{"id":"https://openalex.org/W3049656208","doi":"https://doi.org/10.1016/j.chembiol.2020.07.020","title":"PROTACs: An Emerging Therapeutic Modality in Precision Medicine","display_name":"PROTACs: An Emerging Therapeutic Modality in Precision Medicine","publication_year":2020,"publication_date":"2020-08-01","ids":{"openalex":"https://openalex.org/W3049656208","doi":"https://doi.org/10.1016/j.chembiol.2020.07.020","mag":"3049656208","pmid":"https://pubmed.ncbi.nlm.nih.gov/32795419","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9424844"},"language":"en","primary_location":{"id":"doi:10.1016/j.chembiol.2020.07.020","doi":"https://doi.org/10.1016/j.chembiol.2020.07.020","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2020.07.020","pdf_url":"http://www.cell.com/article/S2451945620302932/pdf","source":{"id":"https://openalex.org/S4210231961","display_name":"Cell chemical biology","issn_l":"2451-9448","issn":["2451-9448","2451-9456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S2451945620302932/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016038137","display_name":"Dhanusha A. Nalawansha","orcid":"https://orcid.org/0009-0002-1938-6188","observed_orcids":["https://orcid.org/0009-0002-1938-6188"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dhanusha A. Nalawansha","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016866989","display_name":"Craig M. Crews","orcid":"https://orcid.org/0000-0002-8456-2005","observed_orcids":["https://orcid.org/0000-0002-8456-2005"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Craig M. Crews","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA; Department of Chemistry, Yale University, New Haven, CT 06511, USA; Department of Pharmacology, Yale University, New Haven, CT 06511, USA. Electronic address: craig.crews@yale.edu","Department of Chemistry, Yale University, New Haven, CT 06511, USA","Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA","Department of Pharmacology, Yale University, New Haven, CT 06511, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA; Department of Chemistry, Yale University, New Haven, CT 06511, USA; Department of Pharmacology, Yale University, New Haven, CT 06511, USA. Electronic address: craig.crews@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Chemistry, Yale University, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pharmacology, Yale University, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016866989"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":5.6107,"has_fulltext":false,"cited_by_count":514,"citation_normalized_percentile":{"value":0.98301456,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"27","issue":"8","first_page":"998","last_page":"1014"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protacs","display_name":"PROTACs","score":0.9940000176429749},{"id":"https://openalex.org/keywords/targeted-protein-degradation","display_name":"targeted protein degradation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9629999995231628},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.9629999995231628},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.8560000061988831},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.5550000071525574},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6468269228935242},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5506606698036194},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.5362675786018372},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.5316942930221558},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4698692262172699},{"id":"https://openalex.org/C2778473898","wikidata":"https://www.wikidata.org/wiki/Q2145110","display_name":"Repertoire","level":2,"score":0.425180047750473},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3310202658176422},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2951573133468628},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2938934564590454},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1618213951587677},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09542715549468994},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015335","descriptor_name":"Molecular Probes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015335","descriptor_name":"Molecular Probes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.chembiol.2020.07.020","doi":"https://doi.org/10.1016/j.chembiol.2020.07.020","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2020.07.020","pdf_url":"http://www.cell.com/article/S2451945620302932/pdf","source":{"id":"https://openalex.org/S4210231961","display_name":"Cell chemical biology","issn_l":"2451-9448","issn":["2451-9448","2451-9456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Chemical Biology","raw_type":"journal-article"},{"id":"pmid:32795419","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32795419","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9424844","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9424844","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Chem Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.chembiol.2020.07.020","doi":"https://doi.org/10.1016/j.chembiol.2020.07.020","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2020.07.020","pdf_url":"http://www.cell.com/article/S2451945620302932/pdf","source":{"id":"https://openalex.org/S4210231961","display_name":"Cell chemical biology","issn_l":"2451-9448","issn":["2451-9448","2451-9456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Chemical Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6052237592","display_name":"Developing Tumor-specific PROTACs","funder_award_id":"R01CA238570","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000865503","display_name":"Inducing Proximity: An Emerging Paradigm for New Therapeutic Modalities","funder_award_id":"R35CA197589","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W3049656208.pdf"},"referenced_works_count":180,"referenced_works":["https://openalex.org/W1488181101","https://openalex.org/W1512690422","https://openalex.org/W1527383154","https://openalex.org/W1565539350","https://openalex.org/W1966060541","https://openalex.org/W1973371898","https://openalex.org/W1982810302","https://openalex.org/W1982855701","https://openalex.org/W1988013217","https://openalex.org/W1988884933","https://openalex.org/W1991167758","https://openalex.org/W1993263392","https://openalex.org/W1994344724","https://openalex.org/W1995079678","https://openalex.org/W1997952190","https://openalex.org/W2003632864","https://openalex.org/W2010789891","https://openalex.org/W2012347139","https://openalex.org/W2015345028","https://openalex.org/W2017396706","https://openalex.org/W2018339027","https://openalex.org/W2023598683","https://openalex.org/W2025031463","https://openalex.org/W2025870139","https://openalex.org/W2026233197","https://openalex.org/W2028415754","https://openalex.org/W2040444669","https://openalex.org/W2042037931","https://openalex.org/W2073651093","https://openalex.org/W2074440680","https://openalex.org/W2078616374","https://openalex.org/W2083469632","https://openalex.org/W2097164847","https://openalex.org/W2099852670","https://openalex.org/W2100200896","https://openalex.org/W2108401385","https://openalex.org/W2124258829","https://openalex.org/W2131441324","https://openalex.org/W2140197221","https://openalex.org/W2151683271","https://openalex.org/W2154626333","https://openalex.org/W2155324869","https://openalex.org/W2161413435","https://openalex.org/W2167786713","https://openalex.org/W2168395641","https://openalex.org/W2176682109","https://openalex.org/W2227431445","https://openalex.org/W2292464399","https://openalex.org/W2299508065","https://openalex.org/W2323939601","https://openalex.org/W2409568753","https://openalex.org/W2417056655","https://openalex.org/W2470671857","https://openalex.org/W2502703983","https://openalex.org/W2520252945","https://openalex.org/W2530302741","https://openalex.org/W2553908226","https://openalex.org/W2560677837","https://openalex.org/W2563559130","https://openalex.org/W2582081516","https://openalex.org/W2582838961","https://openalex.org/W2585495993","https://openalex.org/W2589026097","https://openalex.org/W2593430295","https://openalex.org/W2594386026","https://openalex.org/W2596064219","https://openalex.org/W2596306432","https://openalex.org/W2597078857","https://openalex.org/W2604930678","https://openalex.org/W2604994143","https://openalex.org/W2607978828","https://openalex.org/W2616534571","https://openalex.org/W2621934513","https://openalex.org/W2735419424","https://openalex.org/W2740493003","https://openalex.org/W2743800043","https://openalex.org/W2767251210","https://openalex.org/W2767426216","https://openalex.org/W2767856718","https://openalex.org/W2769590617","https://openalex.org/W2785263247","https://openalex.org/W2792069216","https://openalex.org/W2792397649","https://openalex.org/W2801986983","https://openalex.org/W2805067921","https://openalex.org/W2805296794","https://openalex.org/W2883077013","https://openalex.org/W2886283685","https://openalex.org/W2890850288","https://openalex.org/W2891213440","https://openalex.org/W2898621430","https://openalex.org/W2899147964","https://openalex.org/W2900888512","https://openalex.org/W2901669535","https://openalex.org/W2903964626","https://openalex.org/W2904458560","https://openalex.org/W2904506792","https://openalex.org/W2908027391","https://openalex.org/W2908223531","https://openalex.org/W2908747386","https://openalex.org/W2909034820","https://openalex.org/W2909353434","https://openalex.org/W2910045313","https://openalex.org/W2911264838","https://openalex.org/W2911596654","https://openalex.org/W2913179893","https://openalex.org/W2913684316","https://openalex.org/W2913940235","https://openalex.org/W2914587883","https://openalex.org/W2916045588","https://openalex.org/W2916668400","https://openalex.org/W2917078121","https://openalex.org/W2917565897","https://openalex.org/W2920736663","https://openalex.org/W2924113881","https://openalex.org/W2924474406","https://openalex.org/W2941268034","https://openalex.org/W2944640816","https://openalex.org/W2944917021","https://openalex.org/W2948220248","https://openalex.org/W2949485830","https://openalex.org/W2949862037","https://openalex.org/W2950911502","https://openalex.org/W2955112289","https://openalex.org/W2956604676","https://openalex.org/W2964430254","https://openalex.org/W2965570073","https://openalex.org/W2968449718","https://openalex.org/W2970042698","https://openalex.org/W2973830180","https://openalex.org/W2974217727","https://openalex.org/W2974568688","https://openalex.org/W2976247988","https://openalex.org/W2978105110","https://openalex.org/W2978960573","https://openalex.org/W2980410567","https://openalex.org/W2981857847","https://openalex.org/W2982554531","https://openalex.org/W2983017086","https://openalex.org/W2983144541","https://openalex.org/W2984957859","https://openalex.org/W2985294481","https://openalex.org/W2987448722","https://openalex.org/W2987737568","https://openalex.org/W2990669650","https://openalex.org/W2991059836","https://openalex.org/W2991853974","https://openalex.org/W2992546470","https://openalex.org/W2994376311","https://openalex.org/W2994492843","https://openalex.org/W2994752266","https://openalex.org/W3000297762","https://openalex.org/W3000673710","https://openalex.org/W3000715281","https://openalex.org/W3002367183","https://openalex.org/W3002542796","https://openalex.org/W3004172643","https://openalex.org/W3004830535","https://openalex.org/W3006981712","https://openalex.org/W3008203358","https://openalex.org/W3008322752","https://openalex.org/W3011240628","https://openalex.org/W3011413773","https://openalex.org/W3011787706","https://openalex.org/W3011997563","https://openalex.org/W3012111617","https://openalex.org/W3012324425","https://openalex.org/W3013296766","https://openalex.org/W3014659512","https://openalex.org/W3019334729","https://openalex.org/W3019413018","https://openalex.org/W3020980340","https://openalex.org/W3021210206","https://openalex.org/W3023706389","https://openalex.org/W3024223733","https://openalex.org/W3036563774","https://openalex.org/W3040830058","https://openalex.org/W3088837103","https://openalex.org/W4255980836","https://openalex.org/W6758098855"],"related_works":["https://openalex.org/W2094853261","https://openalex.org/W2936661052","https://openalex.org/W3198775252","https://openalex.org/W4205379795","https://openalex.org/W7160391118","https://openalex.org/W7215318042","https://openalex.org/W2982554531","https://openalex.org/W3138842056","https://openalex.org/W3153520238","https://openalex.org/W7135040867"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":101},{"year":2025,"cited_by_count":113},{"year":2024,"cited_by_count":81},{"year":2023,"cited_by_count":68},{"year":2022,"cited_by_count":88},{"year":2021,"cited_by_count":56},{"year":2020,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-08-21T00:00:00"}
