{"id":"https://openalex.org/W3065086691","doi":"https://doi.org/10.1016/j.reprotox.2020.08.007","title":"The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity","display_name":"The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity","publication_year":2020,"publication_date":"2020-08-19","ids":{"openalex":"https://openalex.org/W3065086691","doi":"https://doi.org/10.1016/j.reprotox.2020.08.007","mag":"3065086691","pmid":"https://pubmed.ncbi.nlm.nih.gov/32827657","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7892636"},"language":"en","primary_location":{"id":"doi:10.1016/j.reprotox.2020.08.007","doi":"https://doi.org/10.1016/j.reprotox.2020.08.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.reprotox.2020.08.007","pdf_url":null,"source":{"id":"https://openalex.org/S1879512","display_name":"Reproductive Toxicology","issn_l":"0890-6238","issn":["0890-6238","1873-1708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.reprotox.2020.08.007","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070767586","display_name":"Lisa Truong","orcid":"https://orcid.org/0000-0003-1751-4617","observed_orcids":["https://orcid.org/0000-0003-1751-4617"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Truong","raw_affiliation_strings":["Department of Environmental and Molecular Toxicology, the Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Molecular Toxicology, the Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084126116","display_name":"Skylar W. Marvel","orcid":"https://orcid.org/0000-0002-2971-9743","observed_orcids":["https://orcid.org/0000-0002-2971-9743"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Skylar Marvel","raw_affiliation_strings":["Bioinformatics Research Center, Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Research Center, Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077108763","display_name":"David M. Reif","orcid":"https://orcid.org/0000-0001-7815-6767","observed_orcids":["https://orcid.org/0000-0001-7815-6767"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Reif","raw_affiliation_strings":["Bioinformatics Research Center, Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Research Center, Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091476377","display_name":"Dennis Thomas","orcid":"https://orcid.org/0000-0002-9209-8740","observed_orcids":["https://orcid.org/0000-0002-9209-8740"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis G. Thomas","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest Laboratory, 902 Battelle Boulevard, P.O. Box 999, Richland, WA 99352 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest Laboratory, 902 Battelle Boulevard, P.O. Box 999, Richland, WA 99352 USA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072385874","display_name":"Paritosh Pande","orcid":"https://orcid.org/0000-0003-4937-5703","observed_orcids":["https://orcid.org/0000-0003-4937-5703"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paritosh Pande","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest Laboratory, 902 Battelle Boulevard, P.O. Box 999, Richland, WA 99352 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest Laboratory, 902 Battelle Boulevard, P.O. Box 999, Richland, WA 99352 USA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077842032","display_name":"Subham Dasgupta","orcid":"https://orcid.org/0000-0001-5996-5948","observed_orcids":["https://orcid.org/0000-0001-5996-5948"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Subham Dasgupta","raw_affiliation_strings":["Department of Environmental and Molecular Toxicology, the Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Molecular Toxicology, the Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052290731","display_name":"Michael T. Simonich","orcid":"https://orcid.org/0000-0003-2277-5192","observed_orcids":["https://orcid.org/0000-0003-2277-5192"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael T. Simonich","raw_affiliation_strings":["Department of Environmental and Molecular Toxicology, the Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Molecular Toxicology, the Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053476989","display_name":"Katrina M. Waters","orcid":"https://orcid.org/0000-0003-4696-5396","observed_orcids":["https://orcid.org/0000-0003-4696-5396"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]},{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katrina M. Waters","raw_affiliation_strings":["Department of Environmental and Molecular Toxicology, the Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR, USA; Biological Sciences Division, Pacific Northwest Laboratory, 902 Battelle Boulevard, P.O. Box 999, Richland, WA 99352 USA","Biological Sciences Division, Pacific Northwest Laboratory, 902 Battelle Boulevard, P.O. Box 999, Richland, WA 99352 USA","Department of Environmental and Molecular Toxicology, the Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Molecular Toxicology, the Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR, USA; Biological Sciences Division, Pacific Northwest Laboratory, 902 Battelle Boulevard, P.O. Box 999, Richland, WA 99352 USA","institution_ids":["https://openalex.org/I131249849","https://openalex.org/I142606810"]},{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest Laboratory, 902 Battelle Boulevard, P.O. Box 999, Richland, WA 99352 USA","institution_ids":["https://openalex.org/I142606810"]},{"raw_affiliation_string":"Department of Environmental and Molecular Toxicology, the Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"last","author":{"id":null,"display_name":"Robyn L. Tanguay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robyn L. Tanguay","raw_affiliation_strings":["Department of Environmental and Molecular Toxicology, the Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR, USA. Electronic address: Robyn.Tanguay@oregonstate.edu","Department of Environmental and Molecular Toxicology, the Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Molecular Toxicology, the Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR, USA. Electronic address: Robyn.Tanguay@oregonstate.edu","institution_ids":["https://openalex.org/I131249849"]},{"raw_affiliation_string":"Department of Environmental and Molecular Toxicology, the Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR, USA","institution_ids":["https://openalex.org/I131249849"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I131249849"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":{"value":3400,"currency":"USD","value_usd":3400},"fwci":1.6993,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.81543329,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"96","issue":null,"first_page":"359","last_page":"369"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.5898000001907349,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.5898000001907349,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.3555000126361847,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flame-retardants","display_name":"flame retardants","score":0.9089999794960022},{"id":"https://openalex.org/keywords/zebrafish-embryos","display_name":"zebrafish embryos","score":0.8370000123977661},{"id":"https://openalex.org/keywords/developmental-toxicity","display_name":"developmental toxicity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9369999766349792},{"id":"https://openalex.org/keywords/organophosphates","display_name":"organophosphates","score":0.7179999947547913},{"id":"https://openalex.org/keywords/polybrominated-diphenyl-ethers","display_name":"polybrominated diphenyl ethers","score":0.9779999852180481},{"id":"https://openalex.org/keywords/toxcast","display_name":"ToxCast","score":0.652999997138977},{"id":"https://openalex.org/keywords/tox21","display_name":"Tox21","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hazard-prediction","display_name":"hazard prediction","score":0.6240000128746033},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7450000047683716},{"id":"https://openalex.org/keywords/physicochemical-properties","display_name":"physicochemical properties","score":0.7879999876022339},{"id":"https://openalex.org/keywords/chemical-safety-assessment","display_name":"chemical safety assessment","score":0.3889999985694885},{"id":"https://openalex.org/keywords/alternative-flame-retardants","display_name":"alternative flame retardants","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.8988397121429443},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.6176254749298096},{"id":"https://openalex.org/C179335377","wikidata":"https://www.wikidata.org/wiki/Q5266825","display_name":"Developmental toxicity","level":4,"score":0.5464944839477539},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5211429595947266},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4992198944091797},{"id":"https://openalex.org/C205474432","wikidata":"https://www.wikidata.org/wiki/Q1354051","display_name":"Fire retardant","level":2,"score":0.47626301646232605},{"id":"https://openalex.org/C206355099","wikidata":"https://www.wikidata.org/wiki/Q3614972","display_name":"Hazard analysis","level":2,"score":0.4323933720588684},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37519216537475586},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34818679094314575},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32953667640686035},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.3227711319923401},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28561824560165405},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.28410112857818604},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14854836463928223},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08117622137069702},{"id":"https://openalex.org/C200601418","wikidata":"https://www.wikidata.org/wiki/Q2193887","display_name":"Reliability engineering","level":1,"score":0.07134079933166504},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005411","descriptor_name":"Flame Retardants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013723","descriptor_name":"Teratogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D013723","descriptor_name":"Teratogens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.reprotox.2020.08.007","doi":"https://doi.org/10.1016/j.reprotox.2020.08.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.reprotox.2020.08.007","pdf_url":null,"source":{"id":"https://openalex.org/S1879512","display_name":"Reproductive Toxicology","issn_l":"0890-6238","issn":["0890-6238","1873-1708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Toxicology","raw_type":"journal-article"},{"id":"pmid:32827657","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32827657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive toxicology (Elmsford, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7892636","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7892636","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Reprod Toxicol","raw_type":"Text"},{"id":"pmh:oai:osti.gov:1668779","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/1668779","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:osti.gov:1774684","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/1774684","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.reprotox.2020.08.007","doi":"https://doi.org/10.1016/j.reprotox.2020.08.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.reprotox.2020.08.007","pdf_url":null,"source":{"id":"https://openalex.org/S1879512","display_name":"Reproductive Toxicology","issn_l":"0890-6238","issn":["0890-6238","1873-1708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4227812736","display_name":"Gene-Environment Interactions Causing Differential Susceptibility to Chemical Exposure in High-Throughput Screening","funder_award_id":"R56ES030007","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4288126918","display_name":"Reducing Susceptibility to Environmental Stress Throughout the Life Span","funder_award_id":"P30ES000210","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6200452847","display_name":null,"funder_award_id":"R56 ES030007","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G677429959","display_name":null,"funder_award_id":"R835168","funder_id":"https://openalex.org/F4320306107","funder_display_name":"U.S. Environmental Protection Agency"},{"id":"https://openalex.org/G8791306544","display_name":"Pacific Northwest Center for Translational Environmental Health Research","funder_award_id":"P30ES030287","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000889426","display_name":"Center for the Science, Technology, and Emerging Health Risks of PAHs","funder_award_id":"P42ES016465","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306107","display_name":"U.S. Environmental Protection Agency","ror":"https://ror.org/03tns0030"},{"id":"https://openalex.org/F4320306250","display_name":"Battelle","ror":"https://ror.org/01h5tnr73"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W161923771","https://openalex.org/W284364657","https://openalex.org/W791534080","https://openalex.org/W1458793797","https://openalex.org/W1554831422","https://openalex.org/W1641778678","https://openalex.org/W1831050183","https://openalex.org/W1964146567","https://openalex.org/W1975618294","https://openalex.org/W1979155257","https://openalex.org/W1981239255","https://openalex.org/W1985370990","https://openalex.org/W1990773849","https://openalex.org/W1998841109","https://openalex.org/W1999603779","https://openalex.org/W2003896813","https://openalex.org/W2011724004","https://openalex.org/W2021360384","https://openalex.org/W2029923782","https://openalex.org/W2036484335","https://openalex.org/W2046982875","https://openalex.org/W2052827499","https://openalex.org/W2061594975","https://openalex.org/W2061611346","https://openalex.org/W2120091527","https://openalex.org/W2125349610","https://openalex.org/W2135033441","https://openalex.org/W2149888309","https://openalex.org/W2151487012","https://openalex.org/W2313727415","https://openalex.org/W2398001191","https://openalex.org/W2484897035","https://openalex.org/W2513128428","https://openalex.org/W2559872178","https://openalex.org/W2571769346","https://openalex.org/W2611498747","https://openalex.org/W2755794824","https://openalex.org/W2795219670","https://openalex.org/W2887078403","https://openalex.org/W2896022704","https://openalex.org/W2899658572","https://openalex.org/W2921351462","https://openalex.org/W2965811022","https://openalex.org/W2981393461"],"related_works":["https://openalex.org/W2896022704","https://openalex.org/W2046982875","https://openalex.org/W2011188574","https://openalex.org/W2512894286","https://openalex.org/W4404128835","https://openalex.org/W2904634922","https://openalex.org/W3163889457","https://openalex.org/W2171954476","https://openalex.org/W2609061311","https://openalex.org/W2162060922"],"abstract_inverted_index":{"Flame":[0],"retardant":[1],"chemicals":[2],"(FRCs)":[3],"commonly":[4],"added":[5],"to":[6,53,60,99,168,200,204,218],"many":[7],"consumer":[8],"products":[9],"present":[10],"a":[11,77,105,170,184,195],"human":[12],"exposure":[13],"burden":[14],"associated":[15],"with":[16],"adverse":[17],"health":[18],"effects.":[19],"Under":[20],"pressure":[21],"from":[22,112],"consumers,":[23],"FRC":[24,161],"manufacturers":[25],"have":[26,48],"adopted":[27],"some":[28],"purportedly":[29],"safer":[30],"replacements":[31],"for":[32,144],"first-generation":[33],"brominated":[34],"diphenyl":[35],"ethers":[36],"(BDEs).":[37],"In":[38,58],"contrast,":[39],"second":[40],"and":[41,44,66,87,115,177],"third-generation":[42],"organophosphates":[43],"other":[45,116],"alternative":[46,117],"chemistries":[47],"limited":[49],"bioactivity":[50,143],"data":[51,102],"available":[52,101],"estimate":[54],"their":[55],"hazard":[56,207],"potential.":[57],"order":[59],"evaluate":[61],"the":[62,92,120,130,147,192,206],"toxicity":[63,86,220],"of":[64,107,124,146,187,194,209],"existing":[65],"potential":[67,88,208],"replacement":[68],"FRCs,":[69,122],"we":[70,82,165],"need":[71],"efficient":[72],"screening":[73],"methods.":[74],"We":[75],"built":[76],"61-FRC":[78],"library":[79],"in":[80,91,104,109,129,135,197],"which":[81],"systemically":[83],"assessed":[84],"developmental":[85,151],"neurotoxicity":[89],"effects":[90],"embryonic":[93,179],"zebrafish":[94,137,140,155,180],"model.":[95,138],"Data":[96],"were":[97,127,133,156,166],"compared":[98],"publicly":[100],"generated":[103],"battery":[106],"cell-based":[108],"vitro":[110],"assays":[111,132,141,181],"ToxCast,":[113],"Tox21,":[114],"models.":[118],"Of":[119],"61":[121],"19":[123],"45":[125],"that":[126,164,182],"tested":[128],"ToxCast":[131],"bioactive":[134],"our":[136,202],"The":[139],"detected":[142],"10":[145],"12":[148],"previously":[149],"classified":[150],"neurotoxic":[152],"FRCs.":[153],"Developmental":[154],"sufficiently":[157],"sensitive":[158],"at":[159],"detecting":[160],"structure-bioactivity":[162],"impacts":[163],"able":[167],"build":[169],"classification":[171],"model":[172],"using":[173],"13":[174],"physicochemical":[175],"properties":[176],"3":[178],"achieved":[183],"balanced":[185],"accuracy":[186],"91.7%.":[188],"This":[189],"work":[190],"illustrates":[191],"power":[193],"multi-dimensional":[196],"vivo":[198],"platform":[199],"expand":[201],"ability":[203],"predict":[205],"new":[210],"compounds":[211],"based":[212,222],"on":[213,223],"structural":[214],"relatedness,":[215],"ultimately":[216],"leading":[217],"reliable":[219],"predictions":[221],"chemical":[224],"structure.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2020-08-24T00:00:00"}