{"id":"https://openalex.org/W3048488331","doi":"https://doi.org/10.1016/j.physbeh.2020.113128","title":"Chronic sleep restriction increases soluble hippocampal A\u03b2-42 and impairs cognitive performance","display_name":"Chronic sleep restriction increases soluble hippocampal A\u03b2-42 and impairs cognitive performance","publication_year":2020,"publication_date":"2020-08-10","ids":{"openalex":"https://openalex.org/W3048488331","doi":"https://doi.org/10.1016/j.physbeh.2020.113128","mag":"3048488331","pmid":"https://pubmed.ncbi.nlm.nih.gov/32791178"},"language":"en","primary_location":{"id":"doi:10.1016/j.physbeh.2020.113128","doi":"https://doi.org/10.1016/j.physbeh.2020.113128","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.physbeh.2020.113128","pdf_url":null,"source":{"id":"https://openalex.org/S167407068","display_name":"Physiology & Behavior","issn_l":"0031-9384","issn":["0031-9384","1873-507X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","erih-plus","jufo-1","ki-jl-1","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology & Behavior","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086251513","display_name":"Kelly N Brice","orcid":"https://orcid.org/0000-0002-3799-5115","observed_orcids":["https://orcid.org/0000-0002-3799-5115"]},"institutions":[{"id":"https://openalex.org/I128956969","display_name":"Texas Christian University","ror":"https://ror.org/054b0b564","country_code":"US","type":"education","lineage":["https://openalex.org/I128956969"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly N. Brice","raw_affiliation_strings":["Texas Christian University, Department of Psychology, 2955 South University Drive, Fort Worth, TX 76109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Christian University, Department of Psychology, 2955 South University Drive, Fort Worth, TX 76109, USA","institution_ids":["https://openalex.org/I128956969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062334042","display_name":"Christopher W. Hagen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I128956969","display_name":"Texas Christian University","ror":"https://ror.org/054b0b564","country_code":"US","type":"education","lineage":["https://openalex.org/I128956969"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher W. Hagen","raw_affiliation_strings":["Texas Christian University, Department of Biology, 2955 South University Drive, Fort Worth, TX 76109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Christian University, Department of Biology, 2955 South University Drive, Fort Worth, TX 76109, USA","institution_ids":["https://openalex.org/I128956969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110768776","display_name":"Julia L. Peterman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I128956969","display_name":"Texas Christian University","ror":"https://ror.org/054b0b564","country_code":"US","type":"education","lineage":["https://openalex.org/I128956969"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia L. Peterman","raw_affiliation_strings":["Texas Christian University, Department of Psychology, 2955 South University Drive, Fort Worth, TX 76109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Christian University, Department of Psychology, 2955 South University Drive, Fort Worth, TX 76109, USA","institution_ids":["https://openalex.org/I128956969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045572862","display_name":"John Figg","orcid":"https://orcid.org/0000-0002-9869-1094","observed_orcids":["https://orcid.org/0000-0002-9869-1094"]},"institutions":[{"id":"https://openalex.org/I128956969","display_name":"Texas Christian University","ror":"https://ror.org/054b0b564","country_code":"US","type":"education","lineage":["https://openalex.org/I128956969"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Figg","raw_affiliation_strings":["Texas Christian University, Department of Biology, 2955 South University Drive, Fort Worth, TX 76109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Christian University, Department of Biology, 2955 South University Drive, Fort Worth, TX 76109, USA","institution_ids":["https://openalex.org/I128956969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107661423","display_name":"Paige N Braden-Kuhle","orcid":"https://orcid.org/0000-0001-9229-3901","observed_orcids":["https://orcid.org/0000-0001-9229-3901"]},"institutions":[{"id":"https://openalex.org/I128956969","display_name":"Texas Christian University","ror":"https://ror.org/054b0b564","country_code":"US","type":"education","lineage":["https://openalex.org/I128956969"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paige N. Braden","raw_affiliation_strings":["Texas Christian University, Department of Psychology, 2955 South University Drive, Fort Worth, TX 76109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Christian University, Department of Psychology, 2955 South University Drive, Fort Worth, TX 76109, USA","institution_ids":["https://openalex.org/I128956969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053374077","display_name":"Michael J. Chumley","orcid":"https://orcid.org/0000-0001-7915-4069","observed_orcids":["https://orcid.org/0000-0001-7915-4069"]},"institutions":[{"id":"https://openalex.org/I128956969","display_name":"Texas Christian University","ror":"https://ror.org/054b0b564","country_code":"US","type":"education","lineage":["https://openalex.org/I128956969"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Chumley","raw_affiliation_strings":["Texas Christian University, Department of Biology, 2955 South University Drive, Fort Worth, TX 76109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Christian University, Department of Biology, 2955 South University Drive, Fort Worth, TX 76109, USA","institution_ids":["https://openalex.org/I128956969"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026676758","display_name":"Gary W. Boehm","orcid":"https://orcid.org/0009-0005-3123-8526","observed_orcids":["https://orcid.org/0009-0005-3123-8526"]},"institutions":[{"id":"https://openalex.org/I128956969","display_name":"Texas Christian University","ror":"https://ror.org/054b0b564","country_code":"US","type":"education","lineage":["https://openalex.org/I128956969"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gary W. Boehm","raw_affiliation_strings":["Texas Christian University, Department of Psychology, 2955 South University Drive, Fort Worth, TX 76109, USA. Electronic address: g.boehm@tcu.edu","Texas Christian University, Department of Psychology, 2955 South University Drive, Fort Worth, TX 76109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Christian University, Department of Psychology, 2955 South University Drive, Fort Worth, TX 76109, USA. Electronic address: g.boehm@tcu.edu","institution_ids":["https://openalex.org/I128956969"]},{"raw_affiliation_string":"Texas Christian University, Department of Psychology, 2955 South University Drive, Fort Worth, TX 76109, USA","institution_ids":["https://openalex.org/I128956969"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026676758"],"corresponding_institution_ids":["https://openalex.org/I128956969"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":1.2111,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.75856642,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"226","issue":null,"first_page":"113128","last_page":"113128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.023000000044703484,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-sleep-restriction","display_name":"chronic sleep restriction","score":0.9819999933242798},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.9210000038146973},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9829999804496765},{"id":"https://openalex.org/keywords/sleep-disruption","display_name":"sleep disruption","score":0.8130000233650208},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C2780937657","wikidata":"https://www.wikidata.org/wiki/Q5141192","display_name":"Sleep restriction","level":4,"score":0.8899945020675659},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.809187650680542},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.7125487327575684},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.6884189248085022},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.6300486922264099},{"id":"https://openalex.org/C2778329153","wikidata":"https://www.wikidata.org/wiki/Q1364801","display_name":"Sleep deprivation","level":3,"score":0.5513550639152527},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5229178667068481},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.479230672121048},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4784819483757019},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.46776077151298523},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3978084325790405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37206462025642395},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33689969778060913},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30235105752944946},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012892","descriptor_name":"Sleep Deprivation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012892","descriptor_name":"Sleep Deprivation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012892","descriptor_name":"Sleep Deprivation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.physbeh.2020.113128","doi":"https://doi.org/10.1016/j.physbeh.2020.113128","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.physbeh.2020.113128","pdf_url":null,"source":{"id":"https://openalex.org/S167407068","display_name":"Physiology & Behavior","issn_l":"0031-9384","issn":["0031-9384","1873-507X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","erih-plus","jufo-1","ki-jl-1","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology & Behavior","raw_type":"journal-article"},{"id":"pmid:32791178","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32791178","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology & behavior","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6200000047683716,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310522","display_name":"Texas Christian University","ror":"https://ror.org/054b0b564"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W84689042","https://openalex.org/W1602771322","https://openalex.org/W1894345071","https://openalex.org/W1925423442","https://openalex.org/W1932861877","https://openalex.org/W1968638135","https://openalex.org/W1997311794","https://openalex.org/W1999009790","https://openalex.org/W1999845971","https://openalex.org/W2007592124","https://openalex.org/W2013333500","https://openalex.org/W2059703710","https://openalex.org/W2075335062","https://openalex.org/W2082950503","https://openalex.org/W2083765418","https://openalex.org/W2119463290","https://openalex.org/W2121912241","https://openalex.org/W2126149232","https://openalex.org/W2140961438","https://openalex.org/W2143795693","https://openalex.org/W2145501808","https://openalex.org/W2160311930","https://openalex.org/W2163225965","https://openalex.org/W2167183660","https://openalex.org/W2262929199","https://openalex.org/W2265194371","https://openalex.org/W2277828123","https://openalex.org/W2341017146","https://openalex.org/W2412332240","https://openalex.org/W2531542945","https://openalex.org/W2552980158","https://openalex.org/W2560517226","https://openalex.org/W2564506494","https://openalex.org/W2584909754","https://openalex.org/W2606342421","https://openalex.org/W2609979439","https://openalex.org/W2610300115","https://openalex.org/W2618910871","https://openalex.org/W2735226312","https://openalex.org/W2790086925","https://openalex.org/W2895292592","https://openalex.org/W2910774779","https://openalex.org/W2910825225","https://openalex.org/W2986236375","https://openalex.org/W3006607037","https://openalex.org/W4211139529"],"related_works":["https://openalex.org/W2897002412","https://openalex.org/W2606342421","https://openalex.org/W2083765418","https://openalex.org/W2584909754","https://openalex.org/W3030408670","https://openalex.org/W2910664039","https://openalex.org/W3178150811","https://openalex.org/W7214240161","https://openalex.org/W2262929199","https://openalex.org/W4281662054"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2020-08-18T00:00:00"}