{"id":"https://openalex.org/W30582164","doi":null,"title":"Role of Synaptic and Non-Synaptic Mechanisms Underlying Motor Neuron Control","display_name":"Role of Synaptic and Non-Synaptic Mechanisms Underlying Motor Neuron Control","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W30582164","mag":"30582164"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/202994","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/202994","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002259533","display_name":"Ann L. Revill","orcid":"https://orcid.org/0000-0002-6071-6866","observed_orcids":["https://orcid.org/0000-0002-6071-6866"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ann L. Revill","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6071-6866","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5002259533"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10784","display_name":"Muscle activation and electromyography studies","score":0.8726000189781189,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10784","display_name":"Muscle activation and electromyography studies","score":0.8726000189781189,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.06949999928474426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10982","display_name":"Motor Control and Adaptation","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/motor-neurons","display_name":"motor neurons","score":0.8169999718666077},{"id":"https://openalex.org/keywords/persistent-inward-currents","display_name":"persistent inward currents","score":0.9879999756813049},{"id":"https://openalex.org/keywords/spike-frequency-adaptation","display_name":"spike frequency adaptation","score":0.9589999914169312},{"id":"https://openalex.org/keywords/motor-unit-firing-rate","display_name":"motor unit firing rate","score":0.8420000076293945},{"id":"https://openalex.org/keywords/motor-unit-recruitment","display_name":"motor unit recruitment","score":0.5960000157356262},{"id":"https://openalex.org/keywords/genioglossus-muscle","display_name":"genioglossus muscle","score":0.890999972820282},{"id":"https://openalex.org/keywords/voluntary-movement","display_name":"voluntary movement","score":0.4779999852180481},{"id":"https://openalex.org/keywords/synaptic-drive","display_name":"synaptic drive","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6604072451591492},{"id":"https://openalex.org/C2776752467","wikidata":"https://www.wikidata.org/wiki/Q1133903","display_name":"Motor neuron","level":3,"score":0.5094016194343567},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.43170610070228577},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3014333248138428},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/202994","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/202994","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},{"id":"mag:30582164","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/bitstream/10150/202994/1/azu_etd_11824_sip1_m.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":286,"referenced_works":["https://openalex.org/W45657630","https://openalex.org/W77634116","https://openalex.org/W165158238","https://openalex.org/W615559726","https://openalex.org/W1276708211","https://openalex.org/W1515193297","https://openalex.org/W1566701182","https://openalex.org/W1599967894","https://openalex.org/W1608846710","https://openalex.org/W1629873406","https://openalex.org/W1719961152","https://openalex.org/W1794386847","https://openalex.org/W1809394698","https://openalex.org/W1859519614","https://openalex.org/W1864545072","https://openalex.org/W1907543087","https://openalex.org/W1918977834","https://openalex.org/W1928891820","https://openalex.org/W1929741796","https://openalex.org/W1931292002","https://openalex.org/W1935022478","https://openalex.org/W1948861218","https://openalex.org/W1964261824","https://openalex.org/W1964640887","https://openalex.org/W1964906652","https://openalex.org/W1965895381","https://openalex.org/W1965942749","https://openalex.org/W1966572165","https://openalex.org/W1967818757","https://openalex.org/W1968280256","https://openalex.org/W1971296796","https://openalex.org/W1971893097","https://openalex.org/W1973478317","https://openalex.org/W1973825209","https://openalex.org/W1974557278","https://openalex.org/W1975054774","https://openalex.org/W1975058292","https://openalex.org/W1976576973","https://openalex.org/W1976929526","https://openalex.org/W1977189021","https://openalex.org/W1978114350","https://openalex.org/W1979903825","https://openalex.org/W1980862338","https://openalex.org/W1981668949","https://openalex.org/W1982750178","https://openalex.org/W1984765030","https://openalex.org/W1985329897","https://openalex.org/W1985425527","https://openalex.org/W1985808169","https://openalex.org/W1985940938","https://openalex.org/W1986878360","https://openalex.org/W1987536777","https://openalex.org/W1987778113","https://openalex.org/W1989109180","https://openalex.org/W1990087668","https://openalex.org/W1990201224","https://openalex.org/W1990217718","https://openalex.org/W1990798869","https://openalex.org/W1991209619","https://openalex.org/W1995352401","https://openalex.org/W1996919407","https://openalex.org/W1997013327","https://openalex.org/W1997805086","https://openalex.org/W1999384656","https://openalex.org/W1999523743","https://openalex.org/W1999967173","https://openalex.org/W2002136658","https://openalex.org/W2005572483","https://openalex.org/W2010029806","https://openalex.org/W2010594222","https://openalex.org/W2012882676","https://openalex.org/W2013151332","https://openalex.org/W2015034722","https://openalex.org/W2016675176","https://openalex.org/W2017013486","https://openalex.org/W2018490093","https://openalex.org/W2018892659","https://openalex.org/W2019229393","https://openalex.org/W2019505581","https://openalex.org/W2020889101","https://openalex.org/W2021200129","https://openalex.org/W2021237659","https://openalex.org/W2021761609","https://openalex.org/W2024313201","https://openalex.org/W2025280287","https://openalex.org/W2025881996","https://openalex.org/W2027132871","https://openalex.org/W2027499530","https://openalex.org/W2028274723","https://openalex.org/W2028848321","https://openalex.org/W2028856372","https://openalex.org/W2030046043","https://openalex.org/W2030602521","https://openalex.org/W2033172139","https://openalex.org/W2033447200","https://openalex.org/W2034489799","https://openalex.org/W2034762693","https://openalex.org/W2035545177","https://openalex.org/W2035845442","https://openalex.org/W2036289091","https://openalex.org/W2037641975","https://openalex.org/W2038421773","https://openalex.org/W2039377798","https://openalex.org/W2039784403","https://openalex.org/W2040322315","https://openalex.org/W2042504442","https://openalex.org/W2042706351","https://openalex.org/W2045221870","https://openalex.org/W2045712239","https://openalex.org/W2046817013","https://openalex.org/W2047012042","https://openalex.org/W2048208292","https://openalex.org/W2049566886","https://openalex.org/W2050826726","https://openalex.org/W2052837743","https://openalex.org/W2054404435","https://openalex.org/W2057086426","https://openalex.org/W2059093744","https://openalex.org/W2060611129","https://openalex.org/W2061306690","https://openalex.org/W2062363695","https://openalex.org/W2064784713","https://openalex.org/W2064904747","https://openalex.org/W2066557685","https://openalex.org/W2067186423","https://openalex.org/W2068511132","https://openalex.org/W2068689726","https://openalex.org/W2069134696","https://openalex.org/W2069284171","https://openalex.org/W2070392522","https://openalex.org/W2071233773","https://openalex.org/W2072277906","https://openalex.org/W2072849304","https://openalex.org/W2073929966","https://openalex.org/W2074644663","https://openalex.org/W2075567772","https://openalex.org/W2076391848","https://openalex.org/W2077244931","https://openalex.org/W2079208692","https://openalex.org/W2080477683","https://openalex.org/W2081126975","https://openalex.org/W2084389065","https://openalex.org/W2084579572","https://openalex.org/W2087211657","https://openalex.org/W2089577722","https://openalex.org/W2090706977","https://openalex.org/W2091479079","https://openalex.org/W2091850962","https://openalex.org/W2092054234","https://openalex.org/W2093891530","https://openalex.org/W2094137255","https://openalex.org/W2094607970","https://openalex.org/W2097400197","https://openalex.org/W2097541219","https://openalex.org/W2097561123","https://openalex.org/W2098118593","https://openalex.org/W2098285915","https://openalex.org/W2099437861","https://openalex.org/W2103328533","https://openalex.org/W2103613081","https://openalex.org/W2104283839","https://openalex.org/W2104904223","https://openalex.org/W2107391591","https://openalex.org/W2107896324","https://openalex.org/W2108382630","https://openalex.org/W2109251880","https://openalex.org/W2110655603","https://openalex.org/W2111880393","https://openalex.org/W2113390309","https://openalex.org/W2113679924","https://openalex.org/W2113690187","https://openalex.org/W2114111541","https://openalex.org/W2114432823","https://openalex.org/W2116403843","https://openalex.org/W2117809091","https://openalex.org/W2117957810","https://openalex.org/W2119432914","https://openalex.org/W2119542666","https://openalex.org/W2120799868","https://openalex.org/W2122371015","https://openalex.org/W2124094502","https://openalex.org/W2124746466","https://openalex.org/W2125050249","https://openalex.org/W2125979878","https://openalex.org/W2128002259","https://openalex.org/W2128912556","https://openalex.org/W2129342577","https://openalex.org/W2129968729","https://openalex.org/W2130509893","https://openalex.org/W2131229150","https://openalex.org/W2132253501","https://openalex.org/W2133425732","https://openalex.org/W2133762721","https://openalex.org/W2135543795","https://openalex.org/W2136252885","https://openalex.org/W2139613967","https://openalex.org/W2139966671","https://openalex.org/W2140591264","https://openalex.org/W2141283676","https://openalex.org/W2142289774","https://openalex.org/W2142416079","https://openalex.org/W2143274945","https://openalex.org/W2145460573","https://openalex.org/W2146387750","https://openalex.org/W2147607877","https://openalex.org/W2148764093","https://openalex.org/W2149223010","https://openalex.org/W2152786417","https://openalex.org/W2155307791","https://openalex.org/W2156333908","https://openalex.org/W2156803627","https://openalex.org/W2156969997","https://openalex.org/W2157126630","https://openalex.org/W2159436976","https://openalex.org/W2160500561","https://openalex.org/W2160719507","https://openalex.org/W2162772948","https://openalex.org/W2164841208","https://openalex.org/W2166018731","https://openalex.org/W2168307960","https://openalex.org/W2172049533","https://openalex.org/W2172129335","https://openalex.org/W2179552831","https://openalex.org/W2180902327","https://openalex.org/W2187063188","https://openalex.org/W2189979991","https://openalex.org/W2191992681","https://openalex.org/W2209403298","https://openalex.org/W2218037715","https://openalex.org/W2226519456","https://openalex.org/W2227291860","https://openalex.org/W2231216177","https://openalex.org/W2234448189","https://openalex.org/W2235855481","https://openalex.org/W2245851929","https://openalex.org/W2247321193","https://openalex.org/W2255066245","https://openalex.org/W2255631793","https://openalex.org/W2256745758","https://openalex.org/W2259666366","https://openalex.org/W2265056075","https://openalex.org/W2265797707","https://openalex.org/W2269366177","https://openalex.org/W2274142243","https://openalex.org/W2276213602","https://openalex.org/W2277032903","https://openalex.org/W2285238963","https://openalex.org/W2287126561","https://openalex.org/W2287127883","https://openalex.org/W2295783741","https://openalex.org/W2297809273","https://openalex.org/W2307347504","https://openalex.org/W2320260698","https://openalex.org/W2320564603","https://openalex.org/W2328062421","https://openalex.org/W2338767728","https://openalex.org/W2342886054","https://openalex.org/W2343482777","https://openalex.org/W2345075193","https://openalex.org/W2396446279","https://openalex.org/W2397991574","https://openalex.org/W2399439848","https://openalex.org/W2401364776","https://openalex.org/W2401400785","https://openalex.org/W2402388036","https://openalex.org/W2402598498","https://openalex.org/W2403560496","https://openalex.org/W2409300940","https://openalex.org/W2410568117","https://openalex.org/W2411241959","https://openalex.org/W2411530637","https://openalex.org/W2411603542","https://openalex.org/W2411800882","https://openalex.org/W2413348376","https://openalex.org/W2415333469","https://openalex.org/W2417197129","https://openalex.org/W2430222263","https://openalex.org/W2437542888","https://openalex.org/W2438281773","https://openalex.org/W2440168604","https://openalex.org/W2467411565","https://openalex.org/W2521122295","https://openalex.org/W2572341398","https://openalex.org/W2790699490","https://openalex.org/W2802387694","https://openalex.org/W3190786843"],"related_works":["https://openalex.org/W2068689726","https://openalex.org/W2020228453","https://openalex.org/W2074644663","https://openalex.org/W2102047259","https://openalex.org/W2487547040","https://openalex.org/W3176540228","https://openalex.org/W2403560496","https://openalex.org/W2966892632","https://openalex.org/W2317801828","https://openalex.org/W3029155313"],"abstract_inverted_index":{"While":[0,150],"motor":[1,44,116,123,293,332],"neuron":[2],"activity":[3,20],"has":[4,152,232],"been":[5,153,233],"studied":[6],"for":[7,131,318],"many":[8],"decades,":[9],"the":[10,29,38,97,111,161,206,221,225,228,242,301],"relative":[11],"contribution":[12],"of":[13,31,40,43,73,167,224,230,303,331],"synaptic":[14,62,132],"and":[15,76,134,148,181,282,339],"non-synaptic":[16,41,54,169,329],"mechanisms":[17,170],"underlying":[18],"this":[19,32,290,312,325],"during":[21,46,211,248,266,321,336],"natural":[22,212,249,267,322,337],"behaviors":[23,338],"is":[24,203,285],"not":[25,241],"well":[26],"understood.":[27],"Thus,":[28],"goal":[30],"dissertation":[33,326],"was":[34,113,217,298],"to":[35,81,95,157,173,186,191,209,245,262,274,289,344],"further":[36],"understand":[37,96],"role":[39,229],"properties":[42,102,330],"neurons":[45,333],"voluntary":[47],"activity.":[48],"In":[49,109],"particular,":[50,110],"I":[51,253],"considered":[52,255],"three":[53],"properties:":[55],"persistent":[56],"inward":[57],"currents":[58],"(PICs)":[59],"that":[60,66,79,100,165,201,238,286,328,340],"boost":[61],"inputs,":[63],"spike-threshold":[64],"accommodation":[65],"affects":[67],"recruitment":[68,147],"threshold":[69,122,145],"as":[70,128],"excitation":[71,89],"rates":[72,272],"rise":[74],"slow,":[75],"spike-frequency":[77],"adaptation":[78,202],"leads":[80],"a":[82,120,129,143],"decrease":[83],"in":[84,136,193,220],"firing":[85,106,125,137,271,295,345],"rate":[86,107,126,138,296,346],"despite":[87,278],"constant":[88],"levels.":[90],"Computer":[91],"simulations":[92],"were":[93,140],"employed":[94],"potential":[98],"effect":[99],"these":[101,168],"could":[103,171],"have":[104,307],"on":[105,114],"behavior.":[108,291],"focus":[112],"paired":[115],"unit":[117,270,294],"recordings":[118],"where":[119,227],"lower":[121],"unit\u2019s":[124,146],"served":[127],"proxy":[130],"drive,":[133],"differences":[135],"(\u0394F)":[139],"compared":[141],"at":[142],"higher":[144],"derecruitment.":[149],"\u0394F":[151,192,210,216,239],"used":[154],"by":[155,177,300],"others":[156],"estimate":[158],"PIC":[159,264,309,319],"activation,":[160],"simulation":[162],"results":[163,196,236],"indicated":[164,200],"each":[166],"lead":[172],"positive":[174,215],"\u0394F.":[175],"Furthermore,":[176],"varying":[178],"contraction":[179],"speed":[180],"duration":[182],"it":[183],"seemed":[184],"possible":[185,316],"determine":[187],"which":[188,305],"property":[189],"contributes":[190],"vivo.":[194],"The":[195],"from":[197],"human":[198],"experiments":[199],"most":[204],"likely":[205],"predominant":[207],"contributor":[208],"behaviors.":[213,250,268,323],"Additionally,":[214],"even":[218],"observed":[219],"genioglossus":[222],"muscle":[223],"tongue,":[226],"PICs":[231,247,287],"debated.":[234],"These":[235],"suggested":[237],"may":[240],"best":[243],"method":[244],"detect":[246],"As":[251],"such,":[252],"also":[254],"whether":[256],"there":[257],"might":[258],"be":[259],"another":[260],"metric":[261],"infer":[263],"activation":[265,320],"Motor":[269],"tend":[273],"plateau,":[275],"or":[276],"saturate,":[277],"continued":[279],"force":[280],"increase,":[281],"one":[283],"hypothesis":[284],"contribute":[288,342],"Indeed,":[292],"saturation":[297],"diminished":[299],"addition":[302],"inhibition,":[304],"should":[306],"limited":[308],"activation.":[310],"Therefore,":[311],"final":[313],"study":[314],"provided":[315],"evidence":[317],"Overall,":[324],"highlights":[327],"are":[334],"activated":[335],"they":[341],"significantly":[343],"output.":[347]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}