{"id":"https://openalex.org/W3048795992","doi":"https://doi.org/10.3390/toxins12080511","title":"Safety, Tolerability, Pharmacokinetics, and Concentration-QTc Analysis of Tetrodotoxin: A Randomized, Dose Escalation Study in Healthy Adults","display_name":"Safety, Tolerability, Pharmacokinetics, and Concentration-QTc Analysis of Tetrodotoxin: A Randomized, Dose Escalation Study in Healthy Adults","publication_year":2020,"publication_date":"2020-08-09","ids":{"openalex":"https://openalex.org/W3048795992","doi":"https://doi.org/10.3390/toxins12080511","mag":"3048795992","pmid":"https://pubmed.ncbi.nlm.nih.gov/32784930","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7472037"},"language":"en","primary_location":{"id":"doi:10.3390/toxins12080511","doi":"https://doi.org/10.3390/toxins12080511","is_oa":true,"landing_page_url":"https://doi.org/10.3390/toxins12080511","pdf_url":"https://www.mdpi.com/2072-6651/12/8/511/pdf?version=1597132501","source":{"id":"https://openalex.org/S128990672","display_name":"Toxins","issn_l":"2072-6651","issn":["2072-6651"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxins","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6651/12/8/511/pdf?version=1597132501","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054216347","display_name":"Mojgan Kavoosi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mojgan Kavoosi","raw_affiliation_strings":["WEX Pharmaceuticals Inc., Vancouver, BC V6E-4A6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WEX Pharmaceuticals Inc., Vancouver, BC V6E-4A6, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109562307","display_name":"Terry E. O\u2019Reilly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Terry E. O\u2019Reilly","raw_affiliation_strings":["Celerion Inc., Tempe, AZ 85283, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celerion Inc., Tempe, AZ 85283, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075048068","display_name":"Mehran Kavoosi","orcid":"https://orcid.org/0000-0002-8518-8895","observed_orcids":["https://orcid.org/0000-0002-8518-8895"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehran Kavoosi","raw_affiliation_strings":["WEX Pharmaceuticals Inc., Vancouver, BC V6E-4A6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WEX Pharmaceuticals Inc., Vancouver, BC V6E-4A6, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069799912","display_name":"Peng Chai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103107","display_name":"Celerion (United States)","ror":"https://ror.org/01gtvsc36","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103107"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Chai","raw_affiliation_strings":["Celerion Inc., Lincoln, NE 68502, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celerion Inc., Lincoln, NE 68502, USA","institution_ids":["https://openalex.org/I4210103107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081750608","display_name":"Caroline Engel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145368","display_name":"Celerion (Canada)","ror":"https://ror.org/0491h6661","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210103107","https://openalex.org/I4210145368"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Caroline Engel","raw_affiliation_strings":["Celerion Inc., Montreal, QC H4M-2P1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celerion Inc., Montreal, QC H4M-2P1, Canada","institution_ids":["https://openalex.org/I4210145368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016238423","display_name":"Walter Korz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter Korz","raw_affiliation_strings":["WEX Pharmaceuticals Inc., Vancouver, BC V6E-4A6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WEX Pharmaceuticals Inc., Vancouver, BC V6E-4A6, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052142852","display_name":"Christopher C. Gallen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher C. Gallen","raw_affiliation_strings":["WEX Pharmaceuticals Inc., Vancouver, BC V6E-4A6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WEX Pharmaceuticals Inc., Vancouver, BC V6E-4A6, Canada","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109340911","display_name":"Robert M. Lester","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert M. Lester","raw_affiliation_strings":["Celerion Inc., Tempe, AZ 85283, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celerion Inc., Tempe, AZ 85283, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054216347"],"corresponding_institution_ids":[],"apc_list":{"value":2000,"currency":"CHF","value_usd":2112},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2112},"fwci":1.0784,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.71451271,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":"8","first_page":"511","last_page":"511"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research","score":0.23849999904632568,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research","score":0.23849999904632568,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.19580000638961792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.12700000405311584,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetrodotoxin","display_name":"tetrodotoxin","score":1.0},{"id":"https://openalex.org/keywords/voltage-gated-sodium-channel-blockers","display_name":"voltage-gated sodium channel blockers","score":0.9359999895095825},{"id":"https://openalex.org/keywords/qtc-prolongation","display_name":"QTc prolongation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cardiac-safety","display_name":"cardiac safety","score":0.7129999995231628},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8299999833106995},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/subcutaneous-administration","display_name":"subcutaneous administration","score":0.6890000104904175},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6959999799728394},{"id":"https://openalex.org/keywords/drug-induced-arrhythmia","display_name":"drug-induced arrhythmia","score":0.7329999804496765},{"id":"https://openalex.org/keywords/moxifloxacin","display_name":"moxifloxacin","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8192411065101624},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7567678689956665},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7138556838035583},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.7123390436172485},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6999925374984741},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.6438243389129639},{"id":"https://openalex.org/C2776414672","wikidata":"https://www.wikidata.org/wiki/Q7553303","display_name":"Sodium channel blocker","level":4,"score":0.5680208206176758},{"id":"https://openalex.org/C42404028","wikidata":"https://www.wikidata.org/wiki/Q864940","display_name":"Bioequivalence","level":3,"score":0.557823657989502},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5189452171325684},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5164718627929688},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.44985708594322205},{"id":"https://openalex.org/C2778616394","wikidata":"https://www.wikidata.org/wiki/Q474959","display_name":"myalgia","level":2,"score":0.4316239655017853},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.41325998306274414},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.41069650650024414},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38859355449676514},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2590540647506714},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.10969653725624084},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008133","descriptor_name":"Long QT Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013779","descriptor_name":"Tetrodotoxin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013779","descriptor_name":"Tetrodotoxin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013779","descriptor_name":"Tetrodotoxin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013779","descriptor_name":"Tetrodotoxin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/toxins12080511","doi":"https://doi.org/10.3390/toxins12080511","is_oa":true,"landing_page_url":"https://doi.org/10.3390/toxins12080511","pdf_url":"https://www.mdpi.com/2072-6651/12/8/511/pdf?version=1597132501","source":{"id":"https://openalex.org/S128990672","display_name":"Toxins","issn_l":"2072-6651","issn":["2072-6651"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxins","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7472037","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7472037","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxins (Basel)","raw_type":"Text"},{"id":"pmid:32784930","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32784930","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxins","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:dae9ef95b54a49d9be979ac7eacb3f38","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dae9ef95b54a49d9be979ac7eacb3f38","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Toxins, Vol 12, Iss 8, p 511 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/toxins12080511","doi":"https://doi.org/10.3390/toxins12080511","is_oa":true,"landing_page_url":"https://doi.org/10.3390/toxins12080511","pdf_url":"https://www.mdpi.com/2072-6651/12/8/511/pdf?version=1597132501","source":{"id":"https://openalex.org/S128990672","display_name":"Toxins","issn_l":"2072-6651","issn":["2072-6651"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxins","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3048795992.pdf","grobid_xml":"https://content.openalex.org/works/W3048795992.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W43308025","https://openalex.org/W120314465","https://openalex.org/W886695988","https://openalex.org/W1492346649","https://openalex.org/W1768063825","https://openalex.org/W1771429770","https://openalex.org/W1909306694","https://openalex.org/W1966133272","https://openalex.org/W1973771269","https://openalex.org/W1978647133","https://openalex.org/W1984220118","https://openalex.org/W1990469660","https://openalex.org/W1999254876","https://openalex.org/W2006060163","https://openalex.org/W2012867732","https://openalex.org/W2013256530","https://openalex.org/W2017266529","https://openalex.org/W2017462460","https://openalex.org/W2018841001","https://openalex.org/W2024177131","https://openalex.org/W2027023361","https://openalex.org/W2027085605","https://openalex.org/W2028993619","https://openalex.org/W2029112648","https://openalex.org/W2035070309","https://openalex.org/W2038770557","https://openalex.org/W2039664528","https://openalex.org/W2046440253","https://openalex.org/W2063482843","https://openalex.org/W2067343156","https://openalex.org/W2076251265","https://openalex.org/W2082801748","https://openalex.org/W2087131253","https://openalex.org/W2096473841","https://openalex.org/W2100078256","https://openalex.org/W2100936946","https://openalex.org/W2105037254","https://openalex.org/W2106492347","https://openalex.org/W2114176091","https://openalex.org/W2116944809","https://openalex.org/W2119563878","https://openalex.org/W2127467308","https://openalex.org/W2132589158","https://openalex.org/W2135900115","https://openalex.org/W2139306343","https://openalex.org/W2145739946","https://openalex.org/W2151290582","https://openalex.org/W2151325894","https://openalex.org/W2158392638","https://openalex.org/W2159332152","https://openalex.org/W2160707037","https://openalex.org/W2297534580","https://openalex.org/W2517388045","https://openalex.org/W2610210672","https://openalex.org/W2618051972","https://openalex.org/W2638093340","https://openalex.org/W2741918516","https://openalex.org/W2771291368","https://openalex.org/W2774939473","https://openalex.org/W2799524133","https://openalex.org/W2894018868","https://openalex.org/W2922022049","https://openalex.org/W2923187798","https://openalex.org/W4205332786","https://openalex.org/W4292004352"],"related_works":["https://openalex.org/W7138382995","https://openalex.org/W2114176091","https://openalex.org/W4378516929","https://openalex.org/W4403738911","https://openalex.org/W2027905639","https://openalex.org/W2894018868","https://openalex.org/W2330186663","https://openalex.org/W2050962425","https://openalex.org/W4401324359","https://openalex.org/W4391252578"],"abstract_inverted_index":{"Tetrodotoxin":[0],"(TTX)":[1],"is":[2],"a":[3,15,68,143],"highly":[4],"specific":[5],"voltage-gated":[6],"sodium":[7],"channel":[8],"(VGSC)":[9],"blocker":[10],"in":[11,39,97,183,191],"clinical":[12],"evaluation":[13],"as":[14],"peripheral-acting":[16],"analgesic":[17],"for":[18,134],"chronic":[19],"pain.":[20],"This":[21],"study":[22,50,193],"presents":[23],"the":[24,29,110,114,140,176,184],"first":[25],"published":[26],"results":[27],"of":[28,34,55,76,91,113,119,142],"safety":[30],"including":[31],"cardiac":[32],"liability":[33],"TTX":[35,63,77,185,188],"at":[36],"therapeutic-relevant":[37],"concentrations":[38],"twenty-five":[40],"healthy":[41],"adults.":[42],"Randomized,":[43],"double-blind,":[44],"placebo-,":[45],"and":[46,60,94,109,123,160,173,197],"positive-":[47],"(moxifloxacin)":[48],"controlled":[49],"evaluated":[51],"single":[52],"ascending":[53],"doses":[54,189],"15":[56],"\u00b5g,":[57,59],"30":[58],"45":[61],"\u00b5g":[62],"over":[64],"3":[65],"periods":[66],"with":[67,154],"7-day":[69],"washout":[70],"between":[71,157],"each":[72],"period.":[73],"Subcutaneous":[74],"injections":[75],"were":[78,175],"readily":[79],"absorbed,":[80],"reaching":[81],"maximum":[82,121],"plasma":[83],"concentration":[84],"(Cmax)":[85],"within":[86],"1.5":[87],"h.":[88],"Both":[89],"extent":[90],"exposure":[92],"(AUC)":[93],"Cmax":[95],"increased":[96],"proportion":[98],"to":[99,165],"dose.":[100],"No":[101],"QT":[102,145],"prolongation":[103],"was":[104],"identified":[105],"by":[106],"concentration-QTc":[107],"analysis":[108],"upper":[111],"bounds":[112],"two-sided":[115],"90%":[116],"confidence":[117],"interval":[118],"predicted":[120],"baseline":[122],"placebo":[124],"corrected":[125],"QTcF":[126],"(\u0394\u0394QTcF)":[127],"value":[128],"did":[129],"not":[130],"exceed":[131],"10":[132],"ms":[133],"all":[135,158],"tetrodotoxin":[136],"doses,":[137],"thereby":[138],"meeting":[139],"criteria":[141],"negative":[144],"study.":[146],"Safety":[147],"assessments":[148],"showed":[149],"no":[150,161],"clinically":[151],"relevant":[152],"changes":[153],"values":[155],"similar":[156],"groups":[159],"subject":[162],"withdrawing":[163],"due":[164],"adverse":[166],"events.":[167],"Paresthesia,":[168],"oral-paresthesia,":[169],"headache,":[170],"dizziness,":[171],"nausea,":[172],"myalgia":[174],"most":[177],"common":[178],"TEAEs":[179],"(overall":[180],"occurrence":[181],"\u22655%)":[182],"treatment":[186],"groups.":[187],"investigated":[190],"this":[192],"are":[194],"safe,":[195],"well-tolerated,":[196],"lack":[198],"proarrhythmic":[199],"proclivity.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-08-18T00:00:00"}