{"id":"https://openalex.org/W3049627893","doi":"https://doi.org/10.3390/ijms21165875","title":"The New Model of Snail Expression Regulation: The Role of MRTFs in Fast and Slow Endothelial\u2013Mesenchymal Transition","display_name":"The New Model of Snail Expression Regulation: The Role of MRTFs in Fast and Slow Endothelial\u2013Mesenchymal Transition","publication_year":2020,"publication_date":"2020-08-16","ids":{"openalex":"https://openalex.org/W3049627893","doi":"https://doi.org/10.3390/ijms21165875","mag":"3049627893","pmid":"https://pubmed.ncbi.nlm.nih.gov/32824297","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7461591"},"language":"en","primary_location":{"id":"doi:10.3390/ijms21165875","doi":"https://doi.org/10.3390/ijms21165875","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms21165875","pdf_url":"https://www.mdpi.com/1422-0067/21/16/5875/pdf","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/21/16/5875/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075877759","display_name":"Katarzyna Sobierajska","orcid":"https://orcid.org/0000-0003-3510-0098","observed_orcids":["https://orcid.org/0000-0003-3510-0098"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Katarzyna Sobierajska","raw_affiliation_strings":["Department of Molecular Cell Mechanisms, Medical University of Lodz, 92-215 Lodz, Poland"],"raw_orcid":"https://orcid.org/0000-0003-3510-0098","affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Mechanisms, Medical University of Lodz, 92-215 Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009027416","display_name":"Wojciech Micha\u0142 Ciszewski","orcid":"https://orcid.org/0000-0001-6251-6043","observed_orcids":["https://orcid.org/0000-0001-6251-6043"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Wojciech M. Ciszewski","raw_affiliation_strings":["Department of Molecular Cell Mechanisms, Medical University of Lodz, 92-215 Lodz, Poland"],"raw_orcid":"https://orcid.org/0000-0001-6251-6043","affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Mechanisms, Medical University of Lodz, 92-215 Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040423086","display_name":"Ewa Macierzy\u0144ska-Piotrowska","orcid":"https://orcid.org/0000-0002-9015-442X","observed_orcids":["https://orcid.org/0000-0002-9015-442X"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Ewa Macierzynska-Piotrowska","raw_affiliation_strings":["Department of Molecular Cell Mechanisms, Medical University of Lodz, 92-215 Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Mechanisms, Medical University of Lodz, 92-215 Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010252186","display_name":"Wanda K\u0142opocka","orcid":"https://orcid.org/0000-0003-4277-1949","observed_orcids":["https://orcid.org/0000-0003-4277-1949"]},"institutions":[{"id":"https://openalex.org/I69984877","display_name":"Cardinal Stefan Wyszynski University in Warsaw","ror":"https://ror.org/05sdyjv16","country_code":"PL","type":"education","lineage":["https://openalex.org/I69984877"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Wanda Klopocka","raw_affiliation_strings":["Department of Biochemistry and Cell Biology, Cardinal Stefan Wyszynski University in Warsaw, 01-938 Warsaw, Poland"],"raw_orcid":"https://orcid.org/0000-0003-4277-1949","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, Cardinal Stefan Wyszynski University in Warsaw, 01-938 Warsaw, Poland","institution_ids":["https://openalex.org/I69984877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003657316","display_name":"Patrycja Przygodzka","orcid":"https://orcid.org/0000-0001-7529-8815","observed_orcids":["https://orcid.org/0000-0001-7529-8815"]},"institutions":[{"id":"https://openalex.org/I4210124861","display_name":"Institute for Medical Biology","ror":"https://ror.org/02kstzn75","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210124861","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Patrycja Przygodzka","raw_affiliation_strings":["Institute of Medical Biology, PAS, 93-232 Lodz, Poland"],"raw_orcid":"https://orcid.org/0000-0001-7529-8815","affiliations":[{"raw_affiliation_string":"Institute of Medical Biology, PAS, 93-232 Lodz, Poland","institution_ids":["https://openalex.org/I4210124861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018901764","display_name":"Magdalena Karakula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Magdalena Karakula","raw_affiliation_strings":["Department of Molecular Cell Mechanisms, Medical University of Lodz, 92-215 Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Mechanisms, Medical University of Lodz, 92-215 Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027759080","display_name":"Karolina Pestka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Karolina Pestka","raw_affiliation_strings":["Department of Molecular Cell Mechanisms, Medical University of Lodz, 92-215 Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Mechanisms, Medical University of Lodz, 92-215 Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059247644","display_name":"Marta Ewelina Wawro","orcid":"https://orcid.org/0000-0001-8327-5277","observed_orcids":["https://orcid.org/0000-0001-8327-5277"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marta E. Wawro","raw_affiliation_strings":["Department of Molecular Cell Mechanisms, Medical University of Lodz, 92-215 Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Mechanisms, Medical University of Lodz, 92-215 Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081426420","display_name":"Jolanta Niewiarowska","orcid":"https://orcid.org/0000-0003-0561-7766","observed_orcids":["https://orcid.org/0000-0003-0561-7766"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Jolanta Niewiarowska","raw_affiliation_strings":["Department of Molecular Cell Mechanisms, Medical University of Lodz, 92-215 Lodz, Poland"],"raw_orcid":"https://orcid.org/0000-0003-0561-7766","affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Mechanisms, Medical University of Lodz, 92-215 Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5075877759","https://openalex.org/A5081426420"],"corresponding_institution_ids":["https://openalex.org/I4210122071"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2112},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2112},"fwci":0.6422,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.59257912,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"16","first_page":"5875","last_page":"5875"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.027400000020861626,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-mesenchymal-transition","display_name":"endothelial-to-mesenchymal transition","score":0.9330000281333923},{"id":"https://openalex.org/keywords/snail-transcription-factor","display_name":"Snail transcription factor","score":0.7960000038146973},{"id":"https://openalex.org/keywords/mrtf","display_name":"MRTF","score":0.9330000281333923},{"id":"https://openalex.org/keywords/mrtf-a","display_name":"MRTF-A","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mrtf-b","display_name":"MRTF-B","score":1.0},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8069999814033508},{"id":"https://openalex.org/keywords/tgf-beta2","display_name":"TGF-beta2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7239999771118164},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.9230068922042847},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7158814072608948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6885428428649902},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5223804116249084},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4955641031265259},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.492306113243103},{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.45821303129196167},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.45692017674446106},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3541629910469055},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16106531023979187},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071250","descriptor_name":"Snail Family Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000071250","descriptor_name":"Snail Family Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms21165875","doi":"https://doi.org/10.3390/ijms21165875","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms21165875","pdf_url":"https://www.mdpi.com/1422-0067/21/16/5875/pdf","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:32824297","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32824297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7461591","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7461591/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2edc6228ce10448290994c6060262ecd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2edc6228ce10448290994c6060262ecd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 21, Iss 5875, p 5875 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms21165875","doi":"https://doi.org/10.3390/ijms21165875","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms21165875","pdf_url":"https://www.mdpi.com/1422-0067/21/16/5875/pdf","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7137184181","display_name":null,"funder_award_id":"MOMENTO Pol-Nor/209521/5/2013","funder_id":"https://openalex.org/F4320335039","funder_display_name":"Narodowe Centrum Bada\u0144 i Rozwoju"}],"funders":[{"id":"https://openalex.org/F4320335039","display_name":"Narodowe Centrum Bada\u0144 i Rozwoju","ror":"https://ror.org/05pwfyy15"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3049627893.pdf","grobid_xml":"https://content.openalex.org/works/W3049627893.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W782467378","https://openalex.org/W1515566746","https://openalex.org/W1907425962","https://openalex.org/W1964847767","https://openalex.org/W1990905198","https://openalex.org/W1994242450","https://openalex.org/W1994589643","https://openalex.org/W2007343355","https://openalex.org/W2030215201","https://openalex.org/W2033962173","https://openalex.org/W2045362835","https://openalex.org/W2048326490","https://openalex.org/W2049777179","https://openalex.org/W2053512383","https://openalex.org/W2058667985","https://openalex.org/W2073235331","https://openalex.org/W2086204811","https://openalex.org/W2087668326","https://openalex.org/W2088071690","https://openalex.org/W2089812396","https://openalex.org/W2096171314","https://openalex.org/W2101243954","https://openalex.org/W2101547995","https://openalex.org/W2103328690","https://openalex.org/W2104002497","https://openalex.org/W2114154136","https://openalex.org/W2115542035","https://openalex.org/W2119505108","https://openalex.org/W2124273275","https://openalex.org/W2127690474","https://openalex.org/W2131432937","https://openalex.org/W2134203671","https://openalex.org/W2138401896","https://openalex.org/W2138991213","https://openalex.org/W2139602514","https://openalex.org/W2145975963","https://openalex.org/W2146445411","https://openalex.org/W2158564701","https://openalex.org/W2161918376","https://openalex.org/W2166899649","https://openalex.org/W2189041637","https://openalex.org/W2193549616","https://openalex.org/W2204732867","https://openalex.org/W2313288017","https://openalex.org/W2314041990","https://openalex.org/W2342853325","https://openalex.org/W2415876455","https://openalex.org/W2525669396","https://openalex.org/W2623343374","https://openalex.org/W2689331186","https://openalex.org/W2752122626","https://openalex.org/W2935938156","https://openalex.org/W2974827020","https://openalex.org/W4211233744"],"related_works":["https://openalex.org/W2158564701","https://openalex.org/W3131979355","https://openalex.org/W2131432937","https://openalex.org/W7120600282","https://openalex.org/W7097551139","https://openalex.org/W2139602514","https://openalex.org/W2048326490","https://openalex.org/W2773826704","https://openalex.org/W2946025531","https://openalex.org/W3134942975"],"abstract_inverted_index":{"Endothelial\u2013mesenchymal":[0],"transition":[1],"(EndMT)":[2],"is":[3,120,132,197],"a":[4,46,167,179,213],"crucial":[5],"phenomenon":[6],"in":[7,51,57,178,199],"regulating":[8],"the":[9,31,39,62,80,126,140,159],"development":[10,24],"of":[11,22,45,122,129,143,162],"diseases,":[12],"including":[13],"cancer":[14],"metastasis":[15],"and":[16,70,138,150,181,209],"fibrotic":[17],"disorders.":[18],"The":[19,95],"primary":[20],"regulators":[21],"disease":[23],"are":[25],"zinc-finger":[26],"transcription":[27,41],"factors":[28],"belonging":[29],"to":[30,88,91,103,109,134],"Snail":[32,187],"family.":[33],"In":[34],"this":[35],"study,":[36],"we":[37,114,171,189],"characterized":[38],"myocardin-related":[40],"factor":[42],"(MRTF)-dependent":[43],"mechanisms":[44],"human":[47,53],"snail":[48,63,93,124,136],"promoter":[49],"regulation":[50],"TGF-\u03b2-stimulated":[52],"endothelial":[54],"cells.":[55],"Although":[56,113],"silico":[58],"analysis":[59,152],"revealed":[60,99,153],"that":[61,74,84,100,116,154,173,191],"promoter\u2019s":[64],"regulatory":[65],"fragment":[66],"contains":[67],"one":[68,111],"GCCG":[69],"two":[71],"SP1":[72,89,105],"motifs":[73],"could":[75,157],"be":[76],"occupied":[77],"by":[78],"MRTFs,":[79],"genetic":[81,149],"study":[82],"confirmed":[83],"MRTF":[85,118],"binds":[86,102],"only":[87,110],"sites":[90],"promote":[92,139],"expression.":[94],"more":[96],"accurate":[97],"studies":[98],"MRTF-A":[101,208],"both":[104,207],"elements,":[106],"whereas":[107,203],"MRTF-B":[108,155,195,210],"(SP1near).":[112],"found":[115],"each":[117],"alone":[119,156],"capable":[121],"inducing":[123],"expression,":[125,211],"direct":[127],"cooperation":[128],"these":[130],"proteins":[131],"required":[133],"reinforce":[135],"expression":[137],"late":[141,160],"stages":[142],"EndMT":[144,177,201,215],"within":[145],"48":[146],"hours.":[147],"Furthermore,":[148],"biochemical":[151],"induce":[158],"stage":[161],"EndMT.":[163],"However,":[164],"it":[165],"requires":[166],"prolonged":[168],"time.":[169],"Therefore,":[170],"concluded":[172],"MRTFs":[174],"might":[175],"cause":[176],"fast-":[180],"slow-dependent":[182],"manner.":[183],"Based":[184],"on":[185],"MRTF-dependent":[186],"upregulation,":[188],"recognized":[190],"TGF-\u03b21,":[192],"as":[193],"an":[194],"regulator,":[196],"involved":[198],"slow":[200],"induction,":[202],"TGF-\u03b22,":[204],"which":[205],"altered":[206],"promotes":[212],"fast":[214],"process.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-08-21T00:00:00"}