{"id":"https://openalex.org/W3048757029","doi":"https://doi.org/10.1111/jocd.13672","title":"A Timosaponin B\u2010II containing scalp care solution for improvement of scalp hydration, dandruff reduction, and hair loss prevention: A comparative study on healthy volunteers before and after application","display_name":"A Timosaponin B\u2010II containing scalp care solution for improvement of scalp hydration, dandruff reduction, and hair loss prevention: A comparative study on healthy volunteers before and after application","publication_year":2020,"publication_date":"2020-08-12","ids":{"openalex":"https://openalex.org/W3048757029","doi":"https://doi.org/10.1111/jocd.13672","mag":"3048757029","pmid":"https://pubmed.ncbi.nlm.nih.gov/32780920"},"language":"en","primary_location":{"id":"doi:10.1111/jocd.13672","doi":"https://doi.org/10.1111/jocd.13672","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jocd.13672","pdf_url":null,"source":{"id":"https://openalex.org/S169297576","display_name":"Journal of Cosmetic Dermatology","issn_l":"1473-2130","issn":["1473-2130","1473-2165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cosmetic Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042938499","display_name":"Lei Xiao","orcid":"https://orcid.org/0000-0002-3638-4486","observed_orcids":["https://orcid.org/0000-0002-3638-4486"]},"institutions":[{"id":"https://openalex.org/I4210145118","display_name":"Infinitus (China)","ror":"https://ror.org/03pchte23","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210145118"]},{"id":"https://openalex.org/I4405272781","display_name":"Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety","ror":"https://ror.org/04q1x5n50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272781"]},{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Xiao","raw_affiliation_strings":["Infinitus (China) Co., Hong Kong, China","School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-3638-4486","affiliations":[{"raw_affiliation_string":"Infinitus (China) Co., Hong Kong, China","institution_ids":["https://openalex.org/I4210145118"]},{"raw_affiliation_string":"School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou, China","institution_ids":["https://openalex.org/I4405272781","https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022754773","display_name":"Xia Zhang","orcid":"https://orcid.org/0000-0003-3201-1700","observed_orcids":["https://orcid.org/0000-0003-3201-1700"]},"institutions":[{"id":"https://openalex.org/I4405272781","display_name":"Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety","ror":"https://ror.org/04q1x5n50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272781"]},{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Zhang","raw_affiliation_strings":["School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou, China","institution_ids":["https://openalex.org/I4405272781","https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100767031","display_name":"Zhiyi Chen","orcid":"https://orcid.org/0009-0006-8826-647X","observed_orcids":["https://orcid.org/0009-0006-8826-647X"]},"institutions":[{"id":"https://openalex.org/I4210099004","display_name":"Guangdong Academy of Agricultural Sciences","ror":"https://ror.org/01rkwtz72","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210099004"]},{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyi Chen","raw_affiliation_strings":["Sericultural & Agri\u2010Food Research Institute Guangdong Academy of Agricultural Sciences Key Laboratory of Functional Foods Ministry of Agriculture and Rural Affairs Guangdong Key Laboratory of Agricultural Products Processing  Guangzhou China","Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sericultural & Agri\u2010Food Research Institute Guangdong Academy of Agricultural Sciences Key Laboratory of Functional Foods Ministry of Agriculture and Rural Affairs Guangdong Key Laboratory of Agricultural Products Processing  Guangzhou China","institution_ids":["https://openalex.org/I4210099004","https://openalex.org/I4210151987"]},{"raw_affiliation_string":"Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou, China","institution_ids":["https://openalex.org/I4210099004","https://openalex.org/I4210151987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100672160","display_name":"Bing Li","orcid":"https://orcid.org/0000-0001-8084-2686","observed_orcids":["https://orcid.org/0000-0001-8084-2686"]},"institutions":[{"id":"https://openalex.org/I4405272781","display_name":"Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety","ror":"https://ror.org/04q1x5n50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272781"]},{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bing Li","raw_affiliation_strings":["School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou, China","institution_ids":["https://openalex.org/I4405272781","https://openalex.org/I90610280"]}]},{"author_position":"last","author":{"id":null,"display_name":"Lin Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799850029","display_name":"Dongguan University of Technology","ror":"https://ror.org/01m8p7q42","country_code":"CN","type":"education","lineage":["https://openalex.org/I2799850029"]},{"id":"https://openalex.org/I4405272781","display_name":"Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety","ror":"https://ror.org/04q1x5n50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272781"]},{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lin Li","raw_affiliation_strings":["School of Chemical Engineering and Energy Technology, Dongguan University of Technology, Dongguan, China","School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Engineering and Energy Technology, Dongguan University of Technology, Dongguan, China","institution_ids":["https://openalex.org/I2799850029"]},{"raw_affiliation_string":"School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou, China","institution_ids":["https://openalex.org/I4405272781","https://openalex.org/I90610280"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100672160"],"corresponding_institution_ids":["https://openalex.org/I2799850029","https://openalex.org/I4405272781","https://openalex.org/I90610280"],"apc_list":{"value":3200,"currency":"USD","value_usd":3200},"apc_paid":null,"fwci":0.5903,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.68455297,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"20","issue":"3","first_page":"819","last_page":"824"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anemarrhena-asphodeloides","display_name":"Anemarrhena asphodeloides","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hair-loss-prevention","display_name":"hair loss prevention","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C2777359526","wikidata":"https://www.wikidata.org/wiki/Q117484","display_name":"Dandruff","level":3,"score":0.9778625965118408},{"id":"https://openalex.org/C2778515351","wikidata":"https://www.wikidata.org/wiki/Q9622","display_name":"Scalp","level":2,"score":0.9637985229492188},{"id":"https://openalex.org/C2776360568","wikidata":"https://www.wikidata.org/wiki/Q2697787","display_name":"Hair loss","level":2,"score":0.6011019945144653},{"id":"https://openalex.org/C3020433029","wikidata":"https://www.wikidata.org/wiki/Q3633540","display_name":"Hair care","level":2,"score":0.5687215328216553},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5229005217552185},{"id":"https://openalex.org/C2777216303","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair follicle","level":2,"score":0.5022797584533691},{"id":"https://openalex.org/C3020618081","wikidata":"https://www.wikidata.org/wiki/Q5937811","display_name":"Hair growth","level":2,"score":0.4908214509487152},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4568733274936676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43127796053886414},{"id":"https://openalex.org/C2781171460","wikidata":"https://www.wikidata.org/wiki/Q180204","display_name":"Shampoo","level":2,"score":0.25195080041885376},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.20740151405334473},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17753875255584717},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11375740170478821},{"id":"https://openalex.org/C126348684","wikidata":"https://www.wikidata.org/wiki/Q3456979","display_name":"Polymer science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000505","descriptor_name":"Alopecia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000505","descriptor_name":"Alopecia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012503","descriptor_name":"Saponins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012535","descriptor_name":"Scalp","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063807","descriptor_name":"Dandruff","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/jocd.13672","doi":"https://doi.org/10.1111/jocd.13672","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jocd.13672","pdf_url":null,"source":{"id":"https://openalex.org/S169297576","display_name":"Journal of Cosmetic Dermatology","issn_l":"1473-2130","issn":["1473-2130","1473-2165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cosmetic Dermatology","raw_type":"journal-article"},{"id":"pmid:32780920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32780920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cosmetic dermatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1745129223","https://openalex.org/W1817947117","https://openalex.org/W2030000641","https://openalex.org/W2033061173","https://openalex.org/W2038415514","https://openalex.org/W2054739294","https://openalex.org/W2072166267","https://openalex.org/W2106656997","https://openalex.org/W2107628464","https://openalex.org/W2119629672","https://openalex.org/W2135277850","https://openalex.org/W2155234518","https://openalex.org/W2165128662","https://openalex.org/W2166641340","https://openalex.org/W2281220653","https://openalex.org/W2293823032","https://openalex.org/W2326865191","https://openalex.org/W2470320751","https://openalex.org/W2559884158","https://openalex.org/W2594831034","https://openalex.org/W2606239134","https://openalex.org/W2625600483","https://openalex.org/W2897721058","https://openalex.org/W2904826044","https://openalex.org/W2939701520"],"related_works":["https://openalex.org/W4381948425","https://openalex.org/W1987825879","https://openalex.org/W2843800913","https://openalex.org/W3193636226","https://openalex.org/W4390598787","https://openalex.org/W3015593404","https://openalex.org/W4390921513","https://openalex.org/W2517818342","https://openalex.org/W3211664511","https://openalex.org/W3180999905"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,96,183],"plant":[2],"species":[3],"Anemarrhena":[4],"asphodeloides":[5,189],"has":[6],"commonly":[7],"been":[8],"used":[9],"for":[10,78,93],"health":[11],"and":[12,33,55,61,136,165,181,196],"therapeutic":[13],"purposes.":[14],"Timosaponin":[15,173],"B-II,":[16],"which":[17],"is":[18],"present":[19],"at":[20],"a":[21,44],"high":[22],"concentration":[23],"in":[24,58,157],"A":[25,188],"asphodeloides,":[26],"was":[27],"found":[28],"to":[29,152],"enhance":[30],"the":[31,66,85,120,144,193],"immune":[32],"anti-inflammatory":[34],"responses":[35],"of":[36,43,84,123,143],"human":[37],"bodies.":[38],"AIMS:":[39],"To":[40],"evaluate":[41],"benefits":[42],"timosaponin":[45,76,91,145],"B-II":[46,77,92,146,174],"containing":[47,89,147,187],"scalp":[48,56,71,86,137,148,160,166,184,194],"care":[49,72,87,149,185],"solution":[50,73,88,186],"on":[51,134,179],"hair":[52,98,102,105,135,158,162,180,197],"loss":[53,198],"prevention":[54],"healthiness":[57,195],"multiple":[59,176],"physiological":[60,177],"biological":[62],"profiles.":[63],"METHODS:":[64],"Prior":[65],"study,":[67],"90":[68],"subjects":[69],"applied":[70],"base":[74],"without":[75],"two":[79],"weeks":[80],"followed":[81],"by":[82,141],"application":[83,142],"0.5%":[90],"28":[94],"days.":[95,130],"subject's":[97],"follicle":[99],"hydrocortisone":[100],"level,":[101,107,109,113,115],"fall":[103,163],"number,":[104,164],"luster":[106],"dandruff":[108],"sensation":[110],"score,":[111],"hydration":[112],"lipid":[114],"redness":[116,167],"as":[117,119],"well":[118],"pH":[121],"level":[122,168],"scalps":[124],"were":[125,139],"quantitatively":[126],"assessed":[127],"every":[128],"7":[129],"RESULTS:":[131],"Multiple":[132],"parameters":[133],"conditions":[138],"promoted":[140],"solution.":[150],"Compared":[151],"baseline":[153],"values,":[154],"significant":[155],"improvements":[156],"luster,":[159],"hydration,":[161],"could":[169],"be":[170],"observed.":[171],"CONCLUSION:":[172],"promotes":[175],"factors":[178],"scalps.":[182],"extracts":[190],"may":[191],"benefit":[192],"prevention.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-08-18T00:00:00"}