{"id":"https://openalex.org/W30622756","doi":null,"title":"[Acquired aphasic epilepsy (Landau-Kleffner syndrome). Report of 10 cases].","display_name":"[Acquired aphasic epilepsy (Landau-Kleffner syndrome). Report of 10 cases].","publication_year":1997,"publication_date":"1997-12-01","ids":{"openalex":"https://openalex.org/W30622756","mag":"30622756","pmid":"https://pubmed.ncbi.nlm.nih.gov/9575121"},"language":"es","primary_location":{"id":"pmid:9575121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9575121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anales espanoles de pediatria","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069114598","display_name":"Manuel Nieto Barrera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M Nieto Barrera","raw_affiliation_strings":["Secci\u00f3n de Neuropediatr\u00eda, Virgen del Roc\u00edo, Sevilla"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Secci\u00f3n de Neuropediatr\u00eda, Virgen del Roc\u00edo, Sevilla","institution_ids":["https://openalex.org/I4210153139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160436090","display_name":"M I L\u00f3pez Alcaide","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M I L\u00f3pez Alcaide","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160400550","display_name":"R Candau Fern\u00e1ndez-Mensaque","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Candau Fern\u00e1ndez-Mensaque","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160553792","display_name":"L Ruiz del Portal Bermudo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Ruiz del Portal Bermudo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160433048","display_name":"M Rufo Campos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Rufo Campos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046284380","display_name":"Correa Charro A","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Correa Charro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.00283415,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":"6","first_page":"611","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10730","display_name":"Language Development and Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3204","display_name":"Developmental and Educational Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/landau-kleffner-syndrome","display_name":"Landau-Kleffner syndrome","score":1.0},{"id":"https://openalex.org/keywords/acquired-aphasia","display_name":"acquired aphasia","score":0.9049999713897705},{"id":"https://openalex.org/keywords/pediatric-epilepsy","display_name":"pediatric epilepsy","score":0.7820000052452087},{"id":"https://openalex.org/keywords/sleep-eeg","display_name":"sleep EEG","score":0.5770000219345093},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.7809371948242188},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.4113411009311676},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.39287787675857544},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3655247986316681}],"mesh":[{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001037","descriptor_name":"Aphasia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002220","descriptor_name":"Carbamazepine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018887","descriptor_name":"Landau-Kleffner Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:9575121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9575121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anales espanoles de pediatria","raw_type":"Journal Article"},{"id":"mag:2413748408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9575121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:30622756","doi":null,"is_oa":false,"landing_page_url":"https://www.aeped.es/sites/default/files/anales/47-6-10.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S136590224","display_name":"Anales de Pediatr\u00eda","issn_l":"1695-4033","issn":["1695-4033","1695-9531"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Anales de Pediatr\u00eda","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1979276780","https://openalex.org/W1982797920","https://openalex.org/W1989773869","https://openalex.org/W2000793352","https://openalex.org/W2001256957","https://openalex.org/W2012820217","https://openalex.org/W2013958179","https://openalex.org/W2027766024","https://openalex.org/W2035025648","https://openalex.org/W2047243927","https://openalex.org/W2049989602","https://openalex.org/W2059986817","https://openalex.org/W2064945713","https://openalex.org/W2069690648","https://openalex.org/W2079951547","https://openalex.org/W2094249620","https://openalex.org/W2099272417","https://openalex.org/W2103637496","https://openalex.org/W2106532696","https://openalex.org/W2109087679","https://openalex.org/W2128483893","https://openalex.org/W2290906478","https://openalex.org/W2338413818","https://openalex.org/W2416503382","https://openalex.org/W3152412704"],"related_works":["https://openalex.org/W61556052","https://openalex.org/W7216880065","https://openalex.org/W7217520991","https://openalex.org/W2337311800","https://openalex.org/W3198445308","https://openalex.org/W2413748408","https://openalex.org/W1984992363","https://openalex.org/W7211897749","https://openalex.org/W2084643954","https://openalex.org/W3194460701"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,48,90],"association":[2],"of":[3,71,106,144,154,164,174,190],"a":[4,17,79,191],"language":[5,37],"disorder":[6],"with":[7,14,44,203],"epilepsy":[8],"is":[9,25,30],"observed":[10],"in":[11,36,53,78,82,87,94,136,161],"some":[12],"circumstance,":[13],"or":[15],"without":[16],"causal":[18],"relationship.":[19],"In":[20],"Landau-Kleffner":[21],"syndrome":[22,196],"(LKS),":[23],"it":[24],"estimated":[26],"that":[27,183,197],"the":[28,133,152,155,162,168,172,175,178,187,200,212],"aphasia":[29,165],"directly":[31],"caused":[32],"by":[33],"epileptic":[34,91,195],"discharges":[35,176],"areas.":[38],"PATIENTS":[39],"AND":[40],"METHODS:":[41],"Ten":[42],"children":[43,96,138],"LKS":[45,184],"are":[46],"studied.":[47],"clinical":[49,157],"and":[50,66,85,101,119,129,158,206,211,221,224],"electroencephalographic":[51],"characteristics":[52],"these":[54],"ten":[55],"cases":[56,84],"were":[57,121,147],"analyzed.":[58],"RESULTS:":[59],"Aphasia":[60],"was":[61],"present":[62,93],"between":[63,98],"3":[64,104],"years":[65,68,75,103,110],"6":[67],"5":[69],"months":[70,100,105],"age":[72,107],"(X:":[73,108],"4":[74,109],"8":[76,83],"months)":[77],"progressive":[80],"form":[81,189],"abruptly":[86],"2":[88],"cases.":[89],"seizures":[92],"nine":[95],"began":[97],"22":[99],"7":[102],"1":[111],"month).":[112],"Focal,":[113],"multifocal":[114],"and/or":[115],"generalized":[116],"discharges,":[117],"unstable":[118],"variable,":[120],"frequently":[122],"noted":[123],"during":[124,132,142,208,228],"awake":[125],"state":[126,135],"EEG":[127,159],"records":[128],"on":[130,177],"EEGs":[131],"sleep":[134,146,179],"four":[137],"continuous":[139,204,225],"spike":[140,205,226],"waves":[141,207,227],"75-80%":[143],"slow":[145,209,229],"observed.":[148],"CONCLUSIONS:":[149],"We":[150],"discuss":[151],"importance":[153],"different":[156],"findings":[160],"evolution":[163],"which":[166],"condition":[167],"longterm":[169],"prognosis,":[170],"emphasizing":[171],"value":[173],"EEGs.":[180],"This":[181],"suggests":[182],"could":[185],"be":[186],"severe":[188],"more":[192],"widespread":[193],"age-dependent":[194],"also":[198],"includes":[199],"CSWS":[201],"(epilepsy":[202],"sleep)":[210],"atypical":[213],"benign":[214],"partial":[215],"epilepsy.":[216],"Three":[217],"syndromes":[218],"have":[219],"cognitive":[220],"behavioral":[222],"manifestations":[223],"sleep.":[230]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}