{"id":"https://openalex.org/W3048865760","doi":"https://doi.org/10.1002/dad2.12095","title":"Clinical and biomarker trajectories in sporadic Alzheimer's disease: A longitudinal study","display_name":"Clinical and biomarker trajectories in sporadic Alzheimer's disease: A longitudinal study","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3048865760","doi":"https://doi.org/10.1002/dad2.12095","mag":"3048865760","pmid":"https://pubmed.ncbi.nlm.nih.gov/32793801","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7421532"},"language":"en","primary_location":{"id":"doi:10.1002/dad2.12095","doi":"https://doi.org/10.1002/dad2.12095","is_oa":true,"landing_page_url":"https://doi.org/10.1002/dad2.12095","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dad2.12095","source":{"id":"https://openalex.org/S2898482455","display_name":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","issn_l":"2352-8729","issn":["2352-8729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-2","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dad2.12095","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025029753","display_name":"Hui-Fu Wang","orcid":"https://orcid.org/0000-0003-0494-2241","observed_orcids":["https://orcid.org/0000-0003-0494-2241"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I4210119987","display_name":"Qingdao Municipal Hospital","ror":"https://ror.org/02jqapy19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui\u2010Fu Wang","raw_affiliation_strings":["Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I4210119987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112273624","display_name":"Xue\u2010Ning Shen","orcid":"https://orcid.org/0009-0001-2658-3799","observed_orcids":["https://orcid.org/0009-0001-2658-3799"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue\u2010Ning Shen","raw_affiliation_strings":["Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101446016","display_name":"Jieqiong Li","orcid":"https://orcid.org/0000-0001-8496-8614","observed_orcids":["https://orcid.org/0000-0001-8496-8614"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie\u2010Qiong Li","raw_affiliation_strings":["Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025660060","display_name":"John Suckling A","orcid":"https://orcid.org/0000-0002-5098-1527","observed_orcids":["https://orcid.org/0000-0002-5098-1527"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210144468","display_name":"Cambridgeshire and Peterborough NHS Foundation Trust","ror":"https://ror.org/040ch0e11","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210144468"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Suckling","raw_affiliation_strings":["Department of Psychiatry, University of Cambridge, Cambridge, UK","Medical Research Council and Wellcome Trust Behavioural and Clinical Neuroscience Institute University of Cambridge Cambridge, UK; Cambridgeshire and Peterborough NHS Trust UK","Cambridgeshire and Peterborough NHS Trust, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Medical Research Council and Wellcome Trust Behavioural and Clinical Neuroscience Institute University of Cambridge Cambridge, UK; Cambridgeshire and Peterborough NHS Trust UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210144468","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Cambridgeshire and Peterborough NHS Trust, UK","institution_ids":["https://openalex.org/I4210144468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100549388","display_name":"Chen\u2010Chen Tan","orcid":"https://orcid.org/0009-0008-2514-5245","observed_orcids":["https://orcid.org/0009-0008-2514-5245"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I4210119987","display_name":"Qingdao Municipal Hospital","ror":"https://ror.org/02jqapy19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen\u2010Chen Tan","raw_affiliation_strings":["Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I4210119987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047480995","display_name":"Yan\u2010Jiang Wang","orcid":"https://orcid.org/0000-0002-6227-6112","observed_orcids":["https://orcid.org/0000-0002-6227-6112"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210092099","display_name":"Daping Hospital","ror":"https://ror.org/00fthae95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092099"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan\u2010Jiang Wang","raw_affiliation_strings":["Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210092099"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lei Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Lei Feng","raw_affiliation_strings":["Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100440836","display_name":"Can Martin Zhang","orcid":"https://orcid.org/0000-0002-4340-5118","observed_orcids":["https://orcid.org/0000-0002-4340-5118"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Can Zhang","raw_affiliation_strings":["Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Diseases (MIND), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Diseases (MIND), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087649543","display_name":"Lan Tan","orcid":"https://orcid.org/0000-0002-8759-7588","observed_orcids":["https://orcid.org/0000-0002-8759-7588"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I4210119987","display_name":"Qingdao Municipal Hospital","ror":"https://ror.org/02jqapy19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lan Tan","raw_affiliation_strings":["Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I4210119987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066750132","display_name":"Qiang Dong","orcid":"https://orcid.org/0000-0002-3874-0130","observed_orcids":["https://orcid.org/0000-0002-3874-0130","https://orcid.org/0009-0001-5839-516X"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Dong","raw_affiliation_strings":["Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107835074","display_name":"Jacques Touchon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210093292","display_name":"Centre Hospitalier Universitaire de Montpellier","ror":"https://ror.org/00mthsf17","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210093292"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jacques Touchon","raw_affiliation_strings":["Memory Research and Resource Center for Alzheimer's Disease, Department of Neurology, University Hospital of Montpellier, University of Montpellier, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memory Research and Resource Center for Alzheimer's Disease, Department of Neurology, University Hospital of Montpellier, University of Montpellier, Montpellier, France","institution_ids":["https://openalex.org/I19894307","https://openalex.org/I4210093292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004968642","display_name":"Serge G. Gauthier","orcid":"https://orcid.org/0000-0003-4272-3330","observed_orcids":["https://orcid.org/0000-0003-4272-3330"]},"institutions":[{"id":"https://openalex.org/I4405276480","display_name":"McGill University Research Centre for Studies in Aging","ror":"https://ror.org/05h8ts335","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4405276480"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Serge Gauthier","raw_affiliation_strings":["McGill Center for Studies in Aging, McGill University, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill Center for Studies in Aging, McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I4405276480","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103002484","display_name":"Jin\u2010Tai Yu","orcid":"https://orcid.org/0000-0002-2532-383X","observed_orcids":["https://orcid.org/0000-0002-2532-383X","https://orcid.org/0000-0002-7686-0547"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jin\u2010Tai Yu","raw_affiliation_strings":["Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106733559","display_name":"Alzheimer\u2019s Disease Neuroimaging Initiative","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alzheimer's Disease Neuroimaging Initiative","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":19,"corresponding_author_ids":["https://openalex.org/A5103002484"],"corresponding_institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210159575"],"apc_list":{"value":2200,"currency":"USD","value_usd":2200},"apc_paid":{"value":2200,"currency":"USD","value_usd":2200},"fwci":3.6423,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.9368577,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"e12095","last_page":"e12095"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.030300000682473183,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sporadic-alzheimer-s-disease","display_name":"sporadic Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.4659999907016754},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.9290000200271606},{"id":"https://openalex.org/keywords/biomarker-trajectories","display_name":"biomarker trajectories","score":0.9190000295639038},{"id":"https://openalex.org/keywords/dementia-onset","display_name":"dementia onset","score":0.5849999785423279},{"id":"https://openalex.org/keywords/memory-decline","display_name":"memory decline","score":0.4740000069141388},{"id":"https://openalex.org/keywords/hippocampal-atrophy","display_name":"hippocampal atrophy","score":0.9739999771118164},{"id":"https://openalex.org/keywords/hypometabolism","display_name":"hypometabolism","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.8980000019073486},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7058786749839783},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6900355219841003},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6818660497665405},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.60865718126297},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.5649457573890686},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.49741604924201965},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4957955777645111},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4827355742454529},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.47537699341773987},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.45291802287101746},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.43170398473739624},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4306853413581848},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39356529712677},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38831987977027893},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3845464587211609},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38013383746147156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14957091212272644},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06319847702980042}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1002/dad2.12095","doi":"https://doi.org/10.1002/dad2.12095","is_oa":true,"landing_page_url":"https://doi.org/10.1002/dad2.12095","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dad2.12095","source":{"id":"https://openalex.org/S2898482455","display_name":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","issn_l":"2352-8729","issn":["2352-8729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-2","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7421532","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7421532","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimers Dement (Amst)","raw_type":"Text"},{"id":"pmid:32793801","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32793801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & dementia (Amsterdam, Netherlands)","raw_type":"Journal Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/196815","doi":null,"is_oa":true,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/196815","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus OA2020","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:b5ece03674e94bc993a3279efb9c42b9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b5ece03674e94bc993a3279efb9c42b9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alzheimer\u2019s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)","raw_type":"article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/309818","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/309818","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.56917","doi":"https://doi.org/10.17863/cam.56917","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.56917","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1002/dad2.12095","doi":"https://doi.org/10.1002/dad2.12095","is_oa":true,"landing_page_url":"https://doi.org/10.1002/dad2.12095","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dad2.12095","source":{"id":"https://openalex.org/S2898482455","display_name":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","issn_l":"2352-8729","issn":["2352-8729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-2","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1012222616","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320309432","funder_display_name":"F. Hoffmann-La Roche"},{"id":"https://openalex.org/G1298807586","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320327918","funder_display_name":"H. Lundbeck A/S"},{"id":"https://openalex.org/G1521519865","display_name":"Genetic Epidemiology of Alzheimer's Disease in African Americans","funder_award_id":"R01AG028786","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1554142629","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320322148","funder_display_name":"Eisai"},{"id":"https://openalex.org/G1593117279","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320309470","funder_display_name":"Meso Scale Diagnostics"},{"id":"https://openalex.org/G1650819308","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320308604","funder_display_name":"Biogen"},{"id":"https://openalex.org/G1838732233","display_name":"White Matter Hyperintentisities in Aging and Dementia","funder_award_id":"R56AG034189","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1880935189","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320327918","funder_display_name":"H. Lundbeck A/S"},{"id":"https://openalex.org/G2100670906","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320310388","funder_display_name":"Novartis Pharmaceuticals Corporation"},{"id":"https://openalex.org/G2144249069","display_name":"Epidemiology of Biomarkers of Risk and Progression in LOAD","funder_award_id":"R01AG037212","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2152643862","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320311551","funder_display_name":"Northern California Institute for Research and Education"},{"id":"https://openalex.org/G2189010064","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G2340207221","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320310045","funder_display_name":"BioClinica"},{"id":"https://openalex.org/G2423387114","display_name":null,"funder_award_id":"W81XWH-12-2\u20130012","funder_id":"https://openalex.org/F4320309697","funder_display_name":"Alzheimer's Disease Neuroimaging Initiative"},{"id":"https://openalex.org/G2471646051","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320327918","funder_display_name":"H. Lundbeck A/S"},{"id":"https://openalex.org/G2522063444","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320332193","funder_display_name":"Genentech"},{"id":"https://openalex.org/G2577200957","display_name":"Epidemiology of Dementia In An Urban Community","funder_award_id":"P01AG007232","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2835601961","display_name":null,"funder_award_id":"U01AG024904","funder_id":"https://openalex.org/F4320309697","funder_display_name":"Alzheimer's Disease Neuroimaging Initiative"},{"id":"https://openalex.org/G29951154","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320309697","funder_display_name":"Alzheimer's Disease Neuroimaging Initiative"},{"id":"https://openalex.org/G3131374986","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320307115","funder_display_name":"Bristol-Myers Squibb"},{"id":"https://openalex.org/G3216574877","display_name":null,"funder_award_id":"W81XWH-12-2-","funder_id":"https://openalex.org/F4320309697","funder_display_name":"Alzheimer's Disease Neuroimaging Initiative"},{"id":"https://openalex.org/G3553156159","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320307115","funder_display_name":"Bristol-Myers Squibb"},{"id":"https://openalex.org/G3708329936","display_name":"Tau PET imaging in racially/ethnically diverse middle-aged adults","funder_award_id":"RF1AG058067","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3710456697","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320307758","funder_display_name":"Eli Lilly and Company"},{"id":"https://openalex.org/G3752451908","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320327235","funder_display_name":"Servier"},{"id":"https://openalex.org/G3783051889","display_name":null,"funder_award_id":"2018YFC1314700","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3870774570","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320332193","funder_display_name":"Genentech"},{"id":"https://openalex.org/G3908963977","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G3939930721","display_name":null,"funder_award_id":"91849126","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3966393351","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320309432","funder_display_name":"F. Hoffmann-La Roche"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G43180419","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320322148","funder_display_name":"Eisai"},{"id":"https://openalex.org/G4475667458","display_name":null,"funder_award_id":"W81XWH-12-2-","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4501223628","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320329118","funder_display_name":"IXICO"},{"id":"https://openalex.org/G470063782","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4800177743","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320310045","funder_display_name":"BioClinica"},{"id":"https://openalex.org/G5207404921","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G5209990037","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320307765","funder_display_name":"Pfizer"},{"id":"https://openalex.org/G528601746","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G5324093878","display_name":null,"funder_award_id":"W81XWH-12","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5365730499","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320308668","funder_display_name":"University of Southern California"},{"id":"https://openalex.org/G5574148142","display_name":null,"funder_award_id":"2018SHZDZX01","funder_id":"https://openalex.org/F4320321851","funder_display_name":"Fudan University"},{"id":"https://openalex.org/G56156818","display_name":"Genetic Epidemiology of Cerebrovascular Factors in Alzheimer's Disease","funder_award_id":"RF1AG054023","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5654639750","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320310045","funder_display_name":"BioClinica"},{"id":"https://openalex.org/G5740349702","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320309470","funder_display_name":"Meso Scale Diagnostics"},{"id":"https://openalex.org/G581420142","display_name":"Resilience Mechanisms Underlying Racial/Ethnic Disparities in Alzheimer\u2019s Disease","funder_award_id":"R01AG054520","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G583188541","display_name":"White matter hyperintensities in Aging and Dementia","funder_award_id":"R01AG034189","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G613619302","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320310388","funder_display_name":"Novartis Pharmaceuticals Corporation"},{"id":"https://openalex.org/G6173816828","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320307765","funder_display_name":"Pfizer"},{"id":"https://openalex.org/G6210868510","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320308604","funder_display_name":"Biogen"},{"id":"https://openalex.org/G6371410416","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320308604","funder_display_name":"Biogen"},{"id":"https://openalex.org/G6412110892","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320332193","funder_display_name":"Genentech"},{"id":"https://openalex.org/G6447063303","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320309470","funder_display_name":"Meso Scale Diagnostics"},{"id":"https://openalex.org/G6719828067","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320329118","funder_display_name":"IXICO"},{"id":"https://openalex.org/G6792506723","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320307115","funder_display_name":"Bristol-Myers Squibb"},{"id":"https://openalex.org/G6899163935","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320322148","funder_display_name":"Eisai"},{"id":"https://openalex.org/G6929861","display_name":null,"funder_award_id":"81471309","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6948409098","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320309432","funder_display_name":"F. Hoffmann-La Roche"},{"id":"https://openalex.org/G7024513677","display_name":"Offpsring Study of Mechanisms for Racial Disparities in Alzheimer's Disease","funder_award_id":"RF1AG054070","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G72415811","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320311551","funder_display_name":"Northern California Institute for Research and Education"},{"id":"https://openalex.org/G7298697282","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320329118","funder_display_name":"IXICO"},{"id":"https://openalex.org/G764699806","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7799614282","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320307765","funder_display_name":"Pfizer"},{"id":"https://openalex.org/G781725486","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320307758","funder_display_name":"Eli Lilly and Company"},{"id":"https://openalex.org/G8151151163","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8228018387","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G8281378126","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320327235","funder_display_name":"Servier"},{"id":"https://openalex.org/G839208290","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320310388","funder_display_name":"Novartis Pharmaceuticals Corporation"},{"id":"https://openalex.org/G8852128998","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320327235","funder_display_name":"Servier"},{"id":"https://openalex.org/G8895907669","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G8897063270","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320308668","funder_display_name":"University of Southern California"},{"id":"https://openalex.org/G8899475930","display_name":null,"funder_award_id":"2018SHZDZX01","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8957659042","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320307758","funder_display_name":"Eli Lilly and Company"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320308604","display_name":"Biogen","ror":"https://ror.org/02jqkb192"},{"id":"https://openalex.org/F4320308668","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60"},{"id":"https://openalex.org/F4320309432","display_name":"F. Hoffmann-La Roche","ror":"https://ror.org/00by1q217"},{"id":"https://openalex.org/F4320309470","display_name":"Meso Scale Diagnostics","ror":"https://ror.org/05jgy0m16"},{"id":"https://openalex.org/F4320309697","display_name":"Alzheimer's Disease Neuroimaging Initiative","ror":"https://ror.org/01j20wc74"},{"id":"https://openalex.org/F4320310045","display_name":"BioClinica","ror":"https://ror.org/03t95yr58"},{"id":"https://openalex.org/F4320310388","display_name":"Novartis Pharmaceuticals Corporation","ror":"https://ror.org/028fhxy95"},{"id":"https://openalex.org/F4320311551","display_name":"Northern California Institute for Research and Education","ror":"https://ror.org/05p48p517"},{"id":"https://openalex.org/F4320319650","display_name":"TauRx Pharmaceuticals","ror":"https://ror.org/015frs841"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321851","display_name":"Fudan University","ror":"https://ror.org/013q1eq08"},{"id":"https://openalex.org/F4320322148","display_name":"Eisai","ror":"https://ror.org/04vvh7p27"},{"id":"https://openalex.org/F4320327235","display_name":"Servier","ror":"https://ror.org/034e7c066"},{"id":"https://openalex.org/F4320327918","display_name":"H. Lundbeck A/S","ror":"https://ror.org/0564cd633"},{"id":"https://openalex.org/F4320329118","display_name":"IXICO","ror":"https://ror.org/00paezp73"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3048865760.pdf","grobid_xml":"https://content.openalex.org/works/W3048865760.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1836749191","https://openalex.org/W1932861877","https://openalex.org/W1949174883","https://openalex.org/W1988404208","https://openalex.org/W1993571512","https://openalex.org/W2007044705","https://openalex.org/W2008301592","https://openalex.org/W2019528205","https://openalex.org/W2025983435","https://openalex.org/W2040104792","https://openalex.org/W2048674585","https://openalex.org/W2053288220","https://openalex.org/W2065338300","https://openalex.org/W2096890121","https://openalex.org/W2098176256","https://openalex.org/W2122280897","https://openalex.org/W2129497119","https://openalex.org/W2134711807","https://openalex.org/W2145909463","https://openalex.org/W2146089088","https://openalex.org/W2150481150","https://openalex.org/W2156220037","https://openalex.org/W2167840686","https://openalex.org/W2167929412","https://openalex.org/W2171250577","https://openalex.org/W2300075947","https://openalex.org/W2302528231","https://openalex.org/W2308877313","https://openalex.org/W2324855862","https://openalex.org/W2787666045","https://openalex.org/W2788507110","https://openalex.org/W2791314414","https://openalex.org/W2791743234","https://openalex.org/W2798054687","https://openalex.org/W2892024211","https://openalex.org/W2920691528","https://openalex.org/W3048865760"],"related_works":["https://openalex.org/W4391990232","https://openalex.org/W3135851890","https://openalex.org/W4406210389","https://openalex.org/W2896247181","https://openalex.org/W2534962305","https://openalex.org/W2767073489","https://openalex.org/W2925455345","https://openalex.org/W2025983435","https://openalex.org/W3021182651","https://openalex.org/W2944858987"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Amyloid":[1],"beta":[2],"(A\u03b2)":[3],"deposition":[4,87],"was":[5,74,99],"identified":[6],"to":[7,32,56,61,76,89,101,120,124],"precede":[8],"tau":[9],"pathology":[10],"and":[11,23,85,116,147],"neurodegeneration":[12],"in":[13,66,129],"familial":[14,24],"Alzheimer's":[15],"disease":[16],"(AD).":[17],"But":[18],"the":[19,27,52,63],"divergence":[20],"between":[21],"sporadic":[22,33,67,130],"AD":[25,131],"limits":[26],"extension":[28],"of":[29,38,51,59],"these":[30],"findings":[31],"AD.":[34,68],"METHODS:":[35],"Longitudinal":[36],"changes":[37],"biomarkers":[39],"among":[40],"different":[41],"stages":[42],"were":[43,54],"assessed":[44],"using":[45],"linear":[46],"mixed-effects":[47],"models.":[48],"The":[49,127],"slopes":[50],"models":[53],"used":[55],"estimate":[57],"rates":[58],"change":[60],"calculate":[62],"biomarker":[64],"trajectories":[65],"RESULTS:":[69],"Cerebrospinal":[70],"fluid":[71],"(CSF)":[72],"A\u03b2":[73,86,135],"estimated":[75,100],"decline":[77],"45.2":[78],"years":[79,92,104,108,111,114,118],"(abnormal:":[80,93],"27.8":[81],"years)":[82,95],"before":[83,96],"dementia,":[84],"seemed":[88],"increase":[90],"31.7":[91],"26.7":[94],"dementia.":[97,125],"It":[98],"take":[102],"29.0":[103],"(CSF":[105],"t-tau),":[106],"12.2":[107],"(memory),":[109],"11.6":[110],"(hippocampus),":[112],"9.3":[113],"(hypometabolism),":[115],"6.1":[117],"(cognition)":[119],"move":[121],"from":[122],"normal":[123],"DISCUSSION:":[126],"trajectory":[128],"is":[132],"led":[133],"by":[134,138],"accumulation,":[136],"followed":[137],"CSF":[139],"t-tau":[140],"increase,":[141],"memory":[142],"deficits,":[143],"brain":[144],"atrophy,":[145],"hypometabolism,":[146],"cognitive":[148],"decline.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-08-18T00:00:00"}
