{"id":"https://openalex.org/W3048237196","doi":null,"title":"Dimethyl fumarate for treatment of multiple sclerosis : clinical effects and mechanisms","display_name":"Dimethyl fumarate for treatment of multiple sclerosis : clinical effects and mechanisms","publication_year":2020,"publication_date":"2020-08-10","ids":{"openalex":"https://openalex.org/W3048237196","mag":"3048237196"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26907007","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Dimethyl_fumarate_for_treatment_of_multiple_sclerosis_clinical_effects_and_mechanisms/26907007","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/47270","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015727455","display_name":"Mathias Granqvist","orcid":"https://orcid.org/0000-0001-6312-069X","observed_orcids":["https://orcid.org/0000-0001-6312-069X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mathias Granqvist","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5015727455"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dimethyl-fumarate","display_name":"dimethyl fumarate","score":0.9929999709129333},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.847000002861023},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.628000020980835},{"id":"https://openalex.org/keywords/fingolimod","display_name":"fingolimod","score":0.9290000200271606},{"id":"https://openalex.org/keywords/natalizumab","display_name":"natalizumab","score":0.8659999966621399},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.968999981880188},{"id":"https://openalex.org/keywords/glatiramer-acetate","display_name":"glatiramer acetate","score":0.9549999833106995},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.7720000147819519},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7390000224113464},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8159999847412109},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9340000152587891},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/kynurenine-pathway","display_name":"kynurenine pathway","score":0.7950000166893005},{"id":"https://openalex.org/keywords/aerobic-exercise","display_name":"aerobic exercise","score":0.8980000019073486},{"id":"https://openalex.org/keywords/high-intensity-exercise","display_name":"high-intensity exercise","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C2776819417","wikidata":"https://www.wikidata.org/wiki/Q418123","display_name":"Dimethyl fumarate","level":3,"score":0.9195423126220703},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7173604369163513},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4012439250946045},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3585283160209656},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33764681220054626},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.21148359775543213},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18641722202301025}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26907007","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Dimethyl_fumarate_for_treatment_of_multiple_sclerosis_clinical_effects_and_mechanisms/26907007","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/47270","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/47270","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:3048237196","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/handle/10616/47270","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/47270","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/47270","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":139,"referenced_works":["https://openalex.org/W20183537","https://openalex.org/W1499839644","https://openalex.org/W1527552685","https://openalex.org/W1573240688","https://openalex.org/W1908756607","https://openalex.org/W1914347682","https://openalex.org/W1937650001","https://openalex.org/W1964947727","https://openalex.org/W1966515383","https://openalex.org/W1966718542","https://openalex.org/W1967838438","https://openalex.org/W1970849805","https://openalex.org/W1971555130","https://openalex.org/W1972403093","https://openalex.org/W1973224303","https://openalex.org/W1974261598","https://openalex.org/W1974654819","https://openalex.org/W1974694291","https://openalex.org/W1976304136","https://openalex.org/W1978094617","https://openalex.org/W1978825269","https://openalex.org/W1988630041","https://openalex.org/W1990507371","https://openalex.org/W1994684119","https://openalex.org/W1995089232","https://openalex.org/W1995404834","https://openalex.org/W2007108464","https://openalex.org/W2009495078","https://openalex.org/W2010084870","https://openalex.org/W2014402612","https://openalex.org/W2016404394","https://openalex.org/W2019582599","https://openalex.org/W2020767502","https://openalex.org/W2023555055","https://openalex.org/W2027129171","https://openalex.org/W2041071307","https://openalex.org/W2046781531","https://openalex.org/W2047801383","https://openalex.org/W2049197285","https://openalex.org/W2053683902","https://openalex.org/W2054119106","https://openalex.org/W2056176542","https://openalex.org/W2063158442","https://openalex.org/W2064177679","https://openalex.org/W2067633002","https://openalex.org/W2068329556","https://openalex.org/W2077730410","https://openalex.org/W2087283639","https://openalex.org/W2091844728","https://openalex.org/W2093009907","https://openalex.org/W2094437129","https://openalex.org/W2095666175","https://openalex.org/W2102515242","https://openalex.org/W2103232683","https://openalex.org/W2105206040","https://openalex.org/W2107581557","https://openalex.org/W2109577352","https://openalex.org/W2112165124","https://openalex.org/W2117415152","https://openalex.org/W2118818657","https://openalex.org/W2120869361","https://openalex.org/W2122542523","https://openalex.org/W2122545833","https://openalex.org/W2123038985","https://openalex.org/W2124780022","https://openalex.org/W2124836944","https://openalex.org/W2126336004","https://openalex.org/W2135403800","https://openalex.org/W2143863752","https://openalex.org/W2144355149","https://openalex.org/W2144818921","https://openalex.org/W2145770957","https://openalex.org/W2147062889","https://openalex.org/W2148563799","https://openalex.org/W2149218665","https://openalex.org/W2149912762","https://openalex.org/W2154132418","https://openalex.org/W2157831456","https://openalex.org/W2159945795","https://openalex.org/W2160488179","https://openalex.org/W2163398467","https://openalex.org/W2163609916","https://openalex.org/W2163950729","https://openalex.org/W2164267257","https://openalex.org/W2164392039","https://openalex.org/W2164832046","https://openalex.org/W2168726651","https://openalex.org/W2170824762","https://openalex.org/W2176880214","https://openalex.org/W2193966886","https://openalex.org/W2203415225","https://openalex.org/W2259687899","https://openalex.org/W2272344902","https://openalex.org/W2273172273","https://openalex.org/W2281589817","https://openalex.org/W2312313151","https://openalex.org/W2313649737","https://openalex.org/W2318010691","https://openalex.org/W2335355888","https://openalex.org/W2343323874","https://openalex.org/W2395316927","https://openalex.org/W2411105085","https://openalex.org/W2432721145","https://openalex.org/W2527140772","https://openalex.org/W2561881161","https://openalex.org/W2564905851","https://openalex.org/W2728771301","https://openalex.org/W2745391459","https://openalex.org/W2747686311","https://openalex.org/W2750436552","https://openalex.org/W2754321750","https://openalex.org/W2759107835","https://openalex.org/W2766371671","https://openalex.org/W2777074421","https://openalex.org/W2785858530","https://openalex.org/W2794813666","https://openalex.org/W2795026898","https://openalex.org/W2807882529","https://openalex.org/W2900790963","https://openalex.org/W2908974689","https://openalex.org/W2918857132","https://openalex.org/W2920664301","https://openalex.org/W2921112006","https://openalex.org/W2921788958","https://openalex.org/W2940868084","https://openalex.org/W2944147248","https://openalex.org/W2953179193","https://openalex.org/W2960061163","https://openalex.org/W2965263041","https://openalex.org/W2966868171","https://openalex.org/W2977883158","https://openalex.org/W2979016565","https://openalex.org/W2980625861","https://openalex.org/W2990072104","https://openalex.org/W2996366052","https://openalex.org/W3002359424","https://openalex.org/W3012517977","https://openalex.org/W3024417029","https://openalex.org/W3048947757"],"related_works":["https://openalex.org/W2896396308","https://openalex.org/W2094803175","https://openalex.org/W2412164637","https://openalex.org/W7018636687","https://openalex.org/W2566605891","https://openalex.org/W2526754594","https://openalex.org/W7001104353","https://openalex.org/W2756864941","https://openalex.org/W3090279788","https://openalex.org/W2165332817"],"abstract_inverted_index":{"Multiple":[0,566],"sclerosis":[1,582],"(MS)":[2],"is":[3,17,88,230,468,486],"a":[4,25,187,413,444],"chronic":[5],"immune-mediated":[6],"disease":[7,147,167],"of":[8,19,62,71,144,174,198,274,296,321,354,357,377,390,431,447,494,500,533,576],"the":[9,20,63,68,78,96,127,175,180,246,271,280,335,352,382,405,537,653],"central":[10],"nervous":[11],"system":[12],"(CNS).":[13],"Dimethyl":[14],"fumarate":[15,535,578],"(DMF)":[16],"one":[18],"more":[21,165,238],"recent":[22,166],"additions":[23],"to":[24,47,66,90,160,192,213,216,332,459,470,479,629],"rapidly":[26],"expanding":[27],"treatment":[28,118,203,276,329,505,541],"repertoire":[29],"for":[30,37,73,453,473,507,542],"MS.":[31,543],"While":[32],"DMF":[33,72,84,121,215,236,275,293,338,420,442],"has":[34,443],"proven":[35],"beneficial":[36],"relapsing-remitting":[38,580],"MS":[39,74,136,422],"(RRMS)":[40],"patients,":[41,476],"its":[42,53],"clinical":[43,69,189,200,281,466],"profile":[44],"in":[45,138,196,245,277,285,301,309,312,324,344,371,381,388,397,404,579,587,652,658],"relation":[46],"current":[48],"alternatives":[49],"as":[50,52,149,232,536],"well":[51,258,488],"immunological":[54,80,110,272],"effects":[55,70,282,353,460],"are":[56],"less":[57,257,487],"known.":[58],"The":[59,171],"overarching":[60],"aim":[61],"thesis":[64],"was":[65,178,256],"assess":[67],"patients":[75,137,423],"and":[76,85,140,162,202,218,226,240,252,288,303,319,359,366,375,394,400,439,502,539,648,655],"investigate":[77],"underlying":[79,279],"mechanisms.":[81,433],"Since":[82],"both":[83,199,398],"physical":[86,463,641],"exercise":[87,356,642],"known":[89],"elicit":[91],"an":[92,233,482],"antioxidative":[93],"response":[94],"through":[95],"transcription":[97],"factor":[98,100,103],"nuclear":[99],"erythroid":[101],"2-related":[102],"2":[104],"(Nrf2),":[105],"we":[106,115,208,269,283,350],"further":[107],"explored":[108,270],"their":[109],"commonalities.":[111],"In":[112,205,266,315,347,434],"Paper":[113,206,267,286,348],"I,":[114],"showed":[116],"that":[117,179,292,304,337],"discontinuations":[119],"with":[120,125,250,419,456,584],"were":[122,158,326],"lower":[123],"than":[124,260,311,490],"interferons,":[126],"main":[128,172],"existing":[129,450,491],"initial":[130,223,504,538],"drug":[131,243],"choice,":[132],"among":[133,328,449],"newly":[134,474],"diagnosed":[135,475],"Stockholm":[139],"V\u00e4sterbotten":[141],"Counties.":[142],"Risks":[143],"having":[145],"persistent":[146],"activity,":[148],"shown":[150],"by":[151,340,436,462],"relapses":[152],"and/or":[153],"magnetic":[154],"resonance":[155],"imaging":[156],"(MRI),":[157],"similar":[159],"fingolimod":[161,261],"natalizumab;":[163],"two":[164,221],"modulatory":[168],"therapies":[169],"(DMTs).":[170],"finding":[173],"article,":[176],"however,":[177,455],"comparator":[181],"treatment,":[182],"rituximab":[183,501],"(Mabthera\u00ae;":[184],"RTX),":[185],"had":[186,241],"superior":[188,469],"effect":[190,201],"compared":[191,331],"all":[193],"other":[194,503],"DMTs":[195,472],"terms":[197],"discontinuation.":[204],"II,":[207],"used":[209,231,263],"Swedish":[210],"nationwide":[211],"data":[212],"compare":[214],"interferons":[217,251],"glatiramer":[219,253],"acetate,":[220],"common":[222],"DMT":[224,451],"choices,":[225],"fingolimod,":[227],"which":[228],"mainly":[229],"escalation":[234,483],"treatment.":[235],"proved":[237],"effective":[239],"better":[242],"survival":[244],"first":[247],"line":[248],"comparison":[249,418],"acetate":[254],"but":[255,477],"tolerated":[259,489],"when":[262],"second":[264],"line.":[265],"III,":[268],"mechanisms":[273],"humans":[278],"observed":[284,291],"I":[287],"II.":[289,530],"We":[290],"increased":[294],"production":[295],"reactive":[297],"oxygen":[298],"species":[299],"(ROS)":[300],"monocytes":[302,310],"methylation":[305],"changes":[306,387],"occurred":[307],"earlier":[308],"T":[313],"cells.":[314,346],"addition,":[316],"monocyte":[317],"counts":[318],"levels":[320],"oxidized":[322],"fat":[323],"blood":[325],"higher":[327],"responders":[330],"non-responders,":[333],"supporting":[334],"notion":[336],"act":[339],"increasing":[341],"oxidative":[342,440],"burst":[343],"myeloid":[345],"IV,":[349],"investigated":[351],"aerobic":[355],"moderate":[358,406],"high":[360,383],"intensity":[361,384,407],"on":[362,643],"immune":[363,392,427,646],"protein":[364],"markers":[365,393,428,647],"kynurenine":[367,649],"pathway":[368,586,650],"(KP)":[369],"metabolites":[370,396,651],"cerebrospinal":[372],"fluid":[373],"(CSF)":[374],"plasma":[376],"healthy":[378,659],"participants.":[379],"Participants":[380],"group":[385,408],"displayed":[386,409],"concentration":[389],"several":[391],"KP":[395],"CSF":[399],"plasma,":[401],"whereas":[402],"participants":[403],"few":[410,425],"changes,":[411],"suggesting":[412],"dose-response":[414],"relationship.":[415],"A":[416],"separate":[417],"treated":[421],"revealed":[424],"overlapping":[426,432],"despite":[429],"indications":[430],"conclusion,":[435],"affecting":[437],"Nrf2":[438],"burst,":[441],"unique":[445],"mode":[446],"action":[448],"options":[452],"RRMS,":[454],"limited":[457],"overlap":[458],"mediated":[461],"exercise.":[464],"Its":[465],"effectiveness":[467,499,532],"traditional":[471],"inferior":[478],"RTX.":[480],"As":[481],"DMT,":[484],"it":[485],"alternatives.":[492],"List":[493],"scientific":[495],"papers":[496],"I.":[497],"Comparative":[498,531],"choices":[506],"multiple":[508,581],"sclerosis.":[509],"Mathias":[510,544,593,663],"Granqvist,":[511,545,664],"Malin":[512],"Boremalm,":[513],"Amyar":[514],"Poorghobad,":[515],"Anders":[516,558],"Svenningsson,":[517,559],"Jonatan":[518],"Salzer,":[519],"Thomas":[520,562],"Frisell,":[521,563],"Fredrik":[522,564,623,677],"Piehl.":[523,565,624,678],"JAMA":[524],"Neurology.":[525],"2018":[526],"Mar":[527],"1;75(3):320-327.":[528],"https://doi.org/10.1001/jamaneurol.2017.4011":[529],"dimethyl":[534,577],"secondary":[540],"Joachim":[546],"Burman,":[547],"Martin":[548],"Gunnarsson,":[549],"Jan":[550],"Lycke,":[551],"Petra":[552],"Nilsson,":[553],"Tomas":[554,619],"Olsson,":[555,620],"Peter":[556],"Sundstr\u00f6m,":[557],"Magnus":[560],"Vrethem,":[561],"Sclerosis":[567],"Journal.":[568],"2019":[569,634],"Aug":[570],"8:1352458519866600.":[571],"https://doi.org/10.1177/1352458519866600":[572],"III.":[573],"Therapeutic":[574],"efficacy":[575],"associates":[583],"ROS":[585],"monocytes.":[588],"Karl":[589],"Carlstr\u00f6m,":[590],"Ewoud":[591],"Ewing,":[592],"Granqvist*,":[594],"Alexandra":[595],"Gyllenberg*,":[596],"Shahin":[597],"Ainehband,":[598],"Sara":[599],"Lind":[600],"Enoksson,":[601],"Antonio":[602],"Checa,":[603],"Tejaswi":[604],"Badam,":[605],"Jesse":[606,667],"Huang,":[607,668],"David":[608],"Gomez-Cabrero,":[609],"Mika":[610],"Gustafsson,":[611],"Faiez":[612],"Al":[613],"Nimer,":[614],"Craig":[615],"Wheelock,":[616],"Ingrid":[617],"Kockum,":[618],"Maja":[621],"Jagodic,":[622],"*These":[625],"authors":[626],"contributed":[627],"equally":[628],"this":[630],"work.":[631],"Nature":[632],"Communications.":[633],"Jul":[635],"12;10(1):3081.":[636],"https://doi.org/10.1038/s41467-019-11139-3":[637],"IV.":[638],"Effects":[639],"from":[640],"measured":[644],"soluble":[645],"intrathecal":[654],"peripheral":[656],"compartment":[657],"subjects.":[660],"Josef":[661],"Isung,":[662],"Ada":[665],"Trepci,":[666],"Lilly":[669],"Schwieler,":[670],"Marie":[671],"Kierkegaard,":[672],"Sophie":[673],"Erhardt,":[674],"Jussi":[675],"Jokinen,":[676],"[Manuscript]":[679]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2020-08-13T00:00:00"}