{"id":"https://openalex.org/W3048801940","doi":"https://doi.org/10.1186/s13059-020-02108-x","title":"Spatial patterns of CTCF sites define the anatomy of TADs and their boundaries","display_name":"Spatial patterns of CTCF sites define the anatomy of TADs and their boundaries","publication_year":2020,"publication_date":"2020-08-11","ids":{"openalex":"https://openalex.org/W3048801940","doi":"https://doi.org/10.1186/s13059-020-02108-x","mag":"3048801940","pmid":"https://pubmed.ncbi.nlm.nih.gov/32782014","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7422557"},"language":"en","primary_location":{"id":"doi:10.1186/s13059-020-02108-x","doi":"https://doi.org/10.1186/s13059-020-02108-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13059-020-02108-x","pdf_url":"https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-020-02108-x","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-020-02108-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079380917","display_name":"Luca Nanni","orcid":"https://orcid.org/0000-0001-7021-2007","observed_orcids":["https://orcid.org/0000-0001-7021-2007"]},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Nanni","raw_affiliation_strings":["Department of Electronics, Information and Bioengineering (DEIB), Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronics, Information and Bioengineering (DEIB), Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048332811","display_name":"Stefano Ceri","orcid":"https://orcid.org/0000-0003-0671-2415","observed_orcids":["https://orcid.org/0000-0003-0671-2415"]},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Ceri","raw_affiliation_strings":["Department of Electronics, Information and Bioengineering (DEIB), Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronics, Information and Bioengineering (DEIB), Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059941956","display_name":"Colin Logie","orcid":"https://orcid.org/0000-0002-8534-6582","observed_orcids":["https://orcid.org/0000-0002-8534-6582"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I4210109357","display_name":"Radboud Institute for Molecular Life Sciences","ror":"https://ror.org/01yb10j39","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4210109357"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Colin Logie","raw_affiliation_strings":["Department of Molecular Biology, Radboud Institute for Molecular Life Sciences, Faculty of Science, Radboud University, PO box 9101, 6500 HG, Nijmegen, The Netherlands. c.logie@science.ru.nl","Department of Molecular Biology, Radboud Institute for Molecular Life Sciences, Faculty of Science, Radboud University, PO box 9101, 6500 HG, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Radboud Institute for Molecular Life Sciences, Faculty of Science, Radboud University, PO box 9101, 6500 HG, Nijmegen, The Netherlands. c.logie@science.ru.nl","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I4210109357"]},{"raw_affiliation_string":"Department of Molecular Biology, Radboud Institute for Molecular Life Sciences, Faculty of Science, Radboud University, PO box 9101, 6500 HG, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I4210109357"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059941956"],"corresponding_institution_ids":["https://openalex.org/I145872427","https://openalex.org/I4210109357"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":3.5733,"has_fulltext":true,"cited_by_count":91,"citation_normalized_percentile":{"value":0.95016853,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"21","issue":"1","first_page":"197","last_page":"197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topologically-associated-domains","display_name":"topologically associating domains","score":0.9120000004768372},{"id":"https://openalex.org/keywords/ctcf-binding-sites","display_name":"CTCF binding sites","score":0.9580000042915344},{"id":"https://openalex.org/keywords/tad-boundaries","display_name":"TAD boundaries","score":0.9610000252723694},{"id":"https://openalex.org/keywords/chromatin-looping","display_name":"chromatin looping","score":0.8040000200271606},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.5849999785423279},{"id":"https://openalex.org/keywords/3d-genome-organization","display_name":"3D genome organization","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2778760011","wikidata":"https://www.wikidata.org/wiki/Q21163346","display_name":"CTCF","level":5,"score":0.9922935962677002},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7937722206115723},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6891748905181885},{"id":"https://openalex.org/C212702","wikidata":"https://www.wikidata.org/wiki/Q178150","display_name":"Insulator (electricity)","level":2,"score":0.582116425037384},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5542148351669312},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5323952436447144},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5057997703552246},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.43777891993522644},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4289749562740326},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.24341034889221191},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.21267303824424744},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1992354393005371},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11018294095993042},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.0},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000076246","descriptor_name":"CCCTC-Binding Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/s13059-020-02108-x","doi":"https://doi.org/10.1186/s13059-020-02108-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13059-020-02108-x","pdf_url":"https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-020-02108-x","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7422557","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7422557","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biol","raw_type":"Text"},{"id":"pmid:32782014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32782014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome biology","raw_type":"Journal Article"},{"id":"pmh:oai:re.public.polimi.it:11311/1145286","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11311/1145286","pdf_url":"https://genomebiology.biomedcentral.com/articles/10.1186/s13059-020-02108-x","source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/224973","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2066/224973","pdf_url":"https://repository.ubn.ru.nl//bitstream/handle/2066/224973/224973.pdf","source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:doaj.org/article:ad22a3f1a43d40b1945f9b42f3293392","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ad22a3f1a43d40b1945f9b42f3293392","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome Biology, Vol 21, Iss 1, Pp 1-25 (2020)","raw_type":"article"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/224973","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/224973","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome Biology, 21, 1 - 25","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s13059-020-02108-x","doi":"https://doi.org/10.1186/s13059-020-02108-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13059-020-02108-x","pdf_url":"https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-020-02108-x","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3796392728","display_name":"Data-Driven Genomic Computing","funder_award_id":"693174","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"}],"funders":[{"id":"https://openalex.org/F4320321013","display_name":"Radboud Universiteit","ror":"https://ror.org/016xsfp80"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3048801940.pdf","grobid_xml":"https://content.openalex.org/works/W3048801940.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1574083126","https://openalex.org/W1605145036","https://openalex.org/W1637500350","https://openalex.org/W1831401007","https://openalex.org/W1873772354","https://openalex.org/W1924378360","https://openalex.org/W1941076503","https://openalex.org/W1945579058","https://openalex.org/W1973062929","https://openalex.org/W1975777043","https://openalex.org/W1977308882","https://openalex.org/W1978696228","https://openalex.org/W1984827465","https://openalex.org/W2014677321","https://openalex.org/W2028022357","https://openalex.org/W2032140335","https://openalex.org/W2047005748","https://openalex.org/W2069721588","https://openalex.org/W2070021921","https://openalex.org/W2074192627","https://openalex.org/W2084620487","https://openalex.org/W2090037139","https://openalex.org/W2097798909","https://openalex.org/W2100148696","https://openalex.org/W2121083656","https://openalex.org/W2136430672","https://openalex.org/W2152791321","https://openalex.org/W2153970111","https://openalex.org/W2161212572","https://openalex.org/W2163068365","https://openalex.org/W2163412235","https://openalex.org/W2163605769","https://openalex.org/W2259938310","https://openalex.org/W2269163732","https://openalex.org/W2401568148","https://openalex.org/W2416744721","https://openalex.org/W2553838260","https://openalex.org/W2594764564","https://openalex.org/W2607008467","https://openalex.org/W2610160407","https://openalex.org/W2614347829","https://openalex.org/W2769885858","https://openalex.org/W2788376770","https://openalex.org/W2810076504","https://openalex.org/W2915166051","https://openalex.org/W2937151182","https://openalex.org/W2942684831","https://openalex.org/W2944948277","https://openalex.org/W2950020758","https://openalex.org/W2953340391","https://openalex.org/W2960979937","https://openalex.org/W2984636935","https://openalex.org/W2989713781","https://openalex.org/W2990380375","https://openalex.org/W2991248607","https://openalex.org/W3009045514","https://openalex.org/W3011951807","https://openalex.org/W3016522754","https://openalex.org/W6968810575"],"related_works":["https://openalex.org/W2971198437","https://openalex.org/W6920926716","https://openalex.org/W6958490264","https://openalex.org/W6906735535","https://openalex.org/W7203499281","https://openalex.org/W2745733514","https://openalex.org/W3009045514","https://openalex.org/W4386637239","https://openalex.org/W6925374280","https://openalex.org/W3038540532"],"abstract_inverted_index":{"BACKGROUND:":[0],"Topologically":[1],"associating":[2],"domains":[3],"(TADs)":[4],"are":[5,17,27,118,124],"genomic":[6],"regions":[7],"of":[8,36,39,46,82,91,96,104,137,144,167,176,218,224,231],"self-interaction.":[9],"Additionally,":[10],"it":[11,55],"is":[12],"known":[13,28],"that":[14,113,178,196,214,238],"TAD":[15,62,145,162,186,200],"boundaries":[16,201],"enriched":[18,125],"in":[19,50,126,184,206,221],"CTCF":[20,25,40,75,83,97,115,122,138,158,168,181,191,203,235],"binding":[21,76,139,192],"sites.":[22],"In":[23],"turn,":[24],"sites":[26,41,84,140,169],"to":[29,43,53,60,129],"be":[30],"asymmetric,":[31],"whereby":[32],"the":[33,44,86,89,109,127,135,171,215,222,228,245],"convergent":[34,114,165,234],"configuration":[35],"a":[37,47,102,142,207],"pair":[38],"leads":[42],"formation":[45],"chromatin":[48,66,220],"loop":[49],"vivo.":[51],"However,":[52],"date,":[54],"has":[56],"been":[57],"unclear":[58],"how":[59],"reconcile":[61],"structure":[63,217],"with":[64],"CTCF-based":[65],"loops.":[67],"RESULTS:":[68],"We":[69,132],"approach":[70],"this":[71],"problem":[72],"by":[73],"analysing":[74],"site":[77,98,116,159,193,204,236],"strengths":[78],"and":[79,173,202,233],"classifying":[80],"clusters":[81,117,123,205,237],"along":[85,108,244],"genome":[87,111],"on":[88,227],"basis":[90],"their":[92,105],"relative":[93],"orientation.":[94],"Analysis":[95],"orientation":[99],"classes":[100],"as":[101,141],"function":[103,143],"spatial":[106],"distribution":[107,136],"human":[110,151],"reveals":[112,156],"depleted":[119],"while":[120],"divergent":[121,157,232],"5-":[128],"100-kb":[130],"range.":[131],"then":[133],"analyse":[134],"boundary":[146],"conservation":[147],"across":[148],"seven":[149],"primary":[150],"blood":[152],"cell":[153],"types.":[154],"This":[155,211],"enrichment":[160],"at":[161,240],"boundaries.":[163],"Furthermore,":[164],"arrays":[166],"separate":[170],"left":[172],"right":[174],"sections":[175],"TADs":[177,225],"harbour":[179],"internal":[180],"sites,":[182],"resulting":[183],"unequal":[185],"'halves'.":[187],"CONCLUSIONS:":[188],"The":[189],"orientation-based":[190],"cluster":[194],"classification":[195],"we":[197],"present":[198],"reconciles":[199],"mechanistically":[208],"elegant":[209],"fashion.":[210],"model":[212],"suggests":[213],"emergent":[216],"nuclear":[219],"form":[223],"relies":[226],"obligate":[229],"alternation":[230],"occur":[239],"different":[241],"length":[242],"scales":[243],"genome.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":21}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-08-18T00:00:00"}