{"id":"https://openalex.org/W3048670563","doi":"https://doi.org/10.1172/jci.insight.139640","title":"Endothelial cell HSPA12B and yes-associated protein cooperatively regulate angiogenesis following myocardial infarction","display_name":"Endothelial cell HSPA12B and yes-associated protein cooperatively regulate angiogenesis following myocardial infarction","publication_year":2020,"publication_date":"2020-08-13","ids":{"openalex":"https://openalex.org/W3048670563","doi":"https://doi.org/10.1172/jci.insight.139640","mag":"3048670563","pmid":"https://pubmed.ncbi.nlm.nih.gov/32790647","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7526558"},"language":"en","primary_location":{"id":"doi:10.1172/jci.insight.139640","doi":"https://doi.org/10.1172/jci.insight.139640","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.139640","pdf_url":null,"source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1172/jci.insight.139640","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086621430","display_name":"Min Fan","orcid":"https://orcid.org/0000-0002-1787-4287","observed_orcids":["https://orcid.org/0000-0002-1787-4287"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Fan","raw_affiliation_strings":["Center of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University (ETSU), Johnson City, Tennessee, USA","Department of Surgery and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University (ETSU), Johnson City, Tennessee, USA","institution_ids":["https://openalex.org/I119443389"]},{"raw_affiliation_string":"Department of Surgery and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109518238","display_name":"Kun Yang","orcid":"https://orcid.org/0000-0002-6232-6271","observed_orcids":["https://orcid.org/0000-0002-6232-6271"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kun Yang","raw_affiliation_strings":["Center of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University (ETSU), Johnson City, Tennessee, USA","Department of Surgery and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University (ETSU), Johnson City, Tennessee, USA","institution_ids":["https://openalex.org/I119443389"]},{"raw_affiliation_string":"Department of Surgery and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100410729","display_name":"Xiaohui Wang","orcid":"https://orcid.org/0000-0002-2299-3977","observed_orcids":["https://orcid.org/0000-0002-2299-3977","https://orcid.org/0000-0002-2109-2157"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohui Wang","raw_affiliation_strings":["Center of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University (ETSU), Johnson City, Tennessee, USA","Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts, USA","Department of Surgery and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University (ETSU), Johnson City, Tennessee, USA","institution_ids":["https://openalex.org/I119443389"]},{"raw_affiliation_string":"Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Surgery and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033854234","display_name":"Yana Wang","orcid":"https://orcid.org/0000-0003-1541-492X","observed_orcids":["https://orcid.org/0000-0003-1541-492X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yana Wang","raw_affiliation_strings":["Department of Surgery and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000108442","display_name":"Fei Tu","orcid":"https://orcid.org/0000-0003-4389-8247","observed_orcids":["https://orcid.org/0000-0003-4389-8247","https://orcid.org/0000-0001-5216-9850"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fei Tu","raw_affiliation_strings":["Department of Surgery and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028927398","display_name":"Tuanzhu Ha","orcid":"https://orcid.org/0000-0001-8244-4585","observed_orcids":["https://orcid.org/0000-0001-8244-4585"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tuanzhu Ha","raw_affiliation_strings":["Center of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University (ETSU), Johnson City, Tennessee, USA","Department of Surgery and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University (ETSU), Johnson City, Tennessee, USA","institution_ids":["https://openalex.org/I119443389"]},{"raw_affiliation_string":"Department of Surgery and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100418899","display_name":"Li Liu","orcid":"https://orcid.org/0000-0003-2314-8756","observed_orcids":["https://orcid.org/0000-0003-2314-8756"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Liu","raw_affiliation_strings":["Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033677559","display_name":"David L. Williams","orcid":"https://orcid.org/0000-0002-4586-9290","observed_orcids":["https://orcid.org/0000-0002-4586-9290"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Williams","raw_affiliation_strings":["Center of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University (ETSU), Johnson City, Tennessee, USA","Department of Surgery and"],"raw_orcid":"https://orcid.org/0000-0002-4586-9290","affiliations":[{"raw_affiliation_string":"Center of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University (ETSU), Johnson City, Tennessee, USA","institution_ids":["https://openalex.org/I119443389"]},{"raw_affiliation_string":"Department of Surgery and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101798536","display_name":"Chuanfu Li","orcid":"https://orcid.org/0000-0002-1224-4358","observed_orcids":["https://orcid.org/0000-0002-1224-4358","https://orcid.org/0000-0002-4901-3297"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chuanfu Li","raw_affiliation_strings":["Center of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University (ETSU), Johnson City, Tennessee, USA","Department of Surgery and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University (ETSU), Johnson City, Tennessee, USA","institution_ids":["https://openalex.org/I119443389"]},{"raw_affiliation_string":"Department of Surgery and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101798536"],"corresponding_institution_ids":["https://openalex.org/I119443389"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":{"value":4100,"currency":"USD","value_usd":4100},"fwci":1.8676,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.85072436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"5","issue":"18","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hspa12b","display_name":"HSPA12B","score":0.9980000257492065},{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":0.8560000061988831},{"id":"https://openalex.org/keywords/tead4","display_name":"TEAD4","score":0.8450000286102295},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9760000109672546},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cardiac-dysfunction","display_name":"cardiac dysfunction","score":0.652999997138977},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.5720000267028809},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.9446814060211182},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5435954332351685},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5140103101730347},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.48448655009269714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4691164791584015},{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.45613744854927063},{"id":"https://openalex.org/C31194975","wikidata":"https://www.wikidata.org/wiki/Q20970095","display_name":"HIF1A","level":3,"score":0.4453580379486084},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4333179295063019},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.4279049038887024},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4138999879360199},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.22343102097511292},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18693694472312927},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.1463288962841034},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06528264284133911},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.05361461639404297},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.048371821641922},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000091102","descriptor_name":"YAP-Signaling Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1172/jci.insight.139640","doi":"https://doi.org/10.1172/jci.insight.139640","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.139640","pdf_url":null,"source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7526558","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7526558/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7526558/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"Text"},{"id":"pmid:32790647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32790647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI insight","raw_type":"Journal Article"},{"id":"pmh:oai:dc.etsu.edu:etsu-works-10618","doi":null,"is_oa":true,"landing_page_url":"https://dc.etsu.edu/etsu-works/9352","pdf_url":null,"source":{"id":"https://openalex.org/S4377196424","display_name":"Digital Commons - East Tennessee State University (East Tennessee State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119443389","host_organization_name":"East Tennessee State University","host_organization_lineage":["https://openalex.org/I119443389"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ETSU Faculty Works","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:77c519d2c6b848528b8cacfe360d2a8c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/77c519d2c6b848528b8cacfe360d2a8c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JCI Insight, Vol 5, Iss 18 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1172/jci.insight.139640","doi":"https://doi.org/10.1172/jci.insight.139640","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.139640","pdf_url":null,"source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3844563540","display_name":"Role of Toll-Like Receptor Signaling in Cardiac Ischemia","funder_award_id":"R01HL071837","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5507603376","display_name":"Training Innate Immunity: A new approach to the treatment of Sepsis","funder_award_id":"R01GM119197","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6332160297","display_name":null,"funder_award_id":"C06RR0306551","funder_id":"https://openalex.org/F4320309134","funder_display_name":"East Tennessee State University"},{"id":"https://openalex.org/G7741479709","display_name":"HSPA12B and YAP cooperatively regulate endothelial cell proliferation and angiogenesis after myocardial infarction.","funder_award_id":"20PRE35120345","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G8627564136","display_name":"Novel Role of Lactate for Cardiovascular Dysfunction in Sepsis","funder_award_id":"R01HL153270","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G94186973","display_name":"Innate Immunity and Cardiovascular Function in Sepsis","funder_award_id":"R01GM083016","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320309134","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3048670563.pdf","grobid_xml":"https://content.openalex.org/works/W3048670563.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1566020745","https://openalex.org/W1888543545","https://openalex.org/W1964665693","https://openalex.org/W1976771389","https://openalex.org/W1998590599","https://openalex.org/W2002935073","https://openalex.org/W2006030544","https://openalex.org/W2009682316","https://openalex.org/W2030895827","https://openalex.org/W2033360354","https://openalex.org/W2033998652","https://openalex.org/W2053873255","https://openalex.org/W2057938879","https://openalex.org/W2060073863","https://openalex.org/W2062121786","https://openalex.org/W2069964279","https://openalex.org/W2075528452","https://openalex.org/W2085197940","https://openalex.org/W2089196685","https://openalex.org/W2099358601","https://openalex.org/W2100592123","https://openalex.org/W2108179886","https://openalex.org/W2119327344","https://openalex.org/W2121072573","https://openalex.org/W2121761542","https://openalex.org/W2122754904","https://openalex.org/W2124059822","https://openalex.org/W2129466238","https://openalex.org/W2130449777","https://openalex.org/W2133733124","https://openalex.org/W2139642434","https://openalex.org/W2140627582","https://openalex.org/W2141571435","https://openalex.org/W2144026946","https://openalex.org/W2148608806","https://openalex.org/W2149805661","https://openalex.org/W2159376228","https://openalex.org/W2195706369","https://openalex.org/W2280948563","https://openalex.org/W2294570287","https://openalex.org/W2513071915","https://openalex.org/W2742951203","https://openalex.org/W2743161371","https://openalex.org/W2758616990","https://openalex.org/W2766400005","https://openalex.org/W2785326673","https://openalex.org/W2791442807","https://openalex.org/W2793223309","https://openalex.org/W2859815935","https://openalex.org/W2901482699","https://openalex.org/W2903459575","https://openalex.org/W2913705661","https://openalex.org/W2954563933","https://openalex.org/W3022062050","https://openalex.org/W6776901941"],"related_works":["https://openalex.org/W6981528789","https://openalex.org/W6889086807","https://openalex.org/W3100625627","https://openalex.org/W4283399627","https://openalex.org/W7028285966","https://openalex.org/W2140833048","https://openalex.org/W2139642434","https://openalex.org/W3154688854","https://openalex.org/W7053835647","https://openalex.org/W2119327344"],"abstract_inverted_index":{"Angiogenesis":[0],"is":[1,12,99,180],"essential":[2],"for":[3,20,185],"cardiac":[4,138],"functional":[5],"recovery":[6],"after":[7,44,68,195],"myocardial":[8],"infarction":[9],"(MI).":[10],"HSPA12B":[11,39,49,61,75,91,98,129,158,179],"predominately":[13],"expressed":[14],"in":[15,29,42,113,151,165],"endothelial":[16,54,81,90,125,178,193],"cells":[17],"and":[18,40,57,65,78,92,110,136,148,160,183,187],"required":[19],"angiogenesis.":[21,31,58,83,115],"Yes-associated":[22],"protein":[23],"(YAP)":[24],"plays":[25],"an":[26,87],"important":[27],"role":[28,37],"tumor":[30],"This":[32],"study":[33],"investigated":[34],"the":[35,120],"cooperative":[36],"of":[38,47,60,71,103,128],"YAP":[41,51,63,72,132,146,190],"angiogenesis":[43,135,194],"MI.":[45,196],"Silencing":[46],"either":[48],"or":[50,131],"impaired":[52,134],"hypoxia-promoted":[53],"cell":[55,82],"proliferation":[56],"Deficiency":[59],"suppressed":[62],"expression":[64,147,159],"nuclear":[66,76,149,161],"translocation":[67,77,150,162],"hypoxia.":[69],"Knockdown":[70],"attenuated":[73],"hypoxia-stimulated":[74],"abrogated":[79],"HSPA12B-promoted":[80],"Mechanistically,":[84],"hypoxia":[85],"induced":[86],"interaction":[88],"between":[89],"YAP.":[93],"ChIP":[94],"assay":[95],"showed":[96,123],"that":[97,124,177],"a":[100,111,181],"target":[101,182],"gene":[102],"YAP/transcriptional":[104],"enhanced":[105],"associated":[106],"domain":[107],"4":[108],"(TEAD4)":[109],"coactivator":[112,184],"YAP-associated":[114],"In":[116],"vivo":[117],"studies":[118],"using":[119],"MI":[121,144,167,172],"model":[122],"cell-specific":[126],"deficiency":[127],"(eHspa12b-/-)":[130],"(eYap-/-)":[133],"exacerbated":[137],"dysfunction":[139],"compared":[140],"with":[141,189],"WT":[142,152,166],"mice.":[143],"increased":[145],"hearts":[153,168],"but":[154,169],"not":[155,170],"eHspa12b-/-":[156],"hearts.":[157],"were":[163],"upregulated":[164],"eYap-/-":[171],"myocardium.":[173],"Our":[174],"data":[175],"demonstrate":[176],"YAP/TEAD4":[186],"cooperates":[188],"to":[191],"regulate":[192]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2020-08-18T00:00:00"}