{"id":"https://openalex.org/W3049460751","doi":null,"title":"Invariant NKT cells in early Rheumatoid Arthritis","display_name":"Invariant NKT cells in early Rheumatoid Arthritis","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W3049460751","mag":"3049460751"},"language":"de","primary_location":{"id":"mag:3049460751","doi":null,"is_oa":false,"landing_page_url":"https://oak.novartis.com/27634/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024766854","display_name":"Salah Mansour","orcid":"https://orcid.org/0000-0002-5982-734X","observed_orcids":["https://orcid.org/0000-0002-5982-734X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salah Mansour","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051950626","display_name":"Anna S. Tocheva","orcid":"https://orcid.org/0000-0002-3327-0811","observed_orcids":["https://orcid.org/0000-0002-3327-0811"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna S. Tocheva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3327-0811","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046364897","display_name":"Joseph P. Sanderson","orcid":"https://orcid.org/0000-0002-1206-8833","observed_orcids":["https://orcid.org/0000-0002-1206-8833"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph P. Sanderson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1206-8833","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089509493","display_name":"Lyndsey Goulston","orcid":"https://orcid.org/0000-0002-0632-2217","observed_orcids":["https://orcid.org/0000-0002-0632-2217"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lyndsey Goulston","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0632-2217","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026433143","display_name":"H Platten","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Platten","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112395846","display_name":"Lina Serhal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lina Serhal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089251053","display_name":"Camille M. Parsons","orcid":"https://orcid.org/0000-0003-3486-8353","observed_orcids":["https://orcid.org/0000-0003-3486-8353"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Camille Parsons","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3486-8353","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006135589","display_name":"Mark Edwards","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Edwards","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035221639","display_name":"Christopher H. Woelk","orcid":"https://orcid.org/0000-0002-1977-0502","observed_orcids":["https://orcid.org/0000-0002-1977-0502"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher H. Woelk","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1977-0502","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082043968","display_name":"Paul T. Elkington","orcid":"https://orcid.org/0000-0003-0390-0613","observed_orcids":["https://orcid.org/0000-0003-0390-0613"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Elkington","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0390-0613","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050218469","display_name":"Tim J Elliott","orcid":"https://orcid.org/0000-0003-1097-0222","observed_orcids":["https://orcid.org/0000-0003-1097-0222"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tim Elliott","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1097-0222","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100774776","display_name":"Cyrus C. Cooper","orcid":"https://orcid.org/0000-0003-3510-0709","observed_orcids":["https://orcid.org/0000-0003-3510-0709"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cyrus Cooper","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3510-0709","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Christopher Edwards","orcid":"https://orcid.org/0000-0002-2222-0640","observed_orcids":["https://orcid.org/0000-0002-2222-0640"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Edwards","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2222-0640","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010334701","display_name":"Stephan Donat Gadola","orcid":"https://orcid.org/0000-0002-5240-4643","observed_orcids":["https://orcid.org/0000-0002-5240-4643","https://orcid.org/0000-0002-3590-3547"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephan D. Gadola","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5240-4643","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30752703,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.548799991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.548799991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.4088999927043915,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inkt-cells","display_name":"invariant natural killer T cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/early-rheumatoid-arthritis","display_name":"early rheumatoid arthritis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.656000018119812},{"id":"https://openalex.org/keywords/immune-dysregulation","display_name":"immune dysregulation","score":0.765999972820282},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C2778607024","wikidata":"https://www.wikidata.org/wiki/Q4216825","display_name":"CD1D","level":5,"score":0.8765990734100342},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7398627996444702},{"id":"https://openalex.org/C2778473898","wikidata":"https://www.wikidata.org/wiki/Q2145110","display_name":"Repertoire","level":2,"score":0.6592967510223389},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.6513851881027222},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5565636157989502},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5386277437210083},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.5094662308692932},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.4871320426464081},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4578264355659485},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.44671767950057983},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.4274216890335083},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.31966453790664673},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.29530179500579834},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.22307759523391724},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1435500979423523},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0678158700466156},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3049460751","doi":null,"is_oa":false,"landing_page_url":"https://oak.novartis.com/27634/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.699999988079071}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2136464107","https://openalex.org/W2317341524","https://openalex.org/W2126647060","https://openalex.org/W2516417453","https://openalex.org/W1489598575","https://openalex.org/W2068928414","https://openalex.org/W2100402344","https://openalex.org/W2629412597","https://openalex.org/W7220676719","https://openalex.org/W1487475526"],"abstract_inverted_index":{"Invariant":[0],"Natural":[1],"Killer":[2],"T":[3,9],"cells":[4,10],"(iNKT)":[5],"are":[6],"potent":[7],"immunoregulatory":[8],"which":[11],"recognise":[12],"CD1d":[13,96,143],"via":[14],"a":[15,23,35,103,151,156,210],"semi-invariant":[16],"TCR":[17],"(iNKT-TCR).":[18],"Despite":[19],"the":[20,39,48,53,64,69,83,88,205,213,218],"knowledge":[21],"of":[22,38,47,56,68,87,102,106,142,159,217,228],"defective":[24,137],"iNKT":[25,50,70,91,110,134,146,161,220],"pool":[26],"in":[27,72,119,138,163,169,183,198,223],"several":[28],"autoimmune":[29,57],"conditions":[30],"including":[31,42],"Rheumatoid":[32],"Arthritis":[33],"(RA),":[34],"clear":[36],"understanding":[37],"intrinsic":[40,214],"mechanisms":[41],"qualitative":[43,215],"and":[44,66,78,85,122,185,240],"structural":[45],"changes":[46],"human":[49],"repertoire":[51,71,92,154,222],"at":[52],"earlier":[54],"stages":[55],"disease":[58],"is":[59,204],"lacking.":[60],"Here,":[61],"we":[62],"compared":[63,189],"structure":[65],"function":[67,86],"early":[73,120,139,164,170,224],"RA":[74,121,171],"patients":[75,187],"with":[76,100,150,155,178],"age-":[77],"gender-matched":[79],"controls.":[80,199],"We":[81,112],"analysed":[82],"phenotype":[84],"ex":[89,107],"vivo":[90,108],"as":[93,95],"well":[94],"antigen":[97],"presentation,":[98],"combined":[99],"analyses":[101],"large":[104],"panel":[105],"sorted":[109],"clones.":[111],"show":[113],"that":[114],"circulating":[115,219],"iNKTs":[116,168,197,229],"were":[117,136,148],"reduced":[118],"their":[123],"frequency":[124],"was":[125],"inversely":[126],"correlated":[127],"to":[128,190,208,237],"Disease":[129],"Activity":[130],"Score":[131],"(DAS28).":[132],"Proliferative":[133],"responses":[135],"RA,":[140,225],"independent":[141],"function.":[144],"Functional":[145],"alterations":[147],"associated":[149],"skewed":[152],"iNKT-TCR":[153],"selective":[157],"reduction":[158],"high-affinity":[160,196,231],"clones":[162],"RA.":[165],"Furthermore,":[166],"High-affinity":[167],"exhibited":[172,194],"an":[173],"altered":[174],"functional":[175],"T-helper":[176,192],"profile":[177],"Th1":[179],"or":[180],"Th2-like":[181],"phenotype,":[182],"treatment-naive":[184],"treated":[186],"respectively,":[188],"Th0-like":[191],"profiles":[193],"by":[195],"To":[200],"our":[201,241],"knowledge,":[202],"this":[203],"first":[206],"study":[207],"provide":[209],"mechanism":[211],"for":[212,246],"defects":[216,227,234],"clonal":[221],"demonstrating":[226],"bearing":[230],"TCRs.":[232],"These":[233],"may":[235],"contribute":[236],"immune":[238],"dysregulation":[239],"findings":[242],"could":[243],"be":[244],"exploited":[245],"future":[247],"therapeutic":[248],"intervention.":[249]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2020-08-21T00:00:00"}
