{"id":"https://openalex.org/W306513073","doi":null,"title":"Intramyocardial electrogram recordings (IMEG) for diagnosis of cellular and humoral mediated cardiac allograft rejection.","display_name":"Intramyocardial electrogram recordings (IMEG) for diagnosis of cellular and humoral mediated cardiac allograft rejection.","publication_year":2000,"publication_date":"2000-04-01","ids":{"openalex":"https://openalex.org/W306513073","mag":"306513073","pmid":"https://pubmed.ncbi.nlm.nih.gov/10870001"},"language":"en","primary_location":{"id":"pmid:10870001","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10870001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073088808","display_name":"Christoph Knosalla","orcid":"https://orcid.org/0000-0002-8127-5019","observed_orcids":["https://orcid.org/0000-0002-8127-5019"]},"institutions":[{"id":"https://openalex.org/I4210105663","display_name":"Deutsches Herzzentrum der Charit\u00e9","ror":"https://ror.org/01mmady97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210105663","https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C Knosalla","raw_affiliation_strings":["Department of Cardiothoracic and Vascular Surgery, German Heart Institute Berlin, Augustenburger Platz 1, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic and Vascular Surgery, German Heart Institute Berlin, Augustenburger Platz 1, Berlin, Germany","institution_ids":["https://openalex.org/I4210105663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111487115","display_name":"O. Grauhan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Grauhan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102904158","display_name":"Johannes M\u00fcller","orcid":"https://orcid.org/0000-0003-1793-0143","observed_orcids":["https://orcid.org/0000-0003-1793-0143"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Muller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057750730","display_name":"Robert Pfitzmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Pfitzmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059552921","display_name":"Ellen Fietze","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Fietze","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108422205","display_name":"Tatjana R. Cohnert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Cohnert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049060150","display_name":"Hans\u2010Dieter Volk","orcid":"https://orcid.org/0000-0002-7743-6668","observed_orcids":["https://orcid.org/0000-0002-7743-6668"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H D Volk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108512926","display_name":"R. Hetzer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Hetzer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4049,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.61332974,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"6","issue":"2","first_page":"89","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intramyocardial-electrograms","display_name":"intramyocardial electrograms","score":0.9760000109672546},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/allograft-rejection","display_name":"allograft rejection","score":0.9229999780654907},{"id":"https://openalex.org/keywords/t-cell-mediated-rejection","display_name":"T cell-mediated rejection","score":0.7639999985694885},{"id":"https://openalex.org/keywords/antibody-mediated-rejection","display_name":"antibody-mediated rejection","score":0.9919999837875366},{"id":"https://openalex.org/keywords/donor-specific-antibodies","display_name":"donor-specific antibodies","score":0.9710000157356262},{"id":"https://openalex.org/keywords/rejection-diagnosis","display_name":"rejection diagnosis","score":0.5759999752044678},{"id":"https://openalex.org/keywords/rejection-monitoring","display_name":"rejection monitoring","score":0.44999998807907104},{"id":"https://openalex.org/keywords/bipolar-leads","display_name":"bipolar leads","score":0.4320000112056732},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.6470000147819519},{"id":"https://openalex.org/keywords/beagle","display_name":"beagle dogs","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8798754215240479},{"id":"https://openalex.org/C2776760755","wikidata":"https://www.wikidata.org/wiki/Q18939","display_name":"Azathioprine","level":3,"score":0.826007604598999},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.7149519324302673},{"id":"https://openalex.org/C2778849806","wikidata":"https://www.wikidata.org/wiki/Q643396","display_name":"Heart transplantation","level":3,"score":0.6124488711357117},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4943981170654297},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.49439001083374023},{"id":"https://openalex.org/C3019230761","wikidata":"https://www.wikidata.org/wiki/Q1765748","display_name":"Graft rejection","level":3,"score":0.47515058517456055},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4523310959339142},{"id":"https://openalex.org/C2776820430","wikidata":"https://www.wikidata.org/wiki/Q21102","display_name":"Beagle","level":2,"score":0.4497803747653961},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.39083725214004517},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32468631863594055},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003348","descriptor_name":"Cortisone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:10870001","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10870001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia","raw_type":"Comparative Study"},{"id":"mag:306513073","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10870001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2005680778","https://openalex.org/W2415653384","https://openalex.org/W4246059141","https://openalex.org/W3030378967","https://openalex.org/W2392841022","https://openalex.org/W224621694","https://openalex.org/W29108200","https://openalex.org/W2383629102","https://openalex.org/W2357358543","https://openalex.org/W2088371931"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,177,190],"purpose":[2],"of":[3,11,21,44,129,147,193,212],"this":[4],"study":[5],"was":[6,133],"to":[7,156,200,206,219],"prove":[8],"the":[9,76,95,117,123,136,141,145,153,170,207,210],"reliability":[10],"intramyocardial":[12],"electrogram":[13],"(IMEG)":[14],"recordings":[15,54],"for":[16,126,135,140],"diagnosis":[17,128],"and":[18,24,92,138,163,181,186],"treatment":[19],"monitoring":[20],"(1)":[22],"cellular":[23,118,180],"(2)":[25],"humoral":[26,182],"mediated":[27,119,183],"allograft":[28],"rejection":[29,82,111,127,168,184,196],"after":[30],"heart":[31],"transplantation.":[32,42],"MATERIAL":[33],"AND":[34],"METHODS:":[35],"Fifteen":[36],"beagle":[37],"dogs":[38],"underwent":[39],"heterotopic":[40],"neck-heart":[41],"Eight":[43],"them":[45],"were":[46,55,62,69,103,150],"previously":[47],"sensitized":[48,77],"through":[49,105],"several":[50],"skin":[51],"transplantations.":[52],"IMEG":[53,106,171,178,198],"performed":[56,70],"daily.":[57,66],"Donor-specific":[58],"antibodies":[59],"(IgG,":[60],"IgM)":[61],"determinated":[63],"in":[64,197],"serum":[65],"Transmyocardial":[67],"biopsies":[68],"every":[71],"two":[72],"days.":[73],"RESULTS:":[74],"In":[75,108,116],"group":[78,120],"(group":[79,121],"I)":[80],"accelerated":[81],"occurred":[83],"under":[84],"triple":[85],"drug":[86],"immunosuppression":[87],"with":[88,187],"cyclosporine":[89],"A,":[90],"azathioprine,":[91],"cortisone":[93],"on":[94],"fifth":[96],"postoperative":[97],"day":[98],"(range:":[99],"4th-5th).":[100],"All":[101],"episodes":[102],"detected":[104],"diagnosis.":[107],"each":[109],"case":[110],"could":[112],"be":[113],"treated":[114],"successfully.":[115],"II),":[122],"average":[124],"sensitivity":[125,154],"a":[130,202],"single":[131],"lead":[132],"24%":[134],"unipolar":[137],"42%":[139],"bipolar":[142],"leads.":[143],"When":[144],"voltages":[146],"different":[148],"leads":[149],"summed":[151],"up":[152],"rose":[155],"36%":[157],"(3":[158,161],"unipolar),":[159],"81%":[160],"bipolar)":[162],"100%":[164],"(all":[165],"leads).":[166],"During":[167],"therapy":[169],"recovered":[172],"within":[173],"24-48":[174],"hours.":[175],"CONCLUSION:":[176],"detects":[179],"early":[185],"high":[188],"reliability.":[189,222],"rejection-related":[191],"changes":[192],"grade":[194],"2/3a":[195],"seem":[199],"follow":[201],"Ofocal":[203],"patternO":[204],"similar":[205],"histology.":[208],"Therefore":[209],"recording":[211],"several,":[213],"preferably":[214],"bipolar,":[215],"electrode":[216],"configurations":[217],"appears":[218],"enhance":[220],"diagnostic":[221]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}