{"id":"https://openalex.org/W304967946","doi":"https://doi.org/10.13028/drhm-q743","title":"Inhibition of Protein Tyrosine Phosphatase 1B by Polyphenol Natural Products: Relevant to Diabetes Management","display_name":"Inhibition of Protein Tyrosine Phosphatase 1B by Polyphenol Natural Products: Relevant to Diabetes Management","publication_year":2020,"publication_date":"2020-06-22","ids":{"openalex":"https://openalex.org/W304967946","doi":"https://doi.org/10.13028/drhm-q743","mag":"304967946"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.umassmed.edu:cts_retreat-1313","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.umassmed.edu/cts_retreat/2014/posters/93","pdf_url":null,"source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"UMass Center for Clinical and Translational Science Research Retreat","raw_type":"text"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.umassmed.edu/cts_retreat/2014/posters/93","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100321225","display_name":"Zhiwei Liu","orcid":"https://orcid.org/0009-0000-6410-1466","observed_orcids":["https://orcid.org/0009-0000-6410-1466"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu, Zhiwei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020451831","display_name":"Maolin Guo","orcid":"https://orcid.org/0000-0002-9330-9239","observed_orcids":["https://orcid.org/0000-0002-9330-9239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guo, Maolin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00030439,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ptp1b","display_name":"PTP1B","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ptp1b-inhibition","display_name":"PTP1B inhibition","score":0.9269999861717224},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.9919999837875366},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.9509999752044678},{"id":"https://openalex.org/keywords/diabetes-management","display_name":"diabetes management","score":0.8899999856948853},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9539999961853027},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8289999961853027},{"id":"https://openalex.org/keywords/michaelis-menten-kinetics","display_name":"Michaelis-Menten kinetics","score":0.9810000061988831},{"id":"https://openalex.org/keywords/inhibition-constant","display_name":"inhibition constant","score":0.4869999885559082},{"id":"https://openalex.org/keywords/hydroxyl-group-substitution","display_name":"hydroxyl group substitution","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.594555139541626},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.4921674132347107},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.46171900629997253},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.45382580161094666},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4482175409793854},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4416120946407318},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.36224690079689026},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27663081884384155},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2034660279750824},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:escholarship.umassmed.edu:cts_retreat-1313","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.umassmed.edu/cts_retreat/2014/posters/93","pdf_url":null,"source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"UMass Center for Clinical and Translational Science Research Retreat","raw_type":"text"},{"id":"mag:304967946","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1313&context=cts_retreat","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"doi:10.13028/drhm-q743","doi":"https://doi.org/10.13028/drhm-q743","is_oa":true,"landing_page_url":"https://doi.org/10.13028/drhm-q743","pdf_url":null,"source":{"id":"https://openalex.org/S7407053131","display_name":"University of Massachusetts (UMass) Chan Medical School","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:escholarship.umassmed.edu:cts_retreat-1313","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.umassmed.edu/cts_retreat/2014/posters/93","pdf_url":null,"source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"UMass Center for Clinical and Translational Science Research Retreat","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4221122216","https://openalex.org/W2949432727","https://openalex.org/W4384926822","https://openalex.org/W4398216027","https://openalex.org/W2915639293","https://openalex.org/W2808432505","https://openalex.org/W2300837561","https://openalex.org/W2096653160","https://openalex.org/W3023031392","https://openalex.org/W4310354866"],"abstract_inverted_index":{"Many":[0],"biologically":[1],"active":[2],"polyphenols":[3,76],"have":[4,52,61],"been":[5,32,53,62],"recognized":[6],"for":[7,37,64,124],"their":[8,15,21],"beneficial":[9],"effects":[10,43],"in":[11,70],"managing":[12],"diabetes":[13],"and":[14,86,98,120],"complications.":[16],"However,":[17],"the":[18,40,74,105,121,130],"mechanisms":[19],"behind":[20],"functions":[22],"are":[23],"poorly":[24],"understood.":[25],"As":[26],"protein-tyrosine":[27],"phosphatase":[28],"1B":[29],"(PTP1B)":[30],"has":[31],"identified":[33,63],"as":[34],"a":[35,45,93],"target":[36],"anti-diabetic":[38],"agents,":[39],"potential":[41],"inhibitory":[42,59,106],"of":[44,66,101,110,112],"dozen":[46],"structurally":[47],"diverse":[48],"polyphenol":[49],"natural":[50],"products":[51],"investigated.":[54],"Among":[55],"these":[56],"polyphenols,":[57],"potent":[58],"activities":[60],"6":[65],"them":[67],"with":[68,129],"IC50":[69],"micromolar":[71],"range,":[72],"while":[73],"other":[75],"showed":[77],"very":[78],"weak":[79],"inhibition.":[80],"A":[81],"structure-activity":[82],"relationship":[83],"(SAR)":[84],"study":[85],"molecular":[87],"ducking":[88],"results":[89],"suggest":[90],"that":[91],"both":[92],"rigid":[94],"planar":[95],"3-ring":[96],"backbone":[97],"appropriate":[99],"substitutions":[100],"hydroxyl":[102],"groups":[103],"benefit":[104],"activity.":[107],"The":[108],"mechanism":[109],"inhibition":[111,122,131],"PTP1B":[113,125],"was":[114,126],"further":[115],"investigated":[116],"by":[117],"Michaelis-Menten":[118],"kinetics":[119],"mode":[123],"determined":[127],"along":[128],"constant.":[132]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}
