{"id":"https://openalex.org/W3048857134","doi":null,"title":"Rescue and Repair of Collapsed Replication Forks","display_name":"Rescue and Repair of Collapsed Replication Forks","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W3048857134","mag":"3048857134"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/633002","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/633002","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068793498","display_name":"Kelvin W. Pond","orcid":"https://orcid.org/0000-0003-0519-4679","observed_orcids":["https://orcid.org/0000-0003-0519-4679","https://orcid.org/0000-0003-2061-9428"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kelvin W. Pond","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0519-4679","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5068793498"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/smc5-6-complex","display_name":"Smc5/6 complex","score":0.8759999871253967},{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.7440000176429749},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.6539999842643738},{"id":"https://openalex.org/keywords/rad51","display_name":"RAD51","score":0.7950000166893005},{"id":"https://openalex.org/keywords/blm-helicase","display_name":"BLM helicase","score":0.9589999914169312},{"id":"https://openalex.org/keywords/sister-chromatid-exchange","display_name":"sister chromatid exchange","score":0.9919999837875366},{"id":"https://openalex.org/keywords/topoisomerase-i-inhibitor","display_name":"topoisomerase I inhibitor","score":0.7979999780654907},{"id":"https://openalex.org/keywords/replication-stress","display_name":"replication stress","score":0.6809999942779541},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.6959999799728394},{"id":"https://openalex.org/keywords/sumoylation","display_name":"SUMOylation","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.44825291633605957},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36374709010124207},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24824896454811096},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.18589287996292114}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/633002","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/633002","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},{"id":"mag:3048857134","doi":null,"is_oa":false,"landing_page_url":"https://repository.arizona.edu/handle/10150/633002","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":158,"referenced_works":["https://openalex.org/W1259155283","https://openalex.org/W1516566300","https://openalex.org/W1536538430","https://openalex.org/W1539685331","https://openalex.org/W1600888450","https://openalex.org/W1601755300","https://openalex.org/W1790075212","https://openalex.org/W1808263692","https://openalex.org/W1833676004","https://openalex.org/W1886260756","https://openalex.org/W1965423281","https://openalex.org/W1965546838","https://openalex.org/W1965749659","https://openalex.org/W1967851694","https://openalex.org/W1968118415","https://openalex.org/W1973857401","https://openalex.org/W1973857553","https://openalex.org/W1977331328","https://openalex.org/W1977428044","https://openalex.org/W1977572530","https://openalex.org/W1979410044","https://openalex.org/W1980184916","https://openalex.org/W1980838719","https://openalex.org/W1983135603","https://openalex.org/W1984373702","https://openalex.org/W1986449016","https://openalex.org/W1986606670","https://openalex.org/W1988815728","https://openalex.org/W1989388273","https://openalex.org/W1991189921","https://openalex.org/W1991666948","https://openalex.org/W1992036233","https://openalex.org/W1994242043","https://openalex.org/W1995093544","https://openalex.org/W1999660230","https://openalex.org/W2004326614","https://openalex.org/W2004722555","https://openalex.org/W2006732453","https://openalex.org/W2008377571","https://openalex.org/W2009309406","https://openalex.org/W2011071523","https://openalex.org/W2013846962","https://openalex.org/W2023540360","https://openalex.org/W2027482274","https://openalex.org/W2027630134","https://openalex.org/W2028084970","https://openalex.org/W2028175380","https://openalex.org/W2029369774","https://openalex.org/W2033792454","https://openalex.org/W2034147929","https://openalex.org/W2034329236","https://openalex.org/W2035151664","https://openalex.org/W2039196623","https://openalex.org/W2040402383","https://openalex.org/W2041051519","https://openalex.org/W2043802763","https://openalex.org/W2045069136","https://openalex.org/W2049576185","https://openalex.org/W2050493898","https://openalex.org/W2052547134","https://openalex.org/W2053779322","https://openalex.org/W2054678629","https://openalex.org/W2054806801","https://openalex.org/W2055667487","https://openalex.org/W2056441912","https://openalex.org/W2058142120","https://openalex.org/W2058322286","https://openalex.org/W2058788882","https://openalex.org/W2062124403","https://openalex.org/W2062739292","https://openalex.org/W2065022250","https://openalex.org/W2067207497","https://openalex.org/W2067826589","https://openalex.org/W2077570881","https://openalex.org/W2078519341","https://openalex.org/W2080079708","https://openalex.org/W2083158919","https://openalex.org/W2084772885","https://openalex.org/W2095934571","https://openalex.org/W2097835632","https://openalex.org/W2098737737","https://openalex.org/W2098865666","https://openalex.org/W2104584181","https://openalex.org/W2106975638","https://openalex.org/W2107333316","https://openalex.org/W2108247013","https://openalex.org/W2108572433","https://openalex.org/W2109529827","https://openalex.org/W2114591766","https://openalex.org/W2114918609","https://openalex.org/W2117256838","https://openalex.org/W2117758622","https://openalex.org/W2117763831","https://openalex.org/W2120126307","https://openalex.org/W2127442777","https://openalex.org/W2128139335","https://openalex.org/W2130972387","https://openalex.org/W2132741246","https://openalex.org/W2133880683","https://openalex.org/W2141599203","https://openalex.org/W2142807050","https://openalex.org/W2146204567","https://openalex.org/W2146488626","https://openalex.org/W2146533600","https://openalex.org/W2149326807","https://openalex.org/W2157899948","https://openalex.org/W2158699530","https://openalex.org/W2159129632","https://openalex.org/W2163056216","https://openalex.org/W2169095840","https://openalex.org/W2169685907","https://openalex.org/W2170450010","https://openalex.org/W2173456459","https://openalex.org/W2217722934","https://openalex.org/W2269181155","https://openalex.org/W2311297552","https://openalex.org/W2312652906","https://openalex.org/W2320129379","https://openalex.org/W2402259557","https://openalex.org/W2404525619","https://openalex.org/W2418797297","https://openalex.org/W2478205319","https://openalex.org/W2490844245","https://openalex.org/W2515420023","https://openalex.org/W2523410070","https://openalex.org/W2544373478","https://openalex.org/W2548136543","https://openalex.org/W2553312780","https://openalex.org/W2558818939","https://openalex.org/W2560889624","https://openalex.org/W2562575763","https://openalex.org/W2566141085","https://openalex.org/W2582452337","https://openalex.org/W2602419737","https://openalex.org/W2604238307","https://openalex.org/W2605193375","https://openalex.org/W2606156013","https://openalex.org/W2610280068","https://openalex.org/W2618543928","https://openalex.org/W2737083047","https://openalex.org/W2739167375","https://openalex.org/W2762278714","https://openalex.org/W2763248055","https://openalex.org/W2767385338","https://openalex.org/W2769583779","https://openalex.org/W2769657708","https://openalex.org/W2771049305","https://openalex.org/W2781597432","https://openalex.org/W2784709079","https://openalex.org/W2789390316","https://openalex.org/W2810325605","https://openalex.org/W2900810167","https://openalex.org/W2905592635","https://openalex.org/W2914441724","https://openalex.org/W2952822665","https://openalex.org/W3173537811","https://openalex.org/W7058541826","https://openalex.org/W7073733100"],"related_works":["https://openalex.org/W2914441724","https://openalex.org/W2887505813","https://openalex.org/W2605276290","https://openalex.org/W2340939710","https://openalex.org/W2992883457","https://openalex.org/W7098874990","https://openalex.org/W2106680800","https://openalex.org/W2159129632","https://openalex.org/W2078519341","https://openalex.org/W1966950471"],"abstract_inverted_index":{"NSMCE2":[0,115,337,351,410,425],"is":[1,143,158,207,248,253,262,303],"an":[2,215,225,422],"E3":[3],"SUMO":[4],"ligase":[5],"and":[6,19,73,116,122,157,235,308,322,352,391],"a":[7,159,177,220,249,333,398,418],"subunit":[8],"of":[9,29,85,93,105,137,162,179,193,227,240,305,340,358,433],"the":[10,16,27,135,151,180,191,210,306,326,347,356,363,430],"SMC5/6":[11],"complex":[12],"that":[13,134,175,245,252,282,294,300,365,409],"associates":[14],"with":[15,219,285],"replication":[17,31,152,201,229,233,260,270,342],"fork":[18,153,155,173,181,217],"protects":[20],"against":[21],"genomic":[22],"instability.":[23],"Here,":[24],"we":[25],"study":[26],"fate":[28],"collapsed":[30,76,138,221,232,269,314,341,359],"forks":[32,50,60,77,139,142,196,202,234,271,315,360],"generated":[33],"by":[34,48,140,150,200,213],"prolonged":[35],"hydroxyurea":[36],"treatment":[37],"in":[38,51,56,78,113,129,182,272,292,320,325,338,355],"human":[39,399],"NSMCE2-deficient":[40,57,79,100,366],"cells.":[41,58,131],"Double":[42],"strand":[43,120,280],"breaks":[44,121,281],"accumulate":[45,96,291],"during":[46],"rescue":[47,136,211,268,288,307,313,339,357],"converging":[49,141],"normal":[52,184,286],"cells":[53,101,111,265,293,367,412],"but":[54,205,436],"not":[55,165,290],"Un-rescued":[59],"persist":[61],"into":[62],"mitosis,":[63],"leading":[64],"to":[65,83,88,95,172,230,255,259,266,274,312,317,361,374,383,385,403],"increased":[66],"mitotic":[67],"DNA":[68,147,185,228,276,278,301,318,323],"damage.":[69],"Excess":[70],"RAD51":[71],"accumulates":[72],"persists":[74],"at":[75,97,190],"cells,":[80],"possibly":[81],"due":[82],"lack":[84],"BLM":[86,94],"recruitment":[87],"stalled":[89,98],"forks.":[90,343],"Despite":[91],"failure":[92],"forks,":[99],"exhibit":[102],"lower":[103,429],"levels":[104,127],"hydroxyurea-induced":[106,118],"sister":[107,123],"chromatid":[108,124],"exchange.":[109],"In":[110],"deficient":[112,296],"both":[114],"BLM,":[117],"double":[119,279],"exchange":[125],"resembled":[126],"found":[128,244],"NSCME2-deficient":[130],"We":[132,223,243,344,380],"conclude":[133],"dependent":[144],"on":[145,371,415],"NSMCE2.":[146],"damage":[148,319,324],"encountered":[149],"causes":[154],"stalling":[156,169],"major":[160],"source":[161],"mutations":[163],"when":[164],"adequately":[166],"repaired.":[167],"Fork":[168],"can":[170],"lead":[171],"collapse,":[174],"is,":[176],"state":[178],"which":[183,214,247,396],"synthesis":[186],"cannot":[187],"be":[188,198],"resumed":[189],"site":[192],"stalling.":[194],"Collapsed":[195],"must":[197],"rescued":[199],"initiated":[203],"nearby,":[204],"little":[206],"known":[208,254],"about":[209,350],"mechanism":[212],"active":[216],"merges":[218],"fork.":[222],"used":[224,346,381],"inhibitor":[226],"generate":[231,362],"then":[236,345],"studied":[237],"genetic":[238],"control":[239],"collapsed-fork":[241,287],"rescue.":[242],"NSMCE2,":[246,298],"gene":[250],"product":[251],"regulate":[256],"repair":[257,309],"responses":[258],"stress,":[261],"required":[263],"for":[264,297,336,387],"effectively":[267],"order":[273],"complete":[275],"synthesis.":[277],"are":[283,295],"associated":[284],"do":[289],"suggesting":[299],"breakage":[302],"part":[304],"mechanism.":[310],"Failure":[311],"leads":[316],"mitosis":[321],"following":[327],"cell":[328,401],"cycle.":[329],"Our":[330],"work":[331],"highlights":[332],"unique":[334],"role":[335,354],"basic":[348],"information":[349],"its":[353],"hypothesis":[364,384],"would":[368],"reply":[369],"more":[370,414],"topoisomerase":[372,404],"proteins":[373],"help":[375],"resolve":[376],"excess":[377],"topological":[378],"stress.":[379],"this":[382],"screen":[386],"potential":[388,394],"NSMC2":[389],"inhibitors":[390],"discovered":[392],"four":[393],"compounds":[395],"sensitized":[397],"cancer":[400],"line":[402],"1":[405],"poison.":[406],"The":[407],"finding":[408],"inhibited":[411],"rely":[413],"topoisomerases":[416],"has":[417],"clear":[419],"impact.":[420],"As":[421],"adjuvant":[423],"therapy,":[424],"inhibition":[426],"could":[427],"significantly":[428],"effective":[431],"dose":[432],"clinically":[434],"approved,":[435],"highly":[437],"toxic":[438],"chemotherapies.":[439]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2020-08-18T00:00:00"}
