{"id":"https://openalex.org/W307266199","doi":"https://doi.org/10.1023/a:1015948720256","title":"Absorption Enhancement of Rectally Infused Cefoxitin Sodium by Medium-Chain Fatty Acids in Conscious Rats: Concentration\u2013Effect Relationship","display_name":"Absorption Enhancement of Rectally Infused Cefoxitin Sodium by Medium-Chain Fatty Acids in Conscious Rats: Concentration\u2013Effect Relationship","publication_year":1988,"publication_date":"1988-07-01","ids":{"openalex":"https://openalex.org/W307266199","doi":"https://doi.org/10.1023/a:1015948720256","mag":"307266199","pmid":"https://pubmed.ncbi.nlm.nih.gov/3247317"},"language":"en","primary_location":{"id":"doi:10.1023/a:1015948720256","doi":"https://doi.org/10.1023/a:1015948720256","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1015948720256","pdf_url":null,"source":{"id":"https://openalex.org/S103865650","display_name":"Pharmaceutical Research","issn_l":"0724-8741","issn":["0724-8741","1573-904X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111988656","display_name":"Ewoud J. van Hoogdalem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ewoud J. van Hoogdalem","raw_affiliation_strings":["Division of Pharmacology, Sylvius Laboratories, Leiden University, The Netherlands","Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, Sylvius Laboratories, Leiden University, RA Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology, Sylvius Laboratories, Leiden University, The Netherlands","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, Sylvius Laboratories, Leiden University, RA Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048085524","display_name":"Martin A. Hardens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Martin A. Hardens","raw_affiliation_strings":["Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, Sylvius Laboratories, Leiden University, 9503, 2300, RA Leiden, The Netherlands","Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, Sylvius Laboratories, Leiden University, RA Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, Sylvius Laboratories, Leiden University, 9503, 2300, RA Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, Sylvius Laboratories, Leiden University, RA Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110510978","display_name":"Albertus Gerrit de Boer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Albertus G. de Boer","raw_affiliation_strings":["Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, Sylvius Laboratories, Leiden University, 9503, 2300, RA Leiden, The Netherlands","Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, Sylvius Laboratories, Leiden University, RA Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, Sylvius Laboratories, Leiden University, 9503, 2300, RA Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, Sylvius Laboratories, Leiden University, RA Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109127184","display_name":"Douwe D. Breimer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Douwe D. Breimer","raw_affiliation_strings":["Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, Sylvius Laboratories, Leiden University, 9503, 2300, RA Leiden, The Netherlands","Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, Sylvius Laboratories, Leiden University, RA Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, Sylvius Laboratories, Leiden University, 9503, 2300, RA Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, Sylvius Laboratories, Leiden University, RA Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I121797337"],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":3.3756,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.90008613,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"5","issue":"7","first_page":"453","last_page":"456"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.8345000147819519,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.8345000147819519,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.15410000085830688,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cefoxitin-sodium","display_name":"cefoxitin sodium","score":0.925000011920929},{"id":"https://openalex.org/keywords/rectal-drug-delivery","display_name":"rectal drug delivery","score":0.7950000166893005},{"id":"https://openalex.org/keywords/absorption-enhancement","display_name":"absorption enhancement","score":0.718999981880188},{"id":"https://openalex.org/keywords/medium-chain-fatty-acids","display_name":"medium-chain fatty acids","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hexanoic-acid","display_name":"hexanoic acid","score":0.878000020980835},{"id":"https://openalex.org/keywords/octanoic-acid","display_name":"octanoic acid","score":0.9810000061988831},{"id":"https://openalex.org/keywords/decanoic-acid","display_name":"capric acid","score":1.0},{"id":"https://openalex.org/keywords/lauric-acid","display_name":"lauric acid","score":0.9359999895095825},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.652999997138977},{"id":"https://openalex.org/keywords/concentration-response-relationship","display_name":"concentration-dependent effects","score":0.9110000133514404},{"id":"https://openalex.org/keywords/fatty-acid-chain-length","display_name":"fatty acid chain length","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mucosal-permeability","display_name":"mucosal permeability","score":0.8849999904632568},{"id":"https://openalex.org/keywords/drug-solubility","display_name":"drug solubility","score":0.7139999866485596},{"id":"https://openalex.org/keywords/rectal-absorption","display_name":"rectal absorption","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C2776950135","wikidata":"https://www.wikidata.org/wiki/Q422613","display_name":"Decanoic acid","level":2,"score":0.9710649251937866},{"id":"https://openalex.org/C2778471300","wikidata":"https://www.wikidata.org/wiki/Q422597","display_name":"Hexanoic acid","level":2,"score":0.8913863301277161},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.714414656162262},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.6342891454696655},{"id":"https://openalex.org/C2991667435","wikidata":"https://www.wikidata.org/wiki/Q334951","display_name":"Carbon chain","level":2,"score":0.608542263507843},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.5836469531059265},{"id":"https://openalex.org/C2909411929","wikidata":"https://www.wikidata.org/wiki/Q422613","display_name":"Capric Acid","level":4,"score":0.5830756425857544},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.5432033538818359},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.5249338746070862},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.5040532350540161},{"id":"https://openalex.org/C2776229602","wikidata":"https://www.wikidata.org/wiki/Q2698455","display_name":"Short-chain fatty acid","level":4,"score":0.48051366209983826},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3716164231300354},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34982556104660034},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2053655982017517},{"id":"https://openalex.org/C2781003072","wikidata":"https://www.wikidata.org/wiki/Q422627","display_name":"Lauric acid","level":3,"score":0.164711594581604},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07584750652313232},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C2776979534","wikidata":"https://www.wikidata.org/wiki/Q193213","display_name":"Butyrate","level":3,"score":0.0},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000285","descriptor_name":"Administration, Rectal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002440","descriptor_name":"Cefoxitin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002440","descriptor_name":"Cefoxitin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1015948720256","doi":"https://doi.org/10.1023/a:1015948720256","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1015948720256","pdf_url":null,"source":{"id":"https://openalex.org/S103865650","display_name":"Pharmaceutical Research","issn_l":"0724-8741","issn":["0724-8741","1573-904X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Research","raw_type":"journal-article"},{"id":"pmid:3247317","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3247317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W22959835","https://openalex.org/W1973287281","https://openalex.org/W1977433674","https://openalex.org/W1978018071","https://openalex.org/W1991374842","https://openalex.org/W2023790536","https://openalex.org/W2036500540","https://openalex.org/W2038205990","https://openalex.org/W2044538513","https://openalex.org/W2061786929","https://openalex.org/W2062704583","https://openalex.org/W2083716078","https://openalex.org/W2297576575","https://openalex.org/W2333557233","https://openalex.org/W2406730295","https://openalex.org/W2407306484","https://openalex.org/W2417332317","https://openalex.org/W2469935172"],"related_works":["https://openalex.org/W1963897640","https://openalex.org/W2048053069","https://openalex.org/W2361157009","https://openalex.org/W600448816","https://openalex.org/W4256278846","https://openalex.org/W1977433674","https://openalex.org/W2095156420","https://openalex.org/W2105670137","https://openalex.org/W2038205990","https://openalex.org/W2465982628"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
