{"id":"https://openalex.org/W30585693","doi":null,"title":"Intraoperative chemohyperthermic peritoneal perfusion as an adjuvant to gastric cancer: final results of a randomized controlled study.","display_name":"Intraoperative chemohyperthermic peritoneal perfusion as an adjuvant to gastric cancer: final results of a randomized controlled study.","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W30585693","mag":"30585693","pmid":"https://pubmed.ncbi.nlm.nih.gov/11813623"},"language":"en","primary_location":{"id":"pmid:11813623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11813623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103020147","display_name":"Yutaka Yonemura","orcid":"https://orcid.org/0000-0001-5796-9603","observed_orcids":["https://orcid.org/0000-0001-5796-9603"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Yonemura","raw_affiliation_strings":["School of Medicine, Kanazawa University, 13-1 Takara-Machi, Kanazawa City, Japan. yonemu@med.kanazawa-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Kanazawa University, 13-1 Takara-Machi, Kanazawa City, Japan. yonemu@med.kanazawa-u.ac.jp","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061075080","display_name":"Xavier de Aretxabala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X de Aretxabala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074701942","display_name":"Takashi Fujimura","orcid":"https://orcid.org/0000-0001-7442-5974","observed_orcids":["https://orcid.org/0000-0001-7442-5974"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Fujimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024644803","display_name":"Sachio Fushida","orcid":"https://orcid.org/0000-0001-5567-7383","observed_orcids":["https://orcid.org/0000-0001-5567-7383"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Fushida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113730734","display_name":"Kanji Katayama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Katayama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084072293","display_name":"Etsurou Bandou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Bandou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108931335","display_name":"K. Sugiyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Sugiyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049043438","display_name":"Takeshi Kawamura","orcid":"https://orcid.org/0000-0003-1613-6968","observed_orcids":["https://orcid.org/0000-0003-1613-6968"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Kawamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112557692","display_name":"K Kinoshita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Kinoshita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028892927","display_name":"Yoshio Endou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Endou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102021442","display_name":"Takamitsu Sasaki","orcid":"https://orcid.org/0000-0002-2248-5382","observed_orcids":["https://orcid.org/0000-0002-2248-5382"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Sasaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.279,"has_fulltext":false,"cited_by_count":225,"citation_normalized_percentile":{"value":0.95537158,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"48","issue":"42","first_page":"1776","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.8330000042915344},{"id":"https://openalex.org/keywords/peritoneal-recurrence","display_name":"peritoneal recurrence","score":0.7559999823570251},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.8579999804496765},{"id":"https://openalex.org/keywords/mitomycin-c","display_name":"mitomycin C","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":1.0},{"id":"https://openalex.org/keywords/curative-gastrectomy","display_name":"curative gastrectomy","score":0.7749999761581421},{"id":"https://openalex.org/keywords/extended-lymphadenectomy","display_name":"extended lymphadenectomy","score":0.8199999928474426},{"id":"https://openalex.org/keywords/serosal-invasion","display_name":"serosal invasion","score":0.6539999842643738},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5920000076293945},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6779999732971191},{"id":"https://openalex.org/keywords/intestinal-perforation","display_name":"intestinal perforation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/postoperative-complications","display_name":"postoperative complications","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9531124830245972},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.6230093836784363},{"id":"https://openalex.org/C2780470880","wikidata":"https://www.wikidata.org/wiki/Q827390","display_name":"Gastrectomy","level":3,"score":0.5407806038856506},{"id":"https://openalex.org/C2780824555","wikidata":"https://www.wikidata.org/wiki/Q1809305","display_name":"Lymphadenectomy","level":3,"score":0.5061964392662048},{"id":"https://openalex.org/C2778456384","wikidata":"https://www.wikidata.org/wiki/Q1508510","display_name":"Perforation","level":3,"score":0.5002920627593994},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4959660470485687},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.47869637608528137},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4737594723701477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2470100224018097},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C2778527123","wikidata":"https://www.wikidata.org/wiki/Q11750728","display_name":"Punching","level":2,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007036","descriptor_name":"Hypothermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007432","descriptor_name":"Intraoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008197","descriptor_name":"Lymph Node Excision","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010478","descriptor_name":"Chemotherapy, Cancer, Regional Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11813623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11813623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Clinical Trial"},{"id":"mag:30585693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11813623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8799999952316284,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W149614540","https://openalex.org/W1528872009","https://openalex.org/W1557409643","https://openalex.org/W1643288909","https://openalex.org/W1857754651","https://openalex.org/W1896531654","https://openalex.org/W1964542341","https://openalex.org/W1972538314","https://openalex.org/W1981593008","https://openalex.org/W1982512889","https://openalex.org/W1987625973","https://openalex.org/W2007339989","https://openalex.org/W2009119246","https://openalex.org/W2018749341","https://openalex.org/W2019695639","https://openalex.org/W2021099440","https://openalex.org/W2024378731","https://openalex.org/W2024406718","https://openalex.org/W2025404024","https://openalex.org/W2025454110","https://openalex.org/W2043298415","https://openalex.org/W2044340157","https://openalex.org/W2045496696","https://openalex.org/W2052293046","https://openalex.org/W2052541990","https://openalex.org/W2054522148","https://openalex.org/W2055083523","https://openalex.org/W2064080343","https://openalex.org/W2080791625","https://openalex.org/W2084123810","https://openalex.org/W2085525864","https://openalex.org/W2089443729","https://openalex.org/W2095521733","https://openalex.org/W2096046927","https://openalex.org/W2097951502","https://openalex.org/W2109552398","https://openalex.org/W2111592517","https://openalex.org/W2112689805","https://openalex.org/W2114204941","https://openalex.org/W2117327695","https://openalex.org/W2126631992","https://openalex.org/W2132262204","https://openalex.org/W2133774018","https://openalex.org/W2134687042","https://openalex.org/W2135344041","https://openalex.org/W2136048184","https://openalex.org/W2149563695","https://openalex.org/W2151104145","https://openalex.org/W2157040738","https://openalex.org/W2157250075","https://openalex.org/W2161854664","https://openalex.org/W2240021046","https://openalex.org/W2333926025","https://openalex.org/W2346808682","https://openalex.org/W2346984541","https://openalex.org/W2524894106","https://openalex.org/W2553103505","https://openalex.org/W2554960318","https://openalex.org/W2564054118","https://openalex.org/W2573522185","https://openalex.org/W2580297764","https://openalex.org/W2599292580","https://openalex.org/W2620453935","https://openalex.org/W2751757223","https://openalex.org/W2768462035","https://openalex.org/W2887519529","https://openalex.org/W4295127969"],"related_works":["https://openalex.org/W2058231119","https://openalex.org/W33255888","https://openalex.org/W2029469088","https://openalex.org/W2398159531","https://openalex.org/W182490603","https://openalex.org/W2376958166","https://openalex.org/W2025319611","https://openalex.org/W2064936790","https://openalex.org/W1989575180","https://openalex.org/W2411857703"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"Although":[1],"the":[2,24,76,82,94,111,165,198,299],"most":[3],"frequent":[4],"cause":[5],"of":[6,11,26,49,123,138,144,164,186,210,285,301,306],"death":[7,286],"after":[8,177,303],"curative":[9,65,304],"resection":[10,305],"advanced":[12,52,307],"gastric":[13,53,62,229,308],"cancer":[14,63,230],"is":[15,311],"peritoneal":[16,27,38,89,101,116,179,250,254,268,289,293],"recurrence,":[17],"there":[18],"was":[19,106,118,181],"no":[20,257],"effective":[21],"therapy":[22],"for":[23,276,298,313],"prevention":[25],"recurrence.":[28],"This":[29],"randomized":[30],"trial":[31],"sought":[32],"to":[33],"determine":[34],"whether":[35],"intraoperative":[36],"chemohyperthermic":[37,88,178,249,267,288],"perfusion":[39,180,255,269,294],"could":[40],"eliminate":[41],"microscopic":[42],"residual":[43],"disease":[44],"and":[45,57,91,113,131,141,161,168,194,201,213,220,310,321],"thereby":[46],"improve":[47],"survival":[48,208,245,258],"patients":[50,59,71,227,314],"with":[51,60,67,120,135,228,248,262,315],"cancer.":[54],"METHODOLOGY:":[55],"One-hundred":[56],"thirty-nine":[58],"T2-4":[61],"underwent":[64,97],"gastrectomy":[66],"extended":[68],"lymphadenectomy.":[69],"These":[70],"were":[72,189,217],"randomly":[73],"allocated":[74],"into":[75],"following":[77],"three":[78],"groups.":[79],"Patients":[80],"in":[81,93,156,197,244],"CHPP":[83,112],"group":[84,96,105,188],"received":[85],"surgery":[86,98,107,169,202,214],"+":[87,99],"perfusion,":[90],"those":[92],"CNPP":[95,114,167,200,212],"chemonormothermic":[100,253],"perfusion.":[102,251,290],"The":[103],"third":[104],"alone":[108,170,203,215,280],"group.":[109],"In":[110,223],"groups,":[115],"cavity":[117],"perfused":[119],"6-8":[121],"liters":[122],"heated":[124],"saline":[125],"at,":[126],"respectively,":[127],"42-43":[128],"degrees":[129,133],"C":[130,134,140],"37":[132],"30":[136],"mg":[137,143],"mitomycin":[139],"300":[142],"cisplatin":[145],"by":[146],"a":[147,224,240],"extracorporeal":[148],"circulation":[149],"machine.":[150],"RESULTS:":[151],"Major":[152],"operative":[153],"complication":[154],"occurred":[155],"19%":[157,162],"(9/48),":[158],"14%":[159],"(6/44)":[160],"(9/47)":[163],"CHPP,":[166,199,211],"group,":[171,204],"respectively.":[172,205,222],"Complication":[173],"which":[174],"uniquely":[175],"developed":[176],"bowel":[182],"perforation.":[183],"Mortality":[184],"rates":[185,209],"each":[187],"4%":[190,195],"(2/48),":[191],"0%":[192],"(0/44)":[193],"(2/47)":[196],"Overall":[206],"5-year":[207],"groups":[216],"61%,":[218],"43%":[219],"42%,":[221],"subset":[225],"analysis,":[226],"having":[231],"serosal":[232,319],"invasion":[233],"or":[234],"lymph":[235],"node":[236,322],"metastasis":[237],"have":[238],"shown":[239],"statistically":[241],"significant":[242],"improvement":[243],"when":[246],"treated":[247],"However,":[252],"had":[256,281,295],"benefit.":[259],"By":[260],"analyzing":[261],"Cox":[263],"proportional":[264],"hazard":[265],"model,":[266],"emerged":[270],"as":[271],"an":[272,296],"independent":[273],"prognostic":[274],"factor":[275],"good":[277],"survival.":[278],"Surgery":[279],"three-fold":[282],"higher":[283],"risk":[284],"than":[287],"CONCLUSIONS:":[291],"Chemohyperthermic":[292],"efficiency":[297],"prophylaxis":[300],"recurrence":[302],"cancer,":[309],"indicated":[312],"tumor":[316],"infiltrating":[317],"beyond":[318],"layer":[320],"positive":[323],"tumor.":[324]},"counts_by_year":[{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}