGR-1/TIS8":[0,34,120],"is":[1,14,100],"a":[2,8,17,23,69,88],"primary":[3],"response":[4],"gene":[5,35,121],"that":[6,87,129],"encodes":[7],"zinc":[9],"finger":[10],"containing":[11],"protein":[12],"and":[13,30,36,46,68,102,116,132],"induced":[15],"in":[16,106],"number":[18],"of":[19,25,81,95,113,118,135],"cell":[20],"types":[21],"by":[22],"variety":[24],"ligands.":[26],"We":[27,85],"have":[28,75],"isolated":[29],"mapped":[31],"the":[32,38,82,114,127],"human":[33,119,136],"sequenced":[37],"5'":[39],"upstream":[40,83],"flanking":[41],"region.":[42,84],"A":[43,110],"'TATA'":[44],"homology":[45],"several":[47,94],"putative":[48],"regulatory":[49,98],"elements,":[50,58,62],"including":[51],"two":[52,59],"Sp1":[53],"sites,":[54],"five":[55],"serum":[56],"response-like":[57,61],"cAMP":[60],"an":[63],"EGR-1":[64],"binding":[65],"site":[66],"(EBS),":[67],"tetra-decanoyl":[70],"phorbol":[71],"acetate":[72],"(TPA)-responsive":[73],"element":[74],"been":[76],"identified":[77],"within":[78],"700":[79],"nucleotides":[80],"demonstrated":[86],"500-base":[89],"pair":[90],"fragment,":[91],"which":[92],"includes":[93],"these":[96],"possible":[97],"sequences,":[99],"functional":[101],"responsive":[103],"to":[104],"TPA":[105],"transient":[107],"transfection":[108],"assays.":[109],"further":[111],"understanding":[112],"regulation":[115],"function":[117],"expression":[122],"may":[123],"provide":[124],"insight":[125],"into":[126],"mechanisms":[128],"control":[130],"normal":[131],"neoplastic":[133],"proliferation":[134],"cells.":[137]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
