{"id":"https://openalex.org/W3049718907","doi":"https://doi.org/10.1002/hep.31523","title":"The Commensal Microbe V eillonella as a Marker for Response to an FGF19 Analog in NASH","display_name":"The Commensal Microbe V eillonella as a Marker for Response to an FGF19 Analog in NASH","publication_year":2020,"publication_date":"2020-08-14","ids":{"openalex":"https://openalex.org/W3049718907","doi":"https://doi.org/10.1002/hep.31523","mag":"3049718907","pmid":"https://pubmed.ncbi.nlm.nih.gov/32794259","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7898628"},"language":"en","primary_location":{"id":"doi:10.1002/hep.31523","doi":"https://doi.org/10.1002/hep.31523","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.31523","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1002/hep.31523","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052059601","display_name":"Rohit Seth Loomba","orcid":"https://orcid.org/0000-0002-4845-9991","observed_orcids":["https://orcid.org/0000-0002-4845-9991"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rohit Loomba","raw_affiliation_strings":["NAFLD Research Center,University of California, San Diego,La Jolla,CA"],"raw_orcid":"https://orcid.org/0000-0002-4845-9991","affiliations":[{"raw_affiliation_string":"NAFLD Research Center,University of California, San Diego,La Jolla,CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101728380","display_name":"Lei Ling","orcid":"https://orcid.org/0000-0002-5051-9797","observed_orcids":["https://orcid.org/0000-0002-5051-9797"]},"institutions":[{"id":"https://openalex.org/I4210121250","display_name":"NGM Biopharmaceuticals (United States)","ror":"https://ror.org/01x8fkj71","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121250"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lei Ling","raw_affiliation_strings":["Clinical Research,NGM Biopharmaceuticals Inc.,South San Francisco,CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research,NGM Biopharmaceuticals Inc.,South San Francisco,CA","institution_ids":["https://openalex.org/I4210121250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039175735","display_name":"Duy M. Dinh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Duy M. Dinh","raw_affiliation_strings":["Diversigen, Inc.,Houston,TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diversigen, Inc.,Houston,TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041247266","display_name":"Alex M. DePaoli","orcid":"https://orcid.org/0000-0001-6365-6099","observed_orcids":["https://orcid.org/0000-0001-6365-6099"]},"institutions":[{"id":"https://openalex.org/I4210121250","display_name":"NGM Biopharmaceuticals (United States)","ror":"https://ror.org/01x8fkj71","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex M. DePaoli","raw_affiliation_strings":["Clinical Research,NGM Biopharmaceuticals Inc.,South San Francisco,CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research,NGM Biopharmaceuticals Inc.,South San Francisco,CA","institution_ids":["https://openalex.org/I4210121250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017311913","display_name":"Hsiao Dee Lieu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121250","display_name":"NGM Biopharmaceuticals (United States)","ror":"https://ror.org/01x8fkj71","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hsiao D. Lieu","raw_affiliation_strings":["Clinical Research,NGM Biopharmaceuticals Inc.,South San Francisco,CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research,NGM Biopharmaceuticals Inc.,South San Francisco,CA","institution_ids":["https://openalex.org/I4210121250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091625375","display_name":"Stephen A. Harrison","orcid":"https://orcid.org/0000-0001-8285-2204","observed_orcids":["https://orcid.org/0000-0001-8285-2204","https://orcid.org/0000-0001-6399-5744"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210117664","display_name":"Pinnacle Clinical Research","ror":"https://ror.org/02k5hnj64","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117664"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Stephen A. Harrison","raw_affiliation_strings":["Pinnacle Clinical Research,San Antonio,CA","Radcliffe Department of Medicine,University of Oxford,London,United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pinnacle Clinical Research,San Antonio,CA","institution_ids":["https://openalex.org/I4210117664"]},{"raw_affiliation_string":"Radcliffe Department of Medicine,University of Oxford,London,United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070639714","display_name":"Arun Jayant Sanyal","orcid":"https://orcid.org/0000-0001-8682-5748","observed_orcids":["https://orcid.org/0000-0001-8682-5748"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arun J. Sanyal","raw_affiliation_strings":["Department of Internal Medicine,Virginia Commonwealth University,Richmond,VA"],"raw_orcid":"https://orcid.org/0000-0001-8682-5748","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine,Virginia Commonwealth University,Richmond,VA","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5052059601","https://openalex.org/A5101728380"],"corresponding_institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210121250"],"apc_list":{"value":2400,"currency":"USD","value_usd":2400},"apc_paid":{"value":2400,"currency":"USD","value_usd":2400},"fwci":4.2964,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.96186974,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"73","issue":"1","first_page":"126","last_page":"143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/veillonella","display_name":"Veillonella","score":0.9259999990463257},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.8980000019073486},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9580000042915344},{"id":"https://openalex.org/keywords/bile-acids","display_name":"bile acids","score":0.8840000033378601},{"id":"https://openalex.org/keywords/microbiome-host-interactions","display_name":"microbiome-host interactions","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C2778753313","wikidata":"https://www.wikidata.org/wiki/Q7918682","display_name":"Veillonella","level":4,"score":0.8064486384391785},{"id":"https://openalex.org/C2775936931","wikidata":"https://www.wikidata.org/wiki/Q18034920","display_name":"FGF19","level":4,"score":0.6600155234336853},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.6103311777114868},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5800626277923584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5642288327217102},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.5539231300354004},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49821901321411133},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4974680244922638},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.48823097348213196},{"id":"https://openalex.org/C2775980262","wikidata":"https://www.wikidata.org/wiki/Q218870","display_name":"Prebiotic","level":2,"score":0.47474509477615356},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.42858558893203735},{"id":"https://openalex.org/C2780423288","wikidata":"https://www.wikidata.org/wiki/Q7242440","display_name":"Prevotella","level":3,"score":0.4205029308795929},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.4175901412963867},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3708838224411011},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.32321739196777344},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30939221382141113},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.29713523387908936},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28064969182014465},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24692347645759583},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23157349228858948},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.19319093227386475},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.19210708141326904},{"id":"https://openalex.org/C2778276568","wikidata":"https://www.wikidata.org/wiki/Q190161","display_name":"Streptococcus","level":3,"score":0.17693322896957397},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14294910430908203},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09622466564178467},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014678","descriptor_name":"Veillonella","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014678","descriptor_name":"Veillonella","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/hep.31523","doi":"https://doi.org/10.1002/hep.31523","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.31523","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7898628","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7898628","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"Text"},{"id":"pmid:32794259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32794259","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt1k58n56m","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1k58n56m","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hepatology, vol 73, iss 1","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/hep.31523","doi":"https://doi.org/10.1002/hep.31523","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.31523","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3109222642","display_name":"DETECTION AND MODELS OF TOXICANT EXPOSURE","funder_award_id":"P42ES010337","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000875062","display_name":"San Diego Digestive Diseases Research Center","funder_award_id":"P30DK120515","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W8935401","https://openalex.org/W1555526329","https://openalex.org/W1964027278","https://openalex.org/W1974616640","https://openalex.org/W1975170354","https://openalex.org/W1980914602","https://openalex.org/W2035378093","https://openalex.org/W2104891233","https://openalex.org/W2132406938","https://openalex.org/W2140571939","https://openalex.org/W2149573313","https://openalex.org/W2171398834","https://openalex.org/W2178380008","https://openalex.org/W2214871873","https://openalex.org/W2342540743","https://openalex.org/W2412282056","https://openalex.org/W2463836225","https://openalex.org/W2465534016","https://openalex.org/W2467200611","https://openalex.org/W2492004251","https://openalex.org/W2515118880","https://openalex.org/W2524544908","https://openalex.org/W2611418622","https://openalex.org/W2765324118","https://openalex.org/W2790364467","https://openalex.org/W2793275191","https://openalex.org/W2793865429","https://openalex.org/W2802404986","https://openalex.org/W2803013275","https://openalex.org/W2885120336","https://openalex.org/W2889488090","https://openalex.org/W2890123251","https://openalex.org/W2891522467","https://openalex.org/W2900274665","https://openalex.org/W2905340379","https://openalex.org/W2909812323","https://openalex.org/W2918007312","https://openalex.org/W2921756348","https://openalex.org/W2933882285","https://openalex.org/W2949339202","https://openalex.org/W2957171936","https://openalex.org/W2995808322","https://openalex.org/W2998972147","https://openalex.org/W3016040653","https://openalex.org/W3040384889","https://openalex.org/W4251445305"],"related_works":["https://openalex.org/W3048169322","https://openalex.org/W3132063234","https://openalex.org/W4220846214","https://openalex.org/W3208716545","https://openalex.org/W4255371666","https://openalex.org/W4288778766","https://openalex.org/W4386910070","https://openalex.org/W1975170354","https://openalex.org/W4243822396","https://openalex.org/W4395957116"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,70],"AIMS:":[2],"The":[3],"composition":[4],"of":[5,18,21,44,48,74,178,248,266,290,293],"the":[6,19,24,42,49,56,176,179,210,291],"human":[7],"gut":[8,50,57,180,267],"microbiota":[9,25,58],"is":[10,26,243],"linked":[11],"to":[12,28,34,218],"health":[13],"and":[14,16,33,98,128,150,153,172,195,221,274],"disease,":[15],"knowledge":[17],"impact":[20],"therapeutics":[22],"on":[23,55,147],"essential":[27],"decipher":[29],"their":[30],"biological":[31],"roles":[32],"gain":[35],"new":[36],"mechanistic":[37],"insights.":[38],"Here":[39],"we":[40],"report":[41],"effect":[43],"aldafermin,":[45,190],"an":[46,263],"analog":[47],"hormone":[51],"FGF19,":[52],"versus":[53],"placebo":[54,136],"in":[59,65,186,209,228,253,256,277],"a":[60,205,214,237,287],"prospective,":[61],"phase":[62],"2":[63],"study":[64,261],"patients":[66,76,162,187],"with":[67,77,189,191,202,226],"NASH.":[68,283],"APPROACH":[69],"RESULTS:":[71],"A":[72],"total":[73],"176":[75],"biopsy-confirmed":[78],"nonalcoholic":[79],"steatohepatitis":[80],"(NASH)":[81],"(nonalcoholic":[82],"fatty":[83],"liver":[84,100],"disease":[85],"activity":[86],"score":[87],"\u2265":[88],"4),":[89],"fibrosis":[90],"(F1-F3":[91],"by":[92,105,245],"NASH":[93],"Clinical":[94],"Research":[95],"Network":[96],"criteria),":[97],"elevated":[99],"fat":[101,110],"content":[102],"(\u2265":[103],"8%":[104],"magnetic":[106],"resonance":[107],"imaging-proton":[108],"density":[109],"fraction)":[111],"received":[112],"0.3":[113],"mg":[114,119,124,130],"(n":[115,120,125,131,137],"=":[116,121,126,132,138],"23),":[117],"1":[118,149,171],"49),":[122,127],"3":[123],"6":[129],"28)":[133],"aldafermin":[134,203,281],"or":[135],"27)":[139],"for":[140,282],"12":[141,152],"weeks.":[142],"Stool":[143],"samples":[144],"were":[145],"collected":[146],"day":[148,170],"week":[151,173],"profiled":[154],"using":[155],"16S":[156],"ribosomal":[157],"RNA":[158],"gene":[159],"sequencing;":[160],"122":[161],"had":[163],"paired":[164],"stool":[165],"microbiome":[166],"profiles":[167],"at":[168],"both":[169],"12.":[174],"Overall,":[175],"state":[177],"microbial":[181],"community":[182],"was":[183],"distinctly":[184],"stable":[185],"treated":[188,201],"all":[192],"major":[193],"phyla":[194],"genera":[196],"unaltered":[197],"during":[198],"therapy.":[199],"Patients":[200],"showed":[204],"significant,":[206],"dose-dependent":[207],"enrichment":[208,242],"rare":[211],"genus":[212],"Veillonella,":[213],"commensal":[215],"microbe":[216],"known":[217],"have":[219],"lactate-degrading":[220],"performance-enhancing":[222],"properties,":[223],"which":[224],"correlated":[225],"changes":[227],"serum":[229,269],"bile":[230,238,249,258,270],"acid":[231,250,271],"profile.":[232],"CONCLUSIONS:":[233],"Veillonella":[234],"may":[235],"be":[236],"acid-sensitive":[239],"bacteria":[240],"whose":[241],"enabled":[244],"aldafermin-mediated":[246],"suppression":[247],"synthesis":[251],"and,":[252],"particular,":[254],"decreases":[255],"toxic":[257],"acids.":[259],"This":[260],"provides":[262],"integrated":[264],"analysis":[265],"microbiome,":[268],"metabolome,":[272],"imaging,":[273],"histological":[275],"measurements":[276],"clinical":[278],"trials":[279],"testing":[280],"Our":[284],"results":[285],"provide":[286],"better":[288],"understanding":[289],"intricacies":[292],"microbiome-host":[294],"interactions":[295],"(clinicaltrials.gov":[296],"trial":[297],"No.":[298],"NCT02443116).":[299]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-08-21T00:00:00"}
