{"id":"https://openalex.org/W3048462249","doi":"https://doi.org/10.1002/anie.202004550","title":"Drug\u2010Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side\u2010Chain Lipophilicity","display_name":"Drug\u2010Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side\u2010Chain Lipophilicity","publication_year":2020,"publication_date":"2020-08-13","ids":{"openalex":"https://openalex.org/W3048462249","doi":"https://doi.org/10.1002/anie.202004550","mag":"3048462249","pmid":"https://pubmed.ncbi.nlm.nih.gov/32789999","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7719619"},"language":"en","primary_location":{"id":"doi:10.1002/anie.202004550","doi":"https://doi.org/10.1002/anie.202004550","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.202004550","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7719619/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031408204","display_name":"Akihiro Furukawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiro Furukawa","raw_affiliation_strings":["Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710 Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062960237","display_name":"Joshua A. Schwochert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joshua Schwochert","raw_affiliation_strings":["Unnatural Products, Inc., 250 Natural Bridges Drive, Santa Cruz, CA, 95060 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unnatural Products, Inc., 250 Natural Bridges Drive, Santa Cruz, CA, 95060 USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020418271","display_name":"Cameron R. Pye","orcid":"https://orcid.org/0000-0002-4122-2078","observed_orcids":["https://orcid.org/0000-0002-4122-2078"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cameron R. Pye","raw_affiliation_strings":["Unnatural Products, Inc., 250 Natural Bridges Drive, Santa Cruz, CA, 95060 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unnatural Products, Inc., 250 Natural Bridges Drive, Santa Cruz, CA, 95060 USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000256016","display_name":"Daigo Asano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daigo Asano","raw_affiliation_strings":["Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710 Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032316644","display_name":"Quinn D. Edmondson","orcid":"https://orcid.org/0000-0002-1133-0852","observed_orcids":["https://orcid.org/0000-0002-1133-0852"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quinn D. Edmondson","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, 94158 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, 94158 USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026447555","display_name":"Alexandra C. Turmon","orcid":"https://orcid.org/0009-0003-3713-570X","observed_orcids":["https://orcid.org/0009-0003-3713-570X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandra C. Turmon","raw_affiliation_strings":["Unnatural Products, Inc., 250 Natural Bridges Drive, Santa Cruz, CA, 95060 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unnatural Products, Inc., 250 Natural Bridges Drive, Santa Cruz, CA, 95060 USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080207890","display_name":"Victoria G. Klein","orcid":"https://orcid.org/0000-0002-3438-2399","observed_orcids":["https://orcid.org/0000-0002-3438-2399"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria G. Klein","raw_affiliation_strings":["Department of Chemistry & Biochemistry, University of California Santa Cruz, Santa Cruz, CA, 96064 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, University of California Santa Cruz, Santa Cruz, CA, 96064 USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013731608","display_name":"Satoshi Ono","orcid":"https://orcid.org/0000-0001-5631-5923","observed_orcids":["https://orcid.org/0000-0001-5631-5923","https://orcid.org/0000-0001-5726-6908"]},"institutions":[{"id":"https://openalex.org/I4387155982","display_name":"Tanabe Pharma Corporation (Japan)","ror":"https://ror.org/038ehsm73","country_code":"JP","type":"company","lineage":["https://openalex.org/I168192097","https://openalex.org/I4387155982"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Ono","raw_affiliation_strings":["Discovery Technology Laboratories, Mitsubishi Tanabe Pharma Corporation, Yokohama, 227-0033 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Technology Laboratories, Mitsubishi Tanabe Pharma Corporation, Yokohama, 227-0033 Japan","institution_ids":["https://openalex.org/I4387155982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012702722","display_name":"Okimasa Okada","orcid":"https://orcid.org/0000-0002-1841-5429","observed_orcids":["https://orcid.org/0000-0002-1841-5429"]},"institutions":[{"id":"https://openalex.org/I4387155982","display_name":"Tanabe Pharma Corporation (Japan)","ror":"https://ror.org/038ehsm73","country_code":"JP","type":"company","lineage":["https://openalex.org/I168192097","https://openalex.org/I4387155982"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Okimasa Okada","raw_affiliation_strings":["Discovery Technology Laboratories, Mitsubishi Tanabe Pharma Corporation, Yokohama, 227-0033 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Technology Laboratories, Mitsubishi Tanabe Pharma Corporation, Yokohama, 227-0033 Japan","institution_ids":["https://openalex.org/I4387155982"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041644296","display_name":"R. Scott Lokey","orcid":"https://orcid.org/0000-0001-9891-1248","observed_orcids":["https://orcid.org/0000-0001-9891-1248"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R. Scott Lokey","raw_affiliation_strings":["Department of Chemistry & Biochemistry, University of California Santa Cruz, Santa Cruz, CA, 96064 USA"],"raw_orcid":"https://orcid.org/0000-0001-9891-1248","affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, University of California Santa Cruz, Santa Cruz, CA, 96064 USA","institution_ids":["https://openalex.org/I185103710"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5041644296"],"corresponding_institution_ids":["https://openalex.org/I185103710"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":4.3776,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.96481159,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"59","issue":"48","first_page":"21571","last_page":"21577"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrocyclic-peptides","display_name":"macrocyclic peptides","score":0.8980000019073486},{"id":"https://openalex.org/keywords/membrane-permeability","display_name":"membrane permeability","score":0.7799999713897705},{"id":"https://openalex.org/keywords/peptoids","display_name":"peptoids","score":0.765999972820282},{"id":"https://openalex.org/keywords/cyclic-decapeptide","display_name":"cyclic decapeptide","score":0.8209999799728394},{"id":"https://openalex.org/keywords/adme-properties","display_name":"ADME properties","score":0.847000002861023},{"id":"https://openalex.org/keywords/drug-likeness","display_name":"drug-likeness","score":0.6710000038146973},{"id":"https://openalex.org/keywords/beta-turn","display_name":"beta-turn","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C201399114","wikidata":"https://www.wikidata.org/wiki/Q898401","display_name":"Lipophilicity","level":2,"score":0.9588389992713928},{"id":"https://openalex.org/C2780474982","wikidata":"https://www.wikidata.org/wiki/Q7166540","display_name":"Peptoid","level":3,"score":0.879464864730835},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7051160335540771},{"id":"https://openalex.org/C160343418","wikidata":"https://www.wikidata.org/wiki/Q185256","display_name":"Rigidity (electromagnetism)","level":2,"score":0.6628601551055908},{"id":"https://openalex.org/C155759531","wikidata":"https://www.wikidata.org/wiki/Q7625050","display_name":"Structural rigidity","level":2,"score":0.5278449058532715},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.4576725959777832},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.4515584409236908},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.4475755989551544},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.4303523898124695},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.41992995142936707},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.39550212025642395},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3704564571380615},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.35517141222953796},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.2325415313243866},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.22846299409866333},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.22410964965820312},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.18493780493736267},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11375820636749268},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.06850963830947876},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.06778216361999512},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047028","descriptor_name":"Macrocyclic Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D047028","descriptor_name":"Macrocyclic Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/anie.202004550","doi":"https://doi.org/10.1002/anie.202004550","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.202004550","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},{"id":"pmid:32789999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32789999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie (International ed. in English)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7719619","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7719619/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Angew Chem Int Ed Engl","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7719619","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7719619/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Angew Chem Int Ed Engl","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1858983374","display_name":"Cyclic peptide permeability","funder_award_id":"R01GM131135","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2846432131","display_name":"NCRR: UCSC Integrated Small Molecule Screening Facility","funder_award_id":"S10RR022455","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W637743980","https://openalex.org/W1827916032","https://openalex.org/W1968682237","https://openalex.org/W1982702481","https://openalex.org/W1992114507","https://openalex.org/W2000788902","https://openalex.org/W2023018411","https://openalex.org/W2033495141","https://openalex.org/W2041026060","https://openalex.org/W2045093121","https://openalex.org/W2050991123","https://openalex.org/W2058289726","https://openalex.org/W2062692230","https://openalex.org/W2065601090","https://openalex.org/W2067990107","https://openalex.org/W2085948054","https://openalex.org/W2087412677","https://openalex.org/W2091492589","https://openalex.org/W2106605095","https://openalex.org/W2129178272","https://openalex.org/W2131192876","https://openalex.org/W2158274171","https://openalex.org/W2160072188","https://openalex.org/W2234248612","https://openalex.org/W2279263454","https://openalex.org/W2332082155","https://openalex.org/W2335897173","https://openalex.org/W2346205968","https://openalex.org/W2473618562","https://openalex.org/W2529268217","https://openalex.org/W2569093964","https://openalex.org/W2605040111","https://openalex.org/W2618351167","https://openalex.org/W2752513086","https://openalex.org/W2754199378","https://openalex.org/W2765959372","https://openalex.org/W2785477444","https://openalex.org/W2795033545","https://openalex.org/W2796027835","https://openalex.org/W2897937537","https://openalex.org/W2900345897","https://openalex.org/W2900679761","https://openalex.org/W2908658631","https://openalex.org/W2942566598","https://openalex.org/W2943220185","https://openalex.org/W2945543430","https://openalex.org/W3004670928"],"related_works":["https://openalex.org/W4391659491","https://openalex.org/W4382794577","https://openalex.org/W3193672628","https://openalex.org/W4286491297","https://openalex.org/W2346205968","https://openalex.org/W7198867198","https://openalex.org/W2161364905","https://openalex.org/W2768272848","https://openalex.org/W2051883847","https://openalex.org/W7060867260"],"abstract_inverted_index":{"Large":[0],"macrocyclic":[1,118],"peptides":[2],"can":[3,105,124],"achieve":[4],"surprisingly":[5],"high":[6,83],"membrane":[7],"permeability,":[8],"although":[9],"the":[10,43,46,49,52,59],"properties":[11,112],"that":[12,39,66,102,121],"govern":[13],"permeability":[14,84],"in":[15,58,69,75],"this":[16],"chemical":[17],"space":[18],"are":[19],"only":[20],"beginning":[21],"to":[22,63,108,127],"come":[23],"into":[24,113],"focus.":[25],"We":[26],"generated":[27],"two":[28],"libraries":[29],"of":[30,45,51],"cyclic":[31],"decapeptides":[32],"with":[33,90],"stable":[34],"cross-\u03b2":[35],"conformations,":[36],"and":[37,79,116,120],"found":[38],"peptoid":[40,56],"substitutions":[41,57],"within":[42],"\u03b2-turns":[44],"macrocycle":[47],"preserved":[48],"rigidity":[50,123],"parent":[53],"scaffold,":[54],"whereas":[55],"opposing":[60],"\u03b2-strands":[61],"led":[62],"\"chameleonic\"":[64],"species":[65],"were":[67],"rigid":[68,78,115],"nonpolar":[70],"media":[71],"but":[72],"highly":[73],"flexible":[74,117],"water.":[76],"Both":[77],"chameleonic":[80],"compounds":[81],"showed":[82],"over":[85],"a":[86],"wide":[87],"lipophilicity":[88,104],"range,":[89],"peak":[91],"permeabilities":[92],"differing":[93],"significantly":[94],"depending":[95],"on":[96],"scaffold":[97,122],"rigidity.":[98],"Our":[99],"findings":[100],"indicate":[101],"modulating":[103],"be":[106,125],"used":[107,126],"engineer":[109],"favorable":[110],"ADME":[111],"both":[114],"peptides,":[119],"tune":[128],"optimal":[129],"lipophilicity.":[130]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-08-18T00:00:00"}
