{"id":"https://openalex.org/W30618619","doi":"https://doi.org/10.2119/molmed.2009.00008","title":"Genome-Wide Association Study of Determinants of Anti-Cyclic Citrullinated Peptide Antibody Titer in Adults with Rheumatoid Arthritis","display_name":"Genome-Wide Association Study of Determinants of Anti-Cyclic Citrullinated Peptide Antibody Titer in Adults with Rheumatoid Arthritis","publication_year":2009,"publication_date":"2009-05-01","ids":{"openalex":"https://openalex.org/W30618619","doi":"https://doi.org/10.2119/molmed.2009.00008","mag":"30618619","pmid":"https://pubmed.ncbi.nlm.nih.gov/19287509","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2654848"},"language":"en","primary_location":{"id":"doi:10.2119/molmed.2009.00008","doi":"https://doi.org/10.2119/molmed.2009.00008","is_oa":true,"landing_page_url":"https://doi.org/10.2119/molmed.2009.00008","pdf_url":"https://molmed.biomedcentral.com/counter/pdf/10.2119/molmed.2009.00008","source":{"id":"https://openalex.org/S6769275","display_name":"Molecular Medicine","issn_l":"1076-1551","issn":["1076-1551","1528-3658"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://molmed.biomedcentral.com/counter/pdf/10.2119/molmed.2009.00008","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069114837","display_name":"Jing Cui","orcid":"https://orcid.org/0000-0001-8657-1741","observed_orcids":["https://orcid.org/0000-0001-8657-1741"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jing Cui","raw_affiliation_strings":["Division of Rheumatology, Immunology & Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. jcui3@partners.org","Division of Rheumatology, Immunology & Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Immunology & Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. jcui3@partners.org","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Rheumatology, Immunology & Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055196283","display_name":"Kimberly E. Taylor","orcid":"https://orcid.org/0000-0001-6848-9074","observed_orcids":["https://orcid.org/0000-0001-6848-9074"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4405273141","display_name":"Russell/Engleman Rheumatology Research Center","ror":"https://ror.org/05bf1vc84","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405273141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly E. Taylor","raw_affiliation_strings":["Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, California, USA","Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4405273141"]},{"raw_affiliation_string":"Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4405273141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003219679","display_name":"Anita L. DeStefano","orcid":"https://orcid.org/0000-0002-9335-2819","observed_orcids":["https://orcid.org/0000-0002-9335-2819"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anita L. DeStefano","raw_affiliation_strings":["School of Public Health, Boston University, Boston, Massachusetts, USA","School of Public Health, Boston University, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Boston University, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"School of Public Health, Boston University, Boston, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082388906","display_name":"Lindsey A. Criswell","orcid":"https://orcid.org/0000-0002-0761-7543","observed_orcids":["https://orcid.org/0000-0002-0761-7543"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4405273141","display_name":"Russell/Engleman Rheumatology Research Center","ror":"https://ror.org/05bf1vc84","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405273141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsey A. Criswell","raw_affiliation_strings":["Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, California, USA","Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4405273141"]},{"raw_affiliation_string":"Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4405273141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012729594","display_name":"Elena S. Izmailova","orcid":"https://orcid.org/0000-0002-7150-1748","observed_orcids":["https://orcid.org/0000-0002-7150-1748"]},"institutions":[{"id":"https://openalex.org/I4405270001","display_name":"Takeda Oncology (United States)","ror":"https://ror.org/05vm7p871","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena S. Izmailova","raw_affiliation_strings":["Millennium Pharmaceuticals, Cambridge, Massachusetts, USA","Millennium Pharmaceuticals, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Millennium Pharmaceuticals, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I4405270001"]},{"raw_affiliation_string":"Millennium Pharmaceuticals, Cambridge, USA","institution_ids":["https://openalex.org/I4405270001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018275556","display_name":"Alex N. Parker","orcid":"https://orcid.org/0000-0003-1278-6680","observed_orcids":["https://orcid.org/0000-0003-1278-6680"]},"institutions":[{"id":"https://openalex.org/I4405270001","display_name":"Takeda Oncology (United States)","ror":"https://ror.org/05vm7p871","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Parker","raw_affiliation_strings":["Millennium Pharmaceuticals, Cambridge, Massachusetts, USA","Millennium Pharmaceuticals, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Millennium Pharmaceuticals, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I4405270001"]},{"raw_affiliation_string":"Millennium Pharmaceuticals, Cambridge, USA","institution_ids":["https://openalex.org/I4405270001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060701001","display_name":"Ronenn Roubenoff","orcid":"https://orcid.org/0000-0002-3959-3179","observed_orcids":["https://orcid.org/0000-0002-3959-3179"]},"institutions":[{"id":"https://openalex.org/I1297540436","display_name":"Biogen (United States)","ror":"https://ror.org/02jqkb192","country_code":"US","type":"company","lineage":["https://openalex.org/I1297540436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronenn Roubenoff","raw_affiliation_strings":["Biogen Idec Inc., Cambridge, Massachusetts, USA","Biogen Idec Incorporated, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biogen Idec Inc., Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I1297540436"]},{"raw_affiliation_string":"Biogen Idec Incorporated, Cambridge, USA","institution_ids":["https://openalex.org/I1297540436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106486411","display_name":"Robert M. Plenge","orcid":"https://orcid.org/0000-0002-3705-5924","observed_orcids":["https://orcid.org/0000-0002-3705-5924"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Plenge","raw_affiliation_strings":["Broad Institute, Cambridge, Massachusetts, USA","Division of Rheumatology Immunology & Allergy, Brigham and Women\u2019s Hospital and Harvard Medical School, 75 Francis Street, PBB-B3, Boston, Massachusetts, 02115, USA","Broad Institute, Cambridge, USA","Division of Rheumatology Immunology & Allergy, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Division of Rheumatology Immunology & Allergy, Brigham and Women\u2019s Hospital and Harvard Medical School, 75 Francis Street, PBB-B3, Boston, Massachusetts, 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Broad Institute, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Division of Rheumatology Immunology & Allergy, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047117557","display_name":"Michael E. Weinblatt","orcid":"https://orcid.org/0000-0001-5215-5512","observed_orcids":["https://orcid.org/0000-0001-5215-5512"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael E. Weinblatt","raw_affiliation_strings":["Division of Rheumatology Immunology & Allergy, Brigham and Women\u2019s Hospital and Harvard Medical School, 75 Francis Street, PBB-B3, Boston, Massachusetts, 02115, USA","Division of Rheumatology Immunology & Allergy, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology Immunology & Allergy, Brigham and Women\u2019s Hospital and Harvard Medical School, 75 Francis Street, PBB-B3, Boston, Massachusetts, 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Rheumatology Immunology & Allergy, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081306729","display_name":"Nancy Ann Shadick","orcid":"https://orcid.org/0000-0003-3953-845X","observed_orcids":["https://orcid.org/0000-0003-3953-845X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy A. Shadick","raw_affiliation_strings":["Division of Rheumatology Immunology & Allergy, Brigham and Women\u2019s Hospital and Harvard Medical School, 75 Francis Street, PBB-B3, Boston, Massachusetts, 02115, USA","Division of Rheumatology Immunology & Allergy, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology Immunology & Allergy, Brigham and Women\u2019s Hospital and Harvard Medical School, 75 Francis Street, PBB-B3, Boston, Massachusetts, 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Rheumatology Immunology & Allergy, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082819294","display_name":"Elizabeth W. Karlson","orcid":"https://orcid.org/0000-0001-5455-7443","observed_orcids":["https://orcid.org/0000-0001-5455-7443"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth W. Karlson","raw_affiliation_strings":["Division of Rheumatology Immunology & Allergy, Brigham and Women\u2019s Hospital and Harvard Medical School, 75 Francis Street, PBB-B3, Boston, Massachusetts, 02115, USA","Division of Rheumatology Immunology & Allergy, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology Immunology & Allergy, Brigham and Women\u2019s Hospital and Harvard Medical School, 75 Francis Street, PBB-B3, Boston, Massachusetts, 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Rheumatology Immunology & Allergy, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5069114837"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":3.4845,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.91579752,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"15","issue":"5-6","first_page":"136","last_page":"143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.030799999833106995,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/anti-ccp-antibodies","display_name":"anti-CCP antibodies","score":0.9490000009536743},{"id":"https://openalex.org/keywords/genetic-factors","display_name":"genetic factors","score":0.6510000228881836},{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"major histocompatibility complex","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hla-drb1","display_name":"HLA-DRB1","score":0.8019999861717224},{"id":"https://openalex.org/keywords/btnl2","display_name":"BTNL2","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hla-dra","display_name":"HLA-DRA","score":0.9829999804496765},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9509999752044678},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.800039529800415},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.6834227442741394},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.5830510258674622},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.564671516418457},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.5290324091911316},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.47816401720046997},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4761764407157898},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.4690293073654175},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44560423493385315},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4144743084907532},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.4106217324733734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4043668508529663},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3953320384025574},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3678429126739502},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35710346698760986},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3266874849796295},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.28976330161094666},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15796276926994324},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071797","descriptor_name":"Butyrophilins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008285","descriptor_name":"Major Histocompatibility Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059805","descriptor_name":"HLA-DR alpha-Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059811","descriptor_name":"HLA-DRB1 Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2119/molmed.2009.00008","doi":"https://doi.org/10.2119/molmed.2009.00008","is_oa":true,"landing_page_url":"https://doi.org/10.2119/molmed.2009.00008","pdf_url":"https://molmed.biomedcentral.com/counter/pdf/10.2119/molmed.2009.00008","source":{"id":"https://openalex.org/S6769275","display_name":"Molecular Medicine","issn_l":"1076-1551","issn":["1076-1551","1528-3658"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2042929","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2654848","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2654848","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2654848","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Med","raw_type":"Text"},{"id":"pmid:19287509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19287509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular medicine (Cambridge, Mass.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2119/molmed.2009.00008","doi":"https://doi.org/10.2119/molmed.2009.00008","is_oa":true,"landing_page_url":"https://doi.org/10.2119/molmed.2009.00008","pdf_url":"https://molmed.biomedcentral.com/counter/pdf/10.2119/molmed.2009.00008","source":{"id":"https://openalex.org/S6769275","display_name":"Molecular Medicine","issn_l":"1076-1551","issn":["1076-1551","1528-3658"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1071208683","display_name":null,"funder_award_id":"R01-AI-065841","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G125397083","display_name":"NARAC The Genetics of Rheumatoid Arthritis","funder_award_id":"R01AR044422","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G1288036168","display_name":null,"funder_award_id":"N01-AR-22263","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G1567724564","display_name":null,"funder_award_id":"U54-RR020278","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2468894170","display_name":null,"funder_award_id":"K08 AI55314-3","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3496748216","display_name":"NIAMS Multidisciplinary Clinical Research Center","funder_award_id":"P60AR047782","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3575724264","display_name":null,"funder_award_id":"M01-RR000079","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5214708651","display_name":"Novel Biomarkers and Prediction Models for Rheumatoid Arthritis","funder_award_id":"R01AR049880","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5256535059","display_name":"Dissecting the HLA contribution to Rheumatoid Arthritis","funder_award_id":"5r01ai065841-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6489194114","display_name":"An NCRR Center for High Throughput SNP Genotyping and Analysis","funder_award_id":"6u54rr020278-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6529575702","display_name":"The Genetic Epidemiology of  RA and SLE","funder_award_id":"K24AR002175","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G699655281","display_name":null,"funder_award_id":"M01 RR-00079","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G780726228","display_name":"Mapping HIV/AIDS genes with haplotype-based strategies","funder_award_id":"K08AI055314","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G849458189","display_name":"General Clinical Research Center","funder_award_id":"5m01rr000079-42","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G98096212","display_name":null,"funder_award_id":"K24 AR0524-01","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320313227","display_name":"Lupus Research Alliance","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W30618619.pdf","grobid_xml":"https://content.openalex.org/works/W30618619.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1524682237","https://openalex.org/W1964890547","https://openalex.org/W1991472750","https://openalex.org/W1991485197","https://openalex.org/W2004304522","https://openalex.org/W2015865604","https://openalex.org/W2017548224","https://openalex.org/W2035036601","https://openalex.org/W2035249926","https://openalex.org/W2041560982","https://openalex.org/W2053282617","https://openalex.org/W2055514573","https://openalex.org/W2063213943","https://openalex.org/W2065805602","https://openalex.org/W2095119242","https://openalex.org/W2119279196","https://openalex.org/W2123361363","https://openalex.org/W2126718956","https://openalex.org/W2133800053","https://openalex.org/W2134783591","https://openalex.org/W2141521401","https://openalex.org/W2146863995","https://openalex.org/W2152421131","https://openalex.org/W2161633633","https://openalex.org/W2162276444","https://openalex.org/W2162530578","https://openalex.org/W2168781986"],"related_works":["https://openalex.org/W2033800025","https://openalex.org/W2067348648","https://openalex.org/W2470370465","https://openalex.org/W2063213943","https://openalex.org/W2066395414","https://openalex.org/W1964890547","https://openalex.org/W2017548224","https://openalex.org/W2396382924","https://openalex.org/W2082719943","https://openalex.org/W4385348273"],"abstract_inverted_index":{"We":[0,217],"carried":[1],"out":[2],"a":[3,138,219],"genome-wide":[4],"association":[5],"study":[6],"of":[7,10,55,234],"genetic":[8],"predictors":[9],"anti-cyclic":[11],"citrullinated":[12],"peptide":[13],"antibody":[14],"(anti-CCP)":[15],"level":[16],"in":[17,27,49,51,184,211,221],"531":[18],"self-reported":[19],"non-Hispanic":[20],"Caucasian":[21],"Rheumatoid":[22,30,63],"Arthritis":[23,31,64],"(RA)":[24],"patients":[25,58],"enrolled":[26],"the":[28,60,74,104,120,127,142,154,175,203,214,235],"Brigham":[29],"Sequential":[32],"Study":[33],"(BRASS).":[34],"For":[35],"replication,":[36],"we":[37],"then":[38],"analyzed":[39],"289":[40],"single":[41,139],"nucleotide":[42],"polymorphisms":[43],"(SNPs)":[44],"with":[45,153,163,226],"P":[46,132],"<":[47,111,134],"0.001":[48],"BRASS":[50,67,100,185],"an":[52],"independent":[53],"population":[54],"849":[56],"RA":[57,212],"from":[59,99,141,158],"North":[61],"American":[62],"Consortium":[65],"(NARAC).":[66],"and":[68,77,85,147,186,192],"NARAC":[69,187],"samples":[70],"were":[71,102],"genotyped":[72],"using":[73,90],"Affymetrix":[75],"100K":[76],"Illumina":[78],"550K":[79],"platforms":[80],"respectively.":[81],"Association":[82],"between":[83],"SNPs":[84,98,129,157,182],"anti-CCP":[86,209,231],"titer":[87,165,232],"was":[88,160],"tested":[89],"general":[91],"linear":[92],"models.":[93],"The":[94,180],"five":[95,156],"most":[96,204],"significant":[97,205],"all":[101],"within":[103],"major":[105],"histocompatibility":[106],"complex":[107],"(MHC)":[108],"region":[109,144,207],"(P":[110,166,177],"or":[112],"=":[113,151,167,178,190],"3.5":[114],"x":[115,169],"10(-6)).":[116],"After":[117],"controlling":[118],"for":[119,174],"human":[121],"leukocyte":[122],"antigen":[123],"shared":[124],"epitope":[125],"(HLA-SE),":[126],"top":[128,155,181],"still":[130],"yielded":[131],"values":[133],"0.0002.":[135],"In":[136],"NARAC,":[137],"SNP":[140,220],"MHC":[143,215],"near":[145],"BTNL2":[146],"HLA-DRA,":[148],"rs1980493":[149],"(r(2)":[150],"0.85":[152],"BRASS),":[159],"associated":[161],"significantly":[162],"CCP":[164],"6.1":[168],"10(-5))":[170],"even":[171],"after":[172],"adjustment":[173],"HLA-SE":[176],"0.0002).":[179],"found":[183],"had":[188],"r(2)":[189],"0.46":[191],"0.64,":[193],"respectively,":[194],"to":[195],"HLA-DRB1":[196],"DR3":[197],"alleles.":[198],"These":[199],"results":[200],"confirm":[201],"that":[202],"genome":[206],"affecting":[208],"titers":[210],"is":[213],"region.":[216],"identified":[218],"moderate":[222],"linkage":[223],"disequilibrium":[224],"(LD)":[225],"HLA-DR3,":[227],"which":[228],"may":[229],"influence":[230],"independently":[233],"HLA-SE.":[236]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
