{"id":"https://openalex.org/W306911265","doi":"https://doi.org/10.1023/a:1007692503817","title":"Toxicity of the heterocyclic amine batracylin: investigation of rodent N-acetyltransferase activity and potential contribution of cytochrome P450 3A","display_name":"Toxicity of the heterocyclic amine batracylin: investigation of rodent N-acetyltransferase activity and potential contribution of cytochrome P450 3A","publication_year":2000,"publication_date":"2000-02-01","ids":{"openalex":"https://openalex.org/W306911265","doi":"https://doi.org/10.1023/a:1007692503817","mag":"306911265","pmid":"https://pubmed.ncbi.nlm.nih.gov/10890504"},"language":"en","primary_location":{"id":"doi:10.1023/a:1007692503817","doi":"https://doi.org/10.1023/a:1007692503817","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1007692503817","pdf_url":null,"source":{"id":"https://openalex.org/S31257671","display_name":"Cell Biology and Toxicology","issn_l":"0742-2091","issn":["0742-2091","1573-6822"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biology and Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046702136","display_name":"Gregory J. Stevens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.J. Stevens","raw_affiliation_strings":["University of Arizona, Tucson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona, Tucson, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039324932","display_name":"Jennifer Burkey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.L. Burkey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109186593","display_name":"Charlene A. McQueen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C.A. McQueen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":0.1996,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.44970845,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"16","issue":"1","first_page":"31","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.11580000072717667,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heterocyclic-amines","display_name":"heterocyclic amines","score":0.9850000143051147},{"id":"https://openalex.org/keywords/n-acetyltransferase","display_name":"N-acetyltransferase","score":0.9269999861717224},{"id":"https://openalex.org/keywords/2-aminofluorene","display_name":"2-aminofluorene","score":0.9010000228881836},{"id":"https://openalex.org/keywords/2-acetylaminofluorene","display_name":"2-acetylaminofluorene","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cyp3a","display_name":"CYP3A","score":0.9549999833106995},{"id":"https://openalex.org/keywords/udp-glucuronosyltransferase","display_name":"UDP-glucuronosyltransferase","score":0.984000027179718},{"id":"https://openalex.org/keywords/hepatic-biotransformation","display_name":"hepatic biotransformation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.5950000286102295},{"id":"https://openalex.org/keywords/species-differences-in-toxicity","display_name":"species differences in toxicity","score":0.7260000109672546},{"id":"https://openalex.org/keywords/hepatocyte-toxicity","display_name":"hepatocyte cytotoxicity","score":0.8270000219345093},{"id":"https://openalex.org/keywords/lactate-dehydrogenase-leakage","display_name":"lactate dehydrogenase leakage","score":0.8629999756813049},{"id":"https://openalex.org/keywords/troleandomycin","display_name":"troleandomycin","score":0.7620000243186951},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9800000190734863}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5797775387763977},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5768290162086487},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5210832357406616},{"id":"https://openalex.org/C2779649592","wikidata":"https://www.wikidata.org/wiki/Q2655970","display_name":"Acetyltransferase","level":4,"score":0.48730647563934326},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.46350306272506714},{"id":"https://openalex.org/C27881333","wikidata":"https://www.wikidata.org/wiki/Q864895","display_name":"Biotransformation","level":3,"score":0.460472047328949},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.419039785861969},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.39797157049179077},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38827866315841675},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.38648122549057007},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3261330723762512},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17186254262924194},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001189","descriptor_name":"Aryl Hydrocarbon Hydroxylases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008805","descriptor_name":"Mice, Inbred A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D010089","descriptor_name":"Oxidoreductases, N-Demethylating","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014453","descriptor_name":"Glucuronosyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1007692503817","doi":"https://doi.org/10.1023/a:1007692503817","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1007692503817","pdf_url":null,"source":{"id":"https://openalex.org/S31257671","display_name":"Cell Biology and Toxicology","issn_l":"0742-2091","issn":["0742-2091","1573-6822"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biology and Toxicology","raw_type":"journal-article"},{"id":"pmid:10890504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10890504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell biology and toxicology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G726771739","display_name":null,"funder_award_id":"ES 07091","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000867487","display_name":"Southwest Environmental Health Sciences Center","funder_award_id":"P30ES006694","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W145821160","https://openalex.org/W1474627061","https://openalex.org/W1495525337","https://openalex.org/W1526490082","https://openalex.org/W1540230761","https://openalex.org/W1579627745","https://openalex.org/W1882310631","https://openalex.org/W1977766724","https://openalex.org/W1985256593","https://openalex.org/W1990449229","https://openalex.org/W2000567622","https://openalex.org/W2007709024","https://openalex.org/W2011235387","https://openalex.org/W2013004253","https://openalex.org/W2014352349","https://openalex.org/W2019736989","https://openalex.org/W2021867944","https://openalex.org/W2027112291","https://openalex.org/W2034927616","https://openalex.org/W2037812043","https://openalex.org/W2038700662","https://openalex.org/W2043844603","https://openalex.org/W2055266236","https://openalex.org/W2063171708","https://openalex.org/W2072694820","https://openalex.org/W2073509461","https://openalex.org/W2074093254","https://openalex.org/W2074508254","https://openalex.org/W2087385211","https://openalex.org/W2089192527","https://openalex.org/W2111529122","https://openalex.org/W2120884522","https://openalex.org/W2125697390","https://openalex.org/W2129910941","https://openalex.org/W2138125869","https://openalex.org/W2142080299","https://openalex.org/W2146307640","https://openalex.org/W2157623788","https://openalex.org/W2160812530","https://openalex.org/W2182920238","https://openalex.org/W2415609596","https://openalex.org/W2416354301","https://openalex.org/W2473824361","https://openalex.org/W4235739337"],"related_works":["https://openalex.org/W356927717","https://openalex.org/W2160812530","https://openalex.org/W1977921226","https://openalex.org/W2465059770","https://openalex.org/W2007709024","https://openalex.org/W2088916264","https://openalex.org/W2033791698","https://openalex.org/W4296028490","https://openalex.org/W2416209176","https://openalex.org/W3194622664"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}