{"id":"https://openalex.org/W3067631960","doi":"https://doi.org/10.1016/j.neuroimage.2020.117285","title":"Ex vivo MR microscopy of a human brain with multiple sclerosis: Visualizing individual cells in tissue using intrinsic iron","display_name":"Ex vivo MR microscopy of a human brain with multiple sclerosis: Visualizing individual cells in tissue using intrinsic iron","publication_year":2020,"publication_date":"2020-08-20","ids":{"openalex":"https://openalex.org/W3067631960","doi":"https://doi.org/10.1016/j.neuroimage.2020.117285","mag":"3067631960","pmid":"https://pubmed.ncbi.nlm.nih.gov/32828923","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7811778"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2020.117285","doi":"https://doi.org/10.1016/j.neuroimage.2020.117285","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2020.117285","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1053811920307710/pdf","source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1053811920307710/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051620091","display_name":"Govind Nair","orcid":"https://orcid.org/0000-0003-3725-615X","observed_orcids":["https://orcid.org/0000-0003-3725-615X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Govind Nair","raw_affiliation_strings":["Quantitative MRI Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, United States. Electronic address: bhagavatheeshg@mail.nih.gov","Quantitative MRI Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, United States"],"raw_orcid":"https://orcid.org/0000-0003-3725-615X","affiliations":[{"raw_affiliation_string":"Quantitative MRI Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, United States. Electronic address: bhagavatheeshg@mail.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"raw_affiliation_string":"Quantitative MRI Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103416615","display_name":"Stephen J. Dodd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Dodd","raw_affiliation_strings":["Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, United\u00a0States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, United\u00a0States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103167577","display_name":"Seung-Kwon Ha","orcid":"https://orcid.org/0000-0003-3671-4454","observed_orcids":["https://orcid.org/0000-0003-3671-4454"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seung-Kwon Ha","raw_affiliation_strings":["Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, United States"],"raw_orcid":"https://orcid.org/0000-0003-3671-4454","affiliations":[{"raw_affiliation_string":"Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048962461","display_name":"Alan P. Koretsky","orcid":"https://orcid.org/0000-0002-8085-4756","observed_orcids":["https://orcid.org/0000-0002-8085-4756"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan P Koretsky","raw_affiliation_strings":["Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, United\u00a0States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, United\u00a0States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024904743","display_name":"Daniel S. Reich","orcid":"https://orcid.org/0000-0002-2628-4334","observed_orcids":["https://orcid.org/0000-0002-2628-4334"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel S Reich","raw_affiliation_strings":["Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, United States"],"raw_orcid":"https://orcid.org/0000-0002-2628-4334","affiliations":[{"raw_affiliation_string":"Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051620091"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.3067,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.55638963,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"223","issue":null,"first_page":"117285","last_page":"117285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/magnetic-resonance-microscopy","display_name":"magnetic resonance microscopy","score":0.9419999718666077},{"id":"https://openalex.org/keywords/normal-appearing-white-matter","display_name":"normal-appearing white matter","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cortical-lesions","display_name":"cortical lesions","score":0.8489999771118164},{"id":"https://openalex.org/keywords/myelin","display_name":"myelin","score":0.7480000257492065},{"id":"https://openalex.org/keywords/iron-accumulation","display_name":"iron accumulation","score":0.5640000104904175},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.5019999742507935},{"id":"https://openalex.org/keywords/t2-weighted-imaging","display_name":"T2-weighted imaging","score":0.722000002861023},{"id":"https://openalex.org/keywords/ex-vivo-brain-tissue","display_name":"ex vivo brain tissue","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.8274312019348145},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.6877503991127014},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.6768447756767273},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6358612775802612},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.6003354787826538},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.5529525279998779},{"id":"https://openalex.org/C16945437","wikidata":"https://www.wikidata.org/wiki/Q7924669","display_name":"Vibratome","level":3,"score":0.5251388549804688},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5094133019447327},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.4812743067741394},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.45684587955474854},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.45536157488822937},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.45255059003829956},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.4226631224155426},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4077697694301605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27961045503616333},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.22649312019348145},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21804547309875488},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2139091193675995},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.16097113490104675},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.1073351502418518},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06538841128349304},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016591","descriptor_name":"Histocytological Preparation Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.neuroimage.2020.117285","doi":"https://doi.org/10.1016/j.neuroimage.2020.117285","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2020.117285","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1053811920307710/pdf","source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:32828923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32828923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:6719347","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7811778","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7811778","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7811778","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuroimage","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d1483a1726d040378d00c022298e37bc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d1483a1726d040378d00c022298e37bc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NeuroImage, Vol 223, Iss , Pp 117285- (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.neuroimage.2020.117285","doi":"https://doi.org/10.1016/j.neuroimage.2020.117285","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2020.117285","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1053811920307710/pdf","source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4988861893","display_name":null,"funder_award_id":"Z99 NS999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3067631960.pdf","grobid_xml":"https://content.openalex.org/works/W3067631960.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W147290092","https://openalex.org/W189861248","https://openalex.org/W191488138","https://openalex.org/W200099984","https://openalex.org/W890895450","https://openalex.org/W1042403926","https://openalex.org/W1742765381","https://openalex.org/W1964318214","https://openalex.org/W1966348592","https://openalex.org/W1976981076","https://openalex.org/W1977308172","https://openalex.org/W1978131006","https://openalex.org/W1978325888","https://openalex.org/W1984825203","https://openalex.org/W1996201704","https://openalex.org/W1998043640","https://openalex.org/W2004107927","https://openalex.org/W2011538447","https://openalex.org/W2017841845","https://openalex.org/W2018275328","https://openalex.org/W2021177193","https://openalex.org/W2035432210","https://openalex.org/W2040160279","https://openalex.org/W2055547320","https://openalex.org/W2068512330","https://openalex.org/W2069760926","https://openalex.org/W2075990711","https://openalex.org/W2135009525","https://openalex.org/W2140073946","https://openalex.org/W2147062889","https://openalex.org/W2155909345","https://openalex.org/W2163429086","https://openalex.org/W2164721910","https://openalex.org/W2169159041","https://openalex.org/W2169411236","https://openalex.org/W2258311975","https://openalex.org/W2284273064","https://openalex.org/W2299959830","https://openalex.org/W2331109341","https://openalex.org/W2406582286","https://openalex.org/W2415405015","https://openalex.org/W2551398945","https://openalex.org/W2560591976","https://openalex.org/W2564667958","https://openalex.org/W2603095844","https://openalex.org/W2787153311","https://openalex.org/W2809802875","https://openalex.org/W2921349131","https://openalex.org/W3038197277","https://openalex.org/W6730116905"],"related_works":["https://openalex.org/W3184189851","https://openalex.org/W2154189431","https://openalex.org/W2072532706","https://openalex.org/W2170991918","https://openalex.org/W1783919535","https://openalex.org/W7100422314","https://openalex.org/W2599805025","https://openalex.org/W2159157868","https://openalex.org/W2115140807","https://openalex.org/W2071718644"],"abstract_inverted_index":{"To":[0,22],"perform":[1],"magnetic":[2],"resonance":[3],"microscopy":[4],"(MRM)":[5],"on":[6,25,51],"human":[7],"cortex":[8],"and":[9,35,46,79,86,108,114,129,131,151,161,226,240,260,273,283],"a":[10,40,60,91,104],"cortical":[11,74,92,175,224,261],"lesion":[12,93],"as":[13,15,154,156,229,231],"well":[14,155,230],"the":[16,26,57,87,174,182,194,232,269,285],"adjacent":[17,80],"normal":[18,72,81,227,258],"appearing":[19,73,82,259],"white":[20,83,183],"matter.":[21],"shed":[23],"light":[24],"origins":[27,270],"of":[28,44,54,59,179,208,271,276,287],"MRI":[29,98,171,277,291],"contrast":[30,221],"by":[31],"comparison":[32],"with":[33,139],"histochemical":[34],"immunostaining.":[36],"3D":[37,110],"MRM":[38,133,246],"at":[39,101],"nominal":[41],"isotropic":[42],"resolution":[43],"15":[45],"18":[47],"\u00b5m":[48],"was":[49,99,185],"performed":[50,100],"2":[52],"blocks":[53],"tissue":[55],"from":[56,257],"brain":[58],"77-year-old":[61],"man":[62],"who":[63],"had":[64],"MS":[65],"for":[66,121,188],"47":[67],"years.":[68],"One":[69],"block":[70,255],"contained":[71],"gray":[75],"matter":[76,84,184],"(CN":[77],"block)":[78],"(NAWM),":[85],"other":[88],"also":[89,243],"included":[90],"(CL":[94],"block).":[95],"Postmortem":[96],"ex-vivo":[97],"11.7T":[102],"using":[103],"custom":[105],"solenoid":[106],"coil":[107],"T2*-weighted":[109],"GRE":[111],"sequence.":[112],"Histochemical":[113],"immunostaining":[115],"were":[116],"done":[117],"after":[118],"paraffin":[119],"embedding":[120],"iron,":[122],"myelin,":[123],"oligodendrocytes,":[124],"neurons,":[125],"blood":[126],"vessels,":[127],"macrophages":[128,160],"microglia,":[130],"astrocytes.":[132],"could":[134,201],"identify":[135],"individual":[136],"iron-laden":[137,158,209],"oligodendrocytes":[138,164],"high":[140],"sensitivity":[141],"(70%":[142],"decrease":[143],"in":[144,149,170,181,206,212,235,280,289],"signal":[145,172,197,234,247,278],"compared":[146],"to":[147,166,193,204,219,245],"surrounding)":[148],"CN":[150],"CL":[152],"blocks,":[153],"some":[157],"activated":[159],"microglia.":[162],"Iron-deficient":[163],"seemed":[165],"cause":[167],"relative":[168,192],"increase":[169],"within":[173,199,215],"lesion.":[176],"High":[177],"concentration":[178],"myelin":[180,239],"primarily":[186],"responsible":[187],"its":[189],"hypointense":[190],"appearance":[191],"cortex,":[195,228],"however,":[196],"variations":[198],"NAWM":[200],"be":[202],"attributed":[203],"changes":[205,279],"density":[207],"oligodendrocytes.":[210],"Changes":[211],"iron":[213],"accumulation":[214],"cells":[216],"gave":[217],"rise":[218],"imaging":[220],"seen":[222],"between":[223],"lesions":[225],"patchy":[233],"NAWM.":[236],"Densely":[237],"packed":[238],"collagen":[241],"deposition":[242],"contributed":[244],"changes.":[248],"Even":[249],"though":[250],"we":[251],"studied":[252],"only":[253],"one":[254],"each":[256],"lesions,":[262],"such":[263],"studies":[264],"can":[265],"help":[266],"better":[267],"understand":[268],"histopathological":[272],"microstructural":[274],"correlates":[275],"multiple":[281],"sclerosis":[282],"contextualize":[284],"interpretation":[286],"lower-resolution":[288],"vivo":[290],"scans.":[292]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":8},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-08-24T00:00:00"}
