{"id":"https://openalex.org/W305322298","doi":null,"title":"Update in internal medicine: intensive glucose lowering does not reduce mortality in type 2 diabetes mellitus.","display_name":"Update in internal medicine: intensive glucose lowering does not reduce mortality in type 2 diabetes mellitus.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W305322298","mag":"305322298","pmid":"https://pubmed.ncbi.nlm.nih.gov/23118827","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3484804"},"language":"en","primary_location":{"id":"pmid:23118827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23118827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Maedica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3484804/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015911274","display_name":"Cristian B\u0103icu\u015f","orcid":"https://orcid.org/0000-0002-7954-0098","observed_orcids":["https://orcid.org/0000-0002-7954-0098"]},"institutions":[{"id":"https://openalex.org/I4210153981","display_name":"Spitalul Clinic Colentina","ror":"https://ror.org/04fkbqt11","country_code":"RO","type":"healthcare","lineage":["https://openalex.org/I4210153981"]}],"countries":["RO"],"is_corresponding":true,"raw_author_name":"Cristian Baicus","raw_affiliation_strings":["Colentina University Hospital, Internal Medicine, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colentina University Hospital, Internal Medicine, Bucharest, Romania","institution_ids":["https://openalex.org/I4210153981"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015911274"],"corresponding_institution_ids":["https://openalex.org/I4210153981"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"1","first_page":"87","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9739999771118164},{"id":"https://openalex.org/keywords/intensive-glycemic-control","display_name":"tight glycemic control","score":0.9610000252723694},{"id":"https://openalex.org/keywords/glycemic-targets","display_name":"glycemic targets","score":0.8349999785423279},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.8700000047683716},{"id":"https://openalex.org/keywords/microvascular-complications","display_name":"microvascular complications","score":0.7910000085830688},{"id":"https://openalex.org/keywords/retinopathy","display_name":"retinopathy","score":0.7639999985694885},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.843999981880188},{"id":"https://openalex.org/keywords/american-diabetes-association-recommendations","display_name":"American Diabetes Association recommendations","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9100936651229858},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7136508822441101},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.630876362323761},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.6027698516845703},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5518574714660645},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5383296012878418},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.5232409834861755},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.49035072326660156},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.48054057359695435},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.477205365896225},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.44685134291648865},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4393082559108734},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19828739762306213}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:23118827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23118827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Maedica","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3484804","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3484804/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Maedica (Bucur)","raw_type":"Text"},{"id":"mag:305322298","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23118827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3484804","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3484804/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Maedica (Bucur)","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W1998186571","https://openalex.org/W2115653936"],"related_works":["https://openalex.org/W1991418188","https://openalex.org/W1968617793","https://openalex.org/W2130442610","https://openalex.org/W1998513529","https://openalex.org/W2129267743","https://openalex.org/W2122210971","https://openalex.org/W74543752","https://openalex.org/W1972581481","https://openalex.org/W7098053009","https://openalex.org/W1985229498"],"abstract_inverted_index":{"After":[0],"several":[1],"large":[2],"RCTs":[3],"did":[4],"not":[5,66,75,95,122,216],"succeed":[6],"in":[7,17,147,152,218,240,281],"showing":[8],"mortality":[9,73,195,280],"or":[10,98,254],"cardiovascular":[11,252],"benefits":[12],"with":[13,19,58,82,160,176,242,257],"intensive":[14,59,89,170,212,267],"glucose":[15,93,114,171,213,238],"control":[16,90,115,172,214,239],"patients":[18,151,175,241],"type":[20,219],"2":[21,220],"diabetes":[22,157,179,221],"mellitus,":[23,158],"two":[24,203],"recent":[25],"metaanalysis":[26,204],"confirmed":[27],"this":[28,78,153],"(1,2).\r\n\r\nThey":[29],"were":[30,56,276],"performed":[31],"on":[32],"14":[33],"and":[34,41,54,120,149,163,180,249,273,284],"13":[35],"randomized":[36],"controlled":[37],"trials,":[38],"including":[39],"28,600":[40],"34,500":[42],"patients,":[43,283],"respectively.\r\n\r\nThe":[44],"risks":[45],"of":[46,51,91,106,125,137,197,201,211],"myocardial":[47],"infarction,":[48],"a":[49,208,235],"composite":[50],"microvascular":[52,118,255],"outcomes,":[53],"retinopathy":[55],"decreased":[57],"control,":[60,270],"but":[61,77,102],"the":[62,104,127,167,194,226,262,287],"information":[63],"size":[64],"was":[65,74],"sufficient":[67],"to":[68,110,144,189,278],"confirm":[69],"these":[70,202,282],"benefits.":[71],"Cardiovascular":[72],"decreased,":[76],"result":[79],"may":[80,140,173],"change":[81],"future":[83],"study.\r\n\r\nWe":[84],"are":[85],"confident":[86],"now":[87],"that":[88,169,207],"blood":[92,268],"does":[94,121],"lengthen":[96],"life":[97,247],"decrease":[99],"nephropathy":[100],"risk,":[101],"doubles":[103],"occurrence":[105],"hypoglycemia":[107],"severe":[108],"enough":[109],"warrant":[111],"intervention.":[112],"Tight":[113],"slightly":[116],"reduces":[117],"complications,":[119,256],"improve":[123],"quality":[124],"life.\r\n\r\nHowever,":[126],"evidence":[128],"is,":[129],"as":[130],"always,":[131],"somewhat":[132],"incomplete.":[133],"The":[134],"mean":[135],"follow-up":[136],"5":[138],"years":[139],"be":[141,286],"too":[142],"short":[143],"show":[145],"reductions":[146],"mortality,":[148],"most":[150],"analysis":[154],"had":[155],"long-standing":[156],"sometimes":[159],"vascular":[161,183],"disease,":[162],"we":[164],"cannot":[165],"exclude":[166],"possibility":[168],"benefit":[174],"newly":[177],"diagnosed":[178,244],"no":[181,250],"preexisting":[182],"disease.":[184],"Metformin":[185],"have":[186,190],"been":[187],"shown":[188],"pleiotropic":[191],"effects,":[192],"decreasing":[193],"independent":[196],"glycemic":[198],"control.\r\n\r\nThe":[199],"findings":[200],"tell":[205],"us":[206],"generalized":[209],"strategy":[210],"is":[215],"beneficial":[217],"mellitus.":[222],"Recent":[223],"recommendations":[224],"from":[225],"American":[227],"Diabetes":[228],"Association":[229],"suggest":[230],"an":[231],"individualized":[232],"approach,":[233],"trying":[234],"more":[236],"tight":[237],"recently":[243],"diabetes,":[245],"long":[246],"expectancy,":[248],"significant":[251],"disease":[253],"less":[258],"stringent":[259],"goals":[260],"for":[261],"others.":[263],"In":[264],"fact,":[265],"only":[266],"pressure":[269],"lipid":[271],"lowering":[272],"smoking":[274],"cessation":[275],"showed":[277],"reduce":[279],"should":[285],"primary":[288],"goals.":[289]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
