{"id":"https://openalex.org/W3049327155","doi":"https://doi.org/10.3390/brainsci10080564","title":"Peripheral Biomarkers in DSM-5 Anxiety Disorders: An Updated Overview","display_name":"Peripheral Biomarkers in DSM-5 Anxiety Disorders: An Updated Overview","publication_year":2020,"publication_date":"2020-08-17","ids":{"openalex":"https://openalex.org/W3049327155","doi":"https://doi.org/10.3390/brainsci10080564","mag":"3049327155","pmid":"https://pubmed.ncbi.nlm.nih.gov/32824625","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7464377"},"language":"en","primary_location":{"id":"doi:10.3390/brainsci10080564","doi":"https://doi.org/10.3390/brainsci10080564","is_oa":true,"landing_page_url":"https://doi.org/10.3390/brainsci10080564","pdf_url":"https://www.mdpi.com/2076-3425/10/8/564/pdf?version=1597829006","source":{"id":"https://openalex.org/S122317144","display_name":"Brain Sciences","issn_l":"2076-3425","issn":["2076-3425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-3425/10/8/564/pdf?version=1597829006","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015234492","display_name":"Matteo E.M. Vismara","orcid":"https://orcid.org/0000-0002-9533-8615","observed_orcids":["https://orcid.org/0000-0002-9533-8615"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Matteo Vismara","raw_affiliation_strings":["Department of Mental Health, Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d, University of Milan, 20157 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9533-8615","affiliations":[{"raw_affiliation_string":"Department of Mental Health, Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d, University of Milan, 20157 Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067056885","display_name":"Nicolaja Girone","orcid":"https://orcid.org/0000-0003-0761-2096","observed_orcids":["https://orcid.org/0000-0003-0761-2096"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicolaja Girone","raw_affiliation_strings":["Department of Mental Health, Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d, University of Milan, 20157 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mental Health, Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d, University of Milan, 20157 Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020620989","display_name":"Giovanna Cirnigliaro","orcid":"https://orcid.org/0000-0003-3812-4933","observed_orcids":["https://orcid.org/0000-0003-3812-4933"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanna Cirnigliaro","raw_affiliation_strings":["Department of Mental Health, Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d, University of Milan, 20157 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0003-3812-4933","affiliations":[{"raw_affiliation_string":"Department of Mental Health, Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d, University of Milan, 20157 Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059635003","display_name":"Federica Fasciana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Fasciana","raw_affiliation_strings":["Department of Mental Health, Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d, University of Milan, 20157 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mental Health, Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d, University of Milan, 20157 Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055743213","display_name":"Simone Vanzetto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simone Vanzetto","raw_affiliation_strings":["Department of Mental Health, Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d, University of Milan, 20157 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mental Health, Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d, University of Milan, 20157 Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046212512","display_name":"Luca Ferrara","orcid":"https://orcid.org/0000-0003-1324-0508","observed_orcids":["https://orcid.org/0000-0003-1324-0508"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Ferrara","raw_affiliation_strings":["Department of Mental Health, Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d, University of Milan, 20157 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0003-1324-0508","affiliations":[{"raw_affiliation_string":"Department of Mental Health, Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d, University of Milan, 20157 Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068817937","display_name":"Alberto Priori","orcid":"https://orcid.org/0000-0002-1549-3851","observed_orcids":["https://orcid.org/0000-0002-1549-3851"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Priori","raw_affiliation_strings":["Department of Health Sciences, Aldo Ravelli Center for Neurotechnology and Brain Therapeutic, University of Milan, 20142 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, Aldo Ravelli Center for Neurotechnology and Brain Therapeutic, University of Milan, 20142 Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079782200","display_name":"Claudio D\u2019Addario","orcid":"https://orcid.org/0000-0002-1275-098X","observed_orcids":["https://orcid.org/0000-0002-1275-098X"]},"institutions":[{"id":"https://openalex.org/I124326101","display_name":"University of Teramo","ror":"https://ror.org/01yetye73","country_code":"IT","type":"education","lineage":["https://openalex.org/I124326101"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["IT","SE"],"is_corresponding":false,"raw_author_name":"Claudio D\u2019Addario","raw_affiliation_strings":["Department of Clinical Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden","Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy","institution_ids":["https://openalex.org/I124326101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037177256","display_name":"Caterina Adele Vigan\u00f2","orcid":"https://orcid.org/0000-0001-7937-1266","observed_orcids":["https://orcid.org/0000-0001-7937-1266"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Caterina Vigan\u00f2","raw_affiliation_strings":["Department of Mental Health, Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d, University of Milan, 20157 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0001-7937-1266","affiliations":[{"raw_affiliation_string":"Department of Mental Health, Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d, University of Milan, 20157 Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064949711","display_name":"Bernardo Maria Dell\u2019Osso","orcid":"https://orcid.org/0000-0001-9370-5365","observed_orcids":["https://orcid.org/0000-0001-9370-5365"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Bernardo Dell\u2019Osso","raw_affiliation_strings":["Department of Health Sciences, Aldo Ravelli Center for Neurotechnology and Brain Therapeutic, University of Milan, 20142 Milan, Italy","Department of Mental Health, Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d, University of Milan, 20157 Milan, Italy","Department of Psychiatry and Behavioral Sciences, Bipolar Disorders Clinic, Stanford University, Stanford, CA 94305, USA","\u201cCentro per lo studio dei meccanismi molecolari alla base delle patologie neuro-psico-geriatriche\u201d, University of Milan, 20100 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, Aldo Ravelli Center for Neurotechnology and Brain Therapeutic, University of Milan, 20142 Milan, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Department of Mental Health, Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d, University of Milan, 20157 Milan, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Bipolar Disorders Clinic, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"\u201cCentro per lo studio dei meccanismi molecolari alla base delle patologie neuro-psico-geriatriche\u201d, University of Milan, 20100 Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5015234492"],"corresponding_institution_ids":["https://openalex.org/I189158943"],"apc_list":{"value":1600,"currency":"CHF","value_usd":1690},"apc_paid":{"value":907,"currency":"EUR","value_usd":978},"fwci":0.5817,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.55398587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"10","issue":"8","first_page":"564","last_page":"564"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.7020999789237976,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.7020999789237976,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.2524000108242035,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anxiety-disorders","display_name":"anxiety disorders","score":0.9399999976158142},{"id":"https://openalex.org/keywords/peripheral-biomarkers","display_name":"peripheral biomarkers","score":0.984000027179718},{"id":"https://openalex.org/keywords/blood-based-biomarkers","display_name":"blood-based biomarkers","score":0.843999981880188},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dsm-5-criteria","display_name":"DSM-5 diagnostic criteria","score":0.6859999895095825},{"id":"https://openalex.org/keywords/neurotransmitters","display_name":"neurotransmitters","score":0.6050000190734863},{"id":"https://openalex.org/keywords/neuropeptides","display_name":"neuropeptides","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurotrophic-factors","display_name":"neurotrophic factors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/immune-system","display_name":"immune system","score":0.8989999890327454},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.7245258688926697},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6034599542617798},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.45592641830444336},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4497123956680298},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.43417873978614807},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.35149693489074707},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.29067856073379517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1034882664680481}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3390/brainsci10080564","doi":"https://doi.org/10.3390/brainsci10080564","is_oa":true,"landing_page_url":"https://doi.org/10.3390/brainsci10080564","pdf_url":"https://www.mdpi.com/2076-3425/10/8/564/pdf?version=1597829006","source":{"id":"https://openalex.org/S122317144","display_name":"Brain Sciences","issn_l":"2076-3425","issn":["2076-3425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7464377","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7464377","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Sci","raw_type":"Text"},{"id":"pmid:32824625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32824625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain sciences","raw_type":"Journal Article"},{"id":"pmh:oai:air.unimi.it:2434/766643","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2434/766643","pdf_url":null,"source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:6514f32176c44d1da86e6c46e3dfab71","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6514f32176c44d1da86e6c46e3dfab71","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain Sciences, Vol 10, Iss 8, p 564 (2020)","raw_type":"article"},{"id":"pmh:oai:research.unite.it:11575/109609","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11575/109609","pdf_url":null,"source":{"id":"https://openalex.org/S4306401171","display_name":"UniTERAMO Research Catalog (University of Teramo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124326101","host_organization_name":"University of Teramo","host_organization_lineage":["https://openalex.org/I124326101"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/brainsci10080564","doi":"https://doi.org/10.3390/brainsci10080564","is_oa":true,"landing_page_url":"https://doi.org/10.3390/brainsci10080564","pdf_url":"https://www.mdpi.com/2076-3425/10/8/564/pdf?version=1597829006","source":{"id":"https://openalex.org/S122317144","display_name":"Brain Sciences","issn_l":"2076-3425","issn":["2076-3425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6499999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313475","display_name":"Universit\u00e0 degli Studi di Milano","ror":"https://ror.org/00wjc7c48"},{"id":"https://openalex.org/F4320334495","display_name":"Center for Neurotechnology, University of Washington","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3049327155.pdf","grobid_xml":"https://content.openalex.org/works/W3049327155.grobid-xml"},"referenced_works_count":277,"referenced_works":["https://openalex.org/W5442471","https://openalex.org/W8789689","https://openalex.org/W13613315","https://openalex.org/W88259924","https://openalex.org/W119650301","https://openalex.org/W195047582","https://openalex.org/W581256308","https://openalex.org/W834462032","https://openalex.org/W1517355001","https://openalex.org/W1567671145","https://openalex.org/W1625910023","https://openalex.org/W1659684171","https://openalex.org/W1787518179","https://openalex.org/W1869439357","https://openalex.org/W1893096072","https://openalex.org/W1925882165","https://openalex.org/W1937492333","https://openalex.org/W1961937252","https://openalex.org/W1963592163","https://openalex.org/W1965007195","https://openalex.org/W1965652346","https://openalex.org/W1966317259","https://openalex.org/W1966576128","https://openalex.org/W1968767819","https://openalex.org/W1970165113","https://openalex.org/W1970296702","https://openalex.org/W1970582968","https://openalex.org/W1970886138","https://openalex.org/W1971842754","https://openalex.org/W1973277030","https://openalex.org/W1973976539","https://openalex.org/W1974383964","https://openalex.org/W1975546210","https://openalex.org/W1976230846","https://openalex.org/W1977091974","https://openalex.org/W1977412046","https://openalex.org/W1977764306","https://openalex.org/W1978047167","https://openalex.org/W1982695729","https://openalex.org/W1985438873","https://openalex.org/W1986211748","https://openalex.org/W1988670765","https://openalex.org/W1989064742","https://openalex.org/W1990196033","https://openalex.org/W1990205123","https://openalex.org/W1990362520","https://openalex.org/W1991002100","https://openalex.org/W1992791211","https://openalex.org/W1993348729","https://openalex.org/W1994025579","https://openalex.org/W1994092198","https://openalex.org/W1997008618","https://openalex.org/W1998091136","https://openalex.org/W1999113647","https://openalex.org/W2000209446","https://openalex.org/W2000717193","https://openalex.org/W2001558060","https://openalex.org/W2003482748","https://openalex.org/W2003864000","https://openalex.org/W2003982930","https://openalex.org/W2006313794","https://openalex.org/W2006923280","https://openalex.org/W2007868150","https://openalex.org/W2010580839","https://openalex.org/W2011816955","https://openalex.org/W2013512535","https://openalex.org/W2013661533","https://openalex.org/W2013914127","https://openalex.org/W2015317165","https://openalex.org/W2016285975","https://openalex.org/W2016625216","https://openalex.org/W2017220635","https://openalex.org/W2019683883","https://openalex.org/W2020016982","https://openalex.org/W2021606909","https://openalex.org/W2021747329","https://openalex.org/W2021836217","https://openalex.org/W2023578523","https://openalex.org/W2024868198","https://openalex.org/W2027109785","https://openalex.org/W2028466691","https://openalex.org/W2029803700","https://openalex.org/W2030757244","https://openalex.org/W2031094958","https://openalex.org/W2031919192","https://openalex.org/W2033162274","https://openalex.org/W2033792083","https://openalex.org/W2034450620","https://openalex.org/W2034681564","https://openalex.org/W2036320151","https://openalex.org/W2037049826","https://openalex.org/W2037600975","https://openalex.org/W2037932756","https://openalex.org/W2038378894","https://openalex.org/W2039235809","https://openalex.org/W2039460830","https://openalex.org/W2040067791","https://openalex.org/W2040635608","https://openalex.org/W2040778237","https://openalex.org/W2041325469","https://openalex.org/W2042061501","https://openalex.org/W2042221209","https://openalex.org/W2043224274","https://openalex.org/W2043334105","https://openalex.org/W2044633941","https://openalex.org/W2045005430","https://openalex.org/W2045784272","https://openalex.org/W2045973153","https://openalex.org/W2046962754","https://openalex.org/W2047844288","https://openalex.org/W2048222841","https://openalex.org/W2050042714","https://openalex.org/W2050781565","https://openalex.org/W2050910981","https://openalex.org/W2051110112","https://openalex.org/W2052580365","https://openalex.org/W2053356425","https://openalex.org/W2053552873","https://openalex.org/W2053868932","https://openalex.org/W2054256503","https://openalex.org/W2054369640","https://openalex.org/W2054372128","https://openalex.org/W2054479977","https://openalex.org/W2059620954","https://openalex.org/W2059820926","https://openalex.org/W2062276181","https://openalex.org/W2062752662","https://openalex.org/W2063294463","https://openalex.org/W2064561667","https://openalex.org/W2066140996","https://openalex.org/W2067055066","https://openalex.org/W2068480672","https://openalex.org/W2068769790","https://openalex.org/W2068804599","https://openalex.org/W2069540232","https://openalex.org/W2070284481","https://openalex.org/W2071811220","https://openalex.org/W2072162518","https://openalex.org/W2072203790","https://openalex.org/W2072919039","https://openalex.org/W2075081458","https://openalex.org/W2076444299","https://openalex.org/W2077890540","https://openalex.org/W2078826300","https://openalex.org/W2079956181","https://openalex.org/W2081476988","https://openalex.org/W2081727465","https://openalex.org/W2081939457","https://openalex.org/W2081999211","https://openalex.org/W2082588922","https://openalex.org/W2084543750","https://openalex.org/W2085352254","https://openalex.org/W2085437790","https://openalex.org/W2086056033","https://openalex.org/W2087237482","https://openalex.org/W2088880330","https://openalex.org/W2090076189","https://openalex.org/W2090985766","https://openalex.org/W2091330411","https://openalex.org/W2091643921","https://openalex.org/W2092774675","https://openalex.org/W2093200355","https://openalex.org/W2093837465","https://openalex.org/W2094621299","https://openalex.org/W2094817522","https://openalex.org/W2095490777","https://openalex.org/W2096699969","https://openalex.org/W2096838333","https://openalex.org/W2098962546","https://openalex.org/W2099827792","https://openalex.org/W2102426591","https://openalex.org/W2103706665","https://openalex.org/W2104771261","https://openalex.org/W2108549244","https://openalex.org/W2110115314","https://openalex.org/W2110359044","https://openalex.org/W2111416664","https://openalex.org/W2113080571","https://openalex.org/W2113665645","https://openalex.org/W2114918469","https://openalex.org/W2115117793","https://openalex.org/W2115430257","https://openalex.org/W2116296032","https://openalex.org/W2116486590","https://openalex.org/W2116698802","https://openalex.org/W2118182252","https://openalex.org/W2118826874","https://openalex.org/W2119444965","https://openalex.org/W2122305679","https://openalex.org/W2122660499","https://openalex.org/W2124103584","https://openalex.org/W2124566592","https://openalex.org/W2125961086","https://openalex.org/W2127187577","https://openalex.org/W2134770848","https://openalex.org/W2134998548","https://openalex.org/W2139089965","https://openalex.org/W2140689667","https://openalex.org/W2141430911","https://openalex.org/W2142474258","https://openalex.org/W2147591778","https://openalex.org/W2148588032","https://openalex.org/W2149747048","https://openalex.org/W2151058338","https://openalex.org/W2154863825","https://openalex.org/W2155693991","https://openalex.org/W2158635786","https://openalex.org/W2158889154","https://openalex.org/W2159463723","https://openalex.org/W2161729260","https://openalex.org/W2164724463","https://openalex.org/W2164841606","https://openalex.org/W2165249749","https://openalex.org/W2165436113","https://openalex.org/W2166835772","https://openalex.org/W2167607018","https://openalex.org/W2168559252","https://openalex.org/W2170016328","https://openalex.org/W2170064356","https://openalex.org/W2170478246","https://openalex.org/W2181902741","https://openalex.org/W2249835165","https://openalex.org/W2290376574","https://openalex.org/W2306047212","https://openalex.org/W2314832567","https://openalex.org/W2324482687","https://openalex.org/W2327208897","https://openalex.org/W2334337188","https://openalex.org/W2397693161","https://openalex.org/W2400310551","https://openalex.org/W2400533248","https://openalex.org/W2404182726","https://openalex.org/W2410218281","https://openalex.org/W2410909732","https://openalex.org/W2411252873","https://openalex.org/W2411372009","https://openalex.org/W2412990078","https://openalex.org/W2413544778","https://openalex.org/W2414888276","https://openalex.org/W2419110430","https://openalex.org/W2462592197","https://openalex.org/W2463095253","https://openalex.org/W2464165726","https://openalex.org/W2502155763","https://openalex.org/W2517170026","https://openalex.org/W2536054032","https://openalex.org/W2558402651","https://openalex.org/W2559884158","https://openalex.org/W2564617265","https://openalex.org/W2604495639","https://openalex.org/W2614579284","https://openalex.org/W2615791284","https://openalex.org/W2747443888","https://openalex.org/W2767119176","https://openalex.org/W2775650297","https://openalex.org/W2784228238","https://openalex.org/W2793650962","https://openalex.org/W2799729996","https://openalex.org/W2800294025","https://openalex.org/W2801598945","https://openalex.org/W2808135368","https://openalex.org/W2885839597","https://openalex.org/W2885929360","https://openalex.org/W2889082270","https://openalex.org/W2896299000","https://openalex.org/W2929275364","https://openalex.org/W2935664692","https://openalex.org/W2964215777","https://openalex.org/W2971707089","https://openalex.org/W2980573788","https://openalex.org/W2989454913","https://openalex.org/W2997028491","https://openalex.org/W3004414630","https://openalex.org/W3004910253","https://openalex.org/W4244141123","https://openalex.org/W4247665917","https://openalex.org/W6653265362"],"related_works":["https://openalex.org/W4408689475","https://openalex.org/W3156831959","https://openalex.org/W2462592197","https://openalex.org/W4392112583","https://openalex.org/W2463095253","https://openalex.org/W2803332209","https://openalex.org/W2805295723","https://openalex.org/W7221315787","https://openalex.org/W3042888962","https://openalex.org/W4323321681"],"abstract_inverted_index":{"Anxiety":[0,96,187],"disorders":[1],"are":[2,144,192],"prevalent":[3],"and":[4,22,38,88,112,118,126,138,141,151,210],"highly":[5],"disabling":[6],"mental":[7],"disorders.":[8],"In":[9,74],"recent":[10],"years,":[11],"intensive":[12],"efforts":[13],"focused":[14],"on":[15,82,122],"the":[16,30,40,51,77,80,107,123,133,139,147,152,156,162,182,200],"search":[17],"for":[18,50,116],"potential":[19,114],"neuroimaging,":[20],"genetic,":[21],"peripheral":[23,45,83,164],"biomarkers":[24,84,128,165],"in":[25,100,106,155,181,207],"order":[26,101],"to":[27,59,71,102,130,185,194,205,211],"better":[28],"understand":[29],"pathophysiology":[31],"of":[32,79,85,91,109,161,202],"these":[33,110],"disorders,":[34,62,204],"support":[35],"their":[36,64,104,113,208],"diagnosis,":[37,209],"characterize":[39,60],"treatment":[41,183],"response.":[42],"Of":[43],"note,":[44],"blood":[46],"biomarkers,":[47],"as":[48,169,178],"surrogates":[49],"central":[52],"nervous":[53],"system,":[54],"represent":[55],"a":[56,159,170,179,213],"promising":[57,153],"instrument":[58,173],"psychiatric":[61],"although":[63],"role":[65,105],"has":[66],"not":[67],"been":[68,167,176],"extensively":[69],"applied":[70],"clinical":[72],"practice.":[73],"this":[75],"report,":[76],"state":[78],"art":[81],"DSM-5":[86,186],"(Diagnostic":[87],"Statistical":[89],"Manual":[90],"Mental":[92],"Disorders,":[93],"5th":[94],"edition)":[95],"Disorders":[97],"is":[98],"presented,":[99],"examine":[103],"pathogenesis":[108,201],"conditions":[111],"application":[115],"diagnosis":[117],"treatment.":[119,214],"Available":[120],"data":[121],"cerebrospinal":[124],"fluid":[125],"blood-based":[127],"related":[129],"neurotransmitters,":[131],"neuropeptides,":[132],"hypothalamic-pituitary-adrenal":[134],"axis,":[135],"neurotrophic":[136],"factors,":[137],"inflammation":[140],"immune":[142],"system":[143],"reviewed.":[145],"Despite":[146],"wide":[148],"scientific":[149],"literature":[150],"results":[154],"field,":[157],"only":[158],"few":[160],"proposed":[163],"have":[166,175],"defined":[168],"specific":[171],"diagnostic":[172],"or":[174],"identified":[177],"guide":[180],"response":[184],"Disorders.":[188],"Therefore,":[189],"further":[190],"investigations":[191],"needed":[193],"provide":[195],"new":[196],"biological":[197],"insights":[198],"into":[199],"anxiety":[203],"help":[206],"tailor":[212]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-08-21T00:00:00"}