{"id":"https://openalex.org/W305388707","doi":"https://doi.org/10.1016/j.toxrep.2015.05.008","title":"The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse","display_name":"The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W305388707","doi":"https://doi.org/10.1016/j.toxrep.2015.05.008","mag":"305388707","pmid":"https://pubmed.ncbi.nlm.nih.gov/26213685","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4512206"},"language":"en","primary_location":{"id":"doi:10.1016/j.toxrep.2015.05.008","doi":"https://doi.org/10.1016/j.toxrep.2015.05.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.toxrep.2015.05.008","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2214750015300019/pdf","source":{"id":"https://openalex.org/S2764757124","display_name":"Toxicology Reports","issn_l":"2214-7500","issn":["2214-7500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2214750015300019/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062253236","display_name":"Aiping Zhang","orcid":"https://orcid.org/0000-0002-6367-9554","observed_orcids":["https://orcid.org/0000-0002-6367-9554"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aiping Zhang","raw_affiliation_strings":["The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066633383","display_name":"Kitipong Uaesoontrachoon","orcid":"https://orcid.org/0009-0004-8955-9763","observed_orcids":["https://orcid.org/0009-0004-8955-9763"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kitipong Uaesoontrachoon","raw_affiliation_strings":["The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001257617","display_name":"Conner J. Shaughnessy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Conner Shaughnessy","raw_affiliation_strings":["The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051677321","display_name":"Jharna R. Das","orcid":"https://orcid.org/0000-0003-1853-1646","observed_orcids":["https://orcid.org/0000-0003-1853-1646"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jharna R. Das","raw_affiliation_strings":["The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035026267","display_name":"Sree Rayavarapu","orcid":"https://orcid.org/0000-0002-5833-4711","observed_orcids":["https://orcid.org/0000-0002-5833-4711"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sree Rayavarapu","raw_affiliation_strings":["The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051366982","display_name":"Kristy J. Brown","orcid":"https://orcid.org/0000-0002-1047-4328","observed_orcids":["https://orcid.org/0000-0002-1047-4328"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristy J. Brown","raw_affiliation_strings":["The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055238958","display_name":"Patricio E. Ray","orcid":"https://orcid.org/0000-0003-2223-9584","observed_orcids":["https://orcid.org/0000-0003-2223-9584"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricio E. Ray","raw_affiliation_strings":["The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024664136","display_name":"Kanneboyina Nagaraju","orcid":"https://orcid.org/0000-0002-1601-8489","observed_orcids":["https://orcid.org/0000-0002-1601-8489"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kanneboyina Nagaraju","raw_affiliation_strings":["The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112406996","display_name":"John N. van den Anker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John N. van den Anker","raw_affiliation_strings":["The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086088688","display_name":"Eric P. Hoffman","orcid":"https://orcid.org/0000-0001-6470-5139","observed_orcids":["https://orcid.org/0000-0001-6470-5139","https://orcid.org/0000-0002-7172-6592"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric P. Hoffman","raw_affiliation_strings":["The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081715473","display_name":"Yetrib Hathout","orcid":"https://orcid.org/0000-0002-7549-0476","observed_orcids":["https://orcid.org/0000-0002-7549-0476"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yetrib Hathout","raw_affiliation_strings":["The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Centers for Genetic Medicine Research and Translational Science, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I1336742384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081715473"],"corresponding_institution_ids":["https://openalex.org/I1336742384"],"apc_list":{"value":2530,"currency":"USD","value_usd":2530},"apc_paid":{"value":2530,"currency":"USD","value_usd":2530},"fwci":1.7165,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.82385096,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"2","issue":null,"first_page":"838","last_page":"849"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.6538000106811523,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.6538000106811523,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.08619999885559082,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.07590000331401825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/duchenne-muscular-dystrophy","display_name":"Duchenne muscular dystrophy","score":0.843999981880188},{"id":"https://openalex.org/keywords/mdx-mice","display_name":"mdx mice","score":0.8169999718666077},{"id":"https://openalex.org/keywords/kidney-injury","display_name":"kidney injury","score":0.5680000185966492},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.7200000286102295},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.8159999847412109},{"id":"https://openalex.org/keywords/meprin-a","display_name":"meprin A","score":0.8220000267028809},{"id":"https://openalex.org/keywords/clusterin","display_name":"clusterin","score":0.8709999918937683},{"id":"https://openalex.org/keywords/exon-skipping","display_name":"exon skipping","score":0.5920000076293945},{"id":"https://openalex.org/keywords/treatment-monitoring","display_name":"treatment monitoring","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C2778750056","wikidata":"https://www.wikidata.org/wiki/Q24976962","display_name":"mdx mouse","level":4,"score":0.7559174299240112},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6354146599769592},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.6341725587844849},{"id":"https://openalex.org/C2778943923","wikidata":"https://www.wikidata.org/wiki/Q1648484","display_name":"Duchenne muscular dystrophy","level":2,"score":0.6332775950431824},{"id":"https://openalex.org/C2776174234","wikidata":"https://www.wikidata.org/wiki/Q974792","display_name":"Albuminuria","level":3,"score":0.5741919279098511},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5355579257011414},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5192780494689941},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5155063271522522},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.5001616477966309},{"id":"https://openalex.org/C2779476363","wikidata":"https://www.wikidata.org/wiki/Q14864935","display_name":"Clusterin","level":3,"score":0.47755393385887146},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4757768213748932},{"id":"https://openalex.org/C2780394045","wikidata":"https://www.wikidata.org/wiki/Q412285","display_name":"Dystrophin","level":3,"score":0.4653976857662201},{"id":"https://openalex.org/C2778776201","wikidata":"https://www.wikidata.org/wiki/Q3474283","display_name":"Exon skipping","level":5,"score":0.4608151316642761},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4461921155452728},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30843350291252136},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.1404973864555359},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08742016553878784},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.05690467357635498},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.toxrep.2015.05.008","doi":"https://doi.org/10.1016/j.toxrep.2015.05.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.toxrep.2015.05.008","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2214750015300019/pdf","source":{"id":"https://openalex.org/S2764757124","display_name":"Toxicology Reports","issn_l":"2214-7500","issn":["2214-7500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Reports","raw_type":"journal-article"},{"id":"pmid:26213685","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26213685","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4512206","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4512206/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicol Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:125cba0abb4b4b699ceae9c3fc968255","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/125cba0abb4b4b699ceae9c3fc968255","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Toxicology Reports, Vol 2, Iss C, Pp 838-849 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.toxrep.2015.05.008","doi":"https://doi.org/10.1016/j.toxrep.2015.05.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.toxrep.2015.05.008","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2214750015300019/pdf","source":{"id":"https://openalex.org/S2764757124","display_name":"Toxicology Reports","issn_l":"2214-7500","issn":["2214-7500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1151281518","display_name":null,"funder_award_id":"UL1RR031988","funder_id":"https://openalex.org/F4320338296","funder_display_name":"National Center for Medical Rehabilitation Research"},{"id":"https://openalex.org/G1902493050","display_name":null,"funder_award_id":"R01 DK-049419","funder_id":"https://openalex.org/F4320338296","funder_display_name":"National Center for Medical Rehabilitation Research"},{"id":"https://openalex.org/G2354744749","display_name":"Role of cytokines and APOL-1 in the pathogenesis of childhood HIV associated nephrology","funder_award_id":"R01DK103564","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2600627288","display_name":"Pediatric toxicity and efficacy in long-term systemic treatment with anti-sense","funder_award_id":"U54HD071601","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G2822494612","display_name":null,"funder_award_id":"U54-HD07160","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3736328150","display_name":"Clinical and Translational Science Institute at Children's National","funder_award_id":"UL1RR031988","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5561503428","display_name":null,"funder_award_id":"2R24HD050846-06","funder_id":"https://openalex.org/F4320338296","funder_display_name":"National Center for Medical Rehabilitation Research"},{"id":"https://openalex.org/G8176285925","display_name":"NCMRR-DC Core Molecular & Functional Outcome Measures in Rehabilitation Medicine","funder_award_id":"R24HD050846","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000917478","display_name":"Role of bFGF low affinity receptors in childhood HIVAN","funder_award_id":"R01DK049419","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320338296","display_name":"National Center for Medical Rehabilitation Research","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W305388707.pdf","grobid_xml":"https://content.openalex.org/works/W305388707.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1510644906","https://openalex.org/W1532018718","https://openalex.org/W1533447420","https://openalex.org/W1771343264","https://openalex.org/W1824984326","https://openalex.org/W1883002930","https://openalex.org/W1963653657","https://openalex.org/W1964257757","https://openalex.org/W1965320523","https://openalex.org/W1966012948","https://openalex.org/W1966216482","https://openalex.org/W1973688956","https://openalex.org/W1975380783","https://openalex.org/W1982213575","https://openalex.org/W1989566133","https://openalex.org/W1997340271","https://openalex.org/W2000966154","https://openalex.org/W2013221937","https://openalex.org/W2014447726","https://openalex.org/W2021078343","https://openalex.org/W2030234137","https://openalex.org/W2033178776","https://openalex.org/W2042334532","https://openalex.org/W2047985986","https://openalex.org/W2048598064","https://openalex.org/W2052451576","https://openalex.org/W2060059504","https://openalex.org/W2060119915","https://openalex.org/W2060383118","https://openalex.org/W2061069563","https://openalex.org/W2062284178","https://openalex.org/W2062442451","https://openalex.org/W2066950610","https://openalex.org/W2069146205","https://openalex.org/W2073262653","https://openalex.org/W2074531756","https://openalex.org/W2076827123","https://openalex.org/W2078661860","https://openalex.org/W2078873770","https://openalex.org/W2087909874","https://openalex.org/W2089033994","https://openalex.org/W2089229823","https://openalex.org/W2089778239","https://openalex.org/W2101279029","https://openalex.org/W2101412937","https://openalex.org/W2108301048","https://openalex.org/W2114790187","https://openalex.org/W2115786681","https://openalex.org/W2116408316","https://openalex.org/W2118019726","https://openalex.org/W2122933784","https://openalex.org/W2124980946","https://openalex.org/W2139511511","https://openalex.org/W2144901332","https://openalex.org/W2145297164","https://openalex.org/W2153119343","https://openalex.org/W2154477830","https://openalex.org/W2157085976","https://openalex.org/W2158156749","https://openalex.org/W2162510215","https://openalex.org/W2162767053","https://openalex.org/W2164301446","https://openalex.org/W2165041545","https://openalex.org/W2176987607","https://openalex.org/W2368941655","https://openalex.org/W2405856919","https://openalex.org/W2409331300","https://openalex.org/W2419618309","https://openalex.org/W2430311900","https://openalex.org/W6717023605","https://openalex.org/W6718429616"],"related_works":["https://openalex.org/W4404181603","https://openalex.org/W6989852168","https://openalex.org/W3205429229","https://openalex.org/W4304182663","https://openalex.org/W2158041351","https://openalex.org/W2192870314","https://openalex.org/W4400525110","https://openalex.org/W2085148213","https://openalex.org/W2007123925","https://openalex.org/W2952588119"],"abstract_inverted_index":{"Phosphorodiamidate":[0,271],"morpholino":[1,272],"oligonucleotides":[2],"(PMO)":[3],"are":[4,36],"used":[5],"as":[6,221],"a":[7,46,110],"promising":[8],"exon-skipping":[9],"gene":[10],"therapy":[11,24],"for":[12,78],"Duchenne":[13],"Muscular":[14],"Dystrophy":[15],"(DMD).":[16],"One":[17],"potential":[18,222],"complication":[19],"of":[20,67,72,88,105,125,144,230,245,254],"high":[21,112,262],"dose":[22,113,263],"PMO":[23,68,115,150,205],"is":[25],"its":[26],"transient":[27,154,227],"accumulation":[28,229],"in":[29,55,140,186,215,257,268],"the":[30,65,70,73,84,89,94,102,166,174,176,208,226,243,246],"kidneys.":[31],"Therefore":[32],"new":[33,61,251],"urinary":[34,142],"biomarkers":[35,62,253],"needed":[37],"to":[38,59,63,93,164,196,224,249],"monitor":[39,64,225],"this":[40,269],"treatment.":[41],"Here,":[42],"we":[43],"carried":[44],"out":[45],"pilot":[47],"proteomic":[48],"profiling":[49],"study":[50],"using":[51],"stable":[52],"isotope":[53],"labeling":[54],"mammals":[56],"(SILAM)":[57],"strategy":[58],"identify":[60,250],"effect":[66],"on":[69],"kidneys":[71],"dystrophin":[74],"deficient":[75],"mouse":[76,91,107],"model":[77],"DMD":[79],"(mdx-23).":[80],"We":[81],"first":[82],"assessed":[83],"baseline":[85,167],"renal":[86,103,126,155,228,255],"status":[87,168],"mdx-23":[90,106,121,258],"compared":[92],"wild":[95],"type":[96],"(C57BL10)":[97],"mouse,":[98],"and":[99,138,162,202,217],"then":[100,194],"followed":[101,179],"outcome":[104],"treated":[108,260],"with":[109,261],"single":[111],"intravenous":[114],"injection":[116],"(800":[117],"mg/kg).":[118],"Surprisingly,":[119],"untreated":[120],"mice":[122,259],"showed":[123],"evidence":[124],"injury":[127,147,256],"at":[128,159,169,191,199],"baseline,":[129],"which":[130,157,234],"was":[131],"manifested":[132],"by":[133,180,237],"albuminuria,":[134],"increased":[135],"urine":[136],"output,":[137],"changes":[139,185],"established":[141],"biomarker":[143],"acute":[145],"kidney":[146],"(AKI).":[148],"The":[149],"treatment":[151],"induced":[152],"further":[153],"injury,":[156],"peaked":[158],"7":[160,201],"days,":[161],"returned":[163,195],"almost":[165],"30":[170,203],"days":[171],"post-treatment.":[172],"In":[173,207],"kidney,":[175],"SILAM":[177,210,247],"approach":[178,211,248],"western":[181],"blot":[182],"validation":[183],"identified":[184,212],"Meprin":[187],"A":[188],"subunit":[189],"alpha":[190],"day":[192,200],"2,":[193],"normal":[197],"levels":[198],"after":[204],"injection.":[206],"urine,":[209],"an":[213],"increase":[214],"Clusterin":[216],"\u03b3-glutamyl":[218],"transpeptidase":[219],"1":[220],"candidates":[223],"PMO.":[231,264],"These":[232],"results,":[233],"were":[235],"confirmed":[236],"Western":[238],"blots":[239],"or":[240],"ELISA,":[241],"demonstrate":[242],"value":[244],"candidate":[252],"Chemical":[265],"compounds":[266],"studied":[267],"article:":[270],"(PubChem":[273,277,282,286,290,294],"CID:":[274,278,283,287,291,295],"22140692);":[275],"isoflurane":[276],"3763);":[279],"formic":[280],"acid":[281],"284);":[284],"acetonitrile":[285],"6342);":[288],"acetone":[289],"180);":[292],"methanol":[293],"887).":[296]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}