{"id":"https://openalex.org/W30741737","doi":null,"title":"The Evolution of Antimycobacterial Agents from Non","display_name":"The Evolution of Antimycobacterial Agents from Non","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W30741737","mag":"30741737"},"language":"en","primary_location":{"id":"mag:2187789912","doi":null,"is_oa":false,"landing_page_url":"https://rossscience.org/ojphm/articles/2075-910X-2-1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053896327","display_name":"MARK S. WAINWRIGHT","orcid":"https://orcid.org/0000-0002-7586-9603","observed_orcids":["https://orcid.org/0000-0002-7586-9603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Wainwright","raw_affiliation_strings":["Centro de Mal\u00e1ria e outras Doen\u00e7as Tropicais (CMDT)"],"raw_orcid":"https://orcid.org/0000-0002-7586-9603","affiliations":[{"raw_affiliation_string":"Centro de Mal\u00e1ria e outras Doen\u00e7as Tropicais (CMDT)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003609205","display_name":"Leonard Amaral","orcid":"https://orcid.org/0000-0003-3127-1295","observed_orcids":["https://orcid.org/0000-0003-3127-1295"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leonard Amaral","raw_affiliation_strings":["Centro de Mal\u00e1ria e outras Doen\u00e7as Tropicais (CMDT)"],"raw_orcid":"https://orcid.org/0000-0003-3127-1295","affiliations":[{"raw_affiliation_string":"Centro de Mal\u00e1ria e outras Doen\u00e7as Tropicais (CMDT)","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Miguel ngel Calleja","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel ngel Calleja","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5107639873","display_name":"Jette Elisabeth Kristiansen","orcid":"https://orcid.org/0000-0002-8630-9249","observed_orcids":["https://orcid.org/0000-0002-8630-9249"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jette E. Kristiansen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5647,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.80946095,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"2","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13454","display_name":"Phenothiazines and Benzothiazines Synthesis and Activities","score":0.053599998354911804,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimycobacterial-agents","display_name":"antimycobacterial agents","score":0.984000027179718},{"id":"https://openalex.org/keywords/non-antibiotic-drugs","display_name":"non-antibiotic drugs","score":0.9539999961853027},{"id":"https://openalex.org/keywords/phenothiazines","display_name":"phenothiazines","score":0.925000011920929},{"id":"https://openalex.org/keywords/methylene-blue","display_name":"methylene blue","score":0.9419999718666077},{"id":"https://openalex.org/keywords/phenothiazinium-dyes","display_name":"phenothiazinium dyes","score":0.8820000290870667},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.7670000195503235},{"id":"https://openalex.org/keywords/tuberculosis-chemotherapy","display_name":"tuberculosis chemotherapy","score":0.7900000214576721},{"id":"https://openalex.org/keywords/lead-compounds","display_name":"lead compounds","score":0.4050000011920929},{"id":"https://openalex.org/keywords/precursor-structure","display_name":"precursor structure","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C2779685592","wikidata":"https://www.wikidata.org/wiki/Q2853298","display_name":"Antimycobacterial","level":4,"score":0.889622151851654},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.7751997709274292},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.774138331413269},{"id":"https://openalex.org/C2778716775","wikidata":"https://www.wikidata.org/wiki/Q410846","display_name":"Phenothiazine","level":2,"score":0.559341311454773},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45416340231895447},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4394097626209259},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.43151259422302246},{"id":"https://openalex.org/C2778487471","wikidata":"https://www.wikidata.org/wiki/Q19903319","display_name":"Antimicrobial chemotherapy","level":3,"score":0.42319124937057495},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.40157026052474976},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3568727374076843},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3480493724346161},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27390867471694946},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.21122753620147705},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2187789912","doi":null,"is_oa":false,"landing_page_url":"https://rossscience.org/ojphm/articles/2075-910X-2-1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:30741737","doi":null,"is_oa":false,"landing_page_url":"https://www.rossscience.org/ojphm/articles/2075-910X-2-1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W78133828","https://openalex.org/W110436513","https://openalex.org/W112145889","https://openalex.org/W114541892","https://openalex.org/W342118358","https://openalex.org/W611632919","https://openalex.org/W1504058802","https://openalex.org/W1982322762","https://openalex.org/W1985175175","https://openalex.org/W1985665707","https://openalex.org/W1986594609","https://openalex.org/W1999249570","https://openalex.org/W2013293889","https://openalex.org/W2015389516","https://openalex.org/W2020855419","https://openalex.org/W2032388942","https://openalex.org/W2032525332","https://openalex.org/W2032684255","https://openalex.org/W2036492728","https://openalex.org/W2038282170","https://openalex.org/W2040339268","https://openalex.org/W2041784097","https://openalex.org/W2042300081","https://openalex.org/W2046588089","https://openalex.org/W2047721231","https://openalex.org/W2050731629","https://openalex.org/W2051068751","https://openalex.org/W2056082659","https://openalex.org/W2058193441","https://openalex.org/W2060712419","https://openalex.org/W2061899845","https://openalex.org/W2066497384","https://openalex.org/W2068811953","https://openalex.org/W2073054610","https://openalex.org/W2073987434","https://openalex.org/W2076427840","https://openalex.org/W2078764878","https://openalex.org/W2087000001","https://openalex.org/W2087256865","https://openalex.org/W2093431262","https://openalex.org/W2094086889","https://openalex.org/W2094420829","https://openalex.org/W2097212680","https://openalex.org/W2098164808","https://openalex.org/W2106837596","https://openalex.org/W2111626553","https://openalex.org/W2111967195","https://openalex.org/W2112214408","https://openalex.org/W2114625913","https://openalex.org/W2117800058","https://openalex.org/W2121050066","https://openalex.org/W2122171540","https://openalex.org/W2124431299","https://openalex.org/W2125273117","https://openalex.org/W2129997370","https://openalex.org/W2131690702","https://openalex.org/W2139610538","https://openalex.org/W2141481816","https://openalex.org/W2141517785","https://openalex.org/W2143016224","https://openalex.org/W2144312659","https://openalex.org/W2144501842","https://openalex.org/W2146792913","https://openalex.org/W2152512157","https://openalex.org/W2154226051","https://openalex.org/W2156522926","https://openalex.org/W2158432972","https://openalex.org/W2159043498","https://openalex.org/W2163341009","https://openalex.org/W2165485153","https://openalex.org/W2168223671","https://openalex.org/W2171266822","https://openalex.org/W2187711834","https://openalex.org/W2279497345","https://openalex.org/W2403326322","https://openalex.org/W2406509374","https://openalex.org/W2415644560","https://openalex.org/W2434482163","https://openalex.org/W2435473527","https://openalex.org/W2461509748","https://openalex.org/W2467315630","https://openalex.org/W2476097276","https://openalex.org/W2611746205","https://openalex.org/W2615696656"],"related_works":["https://openalex.org/W2187789912","https://openalex.org/W2152512157","https://openalex.org/W2103664457","https://openalex.org/W4200105613","https://openalex.org/W2038637429","https://openalex.org/W2110295677","https://openalex.org/W2338595656","https://openalex.org/W3009468562","https://openalex.org/W4315752553","https://openalex.org/W2584056945"],"abstract_inverted_index":{"The":[0],"antimicrobial":[1,55],"action":[2],"of":[3,6,31,54,62,67,86,93],"a":[4,78],"number":[5],"non-antibiotic":[7,74],"drugs":[8],"has":[9,58],"been":[10],"demonstrated":[11],"in":[12,83,90],"recent":[13],"years,":[14],"for":[15],"example":[16],"the":[17,22,45,51,60,68,84,91],"antimycobacterial":[18],"activity":[19,34],"associated":[20],"with":[21,28],"phenothiazine":[23],"neuroleptic":[24],"class.":[25],"However,":[26],"as":[27,44],"other":[29],"classes":[30],"non-antibiotics,":[32],"such":[33,43],"may":[35,76],"be":[36],"traced":[37],"back":[38],"to":[39,81],"common":[40],"precursor":[41],"structures":[42],"phenothiazinium":[46],"dye,":[47],"methylene":[48],"blue.":[49],"While":[50],"rising":[52],"tide":[53],"drug":[56],"resistance":[57],"nullified":[59],"effects":[61],"many":[63],"conventional":[64],"agents,":[65],"several":[66],"original":[69],"lead":[70],"compounds":[71],"and":[72],"their":[73],"derivatives":[75],"have":[77],"new":[79],"part":[80],"play":[82],"chemotherapy":[85],"infectious":[87],"disease,":[88],"particularly":[89],"management":[92]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}